Alcohols-buliding-blocks

A new synthetic route to chiral 3-aryl-5-ethyl-1,4,2-oxazaphosphorines was written by Metlushka, Kirill E.;Sadkova, Dilyara N.;Nikitina, Kristina A.;Yamaleeva, Zilya R.;Ivshin, Kamil A.;Kataeva, Olga N.;Alfonsov, Vladimir A.. And the article was included in Mendeleev Communications in 2018.Application of 5856-63-3 This article mentions the following:

Diastereoselective synthesis of racemic and enantiopure 3-aryl-5-ethyl-1,4,2-oxazaphosphorines, including those bearing phenolic hydroxyl groups in the exocyclic aromatic fragment, was implemented by the reaction of imines derived from (±)-and (R)-(-)-2-aminobutan-1-ol and (hydroxy)benzaldehydes with tri-Et phosphite and trifluoroacetic acid, followed by the one-pot dealkylation of the intermediate esters. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast. was written by Pickar, James H;Komm, Barry S. And the article was included in Post reproductive health in 2015.Electric Literature of C24H23ClO2 This article mentions the following:

Traditional menopausal hormone therapy containing estrogens/progestin has been associated with an increased risk of breast cancer, and estrogen exposure is known to promote growth and proliferation of a majority of breast cancers. Therefore, it is important for clinicians to consider the breast safety profile of any hormone-based therapy used in postmenopausal women. This review provides an overview of the breast safety and tolerability profiles of currently marketed selective estrogen receptor modulators, antiestrogens, and the first tissue selective estrogen complex combining conjugated estrogens with the selective estrogen receptor modulator bazedoxifene in postmenopausal women. Selective estrogen receptor modulators and antiestrogens act as estrogen receptor antagonists in the breast. Tamoxifen, toremifene, and the selective estrogen receptor degrader fulvestrant are used to treat breast cancer, and tamoxifen and raloxifene protect against breast cancer in high-risk women. Postmenopausal women using selective estrogen receptor modulators for prevention or treatment of osteoporosis (raloxifene, bazedoxifene) can be reassured that these hormonal treatments do not adversely affect their risk of breast cancer and may, in the case of raloxifene, even be protective. There are limited data on breast cancer in women who use ospemifene for dyspareunia. Conjugated estrogens/bazedoxifene use for up to two years did not increase mammographic breast density or breast pain/tenderness, and there was no evidence of an increased risk of breast cancer, suggesting that conjugated estrogens/bazedoxifene has an improved breast safety profile compared with traditional menopausal hormone therapies. Future research will continue to focus on development of selective estrogen receptor modulators and selective estrogen receptor modulator combinations capable of achieving the ideal balance of estrogen receptor agonist and antagonist effects. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Electric Literature of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reductive Catalytic Fractionation of Wheat Straw Biomass was written by Brienza, Filippo;Van Aelst, Korneel;Devred, Francois;Magnin, Delphine;Sels, Bert F.;Gerin, Patrick A.;Cybulska, Iwona;Debecker, Damien P.. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Quality Control of 1,2-Propanediol This article mentions the following:

The reductive catalytic fractionation (RCF) is a promising method for the development of “lignin-first” biorefineries. Apart from the widely investigated virgin woody biomass, it is essential to explore the potential of waste biomass feedstocks. Herein, the RCF of wheat straw is examined to produce lignin mono-/oligomers along with a processable carbohydrate pulp. The use of different catalysts (Ru/C and Ru/Al₂O₃) and catalyst loadings (0-20% weight/weight_biomass) revealed the superior performance of Ru/C, which resulted in the largest yield of phenolic monomers (up to ~25 wt % of initial acid-insoluble lignin) and in the lowest formation of high-mol.-weight fragments in the extracted lignin oil. Furthermore, the operating temperature was shown to substantially affect both lignin extraction-depolymerization and polysaccharides preservation-processability. For a reaction time of 3 h, an increase of the temperature from 200 to 250°C resulted in a >2-fold boost of the yields of lignin oil and monophenolics, while the recovery of polysaccharides decreased by about 30 weight % (with ~20% lower enzymic digestibility). An economic assessment highlighted that the high-temperature treatment becomes the most profitable configuration as the market price of lignin products increases. Overall, this work provides insight into the adoption of the RCF for the upgrading of lignocellulose from inexpensive and widely available wheat straw biomass. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Quality Control of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones was written by Yu, Jianfei;Duan, Meng;Wu, Weilong;Qi, Xiaotian;Xue, Peng;Lan, Yu;Dong, Xiu-Qin;Zhang, Xumu. And the article was included in Chemistry – A European Journal in 2017.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

