Category: 96-20-8

Boggu, Pulla Reddy published the artcileDiscovery of benzimidazole analogs as a novel interleukin-5 inhibitors, COA of Formula: C4H11NO, the publication is European Journal of Medicinal Chemistry (2019), 111574pp., database is CAplus and MEDLINE.

A series of novel ((hydroxyalkyl)aminomethyl)benzimidazole analogs I [n = 1, 2, 3, 4; R = H, tert-Bu, Ph, etc.; R¹ = H, cyclohexyl, 4-pyridinylmethyl, etc.] and II [R² = Ph, 4-methoxyphenyl, benzyl, 4-methoxybenzyl] were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, compound I [n = 1, R = Et, R¹ = H] (94.3% inhibition at 30 μM, IC₅₀ = 3.5 μM, cLogP = 4.132) and compound I [n = 1, R = cyclohexylemthyl, R¹ = H] (94.7% inhibition at 30 μM, IC₅₀ = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon played an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of compounds I [n = 1; R = Et, cyclohexylmethyl; R¹ = H] with normal B lymphoblasts revealed that they had no significant effects on cell viability.

European Journal of Medicinal Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Davies, Jacob published the artcileNi-Catalyzed carboxylation of aziridines en route to β-amino acids, Product Details of C4H11NO, the publication is Journal of the American Chemical Society (2021), 143(13), 4949-4954, database is CAplus and MEDLINE.

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO₂ at atm. pressure is disclosed. The protocol is characterized by its mild conditions, exptl. ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.

Journal of the American Chemical Society published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tolmacheva, Irina A. published the artcileSynthesis and evaluation of antiviral activities of triterpenic conjugates with 2-aminobutan-1-ol as potent microbicidal agents, Recommanded Product: 2-Aminobutan-1-ol, the publication is Medicinal Chemistry Research (2019), 28(10), 1648-1660, database is CAplus.

The effect of the synthetic modifications of the triterpenic A ring on the level of antiviral activity of triterpenic C3, C28 amides with a residue of racemic, (S), or (R)-enantiomeric 2-aminobutan-1-ol against herpes simplex viruses type I (HSV-I) and type II (HSV-II), as well as against human immunodeficiency virus type I (HIV-1) was investigated. The 2,3-secolupane racemic amide 5a was selected as a potent microbicidal agent with the highest virus inhibitory (against HSV-I and HSV-II) and virucidal (against HSV-1 and HIV-1) actions, the antiviral activity of which was provided by the (S)-enantiomeric conjugate 5b.

Medicinal Chemistry Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C19H21N3O, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Deng, Danfeng published the artcileNNN-Ruthenium Catalysts for the Synthesis of Pyridines, Quinolines, and Pyrroles by Acceptorless Dehydrogenative Condensation, Formula: C4H11NO, the publication is Organometallics (2018), 37(14), 2386-2394, database is CAplus.

The bidentate 6-picolinoyl 2,2′-bipyridine (bpy) ruthenium complex (6-HOC₅H₃NCO-bpy)Ru(CO)₂Cl₂ (2) transforms to a tridentate product I (3, L¹ = L² = Cl; n = 0), which further reacted with MeONa in the presence of PPh₃ to convert to two complexes, (4, 5; shown as I, 4, L¹ = L² = PPh₃, n = 1; 5, L¹ = Cl, L² = PPh₃, n = 0), via -OH deprotonation. The catalytic coupling cyclizations of secondary alcs. with amino alcs. were investigated, and complex 3 exhibited the highest activity. The coupling reactions proceeded in air with only 0.2 mol % catalyst loading and had a broad scope for the synthesis of pyridines, quinolones, and pyrroles.

Organometallics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Shibo published the artcileNickel-Catalyzed Regio- and Stereospecific C-H Coupling of Benzamides with Aziridines, Application of 2-Aminobutan-1-ol, the publication is Organic Letters (2021), 23(14), 5471-5475, database is CAplus and MEDLINE.

A nickel-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with aryl- and alkyl-substituted aziridines was disclosed. The current strategy provided direct access to benzolactams by the C-H alkylation-intramol. amidation cascade event with the concomitant removal of the aminoquinoline auxiliary. The regioselectivity of ring opening of aziridines was controlled by the substituents. The reaction with chiral aziridines proceeded with inversion of configuration, thus suggesting an SN²-type nucleophilic ring-opening pathway.

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C11H24O3, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghosh, Kousik published the artcileA triple alkoxo bridged dinuclear cobalt(III) complex mimicking phosphatase and showing ability to degrade organic dye contaminants by photocatalysis, COA of Formula: C4H11NO, the publication is Journal of Organometallic Chemistry (2019), 52-64, database is CAplus.

A dinuclear Co(III) complex, [(N₃)L¹Co^IIIL²Co^IIIL¹] (1), was synthesized and characterized {H₂L¹ = 2-((1-hydroxybutan-2-ylimino)methyl)-4-bromophenol and HL² = 2-amino-1-butanol}. Single crystal x-ray diffraction anal. confirmed its structure. Extended supra-mol. architectures were generated in the complex through weak noncovalent interactions. The energetic features of significant supramol. interactions were studied using DFT calculation and further corroborated with NCI plot index computational tool. The complex was found to mimic the role of phosphatase enzyme efficiently by transforming 4-nitrophenylphosphate to 4-nitrophenolate at room temperature The reaction follows Michaelis-Menten enzymic reaction kinetics with turnover numbers of ∼1.4 s^-1 in aqueous DMF (98% DMF, volume/volume) medium. The complex also acts as an efficient photocatalyst for degradation of organic pollutants. Methylene blue (MB), a widely used dye in various industries, was selected as a model pollutant in aqueous media to evaluate the photocatalytic effectiveness of the complex.

Journal of Organometallic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tan, Y. L. published the artcileDeoxygenation of pyrolysis vapour derived from durian shell using catalysts prepared from industrial wastes rich in Ca, Fe, Si and Al, Product Details of C4H11NO, the publication is Science of the Total Environment (2020), 134902, database is CAplus and MEDLINE.

Catalysts prepared from industrial wastes rich in Fe, Ca, Si, and Al were used in catalytic upgrading of pyrolysis vapor derived from durian shell and their effect on product yield and properties were compared. With same SiO₂-to-alumina ratio, catalyst prepared from oil palm ash (AS-OPA) with lower Fe and Ca contents gave higher liquid yield (8.32%) with alcs. (28.90%), hydrocarbons (46.00%), and N-containing compounds (21.46%) while catalyst prepared from elec. arc furnace slag (AS-EAF) with higher Fe and Ca contents produced lower liquid yield (50.21%) with high amount of esters (25.80%) and hydrocarbons (72.82%). The presence of AS-OPA and AS-EAF catalysts enhanced deoxygenation degree of bio-oil to 81.13% and 85.49%, resp. The catalytic performance of AS-EAF at different temperatures (400-600°) and AS-EAF/durian shell ratios (1:30, 2:30, 3:30) was studied. Increasing catalytic temperature enhanced production of bio-oil, reduced oxygenates and enhanced formation of esters. The liquid yield and yield of esters decreased with increasing catalyst loading. Hydrocarbons (mainly neopentane) were the major chem. compounds found in bio-oil produced over AS-EAF. Besides that, AS-EAF showed good deoxygenation performance with highest selectivity of hydrocarbons at 500° and AS-EAF/durian shell ratio of 2:30. Catalytic fast pyrolysis of durian shell using waste-derived catalysts is an effective waste management strategy as the bio-oil produced can be a potential alternative source of energy or chem. feedstocks.

Science of the Total Environment published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C10H9NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karpati, Levente published the artcileThe sequenced structure of amino-alcohol-based random poly(ester amide)s, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Thermal Analysis and Calorimetry (2019), 136(2), 737-747, database is CAplus.

Random amino-alc.-based poly(ester amide)s were synthesized using adipic acid and differently substituted amino-alcs., namely 2-amino-ethan-1-ol, 1-amino-propan-2-ol, 2-amino-butan-1-ol and 2-amino-2-methyl-propan-1-ol. The effect of substitution on the yield and fine structure was investigated using residual functional group anal., SEC and NMR. The functional group anal. and SEC proved the blocking effect of small substituents on direct polycondensation. The NMR data suggested a sequenced structure that could cause the formation of different crystalline phases in linear amino-alc.-based poly(ester amide)s. Three different crystalline phases with different thermal stability and crystallization rate were observed with DSC and WAXS. The crystalline nature of the poly(ester amide)s proves the sequenced organization along the backbone.

Journal of Thermal Analysis and Calorimetry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maji, Ankur published the artcileWell-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(13), 8351-8367, database is CAplus and MEDLINE.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Genyi published the artcileModular click chemistry libraries for functional screens using a diazotizing reagent, Application of 2-Aminobutan-1-ol, the publication is Nature (London, United Kingdom) (2019), 574(7776), 86-89, database is CAplus and MEDLINE.

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles.

Nature (London, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts