Alcohols-buliding-blocks

Cytostatic activity of some novel amidocarbamate derivatives of ketoprofen was written by Sahoo, Prasanta Kumar;Behera, Pritishova. And the article was included in Journal of Cancer Therapy in 2010.HPLC of Formula: 59960-32-6 This article mentions the following:

A series of novel ketoprofen derivatives bearing both amide and carbamate functionalities were prepared using benzotriazole. Selective reduction of ketoprofen produced 3-(HOCHPh)C₆H₄CHMeCO₂H, which reacts with one or two moles of 1-benzotriazolecarboxylic acid chloride to give the mono- and bis(benzotriazole) derivatives, the latter being aminated to give the title products. Antioxidative screenings revealed that the prepared compounds possess excellent lipid peroxidation inhibition at 0.1 mM concentration 3-(RCO₂CHPh)C₆H₄CHMeCOR [R = 1-benzotriazolyl, NHCH₂Ph] also showed high soybean lipoxygenase inhibition activity, whereas the amidocarbamate derivatives of ketoprofen showed only weak reducing activity against 1,1-diphenyl-2-picrylhydrazyl radicals. No selective effects were noted for the tested compounds against a broad variety of DNA and RNA viruses. The majority of the compounds show IC₅₀ values around 10-25 μM, pointing to a relatively minor role of the R substituents on the core structure for cytostatic activity, as long as a bulky lipophilic (cyclic) entity is present. Also, the presence of the amide groups might play an important role to eventually exert cytostatic potential. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6HPLC of Formula: 59960-32-6).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 59960-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stable Dye-Sensitized Solar Cells Based on Copper(II/I) Redox Mediators Bearing a Pentadentate Ligand was written by Rui, Hailong;Shen, Junyu;Yu, Ze;Li, Lihua;Han, Hongxian;Sun, Licheng. And the article was included in Angewandte Chemie, International Edition in 2021.HPLC of Formula: 1122-71-0 This article mentions the following:

In recent years, copper redox mediators have attracted growing interest in dye-sensitized solar cells (DSCs). However, experiments revealed that ubiquitously used Lewis-base additives in the electrolytes coordinate to the CuII species, which restricts further enhancement of device performance and stability. We report the application of copper complexes endowed with diamine-tripyridine pentadentate ligands, [Cu(tpe)]^2+/+ (tpe=N-benzyl-N,N,N-tris(pyridin-2-ylmethyl)ethylenediamine) and [Cu(tme)]^2+/+ (tme=N-benzyl-N,N,N-tris(6-methylpyridin-2-ylmethyl)ethylenediamine), as redox mediators in DSCs. Exptl. measurements demonstrate that the coordination environment of Cu(II) complexes with pentadentate ligands remains unchanged in the presence of TBP, which is in stark contrast to the state-of-the-art bipyridyl counterpart. DSCs based on [Cu(tme)]^2+/+ complexes exhibit an excellent long-term stability and maintain more than 90 % of the initial efficiency after 400 h under continuous illumination, which outperform the reference devices incorporating the bipyridyl counterpart (less than 80 %) under identical conditions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0HPLC of Formula: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of aroma characteristics in grass carp mince as affected by different washing processes using an E-nose, HS-SPME-GC-MS, HS-GC-IMS, and sensory analysis was written by Xiao, Naiyong;Xu, Huiya;Jiang, Xin;Sun, Tongtong;Luo, Yixuan;Shi, Wenzheng. And the article was included in Food Research International in 2022.Recommanded Product: Oct-1-en-3-ol This article mentions the following:

The aroma characteristics of grass carp mince washed in four processes were analyzed via electronic nose (E-nose), headspace solid-phase microextraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS), headspace gas chromatog.-ion mobility spectrometry (HS-GC-IMS), and sensory anal. techniques. Significant differences were revealed in the E-nose and sensory anal. results of the aroma characteristics of grass carp mince samples washed via different washing processes, while fifty-seven volatile compounds (thirteen aldehydes, eighteen alcs., two ketones, eighteen hydrocarbons, two aromatic compounds, one furan, and two other compounds) and twenty volatile compounds (five aldehydes, four ketones, six alcs., four esters, and one acid) were identified via HS-SPME-GC-MS and HS-GC-IMS of the Raw and washed grass carp mince samples, resp. All these techniques revealed that the types and relative contents of volatile compounds in the grass carp mince decreased significantly and differently after each of the four washing processes. Moreover, compared with the water and saline solution washing processes, washing with weak alk. solution processes exhibited the most significant removal effect on the volatile compounds of grass carp mince. Besides, the sensory anal. results also showed that weak alk. solution washing processes (washing twice with pure water and once with 0.3% sodium bicarbonate solution) may be most effective in removing fishy off-odor compounds and contributing to a better overall aroma profile in grass carp mince. The findings of this study may provide some basic knowledge for the rational screening of washing methods in the production of high-quality grass carp surimi. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Recommanded Product: Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic hydrosilylation of carbonyl compounds by hydrido thiophenolato iron(II) complexes was written by Xue, Benjing;Sun, Hongjian;Niu, Qingfen;Li, Xiaoyan;Fuhr, Olaf;Fenske, Dieter. And the article was included in Catalysis Communications in 2017.Computed Properties of C7H6Cl2O This article mentions the following:

The hydrosilylation of aldehydes RCHO (R = C₆H₅, 4-ClC₆H₅, furan-2-yl, etc.) and ketones R¹C(O)R² (R¹ = C₆H₅, R² = CH₃; R¹ = naphthalen-2-yl, R² = CH₃; R¹R² = -(CH₂)₅-) under mild conditions with hydrido thiophenolato iron(II) complexes I (R³ = H, 2-Si(CH₃)₃, 3-OCH₃, 4-CH₃) as catalysts and (EtO)₃SiH as an efficient reducing agent in the yields up to 95% has been reported. Among them complex I (R³ = H) is the best catalyst. Complex I (R³ = H) could also be used as catalyst to reduce the α,β-unsaturated carbonyl compounds, e.g., 3-phenylprop-2-ynal selectively to the α,β-unsaturated alcs., e.g., 3-phenylprop-2-yn-1-ol in high yields. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Computed Properties of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron(III) trifluoroacetate [Fe(O₂CCF₃)₃] catalyzed epoxide opening with amines was written by Erturk, Erkan;Demir, Ayhan S.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2008.Recommanded Product: Trans-2-(benzylamino)cyclohexanol This article mentions the following:

Non-hygroscopic, non-toxic, and readily available iron(III) trifluoroacetate [Fe(O₂CCF₃)₃] was found to be a highly regioselective catalyst for the ring opening of a wide variety of epoxides with diverse amines under solvent-free conditions. The stereospecific ring opening of (R)-styrene oxide with p-anisidine in the presence of 1 mol% of Fe(O₂CCF₃)₃ gave 2-(p-methoxyphenylamino)-2-phenylethanol (5b) in enantiopure form (>99% ee) within 60 min. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Recommanded Product: Trans-2-(benzylamino)cyclohexanol).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: Trans-2-(benzylamino)cyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron-catalyzed asymmetric hydrosilylation of ketones was written by Zuo, Ziqing;Zhang, Lei;Leng, Xuebing;Huang, Zheng. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Recommanded Product: 120121-01-9 This article mentions the following:

A series of iron complexes of chiral iminopyridine-oxazoline (IPO) ligands were synthesized. The most sterically hindered iron catalyst exhibits excellent activity (up to 99% yield) and high enantioselectivity (up to 93% ee) in asym. hydrosilylation of aryl ketones. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Unsymmetrical 1,1-diborated multisubstituted sp³-carbons formed via a metal-free concerted-asynchronous mechanism was written by Cuenca, Ana B.;Cid, Jessica;Garcia-Lopez, Diego;Carbo, Jorge J.;Fernandez, Elena. And the article was included in Organic & Biomolecular Chemistry in 2015.Recommanded Product: 1214264-88-6 This article mentions the following:

Authors have exptl. proved the unsym. 1,1-diboration of diazo compounds, formed in situ from aldehydes and cyclic and non-cyclic ketones, in the absence of any transition metal complex. The heterolytic cleavage of the mixed diboron reagent, Bpin-Bdan, and the formation of two geminal C-Bpin and C-Bdan bonds has been rationalized based on DFT calculations to occur via a concerted-asynchronous mechanism. Diastereoselection is attained on substituted cyclohexanones and DFT studies provide understanding on the origin of the selectivity. The alkoxide-assisted selective deborylation of Bpin from multisubstituted sp³-carbon and generation of a Bdan stabilized carbanion, easily conducts a selective protodeboronation sequence. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Recommanded Product: 1214264-88-6).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 1214264-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The formulation and physicochemical properties of betaine-based natural deep eutectic solvent was written by Mohd Fuad, Faiznur;Mohd Nadzir, Masrina. And the article was included in Journal of Molecular Liquids in 2022.Quality Control of 1,2-Propanediol This article mentions the following:

Eleven different types of natural deep eutectic solvent (NADES) were synthesized using betaine (Bet) as a hydrogen bond acceptor (HBA) with glycerol (Gly), 1,2-propanediol (1,2P), lactic acid (LA), levulinic acid (Lev), anhydrous citric acid (CA), malic acid (MA), tartaric acid (TA), xylitol (Xyl), sorbitol (Sor), glucose (Glu), and sucrose (Suc) as the hydrogen bond donors (HBD). They were synthesized at different molar ratios (3:1, 2:1, 1:1, 1:2, 1:3) to determine their appropriate formulation. Formulations that gave a clear, homogenous liquid were identified as Bet-Gly (1:2), Bet-1,2P (1:4), Bet-LA (1:2), Bet-Lev (1:2), Bet-CA (1:1, 20% weight/weight water), Bet-MA (1:1, 20% weight/weight water), Bet-TA (1:1, 20% weight/weight water), Bet-Xyl (1:2, 20% weight/weight water), Bet-Sor (1:2, 20% weight/weight water), Bet-Glu (1:1, 20% weight/weight water), and Bet-Suc (1:1, 20% weight/weight water). The successfully synthesized NADESs remained as stable liquids for more than 30 days. Based on the anal. using Fourier transform IR (FTIR) spectroscopy, it was confirmed that a hydrogen bonding interaction was established between the HBA and the HBD in the NADES system. In addition, the thermal stabilities of these NADESs were evaluated through a thermogravimetry anal. (TGA). The onset decomposition temperatures of the NADESs were in the range of 106.92°C-233.66°C. Furthermore, the NADESs were evaluated for their physicochem. properties, including viscosity, d., polarity, surface tension, elec. conductivity, and pH. The NADESs were often diluted with water to reduce viscosity during their application. Therefore, the influence of the addition of water on the physicochem. properties of NADESs was evaluated. This knowledge provides an in-depth understanding of the characteristics and behavior of the NADESs during any process. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Quality Control of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fragmentation of Fiber-like Micelles with a π-Conjugated Crystalline Oligo(p-phenylenevinylene) Core and a Photocleavable Corona in Water: A Matter of Density of Corona-Forming Chains was written by Ma, Chen;Tao, Daliao;Cui, Yinan;Huang, Xiaoyu;Lu, Guolin;Feng, Chun. And the article was included in Macromolecules (Washington, DC, United States) in 2020.Electric Literature of C7H7NO4 This article mentions the following:

Although fiber-like micelles with a crystalline core prepared by living crystallization-driven self-assembly show promising applications in biomedicine, undesirable fragmentation of fiber-like micelles in water usually occurs, which is a frustrating hindrance toward the exploration of their applications. To deepen our understanding on the fragmentation of fiber-like micelles with a crystalline core, we herein developed a strategy to prepare uniform fiber-like micelles with tunable densities of corona-forming chains and systematically examined the influence of the d. of corona-forming chains on the resistance toward micellar fragmentation in water. A block copolymer consisting of a crystalline oligo(p-phenylenevinylene) (OPV₅) segment, a hydrophilic poly(N-isopropylacrylamide) (PNIPAM₄₀) block, and a photocleavable o-nitrobenzyl (ONB) junction (OPV₅-ONB-b-PNIPAM₄₀, the subscripts represent the (mean) number of repeat unit of each block) was first synthesized. Subsequently, uniform fiber-like micelles with an L_n of 396 nm composed of an OPV core and PNIPAM corona chains were prepared by the self-seeding approach. By taking advantage of photocleavable ONB junctions and varying UV irradiation time, uniform fiber-like micelles with different densities of PNIPAM chains tethered on the surface of micelles were obtained in ethanol. By employing these fiber-like micelles as a model, the influence of d. of PNIPAM chains on the resistance toward fragmentation of micelles in water was investigated. The results showed that pristine micelles without removal of corona chains significantly fragmented with the decrease of length from about 396 to 134 nm in water, whereas micellar fragmentation could be effectively retarded by decreasing the grafting d. of the PNIPAM corona-forming block. For the micelles with the removal of about 73% of PNIPAM chains, almost no micellar fragmentation was observed after aging in water for 15 days. By taking advantage of the structural similarities existing between bottom-brush polymers and fiber-like micelles with a crystalline core, we proposed that as the d. of PNIPAM chains decreased, more space would be provided for remaining PNIPAM chains to adjust their conformation. Consequently, the tension on the OPV core induced by the stress of corona layers of PNIPAM chains decreased. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Occupational methacrylate and acrylate allergy from glues was written by Aalto-Korte, Kristiina;Alanko, Kristiina;Kuuliala, Outi;Jolanki, Riitta. And the article was included in Contact Dermatitis in 2008.Formula: C10H14O5 This article mentions the following:

Background: Glues and sealants are important causes of methacrylate and acrylate allergy. Aim: This study aimed to analyze patterns of allergic patch test reactions to acrylic monomers in relation to exposure in patients sensitized from glues. Patients/Methods: We screened the patch test files at the Finnish Institute of Occupational Health from 1994 to 2006 for allergic reactions in the “Methacrylate series” and analyzed the clin. records of sensitized patients. Only patients who had handled acrylic glues at work here included. Results: 10 patients had allergic reactions to acrylic monomers and had been sensitized from glues at work. Nine of them had used anaerobic sealants, 3 cyanoacrylate-based instant adhesives, and 1 patient a bi-component instant adhesive. All the patients reached to 2-hydroxyethyl methacrylate (2-HEMA) and ethyleneglycol dimethacrylate (EGDMA); reactions to 2-hydroxypropyl methacrylate, triethyleneglycol dimethacrylate, and tetrahydrofurfuryl methacrylate were also common. The first 4 methacrylates were found in the glues used by the patients. Et cyanoacrylate (ECA) gave no reactions, but 1 patient reacted weakly to her own ECA-based glue. Conclusion: 2-HEMA and EGDMA are good screeners for contact allergy to anaerobic sealants and also detected a single case deriving from bi-component acrylic glue. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts