Alcohols-buliding-blocks

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 722-92-9

Step A: 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol To a stirred solution of copper(II) bromide (1.293 g, 5.79 mmol) in acetonitrile (15 mL) was added tert-butyl nitrite (0.764 mL, 5.79 mmol) in one portion at 60¡ã C. A solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1 g, 3.86 mmol) in acetonitrile (3 mL) was then added dropwise at 60¡ã C. After stirring for 15 min at 60¡ã C., the mixture was concentrated. The residue was diluted with water (20 mL) and extracted with EtOAc (10 mL, 2*4 mL). The combined organic solutions were dried over anhydrous sodium sulfate and concentrated. Flash chromatography purification using (24 g silica gel column, gradient elution from 0 to 30percent of ethyl acetate in hexanes) afforded 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1.3 g, 4.02 mmol, 104percent yield) as a liquid.

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; Duan, Jingwu; Dhar, T. G. Murali; Jiang, Bin; Lu, Zhonghui; Xiao, Hai-Yun; US2015/191483; (2015); A1;,
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3597-91-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a mixture of alcohol (1 mmol) and KBr (1.5 mmol, 0.18 g) in acetonitrile (5 mL), P2O5 (1.5 mmol, 0.23 g) was added and the reaction was stirred at room temperature for the time specified in Table 3. After reaction completion (TLC or GC), the reaction mixture was filtered and the residue washed with ethyl acetate (3 ¡Á 8 mL). The combined organic layers were washed with water (10 mL) and dried over Na2SO4. The solvent was removed under reduced pressure to afford the corresponding product. If necessary, further purification was performed by column chromatography.

The chemical industry reduces the impact on the environment during synthesis 3597-91-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Khazdooz, Leila; Zarei, Amin; Aghaei, Hamidreza; Azizi, Ghobad; Gheisari, Mohammad Mehdi; Tetrahedron Letters; vol. 57; 2; (2016); p. 168 – 171;,
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109-83-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N-Methylethanolamine (2.0 g, 26.63 mmol) was added to a solution of sodium methoxide (1.44 g, 26.63 mmol, 6.0 mL of a 25% w/v solution in methanol) and ether (30 mL) with stirring at 25 C. The flask was evacuated and then charged with nitric oxide (NO) (40 psi internal pressure) and stirred at 25 C for 24 hrs. The product was isolated by filtration and then suspended in ether (30 mL) and stirred for 15 min. The suspension was filtered, collected and dried at 25 C under reduced pressure to give (NS-06) as a white fine powder (2.72 g, 65% yield). 1H NMR (400 MHz, D20) delta 3.42-3.40 (m, 2H), 2.95-2.92 (m, 2H), 2.63 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SARMONT LLC; MARTINEZ, Eduardo J.; TALLEY, John J.; JEROME, Kevin D.; BOEHM, Terri L.; WO2015/108835; (2015); A1;,
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4654-39-1, Adding some certain compound to certain chemical reactions, such as: 4654-39-1, name is 2-(4-Bromophenyl)ethanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4654-39-1.

EXAMPLE 10 This example demonstrates the preparation of 2-AMINO-2- [2- (2 , 3′, 4′- trimethoxybiphenyl-4-yl) ETHYL]-1, 3-propanediol hydrochloride. (10-1) PREPARATION OF 2- (4-BROMOPHENYL) ETHYL IODIDE Methanesulfonylchloride (11.5 ml) was added to a solution of 2- (4- BROMOPHENYL) ethylalcohol (25.0 G) and triethylamine (22.6 ml) in dichloromethane (250 ml) at 0 C. The resulting suspension was stirred at room temperature for 2 hours. The reaction mixture was washed with brine and dried over sodium sulfate and concentrated in vacuo to yield a red oil (39. 1 g). Sodium iodide (18.6 g) was added to a solution of methanesulfonate in 2-butanone (400 ml), and the resulting suspension was heated under reflux for 4.5 hours. The reaction mixture was diluted with ethyl acetate and washed with water, 10% aqueous sodium thiosulfate, and brine. The organic layer was dried over sodium sulfate and concentrated in vacuo. Purification by silica-gel column chromatography using hexane/ethyl acetate 30: 1 gave the title compound (34.2 g) as a colorless oil.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4654-39-1.

Reference:
Patent; Mitsubishi Pharma Corporation; WO2005/14525; (2005); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1736-74-9, name is 4-(Trifluoromethoxy)benzyl alcohol, molecular formula is C8H7F3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 1736-74-9

General procedure: To a stirred solution of alcohol 2 (1 mmol) in dry ether (10 mL)was added phosphorus tribromide (0.5 mL) dropwise at 0 C and the reaction mixture was stirred for 0.5 h. After completion of thereaction (TLC monitoring), the reaction mixture was carefullypoured over ice, and the aqueous phase was extracted with ether.The combined organic layers werewashed with NaHCO3 and water,followed by brine. Drying over Na2SO4 and evaporation of thesolvents under reduced pressure affords the desired benzyl bromide3 which was used without further purification.

The chemical industry reduces the impact on the environment during synthesis 1736-74-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Sri Ramya; Angapelly, Srinivas; Guntuku, Lalita; Singh Digwal, Chander; Nagendra Babu, Bathini; Naidu; Kamal, Ahmed; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 100 – 114;,
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349-75-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10.1 Ethyl 6-trimethylsilyl-1-[[(3-trifluoromethyl)phenyl]methyl]-1H-indole-2-carboxylate 0.52 ml (3.83 mmol) of 3-(trifluoromethyl)phenylmethanol and 0.92 g (3.83 mmol) of (cyanomethylene)tributylphosphorane (CMBP) are added, at ambient temperature, to a solution of 0.5 g (1.91 mmol) of ethyl 6-trimethylsilyl-1H-indole-2-carboxylate, obtained according to the protocol described in stage 1.2, in 8 ml of dry toluene, maintained under an inert atmosphere. The reaction mixture is stirred at 110 C. for 15 hours and then concentrated to dryness. The reaction crude is subsequently purified by successive rounds of flash chromatography on a silica gel column, to give 0.72 g of expected ethyl 6-trimethylsilyl-1-[[(3-trifluoromethyl)phenyl]methyl]-1H-indole-2-carboxylate in the form of an oil. 1H NMR (DMSO D6), delta (ppm): 7.49-7.45 (m, 2H); 7.36-7.33 (m, 2H); 7.25 (t, 1H); 7.12 (s, 1H); 7.04-7.00 (m, 2H); 5.73 (s, 2H); 4.04 (q, 2H); 1.03 (t, 3H); 0.00 (s, 9H). LC-MS: 420 ([M+H]+, Rt=3.57).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-75-7, (3-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI-AVENTIS; US2011/9365; (2011); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 23377-40-4, blongs to alcohols-buliding-blocks compound. 23377-40-4

3-(Hexadecyloxy)propan-1-ol was synthesized in one step according to the method ofYamano, Y. et al., Biorg. Med. Chem. (2012) 20:3658-3665 and recrystallized from hexane. The crystalline product (200mg, 0.67mmol) was dissolved in dry CH2C12 and diisopropylethylamine (0.70 mL, 2.68 mmol, 4 equiv) was added while stirring at RT. 2- Cyanoethyloxy(N,N-diisopropylamino) phosphonamidic chloride (0. l8mL, 0.8mmol, 1.2 eq) was added dropwise and the solution was stirred for 45mm. After completion lSmL of CH2C12 were added and the organic phase was washed with saturated aqueous NaHCO3 anddried over MgSO4. The crude product was purified on a silica column with Hex:EtOAc:NEt350:50:1 as eluent to afford the title compound as a colorless liquid (175mg, 52% yield). Rf inEtOAc =0.28. MS (ESI): found 501 (M+H); mass expected for (C28H57N203P + H = 501.4).?H NMR (400 MHz, CDC13) 0.89 (t, J=6.85 Hz, 3H, CH3CH2) 1.19 (dd, J=6.72, 3.42 Hz,12H, 2 (CH3)2CHN) 1.26 (s, 26 H, 13 (Cl2)11) 1.56 (quin, J=6.94 Hz, 2H, OCH2CH2CH2)1.88 (quin, J=6.30 Hz, 2H, POCH2CH2CH2O) 2.64 (t, J6.60 Hz, 2H, CH2CN) 3.40 (t,J=6.66 Hz, 2H, OC1j2CH2CH2) 3.50 (t, J=6.30 Hz, 2H, POCH2CH2CLLaO) 3.54 – 3.65 (m,2H, 2 CH) 3.65 – 3.79 (m, 2H, POC1j2CH2CH2O) 3.79 – 3.93 ppm (m, 2H, POCH2CH2CN).?3C NMR (101 MHz, CDC13) oe 14.1 (s, 1C, CH3CH2) 20.3 (d, J6.60 Hz, 1C, CH2CN) 22.7(s, 1C, CH2CH2CH3) 24.5 and 24.63 (2 d, J=7.70 Hz, 2x2C, (CH3)2CHN) 26.2 (s, 1C,OCH2CH2CH2) 29.3 (s, 1CH211) 29.5 (s, 1CH211) 29.6 (s, 2CH211) 29.6 (s, 1CH211) 29.7 (s,5CH211) 29.8 (s, 1CH211) 31.5 (d,J7.34 Hz, 1C, POCH2CH2CH2O) 31.9 (s, 1CH211) 43.0 (d,J=1 1.74 Hz, 2C, 2 CH) 58.3 (d, J=19.07 Hz, 1C, POCH2CH2CN) 60.7 (d, J17.61 Hz, 1C,POCH2CH2CH2O) 67.3 (s, 1C, POCH2CH2CH2O) 71.1 (s, 1C, OCH2CH2CH2), 117.6 ppm (s,1C, CN). 3?P NMR (162 MHz, CDC13, ?H-decoupled) 8 147.56 ppm (s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23377-40-4, its application will become more common.

Reference:
Patent; UNIVERSITY OF MASSACHUSETTS; UNIVERSITY OF SOUTHAMPTON; WATTS, Jonathan; HAITCHI, Hans, Michael; PENDERGRAFF, Hannah; (88 pag.)WO2018/226788; (2018); A1;,
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1805-32-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1805-32-9 as follows.

General procedure: Cu/OMS-2 (10 mg, 0.25 mol%), benzyl alcohol (2 mmol), N-arylamidine (0.5 mmol), toluene (2 mL) were added to a flask with a bar. The flask was stirred at 90 C for 20 h under air. After cooling to room temperature, the mixture was diluted with ethyl acetate and filtered. The filtrate was removed under reduced pressure to get the crude product, which was further purified by silica gel chromatography (petroleum/ethyl acetate = 40/1-50/1 as eluent) to yield corresponding product. The identity and purity of the products were confirmedby 1H, 13C NMR spectroscopic and HRMS analysis.

The chemical industry reduces the impact on the environment during synthesis 1805-32-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Meng, Xu; Bi, Xiuru; Wang, Yanmin; Chen, Gexin; Chen, Baohua; Jing, Zhenqiang; Zhao, Peiqing; Catalysis Communications; vol. 89; (2017); p. 34 – 39;,
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27489-62-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

(To a reaction flask, DMF (2 L) was added, 2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-chloro-4-methoxybenzylamino)pyrimidine-5-carboxylic acid (300 g, 0.8 mol) was added under stirring, DIEA (209 mL, 1.2 mol) was added dropwise under ice-water, then HATU (456 g, 1.2 mol) was added, the mixture was stirred for 30 min, trans-4-aminocyclohexanol (138.2 g, 1.2 mol) was added. The temperature of the reaction was naturally elevated to room temperature, stirring was carried out for 2 h, and TLC was used to monitor the reaction. After the end of reaction, the reaction liquid was poured into water (3 L) to precipitate solid and filtrated, the filter cake was washed with water, air-dried, then recrystallized with acetone twice to obtain white solid (240 g, yield of 63%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Shu, Chutian; Wu, Yongqian; (34 pag.)US2016/46654; (2016); A1;,
Alcohol – Wikipedia,
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42514-50-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

a. Tert-butyl (3-hvdroxy-1 ,1-dimethylpropyl)-carbamidate200 g (1.94 mol) 3-amino-3-methylbutan-1 -ol in 0.75 I ethyl acetate are combined with a solution of 435.0 g (1.99 mol) di-tert-butyl-dicarbonate in 0.75 I ethyl acetate within one hour. The reaction mixture is stirred for 30 min and the solvent is eliminated in vacuo. The residue obtained is used in the next step without further purification. Yield: 412.5 g1H-NMR (DMSO, 400 MHz): 1.19 (s, 9H); 1.36 (s, 6H); 1.68-1.74 (m, 2H); 3.42-3.50 (m, 2H); 4.39 (t, J = 4.8, 1 H); 6.36 (br s, 1 H).Alternatively, tert-butyl (3-hydroxy-1 ,1-dimethylpropyl)-carbamidate may also be prepared by the methods described for example in J. of Labell. Compounds & Radioph. 2001 , 44(4), 265-275 or WO 03/037327, p. 82/83.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2008/132162; (2008); A1;,
Alcohol – Wikipedia,
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