Category: 96-76-4

On January 31, 2022, Vahdati, Saeed Niazi; Lashkari, Ali; Navasatli, Sepideh Aliniaye; Ardestani, Susan Kabudanian; Safavi, Maliheh published an article.Electric Literature of 96-76-4 The title of the article was Butylated hydroxyl-toluene, 2,4-Di-tert-butylphenol, and phytol of Chlorella sp. protect the PC12 cell line against H2O2-induced neurotoxicity. And the article contained the following:

Oxidative stress is considered the main cause of cellular damage in a number of neurodegenerative disorders. One suitable ways to prevent cell damage is the use of the exogenous antioxidant capacity of natural products, such as microalgae. In the present study, four microalgae extracts, isolated from the Persian Gulf, were screened to analyze their potential antioxidant activity and free radical scavenging using ABTS, DPPH, and FRAP methods. The methanolic extracts (D1M) of green microalgae derived from Chlorella sp. exhibited potent free radical scavenging activity. In order to characterize microalgae species, microscopic observations and anal. of the expression of 18S rRNA were performed. The antioxidant and neuroprotective effects of D1M on H2O2-induced toxicity in PC12 cells were investigated. The results demonstrated that D1M significantly decreased the release of nitric oxide (NO), formation of intracellular reactive oxygen species (ROS), and the level of malondialdehyde (MDA), whereas it enhanced the content of glutathione (GSH), and activity of heme oxygenase 1 (HO-1), NAD(P)H: quinone oxidoreductase 1 (NQO1), and catalase (CAT) in PC12 cells exposed to H2O2. The pretreatment of D1M improved cell viability as measured by the MTT assay and invert microscopy, reduced cell apoptosis as examined by flow cytometry anal., increased mitochondrial membrane potential (MMP), and diminished caspase-3 activity. The GC/MS anal. revealed that D1M ingredients have powerful antioxidant and anti-inflammatory compounds, such as butylated hydroxytoluene (BHT), 2,4-di-tert-butyl-phenol (2,4-DTBP), and phytol. These results suggested that Chlorella sp. extracts have strong potential to be applied as neuroprotective agents, for the treatment of neurodegenerative disorders. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4

The Article related to phytol butylated hydroxyl toluene hydrogen peroxide butylphenol chlorella neurotoxicity, anti-inflammatory, antioxidant, chlorella sp, microalgae, neuroprotective, pc12 cell and other aspects.Electric Literature of 96-76-4

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Razali, Shakirah; Khan, Al’aina Yuhainis Firus; Khatib, Alfi; Ahmed, Qamar Uddin; Abdul Wahab, Ridhwan; Zakaria, Zainul Amiruddin published an article in 2021, the title of the article was An in vitro anticancer activity evaluation of Neolamarckia cadamba (Roxb.) bosser leaves’ extract and its metabolite profile.Application of 96-76-4 And the article contains the following content:

The leaves of Neolamarckia cadamba (NC) (Roxb.) Bosser (family: Rubiaceae) are traditionally used to treat breast cancer in Malaysia; however, this traditional claim is yet to be scientifically verified. Hence, this study was aimed to evaluate the anticancer effect of NC leaves ethanol extract against breast cancer cell line (MCF-7 cells) using an in vitro cell viability, cytotoxicity, and gene expression assays followed by the gas chromatog. anal. to further confirm active principles. Results revealed 0.2 mg/mL as the half maximal inhibitory concentration (IC50) against MCF-7. The extract exerted anticancer effect against MCF-7 cells in a dose- and time-dependent manner. The cell cycle assay showed that the extract arrested MCF-7 cells in the G0/G1 phase, and apoptosis was observed after 72 h by the Annexin-V assay. The gene expression assay revealed that the cell cycle arrest was associated with the downregulation of CDK2 and subsequent upregulation of p21 and cyclin E. The extract induced apoptosis via the mediation of the mitochondrial cell death pathways. A chromatog. anal. revealed the contribution of D-pinitol and myo-inositol as the two major bioactive compounds to the activity observed Overall, the study demonstrated that NC leaves ethanol extract exerts anticancer effect against MCF-7 human breast cancer cells through the induction of apoptosis and cell cycle arrest, thereby justifying its traditional use for the treatment of breast cancer in Malaysia. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application of 96-76-4

The Article related to neolamarckia leaf extract anticancer agent breast cancer, neolamarckia cadamba, breast cancer, gas chromatography, gene expression assay, in vitro anticancer, mechanisms of action and other aspects.Application of 96-76-4

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Li, Tianpeng; Fan, Jing; Sun, Tingting published an article in 2021, the title of the article was Effective removal of methylene blue dye from water with nanocomposite ceramsites in a fixed-bed column.Application of 96-76-4 And the article contains the following content:

The study aims to remove methylene blue dye from water with a fixed-bed column packed with Cu2O nanocomposite ceramsites. The column showed the advantages of fixed-bed column adsorption and photocatalytic oxidation The Cu2O nanocomposite ceramsites with strong photocatalytic oxidation activity and well-developed porous structure were successfully prepared with the chem. vapor deposition process, which also met with the China’s industrial standard of CJ/T 299-2008 and China’s national standard of GB 5085.3-2007. The breakthrough time and saturation time under UV radiation were 36.0% and 26.83% longer than those under the conditions without UV radiation, because the micro-pore structure of ceramsite was closely related to optical excitation properties of nano-Cu2O. The Yoon-Nelson and Adams-Bohart models were applied to describe the obtained breakthrough curves using non-linear regression, in which the Yoon-Nelson model gave the better prediction results for breakthrough curves, with R2>0.98. Besides, amines were the dominant intermediates at saturation point and final products were inorganic anions. This study confirmed that the fixed-bed column packed with Cu2O nanocomposite ceramsites could efficiently treat methylene blue dye wastewater, due to the structure-function relationship between ceramsite and nano-Cu2O. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application of 96-76-4

The Article related to methylene blue adsorption photocatalytic oxidation copper oxide ceramsite nanocomposite, ceramsite, breakthrough curves, kinetic analysis, nanocomposite, structure-function relationship and other aspects.Application of 96-76-4

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On August 4, 2020, Behm, Kira; Fazekas, Eszter; Paterson, Martin J.; Vilela, Filipe; McIntosh, Ruaraidh D. published an article.Formula: C14H22O The title of the article was Discrete Ti-O-Ti Complexes: Visible-Light-Activated, Homogeneous Alternative to TiO2 Photosensitisers. And the article contained the following:

A series of novel bimetallic TiIV amine bis(phenolate) complexes was synthesized and fully characterised. X-ray crystallog. studies revealed distorted octahedral geometries around the Ti centers with single or double oxo-bridges connecting the two metals. These robust, air- and moisture-stable complexes were employed as photosensitizers generating singlet oxygen following irradiation with visible light (420 nm) LED module in a com. flow reactor. All five complexes showed high activity in the photo-oxygenation of α-terpinene and achieved complete conversion to ascaridole in four hours at ambient temperature The excellent selectivity of these photosensitizers towards ascaridole (vs. transformation to p-cymene) was demonstrated with control experiments using a traditional TiO2 catalyst. Further comparative studies employing the free pro-ligands as well as a monometallic analog highlighted the importance of the ′TiO2-like′ moiety in the polymetallic catalysts. Computational studies were used to determine the nature of the ligand to metal charge transfer (LMCT) states and singlet-triplet gaps for each complex, the calculated trends in the UV-vis absorption spectra across the series agreed well with the exptl. results. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to discrete tioti complex visible light activated photosensitizers, crystal structure discrete tioti complex, amine bis(phenolate), flow chemistry, photosensitiser, singlet oxygen, titanium and other aspects.Formula: C14H22O

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On February 28, 2022, Gautam, Veer Singh; Singh, Arti; Kumari, Puja; Nishad, Jay Hind; Kumar, Jitendra; Yadav, Monika; Bharti, Rajnish; Prajapati, Priyanka; Kharwar, Ravindra Nath published an article.Formula: C14H22O The title of the article was Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.. And the article contained the following:

Since endophytic fungi are pivotal sources of various bioactive natural compounds, the present study is aimed to investigate the antioxidant compounds of the endophytic fungus Nigrospora sphaerica isolated from a pantropical weed, Euphorbia hirta L. The fungus was fermented in four different media and each filtered broth was sequentially extracted in various solvents. Crude extracts collected from different solvents were subjected to phytochem. anal. and antioxidant activity. The total phenolic content (TPC) and total flavonoid content (TFC) were maximal in Et acetate crude extract (EtOAcE) of endophyte fermented in potato dextrose broth (PDB) medium (77.74 ± 0.046mgGAE/g and 230.59 ± 2.0 mgRE/g) with the highest 96.80% antioxidant activity. However, TPC and TFC were absent in hexane extract of Czapek Dox broth (CDB) medium exhibiting the lowest 4.63 ± 2.75% activity. The EtOAcE (PDB) showed a pos. correlation between TFC and antiradical activity (R2 = 0.762; P < 0.05), whereas a high pos. correlation was noticed between TPC and antioxidant activity (R2 = 0.989; P < 0.05). Furthermore, to determine the antioxidant activity, EtOAcE (PDB) was subjected to TLC bioautog.-based partial purification, while GC/MS anal. of the partial purified extract was done to confirm the presence of phenolics along with antioxidant compounds that resulted in the detection of 2,4-Di-tert-butylphenol (13.83%), a phenolic compound accountable for the antioxidant potential. Conclusively, N. sphaerica is a potential candidate for natural antioxidant. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to nigrospora sphaerica euphorbia hirta phenolic flavonoid antioxidant, antioxidant activity, compounds purification, gc–ms analysis, n. sphaerica, phytochemical analysis, tlc bioautography and other aspects.Formula: C14H22O

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On November 1, 2020, Tsochatzis, Emmanouil D.; Mieth, Anja; Alberto Lopes, Joao; Simoneau, Catherine published an article.Formula: C14H22O The title of the article was A Salting-out Liquid-Liquid extraction (SALLE) for the analysis of caprolactam and 2,4-di-tert butyl phenol in water and food simulants. Study of the salinity effect to specific migration from food contact materials. And the article contained the following:

Caprolactam and 2,4-di-tert-Bu phenol (2,4-DTBP) are substances typically found in some food contact materials (FCMs). They are known to often migrate into food, and are difficult to analyze in liquid food simulants using GC. In this work a simple salting-out Liquid-Liquid Extraction (SALLE) for the anal. of both substances in water and the official food simulant A (10% volume/volume ethanol, Regulation (EU) Number 10/2011) is presented. The method, which included anal. determination by GC-MS, was optimized and validated to ensure sufficient anal. quality. The method’s LOQs allowed the proper quantification of caprolactam at its EU legislative limit (15 mg kg-1). For 2,4-DTBP the method also revealed good sensitivity, although no official limits have been established yet. Linear regression coefficients (R2) were in all cases higher than 0.999, and recoveries ranged from 87% and 95% for caprolactam and 2,4-DTBP, resp. Precision was also acceptable, with the RSDs (%) below 12%. The method proved to be adequate to be used for routine anal. The presence of salt during migration of caprolactam and 2,4-DTBP was also investigated in this work. Polyamide/polyethylene FCM multilayer films have been tested with water and simulant A, containing different amounts of NaCl (up to 15% m/v), and applying different migration conditions (temperature and time). The results indicated that salinity plays an important effect on the migration of caprolactam, with the presence of salt reducing its migration in case of water and increasing it in case of simulant A. These preliminary results seem to indicate that migration testing should consider not only the well-known fatty content of a food, but also its salinity content, as it may end up affecting drastically the migration of polar substances. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to caprolactam 24 dtbp food contact material, food contact materials, gc-ms, method validation, migration testing and food simulants, salle – salt assisted liquid extraction, salinity effect and other aspects.Formula: C14H22O

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On December 31, 2020, Fagbohun, Oladapo F.; Olawoye, Babatunde; Ademakinwa, Adedeji N.; Jolayemi, Kehinde A.; Msagati, Titus A. M. published an article.Synthetic Route of 96-76-4 The title of the article was Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ-induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes. And the article contained the following:

The management of diabetes is considered a global problem, and a cure is yet to be discovered. This study investigated the modulatory effect of Kigelia africana fruit on oxidative stress and hyperlipidemic biomarkers in STZ-induced diabetic rats, profiled phytoconstituents using GC-TOF-MS and evaluated antidiabetic effects on 3T3 L1 adipocytes. Thirty male Wistar rats (120-150 g) were divided into six groups (n = 5). Diabetes was induced by a single i.p. injection of STZ (60 mg/kg) and treated with 100, 200 and 400 of hexane fraction of KA for 28 days. Immunohistochem. evaluation was carried out using avidin-biotin immunoperoxidase (ABI) method. Catalase and SOD activities as well as the levels of total protein, albumin, bilirubin, triglyceride, cholesterol, and high-d. lipoprotein were measured. The expressions of oxidative stress and hyperlipidemic biomarkers alongside fasting blood glucose concentrations were remarkedly decreased in KA-treated diabetic rats. Moreover, there was a significant increase in endocrine cell distribution, area covered with increase in β-cell mass, composition and morphol. of KA-treated animals. Addnl., there was constant up-regulation in 3T3 L1 adipocytes due to the presence of phytoconstituents. Kigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Synthetic Route of 96-76-4

The Article related to metabolome modulatory effect kigelia africana oxidative stress hyperlipidemic biomarker, kigelia africana , diabetes mellitus , gc-tof-ms, antioxidant enzymes, avidin-biotin immunoperoxidase and other aspects.Synthetic Route of 96-76-4

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On August 31, 2022, Ghamry, Mohamed; Ghazal, Ahmed Fathy; Al-Maqtqri, Qais Ali; Li, Li; Zhao, Wei published an article.HPLC of Formula: 96-76-4 The title of the article was Impact of a novel probiotic Lactobacillus strain isolated from the bee gut on GABA content, antioxidant activity, and potential cytotoxic activity against HT-29 cell line of rice bran. And the article contained the following:

Rice bran was fermented with Lactobacillus apis, isolated from the bee gut as a novel probiotic strain, and Saccharomyces cerevisiae to investigate the relationship between its metabolites and antioxidant activity, nutraceutical value, and cytotoxic activity against the HT-29 cell line. The findings showed that L. apis improved the antioxidant activity (DPPH of 37.73%) and antioxidant capacity (ABTS of 37.62 mg Trolox/g,), as well as, hydroxyl radical-scavenging activity (91.55%) of rice bran compared to S. cerevisiae. The metabolic anal. of volatile compounds revealed an increase of alcs. and lactones in the samples fermented with S. cerevisiae. While the samples fermented with L. apis displayed an increase of ketones, esters, and thiazoles. On the other hand, L. apis and S. cerevisiae exhibited a significant ability to increase γ-aminobutyric acid during different fermentation times. Compared with non-fermented samples (18.54%), L. apis increased the cytotoxic activity of rice bran against the HT-29 cell line to 34.17%, and S. cerevisiae to 31.34%. These results suggest that the fermentation of rice bran with S. cerevisiae and L. apis provides a promising strategy to improve the antioxidant activity and nutraceuticals of rice bran, and a potential source for plant-based pharmaceutical products. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to lactobacillus apis saccharomyces cerevisiae fermentation antioxidant nutraceutical cytotoxic activity, antioxidants, cytotoxic activity, lactobacillus apis, rice bran, saccharomyces cerevisiae and other aspects.HPLC of Formula: 96-76-4

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On May 31, 2021, Thekkangil, Aswani; George, Benu; Prakash, S. M. Udaya; Suchithra, T. V. published an article.Safety of 2,4-Di-tert-butylphenol The title of the article was Mechanism of streptomyces albidoflavus STV1572a derived 1-heneicosanol as an inhibitor against squalene epoxidase of Trichophyton mentagrophytes. And the article contained the following:

An increase in incidences of tinea infections paves the way to discover the novel antifungal drugs from unexplored natural resources. The quality of life in patients with tinea infection may be affected by different factors, including morbidity, length of illness, social and demog. factors. The present investigation explores the functional principle of a bioactive compound isolated from actinomycetes, S. albidoflavus STV1572a by in-silico and in-vitro studies. In continuation of our previous reports on the antidermatophytic potential of S. albidoflavus STV1572a, this study progresses with the in-silico mol. docking study of the seven GC-MS discovered ligands, and six dermatophytic modelled targets. Through virtual screening, it was revealed that a docking score -8.8 between 1-heneicosanol and squalene epoxidase favored partially in understanding the mode of action. Further validation of in-silico study was performed by a sterol quantification assay which confirmed the antidermatophytic mechanism of 1-heneicosanol. Taken together, the evidence from this study suggests that 1-heneicosanol has a potential antidermatophytic compound and can be considered for dermatophytic treatment. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Safety of 2,4-Di-tert-butylphenol

The Article related to trichophyton mentagrophytes streptomyces albidoflavus heneicosanol squalene epoxidase, 1-heneicosanol, squalene epoxidase, sterol quantification assay, streptomyces, t. mentagrophytes, tinea infection and other aspects.Safety of 2,4-Di-tert-butylphenol

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On January 8, 2020, Wang, Zhuolin; Xiao, Qing; Zhuang, Jinda; Feng, Tao; Ho, Chi-Tang; Song, Shiqing published an article.Related Products of 96-76-4 The title of the article was Characterization of aroma-active compounds in four yeast extracts using instrumental and sensory techniques. And the article contained the following:

Gas chromatog.-olfactometry coupled with sensory anal. and partial least-squares regression (PLSR) anal. led to the identification of the odorants responsible for the different flavors of four yeast extracts Sensory anal. showed that LA00L had an intense sulfurous attribute, and LA00 was characterized by fatty and green notes, FA31 exhibited the floral odor, while KA02 had strong phenolic, animal, fermented, roasted, and caramellic notes. A total of 37 key aroma compounds with odor activity values greater than 1 were determined 2,4-Di-tert-butylphenol and methional were the most potent aroma compounds In addition, the key aroma compounds in LA00L were nonanal, di-Me disulfide, and γ-decalactone. Octanal, di-Me disulfide, and benzeneacetaldehyde were the key aroma compounds in LA00. In FA31, styrene, benzeneacetaldehyde, and acetophenone were the key aroma compounds, while indole, 2-methoxyphenol, benzeneacetaldehyde, and p-cresol contributed significantly to the aroma of KA02. PLSR showed that p-cresol and indole were significantly responsible for the phenolic and animal notes inducing the off-flavor (yeasty odor) of yeasty extracts More significantly, indole was first reported to have an important effect on yeasty odor. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Related Products of 96-76-4

The Article related to aroma yeast extract olfactometry gc, aroma-active compounds, gas chromatography−olfactometry, odor activity value, partial least-squares regression, solvent-assisted flavor evaporation, yeast extracts and other aspects.Related Products of 96-76-4

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