Category: alcohols-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-18-6, name is 1,3-Benzenedimethanol. This compound has unique chemical properties. The synthetic route is as follows. 626-18-6

To a stirred solution of 1,3-phenylenedimethanol (1.0 g, 7.2 mmol) and imidazole (0.74 g, 11 mmol) in DMF (36 mL) at 0C was added TBDPS-Cl (2.0 mL, 7.6 mmol). After 30 min, the reaction mixture was allowed to warm to rt and stirred for 18h. The mixture was diluted with Et2O, washed with water (4X), then brine, dried over Na2SO4, filtered and concentrated. The crude product was purified by flash chromatography to give 9A (1.2 g, 44 %).1H NMR (500MHz, CDCl3) delta 7.72 (dd, J=8.0, 1.4 Hz, 4H), 7.45 (d, J=7.4 Hz, 2H), 7.43 – 7.37 (m, 4H), 7.34 (d, J=11.8 Hz, 3H), 7.29 (s, 2H), 4.81 (s, 2H), 4.71 (d, J=5.8 Hz, 2H), 1.59 (d, J=11.8 Hz, 1H), 1.13 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 626-18-6, 1,3-Benzenedimethanol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SMALLHEER, Joanne M.; KICK, Ellen K.; VALENTE, Meriah Neissel; HU, Carol Hui; HALPERN, Oz Scott; JUSUF, Sutjano; (133 pag.)WO2018/5336; (2018); A1;,
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2854-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 2,4,6,8-tetrachloro-pyrimido[5,4-djpyrimidine (1) (3.50 g,i3.Oi mmol) in THF (200 mL) at -78¡ãC, i-amino-2-methyl-propan-2-ol (i.i7 mL, i2.36 mmol) in THF (20 mL) was added via syringe pump (during about 30 mm) followed byDIPEA (2.93 mL, i6.9i mmol) in THF (20 mL). The reaction mixture was stirred at -78¡ãC for additional 30 mi and then allowed to reach the room temperature. Water (250 mL) was added and the resulting suspension was extracted with EtOAc (3 x iOO mL). The combined organic extracts were washed with water (iSO mL), then with brine (iSO mL) and dried over solid anhydrous MgSO4. After filtration, the solvent was removed and the residue waspurified by flash column chromatography using gradient elution from PE/EtOAc (iO:4) toPE/EtOAc (i : i) to give 2-methyl-i -(2,6,8-trichloro-pyrimido[5,4-djpyrimidin-4-ylamino)-propan-2-ol (29)(3.67 g, 92percent yield). 300 MHz ?H NMR (CDC13, ppm): 7.70-7.58 (iH, m)3.70 (2H, d, J=6.i Hz) i.80 (iH, s) i.36 (6H, s). ESI-MS (m/z): 322, 324, 326, 328 [M+Hf?.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2854-16-2, 1-Amino-2-methylpropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott L.; MENCEL, James Joseph; OZOLA, Vita; SUNA, Edgars; SHUBIN, Kirill; (294 pag.)WO2017/3822; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 558-42-9, name is 1-Chloro-2-methyl-2-propanol. A new synthetic method of this compound is introduced below., 558-42-9

[0309] To a solution of 7-chloro-6-fluoro-lH-pyrazolo[4,3-b]pyridine (300 mg, 1.749 mmol) in DMF (5 mL) was added Cs2C03 (855 mg, 2.62 mmol) and 1 -chloro-2-methylpropan-2-ol (209 mg, 1.924 mmol) and the mixture was heated at 110 ¡ãC for 2 hours. Water (20 mL) was then added and the mixture was extracted with EtOAc (2 x 50 mL). The combined organic layers were dried over Na2S04, filtered, and evaporated to give l-(7-chloro-6-fluoro-2H- pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropan-2-ol and l-(7-chloro-6-fluoro-lH- pyrazolo[4,3-b]pyridin-l-yl)-2-methylpropan-2-ol which were used i without further purification. MS [M+H] found 244.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,558-42-9, 1-Chloro-2-methyl-2-propanol, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KWOK, Lily; LARSON, John David; SABAT, Mark; WO2011/146287; (2011); A1;,
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627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a flask, 10.0 g (0.058 mol) of the compound represented by the formula (I-1a), 7.10 g (0.075 mol) of 3-chloropropanol, potassium carbonate 11.99 g (0.087 mol), and 100 mL of ethanol were added and heated under reflux for 5 days. After filtration, the solvent was distilled off and redissolved in toluene. After washing with brine, purification by column chromatography (silica gel) gave 10.7 g (0.046 mol) of the compound represented by the formula (I-11a).

Statistics shows that 627-30-5 is playing an increasingly important role. we look forward to future research findings about 3-Chloropropan-1-ol.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; KUSUMOTO, TETSUO; (90 pag.)JP6102423; (2017); B2;,
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56-81-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-81-5, name is Propane-1,2,3-triol, molecular formula is C3H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Diols and polyol reactants (100 mg) were allowed to react with benzoic anhydride (1.1 equiv) in acetonitrile (1 mL) at 40C for 8-12 h in the presence of TBAOBz (0.2 equiv). The reaction mixture was directly purified by flash column chromatography (hexanes/EtOAc=2:1 to 1:1), affording the pure selectively protected derivatives.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-81-5, Propane-1,2,3-triol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Xiaoling; Ren, Bo; Ge, Jiantao; Pei, Zhichao; Dong, Hai; Tetrahedron; vol. 72; 7; (2016); p. 1005 – 1010;,
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Adding a certain compound to certain chemical reactions, such as: 623-04-1, (4-Aminophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-04-1, blongs to alcohols-buliding-blocks compound. 623-04-1

a tert-Butyl N-(4-(hydroxymethyl)phenyl)carbamate (4-Aminophenyl)methanol (1.23 g, 10 mmol) and diisopropylethylamine (2.6 mL, 15 mmol) was mixed with di-tert-butyl dicarbonate (2.62 g, 12 mmol) in dichloromethane (50 mL). The mixture was stirred at room temperature overnight. Ethyl acetate was added and the organic layer was washed with water, 1.0N HCl, saturated sodium carbonate, water, brine, dried over MgSO4, filtered and evaporated. The crude product was purified by flash column chromatography with Ethyl acetate/heptane (2:3) to give tert-butyl N-(4-(hydroxymethyl)phenyl)carbamate (2.16 g, 9.67 mmol). 1H NMR (CDCl-d) delta1.52 (s, 9H), 4.63 (s, 2H), 6.47 (bs, 1H), 7.30 (d, 8.5 Hz, 2H), 7.36 (d, 8.5 Hz,2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.

Reference:
Patent; Hirst, Gavin C.; Calderwood, David; Munschauer, Rainer; Arnold, Lee D.; Johnston, David N.; Rafferty, Paul; US2003/153752; (2003); A1;,
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558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-hydroxy-3,5-dimethylbenzonitrile (2.00 g, 13.5 mmol) and 1-chloro-2-methyl propan-2-ol (8.85 g, 81.5 mmol) in ethanol (50 mL) was added potassium carbonate (7.5 g, 54 mmol) and water (5 mL). The reaction mixture was stirred at reflux for 24 h and cooled to room temperature. The precipitated solid was filtered off and washed with water. The solid was dissolved in ethyl acetate (100 mL), washed with water (50 mL), brine (50 mL), and dried over anhydrous Na2SO4. Removal of solvent gave 4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile (2.9 g, 97percent) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 558-42-9, 1-Chloro-2-methyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald; US2013/281397; (2013); A1;,
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Adding some certain compound to certain chemical reactions, such as: 4415-82-1, name is Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4415-82-1. 4415-82-1

General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4415-82-1.

Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
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95-12-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95-12-5, name is Bicyclo[2.2.1]hept-5-en-2-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 2; Synthesis of Norbornene Monomers Containing Olefin Side Chain (NBMOAC); The procedure for synthesizing norbornene monomers containing olefin side chain was as following scheme: Norbornene methylene alcohol (11.2 g, 0.1 mol) and little hydroquinone were dissolved in 20 ml of tetrahydrofuran in a two-mouth bottle. The mixture of methylacrylethoxy isocyanate (15.0 g, 0.1 mol excess) and tetrahydrofuran (15 ml) were dropwise added into the solution with a funnel at rate of 1 drop/sec. The mixture was heated to reflux with stirring at 50 C. for 6 h. Small amount of methanol was then added to react with rest methylacrylethoxy isocyanate and the solution became transparent. Solvent was then removed by rotational evaporation to give pale white liquid. A white solid formed from said pale white liquid after a period of time without any disturbance.After comparison of practical atom analysis and theoretical distribution we found that the theoretical distribution of monomer norbornene containing olefin end (C15H21O4N) was C=64.52%, H=7.52%, N=5.02%; while the practical analysis was C=64.07%, H=7.50%, N=4.98%.The NMR spectrum of monomer norbornene containing olefin end was as following: 1H NMR(CDCl3): delta (ppm)=0.44-0.46(Hn3n), 1.06-1.08(Hx3x), 1.14-1.16(Hn7a), 1.22-1.24(H3), 1.33-1.35(Hn7s), 1.59(Hx2n), 1.70-1.74(Hn3x), 1.83-1.89(H10), 2.27(Hn2x), 2.60(Hx4), 2.70-2.71(Hn4, Hx1), 2.76(Hn1), 3.39-3.40(Hn8), 3.51-3.55(H12), 3.73-3.77(H13), 4.11-4.15(Hx8), 5.50, 5.85(H11, CC), 5.98(Hn6), 6.01(Hx6,Hx5), 6.04(Hn5). 13C NMR(CDCl3): delta (ppm)=18.53(C10), 29.20(Cn3), 29.78(Cx3), 38.46(Cx2), 39.59(Cn2), 40.39(C12), 41.88(C13), 42.50(Cx1,Cn4), 43.90, 44.16(Cx4, Cn1), 45.25(Cx7), 49.66(Cn7), 64.01(Cn8), 68.69(Cx8), 126.20(C11), 132.50(Cn6), 136.46-136.51(Cx5,Cx6), 137.21(Cn5) 137.77(C14), 157.09(C15), 167.57(C16).IR analysis for monomer norbornene with olefin end was as following:3360(upsilonN-H), 3050(upsilonC-H), 2960(upsilonC-H), 1715(upsilonCO), 1640(upsilonCC), 1540(upsilonC-H), 1300(upsilonC-O).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 95-12-5, Bicyclo[2.2.1]hept-5-en-2-ylmethanol.

Reference:
Patent; National Taiwan University of Science & Technology; US7132565; (2006); B2;,
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597-31-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal, molecular formula is C5H10O2, molecular weight is 102.1317, as common compound, the synthetic route is as follows.

The hydrogenation feed as described in example 1 was used.Catalyst UsedThe catalyst from example 1 was used.HydrogenationThe hydrogenation input was passed in the downflow mode at an H2 pressure of 37 bar through the reactor which was heated to 105 C. The WHSV was 0.32 kg of HPA/(kgcat*h). From 0 to 17% by weight (based on the hydrogenation feed) of a 50% strength by weight aqueous solution of trimethylamine were added to this mixture in order to set a pH of the hydrogenation output of greater than 8 (hydrogen/hydroxypivalaldehyde molar ratio: about 1.5). Part of the hydrogenation output was mixed back into the input (recycle mode). The ratio of recycle to input was 16:1. A mean conversion of 88.1% at a mean pH of 8.4 were achieved over a number of days.

Statistics shows that 597-31-9 is playing an increasingly important role. we look forward to future research findings about 3-Hydroxy-2,2-dimethylpropanal.

Reference:
Patent; BASF Aktiengesellschaft; US2007/282135; (2007); A1;,
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