We have successfully developed a series of novel and modular ferrocene-based amino-phosphine-alc. (f-Amphol) ligands and applied them to iridium-catalyzed asym. hydrogenation of various simple ketones to afford the corresponding chiral alcs. with excellent enantioselectivities and conversions (98-99.9 % ee, >99 % conversion, turnover number up to 200,000). Control experiments and d. functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asym. hydrogenation. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

TiO₂ supported-reduced graphene oxide co-doped with gallium and sulfur as an efficient heterogeneous catalyst for the selective photochemical oxidation of alcohols; DFT and mechanism insights was written by Khavar, Amir Hossein Cheshme;Khazaee, Zeynab;Mahjoub, Ali Reza;Nejat, Razieh. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Product Details of 873-76-7 This article mentions the following:

Achieving organic transformation reactions using green synthesis methods under mild conditions is always an aspiration of scientists. In this study, Ga, S co-doped TiO₂/reduced graphene oxide (GaxSy@TRG) nanocomposite was synthesized by an innovative surfactant-free ultrasonic-assisted solvothermal method and used to catalyze the selective photocatalytic oxidation of benzyl alc. under visible light irradiation The prepared photocatalyst was analyzed via XRD, FT-IR, Raman, N₂ adsorption-desorption, SEM, TEM, EDX, ICP-MS, UV-Vis absorption, and electrochem. impedance spectroscopy (EIS) measurement. The characterization outcomes indicated the prepared co-doped TiO₂ nanoparticles with anatase crystal structure possessed a mesoporous texture and were uniformly distributed on the RGO surface. The conversion of GO to RGO was confirmed through FT-IR and Raman spectra. The prepared nanocomposites were examined for their ability in artificial photocatalysis and displayed remarkable catalytic activity for the selective oxidation of alcs. into benzaldehyde. The co-doped catalysts showed significantly enhanced photocatalytic ability, due to improved photogenerated electrons transfer, enhanced charge carriers separation and extended optical absorption to the visible light range. Moreover, the synergistic effect of dopants that could act as electron trapping centers and RGO as a powerful acceptor material efficiently reduced photogenerated electron-hole recombination and promoted charge migration. A high conversion rate of 85% was obtained over the Ga_5.0S_10.0@TRG photocatalyst after 110 min under visible light irradiation The results from d. functional theory (DFT) calculations revealed that the hybridization of Ga 4s and S 3p orbitals with valance band can remarkably affect the decreasing of band gap energy. The mechanism of photocatalytic oxidation of benzyl alc. under visible light irradiation was proposed using the combination of exptl. and computational methods. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Product Details of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases was written by Vymetalova, Ladislava;Havlicek, Libor;Sturc, Antonin;Skraskova, Zuzana;Jorda, Radek;Pospisil, Tomas;Strnad, Miroslav;Krystof, Vladimir. And the article was included in European Journal of Medicinal Chemistry in 2016.Related Products of 5856-63-3 This article mentions the following:

A series of 5-substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives was synthesized and evaluated for their cyclin-dependent kinase (CDK) inhibition activity. The most potent compounds contained various hydroxyalkylamines at the 5 position and possessed low nanomolar IC₅₀ values for CDK2 and CDK5. Preliminary profiling of one of the most active compounds on a panel of 50 protein kinases revealed its high selectivity for CDKs. The compounds arrested cells in S and G2/M phases, and induced apoptosis in various cancer cell lines. Significant dephosphorylation of the C-terminus of RNA polymerase II and focal adhesion kinase (FAK), well-established substrates of CDKs, has been found in treated cells. Cleavage of PARP-1, down-regulation of Mcl-1 and activation of caspases correlated well with CDK inhibition and confirmed apoptosis as the primary type of cell death induced in cancer cells treated with the compounds in vitro. A comparison of known purine-based CDK inhibitor CR8 with its pyrazolo[4,3-d]pyrimidine bioisosteres confirmed that the novel compounds are more potent in cellular assays than purines. Therefore, pyrazolo[4,3-d]pyrimidine may emerge as a novel scaffold in medicinal chem. and as a source of potent CDK inhibitors. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Related Products of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An environmentally-friendly one-pot synthesis of 4-sulfonyl benzoic acids was written by Frieman, Bryan A.. And the article was included in Tetrahedron Letters in 2014.SDS of cas: 29364-29-2 This article mentions the following:

This Letter reported an environmentally-friendly one-pot S_NAr reaction of thiols to 4-halobenzoic acid Me esters to provide 4-substituted sulfone benzoic acids and picolinic acids after bleach-mediated oxidative workup. These acid intermediates were synthesized on gram scale, are perfect partners for library synthesis, and have good phys. chem. properties useful for drug discovery. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2SDS of cas: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nuclear magnetic resonance chemical shifts for alcoholic and phenolic protons in dimethyl sulfoxide. Utility as a structural parameter was written by Murakami, Yukito;Sunamoto, Junzo. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1973.Electric Literature of C7H9NO This article mentions the following:

The temperature dependent OH resonances in the NMR spectra of pyridyl alcs. and phenols, determined in Me2SO, were explained by intermol. and intramol. H bonding. The correlation between δOH and pKHA of the corresponding phosphates proved the reliability of δOH as a structural parameter for a linear free energy relation study of phosphate hydrolysis. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Electric Literature of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C7H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Attenuation of isoprenaline-induced myocardial infarction by Rheum turkestanicum was written by Hossini, Azar;Rajabian, Arezoo;Sobhanifar, Mohammad-Ali;Alavi, Mohaddeseh Sadat;Taghipour, Zahra;Hasanpour, Maede;Iranshahi, Mehrdad;Boroumand-Noughabi, Samaneh;Banach, Maciej;Sahebkar, Amirhossein. And the article was included in Biomedicine & Pharmacotherapy in 2022.Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Oxidative stress plays a major role in the pathogenesis of myocardial infarction. This study evaluated the cardioprotective effects of the hydroalcoholic extract of Rheum turkestanicum on isoprenaline-induced myocardial infarction (MI) in Wistar rats. In this study, we used liquid chromatog.-mass spectrometry to determine the active compounds present in the extract Thirty rats were divided to 5 groups (6 rats in each group). The extract was administered orally at the doses of 100 and 300 mg/kg body weight and then a s.c. injection of isoprenaline (85 mg/kg) was administered on the 8th and 9th days. Serum levels of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and creatinine kinase (CPK) were measured using standard com. kits. Serum activities of superoxide dismutase, catalase, and cardiac levels of thiol and lipid peroxidation were also determined Hematoxylin and eosin were used for histopathol. staining. Phytochem. anal. revealed the presence of 24 compounds in the hydro-ethanolic extract of R. turkestanicum. Isoprenaline increased malondialdehyde (4.002 ± 0178, P < 0.001) while decreased thiol content (101.7 ± 6.186, P < 0.001). Moreover, reduced activities of superoxide dismutase (139 ± 10.88, P < 0.001) and catalase (2.812 ± 0.215, P < 0.001), and elevated levels of LDH (1245 ± 62.28, P < 0.001), CPK (898 ± 23.06, P < 0.001) and CK-MB (697 ± 50.22, P < 0.001) were observed Pretreatment with the R. turkestanicum extract significantly reduced cardiac markers and increased thiol content as well as the activity of antioxidant enzymes. The extract attenuated the histopathol. changes induced by isoprenaline. According to the obtained results, R. turkestanicum may be an appropriate candidate to reduce isoprenaline-induced MI through modulation of oxidative stress. Administration of the extract attenuated cardiac enzymes following isoprenaline administration. The cardioprotective action of the extract can be attributed to the bioactive antioxidant ingredients of R. turkestanicum. To identify the precise mechanisms, further investigations are required.ga1 In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on the Effect of Mentha x piperita L. Essential Oil on Electroencephalography upon Stimulation with Different Visual Effects was written by Lin, Shifan;Wang, Yue;Wu, Kaiwen;Yu, Genfa;Liu, Chuanxiang;Su, Chang;Yi, Fengping. And the article was included in Molecules in 2022.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Essential oils have long been used to fight infections and treat various diseases. Peppermint (Mentha x piperita L.) is an herbal medicine that has been widely used in daily life since ancient times, and it has a wide range of applications in food, cosmetics, and medicine. Mint oil is refreshing because of its cool and comfortable smell; therefore, it is often used in ethnopharmacol. studies. The present study investigated the effects of peppermint essential oil in electroencephalog. activity response to various visual stimuli. The electroencephalog. changes of participants during peppermint essential oil inhalation under white, red, and blue color stimulations were recorded. A rapid Fourier transform anal. was used to examine the electroencephalograph power spectra of the various microstates induced by inhaling the oils. Peppermint essential oil had various effects on the brain when subjected to different visual stimuli. Alpha waves increased in the prefrontal area in the white-sniffing group, which facilitated learning and thinking. In the blue-sniffing group, the changes were less pronounced than those in the red group, and the increased alpha wave activity in the occipital area was more controlled, indicating that the participants’ visual function increased in this state. Based on EEG investigations, this is the first study to indicate that vision influences the effects of peppermint essential oils. Hence, the results of this study support the use of essential oils in a broader context to serve as a resource for future studies on the effects of different types of essential oils. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts