Tag: 0-100

Linking the Salmonella enterica 1,2-propanediol utilization bacterial microcompartment shell to the enzymatic core via the shell protein PduB was written by Kennedy, Nolan W.;Mills, Carolyn E.;Abrahamson, Charlotte H.;Archer, Andre G.;Shirman, Sasha;Jewett, Michael C.;Mangan, Niall M.;Tullman-Ercek, Danielle. And the article was included in Journal of Bacteriology in 2022.Product Details of 57-55-6 This article mentions the following:

Bacterial microcompartments (MCPs) are protein-based organelles that house the enzymic machinery for metabolism of niche carbon sources, allowing enteric pathogens to outcompete native microbiota during host colonization. While much progress has been made toward understanding MCP biogenesis, questions still remain regarding the mechanism by which core MCP enzymes are enveloped within the MCP protein shell. Here, we explore the hypothesis that the shell protein PduB is responsible for linking the shell of the 1,2-propanediol utilization (Pdu) MCP from Salmonella enterica serovar Typhimurium LT2 to its enzymic core. Using fluorescent reporters, we demonstrate that all members of the Pdu enzymic core are encapsulated in Pdu MCPs. We also demonstrate that PduB is critical for linking the entire Pdu enzyme core to the MCP shell. Using MCP purifications, transmission electron microscopy, and fluorescence microscopy, we find that shell assembly can be decoupled from the enzymic core, as apparently empty MCPs are formed in Salmonella strains lacking PduB. Mutagenesis studies reveal that PduB is incorporated into the Pdu MCP shell via a conserved, lysine-mediated hydrogen bonding mechanism. Finally, growth assays and system-level pathway modeling reveal that unencapsulated pathway performance is strongly impacted by enzyme concentration, highlighting the importance of minimizing polar effects when conducting these functional assays. Together, these results provide insight into the mechanism of enzyme encapsulation within Pdu MCPs and demonstrate that the process of enzyme encapsulation and shell assembly are sep. processes in this system, a finding that will aid future efforts to understand MCP biogenesis. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Product Details of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Product Details of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New phosphine oxide aziridinyl phosphonates as chiral Lewis bases for the Abramov-type phosphonylation of aldehydes was written by Dogan, Ozdemir;Isci, Muhammet;Aygun, Muhittin. And the article was included in Tetrahedron: Asymmetry in 2013.Safety of (R)-2-Aminobutan-1-ol This article mentions the following:

A series of Lewis bases were screened for Abramov-type phosphine additions to aldehydes. A novel phosphine oxide aziridinyl phosphonate POAP-A was found to be better than the others in forming the product in 96% yield and with 42% ee. The absolute configuration of the newly synthesized POAP Lewis bases was determined by single-crystal X-ray anal. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Safety of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Safety of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sonochemical synthesis and characterization of CuInS₂ nanostructures using new sulfur precursor and their application as photocatalyst for degradation of organic pollutants under simulated sunlight was written by Jafarinejad, Aazam;Bashiri, Hadis;Salavati-Niasari, Masoud. And the article was included in Arabian Journal of Chemistry in 2022.Synthetic Route of C3H8O2 This article mentions the following:

In this research, we investigated the photocatalytic activity of CuInS₂ nanoparticles in visible light during the decomposition of three toxic dyes (Eriochrome Black T, Rhodamine B, and Erythrosine). The CuInS₂ nanostructures were synthesized by a rapid and simple sonochem. method using dithiooxamide as a sulfur reagent and various capping agents, including SDS, CTAB, and PVP, were applied to achieve a pure structure with fine morphol. The flower-like structure was observed through FESEM images, implying different capping agents and fabrication had a considerable influence on the morphol. of samples. The suitable bandgap of CuInS₂ (1.53 eV) was obtained from DRS anal. and resulted in higher photodegradation efficiency. The fabricated CuInS₂ revealed better photodegradation efficiency (74.8%) to the anionic dyes than cationic dye. A possible photodegradation mechanism was suggested based on scavenger tests of active species. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Synthetic Route of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Soil VOC emissions of a Mediterranean woodland are sensitive to shrub invasion was written by Meischner, M.;Haberstroh, S.;Daber, L. E.;Kreuzwieser, J.;Caldeira, M. C.;Schnitzler, J.-P.;Werner, C.. And the article was included in Plant Biology (Berlin, Germany) in 2022.Related Products of 57-55-6 This article mentions the following:

Many belowground processes, such as soil respiration and soil-atm. VOC (volatile organic compounds) exchange, are closely linked to soil microbiol. processes. However, little is known about how changes in plant species cover, i.e. after plant invasion, alter these soil processes. In particular, the response of soil VOC emissions to plant invasion is not well understood. We analyzed soil VOC emissions and soil respiration of a Mediterranean cork oak (Quercus suber) ecosystem, comparing soil VOC emissions from a non-invaded Q. suber woodland to one invaded by the shrub Cistus ladanifer. Soil VOC emissions were determined under controlled conditions using online proton-transfer time-of-flight mass spectrometry. Net soil VOC emissions were measured by exposing soils with or without litter to different temperature and soil moisture conditions. Soil VOC emissions were sensitive to C. ladanifer invasion. Highest net emission rates were determined for oxygenated VOC (acetaldehyde, acetone, methanol, acetic acid), and high temperatures enhanced total VOC emissions. Invasion affected the relative contribution of various VOC. Methanol and acetaldehyde were emitted exclusively from litter and were associated with the non-invaded sites. In contrast, acetone emissions increased in response to shrub presence. Interestingly, low soil moisture enhanced the effect of shrub invasion on VOC emissions. Our results indicate that shrub invasion substantially influences important belowground processes in cork oak ecosystems, in particular soil VOC emissions. High soil moisture is suggested to diminish the invasion effect through a moisture-induced increase in microbial decomposition rates of soil VOC. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Depolymerizable Poly(O-vinyl carbamate-alt-sulfones) as Customizable Macromolecular Scaffolds for Mucosal Drug Delivery was written by Kumar, Kaushlendra;Castano, Eduard Jimenez;Weidner, Andrew R.;Yildirim, Adem;Goodwin, Andrew P.. And the article was included in ACS Macro Letters in 2016.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

Interest in stimulus responsive materials and polymers has grown over the years, having shown great promise in a diverse set of applications. For drug delivery, stimulus-responsive polymers have been shown to encapsulate therapeutics such as small mol. drugs or proteins, deliver them to specific locations in the body, and release them so that they can induce a therapeutic effect in the patient. Most hydrolytically degradable polymers are synthesized via nucleophilic, anionic, or cationic polymerization, which generally requires protection of nucleophilic or protic side chains prior to polymerization Here, we report the synthesis of novel, alternating copolymers of sulfur dioxide and O-vinyl carbamate monomers that boast excellent functional group tolerance and pH-dependent instability. Alternating copolymers were synthesized containing pendant functionalities such as alc., carboxylic acid, ester, and azide without deprotection or postpolymn. modification. The copolymers were then formulated via nanopptn. into polymer nanoparticles capable of encapsulating small mol. dyes. The polymer nanoparticles were found to degrade rapidly at pH > 6 but were stable even in highly acidic conditions. Based on this observation, a proof-of-concept study for mucosal delivery was performed using polymer nanoparticles entrapped in a mucus model. At pH 8, the diffusion of encapsulated dye was found to be similar to free dye, while at pH 5 the diffusion coefficient was an order of magnitude lower. Cell viability was retained at 200 μg/mL particles after 24 h incubation. These polymers thus show promise as customizable scaffolds for mucosal drug delivery. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents was written by Houze, Sandrine;Hoang, Nha-Thu;Lozach, Olivier;Le Bras, Jacques;Meijer, Laurent;Galons, Herve;Demange, Luc. And the article was included in Molecules in 2014.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly proposed anti-malaria targets, are the P. falciparum cyclin-dependent kinases (PfCDKs). There are involved in different stages of the protozoan growth and development but share high sequence homol. with human cyclin-dependent kinases (CDKs). We previously reported the synthesis of CDKs inhibitors that are structurally-related to (R)-roscovitine, a 2,6,9-trisubstituted purine, and they showed activity against neuronal diseases and cancers. In this report, we describe the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains). Six compounds are more potent inhibitors than roscovitine, and three exhibited IC50 values close to 1 μM for both 3D7 and 7G8 strains. Although, such mols. do inhibit P. falciparum growth, they require further studies to improve their selectivity for PfCDKs. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA-binding properties was written by Li, Zhen;Yan, Hui;Chang, Guoliang;Hong, Min;Dou, Jianmin;Niu, Meiju. And the article was included in Journal of Photochemistry and Photobiology, B: Biology in 2016.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

A series of novel copper(II) and nickel(II) complexes derived from chiral Schiff-base ligands [(R)/(S)-H₂L¹ = (R)/(S)-2-[(1-Hydroxymethyl-propylimino)-methyl]-5-methoxy-phenol and (R)/(S)-H₂L² = (R)/(S)-2-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-5-methoxy-phenol], were synthesized and characterized by elemental analyses, ¹H NMR spectra, FTIR spectrum. The crystal structures of 1–5 [Ni₂L₂(OAc)₂(solv)₂] were determined through single crystal x-ray diffraction (SXRD). The structures showed the ligands coordinated to the Cu/Ni(II) ion in a neutral manner via ONO donor atoms, and oxygen atoms of solvent mols. occupy the axial positions in Ni(II) complexes 3 and 4. The complexes interactions with BSA and CT-DNA were investigated by various spectroscopic methods (UV-Visible, CD spectrum, fluorescence spectroscopic and synchronous fluorescence spectra). Interactions of chiral copper(II) complexes are stronger than nickel(II) complexes. Further, the cytotoxicities of 1–6 towards three kinds of cancerous cell lines, were human lung adenocarcinoma (A549), human cervical carcinoma cell (HeLa) and human breast cancer cell (MCF-7), resp., were evaluated by MTT assay. All complexes exhibited good cytotoxic activity. Furthermore, Cu(II) complex 5 derived from (R)-Schiff-base ligand is more effective towards HeLa cancerous cell. Chirality and metal ion have important influence on their anticancer activities and interactions with DNA/BSA. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly regioselective tandem hydroformylation of substituted styrene using Iminophosphine rhodium complex immobilized on carbon was written by Singh, Amravati S.;Jindani, Sana;Ganguly, Bishwajit;Biradar, Ankush V.. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

Reported the sustainable route for the synthesis of ionic carbon from bio-derived sugarcane-waste (Bagasse) and further anchoring with iminophosphine rhodium complex (Rh@BCNP) and utilized for tandem hydroformylation reaction. The SEM anal. confirmed the formation of spherical shape morphol. of carbon with sizes ranging from 30-150 nm. The successful functionalization of the iminophosphine rhodium complex on the carbon surface were determined by XPS, TEM, FE-SEM, ³¹P NMR, ¹³C CP-MAS-NMR and FTIR anal. Furthermore, ICP-OES anal. confirmed the presence of 0.307 mmoles/g of Rh and 0.484 mmoles/g of P on the carbon surface. Rh@BCNP catalyst was the best combination of triphenylphosphine ligand, imine and rhodium metal, resulting in hybrid material with some acidic properties of carbon that favor the selectivity towards linear products. Rh@BCNP showed remarkable catalytic performance under moderate reaction conditions (80°C, 40 bar (CO + H₂)) in 5 h. This sharp divergence from other methods leading to linear amines and acetals results in a novel atom economic approach to synthesize pharmaceuticals and industrial products. The Rh@BCNP catalyst gave recyclability up to five cycles. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biogenesis of a bacterial metabolosome for propanediol utilization was written by Yang, Mengru;Wenner, Nicolas;Dykes, Gregory F.;Li, Yan;Zhu, Xiaojun;Sun, Yaqi;Huang, Fang;Hinton, Jay C. D.;Liu, Lu-Ning. And the article was included in Nature Communications in 2022.Related Products of 57-55-6 This article mentions the following:

Bacterial metabolosomes are a family of protein organelles in bacteria. Elucidating how thousands of proteins self-assemble to form functional metabolosomes is essential for understanding their significance in cellular metabolism and pathogenesis. Here we investigate the de novo biogenesis of propanediol-utilization (Pdu) metabolosomes and characterize the roles of the key constituents in generation and intracellular positioning of functional metabolosomes. Our results demonstrate that the Pdu metabolosome undertakes both “Shell first” and “Cargo first” assembly pathways, unlike the β-carboxysome structural analog which only involves the “Cargo first” strategy. Shell and cargo assemblies occur independently at the cell poles. The internal cargo core is formed through the ordered assembly of multiple enzyme complexes, and exhibits liquid-like properties within the metabolosome architecture. Our findings provide mechanistic insight into the mol. principles driving bacterial metabolosome assembly and expand our understanding of liquid-like organelle biogenesis. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stereodynamic Chemosensor with Selective Circular Dichroism and Fluorescence Readout for in Situ Determination of Absolute Configuration, Enantiomeric Excess, and Concentration of Chiral Compounds was written by Bentley, Keith W.;Wolf, Christian. And the article was included in Journal of the American Chemical Society in 2013.Formula: C4H11NO This article mentions the following:

A stereodynamic chemosensor, 1-(4′-pyridyl)-8-(3′-formyl-4′-hydroxyphenyl)naphthalene N-oxide, having a parallel arrangement of a substrate-binding salicylaldehyde unit and an adjacent pyridyl N-oxide fluorophore undergoes rapid condensation with chiral amino alcs. and subsequent asym. transformation of the 1st kind toward a single rotamer. Crystallog. anal. shows that the concomitant central-to-axial chirality imprinting is controlled by minimization of steric repulsion and by intramol. hydrogen bonding between the bound amino alc. and the proximate N-oxide group. The substrate binding event results in strong CD effects and characteristic fluorescence changes which can be used for instantaneous in situ determination of the absolute configuration, enantiomeric composition and total concentration of a variety of chiral amino alcs. This chemosensing approach avoids time-consuming workup and purification steps, and it is applicable to minute sample amounts which reduces the use of solvents and limits waste production In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Formula: C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts