Category: 96-20-8

Gao, Peng published the artcileIBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines, HPLC of Formula: 96-20-8, the publication is Journal of Organic Chemistry (2020), 85(12), 7939-7951, database is CAplus and MEDLINE.

An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alc., followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheuka, Peter Mubanga published the artcileNew Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase, Name: 2-Aminobutan-1-ol, the publication is ACS Infectious Diseases (2021), 7(1), 34-46, database is CAplus and MEDLINE.

Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated analogs and demonstrate that these compounds potently inhibit Plasmodium phosphatidylinositol-4-kinase (PI4K) type IIIβ while moderately inhibiting cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) activity in vitro. Using in silico docking, we predict key binding interactions for these analogs within the ATP (ATP)-binding site of PI4K and PKG, paving the way for structure-based optimization of imidazopyridazines targeting both Plasmodium PI4K and PKG. While several derivatives showed low nanomolar antiplasmodium activity (IC₅₀ < 100 nM), some compounds, including piperazine analog I, resulted in strong dual PI4K and PKG inhibition. The compounds also demonstrated transmission-blocking potential, evident from their potent inhibition of early- and late-stage gametocytes. Finally, the current compounds generally showed improved aqueous solubility and reduced hERG (human ether-a-go-go-related gene) channel inhibition.

ACS Infectious Diseases published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ya-Yi published the artcileOlefin Amine (OLA) Reagents for the Synthesis of Bridged Bicyclic and Spirocyclic Saturated N-Heterocycles by Catalytic Hydrogen Atom Transfer (HAT) Reactions, Quality Control of 96-20-8, the publication is Journal of the American Chemical Society (2019), 141(24), 9739-9745, database is CAplus and MEDLINE.

Using tandem imine formation and (diastereoselective) reductive cyclization reactions via iron- or manganese-catalyzed hydrogen-atom transfer, unsaturated amines (olefin-amine reagents, OLA) such as I, II, and III yielded spirocyclic, bridged, and fused saturated nitrogen heterocycles such as IV, V, and VI. A mechanism is proposed using a metal hydride hydrogen atom transfer to generate a C-centered radical that undergoes addition to an unactivated imine, leading to an N-centered radical; regeneration of the metal catalyst by O₂ and a second HAT to form the unprotected saturated N-heterocycle yields the observed products.

Journal of the American Chemical Society published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C13H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luescher, Michael U. published the artcileEvidence for a Radical Mechanism in Cu(II)-Promoted SnAP Reactions, Formula: C4H11NO, the publication is Synlett (2019), 30(4), 464-470, database is CAplus.

Saturated nitrogen heterocycles could be found with increasing abundance in bioactive mols. despite a limited number of methods to access these scaffolds. However, the coupling of recently introduced SnAP [tin (Sn) amine protocol] reagents with a wide range of aldehydes and ketones had proven to be a reliable, practical, and versatile one-step approach to saturated N-heterocycles, e.g., I. While effective, the lack of mechanistic understanding limits efforts to develop new catalytic and enantioselective variants. To distinguish between a polar or radical mechanism, Lewis and Bronsted acids, radical trapping experiments, and radical clock SnAP reagents were assessed reinforcing the current understanding of the SnAP protocol as a radical cyclization.

Synlett published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alanthadka, Anitha published the artcileNickel-Catalyzed Double Dehydrogenative Coupling of Secondary Alcohols and β-Amino Alcohols To Access Substituted Pyrroles, SDS of cas: 96-20-8, the publication is Journal of Organic Chemistry (2019), 84(21), 13557-13564, database is CAplus and MEDLINE.

Herein, we demonstrate the first nickel-catalyzed double dehydrogenative condensation of secondary alcs. and β-amino alcs. in one pot to the pyrrole derivatives A series of 2,5- and 2,3,5-substituted pyrroles were obtained in â‰?3% yield, releasing water and hydrogen gas as byproducts. Initial mechanistic studies, including defined Ni catalyst, deuterium labeling experiments, quant. determination of hydrogen gas evaluation, and detection of water generation in the reaction mixture, were performed.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, SDS of cas: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gholivand, Khodayar published the artcileSynthesis, characterized, QSAR studies and molecular docking of some phosphonates as COVID-19 inhibitors, Product Details of C4H11NO, the publication is Polyhedron (2022), 115824, database is CAplus and MEDLINE.

The global coronavirus (COVID-19) outbreak has prompted scientists to discover a cure for the disease. So far, phosphorus-based drugs have been proposed. These drugs have good inhibitory activity against the main protease (Mpro). Hence, in order to introduce a group of inhibitors the coronavirus, 51 compounds containing different mono, bis, and tetra phosphonates as Remdesivir derivatives, 32 of which are new, were synthesized and characterized by ³¹P, ¹³C, and ¹H NMR and IR spectroscopy. Their biol. activities were also investigated by Mol. Docking, QSAR, and Pharmacophore. Van der Waals, hydrogen bonding, and hydrophobic interactions were studied for all compounds as well as binding energy (ΔG, Kcal/mol) and the inhibitory constant Ki (μM) obtained by Mol. Docking. The results showed that the topol. of the ligands and the change of the different groups attached to them can be effective in the placement position in the active site of the enzyme (Glu 166 and Gln 189). And bisphosphonates have a high interaction tendency with Mpro COVID-19. Compound L24 was identified as the best inhibitor with the -6.38 kcal/mol binding energy. The quant. structure-activity relationship (QSAR) findings demonstrated that the polarity and topol. of mols. in all phosphonate derivatives were important parameters affecting the effecting on the binding energy and inhibitory ability of compounds The DFT and pharmacophore results are in good accordance with those of QSAR and mol. docking. This study can be helpful to gain a better understanding of the interactions between the Mpro of virus and its inhibitors in order to attain drugs with more effect on coronavirus (COVID-19).

Polyhedron published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Thanzeel, F. Yushra published the artcileClick chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures, Application In Synthesis of 96-20-8, the publication is Nature Communications (2018), 9(1), 5323, database is CAplus and MEDLINE.

Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chem., metal coordination or supramol. assemblies, quant. anal. of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. This method has several attractive features, including wide scope, fast substrate fixation without byproduct formation or complicate equilibrium often encountered in reversible substrate binding, excellent solvent compatibility, and tolerance of air and water. The ruggedness and practicality of this approach are demonstrated by comprehensive anal. of nonracemic monoamine samples and crude asym. imine hydrogenation mixtures without work-up. Click chemosensing addresses increasingly important time efficiency, cost, labor and chem. sustainability aspects and streamlines asym. reaction development at the mg scale.

Nature Communications published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C16H12O, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Verevkin, Sergey P. published the artcilePaving the way to the sustainable hydrogen storage: Thermochemistry of amino-alcohols as precursors for liquid organic hydrogen carriers, Name: 2-Aminobutan-1-ol, the publication is Journal of Chemical Thermodynamics (2021), 106610, database is CAplus.

The absolute vapor pressures of four amino-alcs. were measured using the transpiration method. A consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. The averaged values of vaporization enthalpies are recommended as reliable benchmark properties for thermochem. calculations of the energetics of chem. reactions including synthesis of alkyl-substituted pyrazines, compounds considered as seminal liquid organic hydrogen carriers (LOHC).

Journal of Chemical Thermodynamics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C17H14N2O2, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Verevkin, Sergey P. published the artcileEvaluation of vaporization thermodynamics of pure amino-alcohols, Quality Control of 96-20-8, the publication is Journal of Molecular Liquids (2021), 116568, database is CAplus.

The absolute vapor pressures of three amino-alcs. were measured using the transpiration method. The consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. Correlation of vaporization enthalpies with normal boiling temperatures was established. Vaporization enthalpies of amino-alcs. obey the group-additivity rules. The averaged values of vaporization enthalpies were recommended as reliable benchmark properties for the heat management of CO₂ capture technologies.

Journal of Molecular Liquids published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C13H16O2, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Fengqian published the artcileCopper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides, Product Details of C4H11NO, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202200062, database is CAplus and MEDLINE.

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions.

Angewandte Chemie, International Edition published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H6O3, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts