Category: alcohols-buliding-blocks

A common compound: 13401-56-4, name is 3-Chloro-2,2-dimethylpropan-1-ol,molecular formula is C5H11ClO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 13401-56-4

Example 1; :3-iodo-2,2-dimethyl-1-propandioxolane (formula (IVA))A); Preparation according to scheme 5: a) 3-iodo-2,2-dimethyl-propanol (formula (VI): X=I (VIC)): 80 g (0.53 mol) of dry Nal and 5 g (0.03 mol) of K2CO3 are added under argon to a solution of 50 g (0.4 mol) of 3-chloro-2,2-dimethyl-1-propanol (formula VIA) in 75 ml of DMF. The mixture is stirred at reflux for 8 hours. The reaction mixture is subsequently brought to room temperature and diluted by addition of 500 ml of water. The organic phase is extracted with 1050 ml of ethyl acetate, washed with a saturated aqueous solution of Na2SO3, then with a 250 ml of a saturated solution of sodium bicarbonate dried over 60 g of anhydrous magnesium sulfate and evaporated to give crude compound of formula (VIC). H1RMN delta ppm : 0.97 (s,6H,CH3); 2.48 (s, broad, OH) ; 3.17 (s, 2H, CH2); 3.37 (s,2H, CH2). 13C RMN delta ppm : 20.3 (CH2l); 23.7 (2C,CH3); 35.5 (q, 1C) ; 69.7 (CH20)

With the rapid development of chemical substances, we look forward to future research findings about 13401-56-4.

Reference:
Patent; Merck Sante; EP1591434; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929-06-6, name is 2-(2-Aminoethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 929-06-6

To the solution of dioxane (40 mL), H20 (20 mL) and NaOH ( 20 mL; 1 M) was added 2-(2- aminoetoxy) ethanol. The reaction mixture was cooled to 0C and di-t-Bu dicarbonate ( 4,8 g) was added. The mixture was stirred for 30 min at 0C, and then the stirring was continued for 2 hours at room temperature. In next 3 hours two portion of di-t-Bu dicarbonate ( 2x 0,22 g) were added. The mixture was stirred over night at room temperature and then concentrated (20-30 mL). EtOAc (60 mL) was added to the solution and pH was adjusted to 2.5. Aqueous layer was extracted with EtOAc (3×20 mL). Organic layers was washed with H2O (3×30 mL), dried over KzC03 and evaporated in vacuum to give 3,7 g of the title product as oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 929-06-6, 2-(2-Aminoethoxy)ethanol.

Reference:
Patent; PLIVA-ISTRAZIVACKI INSTITUT D.O.O.; WO2005/108412; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

35364-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PREPARATION 14 Preparation of 3,4-dichlorophenethyl bromide STR37 Phosphorus tribromide (2.17 g) was added, dropwise, to a solution of 3,4-dichlorophenethyl alcohol (4.26 g) in carbon tetrachloride (30 ml). The mixture was stirred at room temperature for 10 minutes then heated under reflux for 2 hours. 5% Aqueous sodium carbonate (10 ml) was added dropwise and the mixture was extracted with dichloromethane (3*70 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give a yellow oil which was purified by column chromatography on silica eluding with dichloromethane containing hexane (30% down to 0%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a colourless oil, yield, 1.8 g. 1 H-N.M.R. (CDCl3) delta=7.50-7.30 (m, 2H); 7.15-7.05 (m, 1H); 3.65-3.50 (t, 2H); 3.20-3.10 (t, 2H) ppm.

The chemical industry reduces the impact on the environment during synthesis 35364-79-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Pfizer Inc.; US5340831; (1994); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts