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Capon, Brian’s team published research in Tetrahedron Letters in 29 | CAS: 17236-59-8
Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, SDS of cas: 17236-59-8.
Capon, Brian published the artcileThe tautomerism of hydroxy derivatives of five-membered oxygen, nitrogen, and sulfur heterocycles [Erratum to document cited in CA106(19):155813y], SDS of cas: 17236-59-8, the publication is Tetrahedron Letters (1988), 29(3), 250, database is CAplus.
An error in a kH+ value for ketonization of 2-hydroxyindene was corrected (3.48 M-1s-1, not 83 M-1s-1. The error was not reflected in the abstract or the index entries.
Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, SDS of cas: 17236-59-8.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts
Zhu, Yue’s team published research in Journal of Catalysis in 410 | CAS: 111-29-5
Journal of Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C13H14BNO2, Quality Control of 111-29-5.
Zhu, Yue published the artcileCu nanoparticles supported on core-shell MgO-La2O3 catalyzed hydrogenolysis of furfuryl alcohol to pentanediol, Quality Control of 111-29-5, the publication is Journal of Catalysis (2022), 42-53, database is CAplus.
Selective ring-opening hydrogenolysis of the furan ring is the key to the efficient conversion of furfuryl alc. (FFA) to high-value pentanediol. In this work, highly dispersed Cu@MgO-La2O3 was designed and synthesized with a core-shell structure, and bifunctional metal and alk. sites for the direct hydrolysis of FFA (94.9% conversion) to 1,2-pentanediol (1,2-PeD, with 67.1% selectivity) and 1,5-pentanediol (1,5-PeD, with 18.8% selectivity). Multiple characterization results indicated that at an Mg/La ratio of 1.9, the outer surface contained distributed La2O3-MgO species with uniformly dispersed Cu0 nanoparticles, and the inner layer of the catalyst possessed MgO, while some Cu0 were distributed at the La2O3 and MgO interface. The addition of MgO increased the sp. surface area of the outer layer, improving the dispersion of Cu and facilitating the formation of Cu0. In-situ FTIR experiments showed that FFA was adsorbed on the La2O3 alk. site of the carrier through the O atoms of the furan ring and CH2OH, which induced ring-opening to generate enol intermediates, which further hydrogenated to 1,2-PeD and 1,5-PeD over the Cu0 nanoparticles. Thus, this new core-shell structure combining with metal and alk. sites provides new insight for developing effective and selective hydrogenolysis catalysts.
Journal of Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C13H14BNO2, Quality Control of 111-29-5.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts
Liu, Guo-ku’s team published research in International Journal of Biological Macromolecules in 2019-07-01 | CAS: 59-23-4
International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
Liu, Guo-ku published the artcileThree exopolysaccharides from the liquid fermentation of Polyporus umbellatus and their bioactivities, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Polyporus macrophage exopolysaccharide liquid fermentation antioxidant phagocytosis; Antioxidant activity; Exopolysaccharides; Polyporus umbellatus (Pers.) fries.
The exopolysaccharides were extracted and separated from the broth of the liquid fermentation of P. umbellatus, and the antioxidant activities and other relative bioactivities were investigated, aiming to find clues for a wider use in the future. Three novel exopolysaccharides of PPS1, PPS2 and PPS3 with mol. weight of 3.7 × 104-6.9 × 104 Da were obtained. Monosaccharide anal. showed that they were mainly composed of mannose, along with galactose and glucose with different molar ratio, and their structural features were also investigated by FT-IR, NMR and SEM. The antioxidant activity assay in vitro showed these exopolysaccharides exhibited a significant scavenging effect on DPPH· and other free radicals in a dose-dependent manner. Significantly, the stimulate nitric oxide production and phagocytic activity implied that the polysaccharides could enhance the immunity of RAW 264.7 macrophages. Other assays revealed that they have obvious cellular aging delaying activity and the DNA damage protecting activity. In conclusion, these three exopolysaccharides might have potential applications in the fields of pharmaceuticals, cosmetics, and food products.
International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts
Kobayashi, Marina et al. published their research in Biochemical and Biophysical Research Communications in 2022 | CAS: 29106-49-8
(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol
Apple polyphenols exhibits chondroprotective changes of synovium and prevents knee osteoarthritis was written by Kobayashi, Marina;Harada, Seiyu;Fujimoto, Naoki;Nomura, Yoshihiro. And the article was included in Biochemical and Biophysical Research Communications in 2022.Quality Control of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol The following contents are mentioned in the article:
Apple polyphenols (AP) have strong antioxidant and anti-inflammatory properties. We examined the effects of AP on the progression of osteoarthritis (OA) AP was administered to surgically-induced OA model rats for 4 or 8 wk. This treatment suppressed inflammation and oxidative stress in the synovium, resulting in a decrease in the OA severity score, and the expression of tumor necrosis factor (TNF)-α and matrix metalloproteinase (MMP)-13 in the synovium. It was suggested that long-term administration of AP may be effective for the treatment of OA. In addition, superoxide dismutase (SOD) activity was enhanced in serum samples by AP. AP or its constituent procyanidin B2 (PC) were added to HIG-82 synoviocytes. The showed that AP enhanced cell proliferation and hyaluronan production This indicates that AP may improve synovial conditions in OA and suppress OA progression. These effects may be attributed to the antioxidant and anti-inflammatory properties of AP. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Quality Control of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol).
(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts
Ji, Shuohan’s team published research in Organic Letters in 2022 | CAS: 401797-00-0
2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Product Details of 401797-00-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.
Ji, Shuohan; Qin, Shengxiang; Yin, Chunyu; Luo, Lu; Zhang, Hua published an article on January 14 ,2022. The article was titled 《Unreactive C-N Bond Activation of Anilines via Photoinduced Aerobic Borylation》, and you may find the article in Organic Letters.Product Details of 401797-00-0 The information in the text is summarized as follows:
Unreactive C-N bond activation of anilines was achieved by photoinduced aerobic borylation. A diverse range of tertiary and secondary anilines were converted to aryl boronate esters in moderate to good yields with wide functional group tolerance under simple and ambient photochem. conditions. This transformation achieved the direct and facile C-N bond activation of unreactive anilines, providing a convenient and practical route transforming widely available anilines into useful aryl boronate esters. In the experiment, the researchers used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Product Details of 401797-00-0)
2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Product Details of 401797-00-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts
Sinha, Suman’s team published research in Dalton Transactions in 2020 | CAS: 873-75-6
(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.
《Cobalt complexes of redox noninnocent azo-aromatic pincers. Isolation, characterization, and application as catalysts for the synthesis of quinazolin-4(3H)-ones》 was published in Dalton Transactions in 2020. These research results belong to Sinha, Suman; Das, Siuli; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D.. Electric Literature of C7H7BrO The article mentions the following:
Herein we report the synthesis, characterization and catalytic application of three new cobalt(II)-complexes of redox noninnocent arylazo ligands, 2-(phenylazo)-1,10-phenanthroline (L1a), 2-(4-chlorophenylazo)-1,10-phenanthroline (L1b) and 2,9-bis(phenyldiazo)-1,10-phenanthroline (L2) resp. The reaction of L1a with CoIICl2·6H2O produced a μ-dichloro bridged binuclear cobalt(II)-complex [CoII2(L1a)2Cl2] (1a) while the same reaction when carried out with 2-(4-chlorophenyl)azo-1,10-phenanthroline (L1b) and 2,9-bis(phenyldiazo)-1,10-phenanthroline (L2) ligands produced two new mononuclear five-coordinate cobalt(II)-complexes 1b and 2 resp. In complex 1a and 1b, the ligands L1a and L1b are coordinated to the cobalt(II)-center in a tridentate mode utilizing all of its nitrogen donor sites while in complex 2 one of the azo-donor sites of the ligand L2 remain pendant. All these complexes were characterized using available spectroscopic techniques and DFT studies. We further explored the potential of these complexes as catalysts for the synthesis of pharmaceutically important organic compounds via the functionalization of alcs. A variety of substituted quinazolin-4(3H)-ones were synthesized under aerobic conditions via the coupling of alcs. and 2-aminobenzamide using 1b as the catalyst. Mechanistic investigations revealed that both cobalt and the arylazo scaffold act synergistically during catalysis. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)
(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts
Jones, David S. et al. published their research in Carbohydrate Polymers in 2021 |CAS: 111-29-5
The Article related to hydroxypropylcellulose gel metronidazole release viscoelasticity viscometry, drug diffusion, gel erosion, statistical modelling, viscoelasticity, viscometric properties, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: Pentane-1,5-diol
On March 15, 2021, Jones, David S.; Rafferty, Gerard P.; Andrews, Gavin P. published an article.Recommanded Product: Pentane-1,5-diol The title of the article was Drug release from hydroxypropylcellulose gels cannot be statistically predicted from their viscometric and initial viscoelastic properties. And the article contained the following:
This study questioned whether rheol. properties can predict drug (metronidazole) release from Hydroxypropylcellulose (HPC) platforms. Viscometric and viscoelastic properties of aqueous, alcs./diols and mixed solvent HPC solutions and gels were determined using viscometry and oscillatory anal. Drug release was conducted at pH 7.4 under sink conditions. Relationships between rheol. parameters and drug release were modelled using multiple linear stepwise regression. Viscometry identified ethanol and water as good solvents for HPC. Diol solvents were predicted to exhibit greater interactions with HPC (COSMO modeling) but possessed lowest intrinsic viscosities. Pentanediol or ethylene glycol prepared gels exhibited greatest elasticity. No relationships were observed between dilute solution properties and initial gel viscoelasticity. Drug release from HPC gels occurred via gel erosion and diffusion. No relationships were observed between initial gel viscoelasticity and drug release and thus, for gel platforms that undergo erosion in aqueous media, drug release cannot be predicted from initial gel viscoelasticity. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: Pentane-1,5-diol
The Article related to hydroxypropylcellulose gel metronidazole release viscoelasticity viscometry, drug diffusion, gel erosion, statistical modelling, viscoelasticity, viscometric properties, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: Pentane-1,5-diol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts
Ren, Boxu’s team published research in Cancer Letters (New York, NY, United States) in 2021-09-01 | 501-36-0
Cancer Letters (New York, NY, United States) published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.
Ren, Boxu; Kwah, Marabeth Xin-Yi; Liu, Cuiliu; Ma, Zhaowu; Shanmugam, Muthu K.; Ding, Lingwen; Xiang, Xiaoqiang; Ho, Paul Chi-Lui; Wang, Lingzhi; Ong, Pei Shi; Goh, Boon Cher published the artcile< Resveratrol for cancer therapy: Challenges and future perspectives>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review cancer resveratrol therapy; Cancer treatment; Pharmacodynamics; Pharmacokinetics; Resveratrol; Toxicity.
A review. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclin. studies on the anticancer activity of resveratrol, little progress has been made in translational research and clin. trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogs of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy.
Cancer Letters (New York, NY, United States) published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts
Coote, Michelle L. team published research on Tetrahedron in 2016 | 16545-68-9
Name: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.
With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 16545-68-9, formula is C3H6O, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Name: Cyclopropanol
Coote, Michelle L.;Zavitsas, Andreas A. research published 《 Using inherent radical stabilization energies to predict unknown enthalpies of formation and associated bond dissociation energies of complex molecules》, the research content is summarized as follows. Many free radical reactions are used currently for syntheses not easily accomplished by other methods. Hence, there is an increasing need for information about bond dissociation energies and enthalpies of formation of the mols. and radicals than is currently available for the more complex species involved in such reactions. We provide 98 standard enthalpies of formation that are not available in the extensive NIST database (number 69), 127 bond dissociation energies not exptl. available, and many previously unknown or uncertain enthalpies of formation of radicals, all at 298 K. A method is presented that allows one to obtain good predictions of the thermodn. properties of new species using the inherent radical stabilities of their components. The information should be useful for designing and rationalizing synthetic radical reactions.
Name: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts