Category: 96-20-8

Podjed, Nina published the artcileStructural diversity and magnetic properties of copper(II) quinaldinate compounds with amino alcohols, COA of Formula: C4H11NO, the publication is New Journal of Chemistry (2022), 46(15), 6899-6920, database is CAplus.

The reactions between [Cu(quin)₂(H₂O)] (quin^– = the anionic form of quinoline-2-carboxylic acid) and a series of aliphatic amino alcs. have yielded structurally very diverse copper(II) complexes, labeled a–g. Single-crystal X-ray structure anal. has revealed either intact amino alc. mols. or amino alcoholate ions serving as ligands. In type a complexes, the amino alcs. are bound in a monodentate manner via NH₂. Engagement of both functional groups in coordination was observed for types b and e (a bidentate chelating mode) and type c (a bidentate bridging one) complexes. In view of the strong bidentate chelating coordination of quinaldinate in [Cu(quin)₂(H₂O)], the formation of homoleptic amino alc. complexes e was not anticipated. Equally surprising was the transformation of a mononuclear starting material into a one-dimensional (1D) coordination polymer, [Cu(quin)₂]_n (g). Spontaneous deprotonation of some amino alcs. and coordination of, thus formed, amino alcoholates via both donors also took place. Dinuclear complexes (d) contained two bridging amino alcoholates, while bidentate chelating mode was observed for type f. Interestingly, the dinuclear complex exists as two isomers which differ in the position of quinaldinates with respect to the Cu(μ-OR)₂Cu core. DFT calculations on isolated syn- and anti-[Cu₂(quin)₂(3a1pO)₂] (3a1pO^– = anion of 3-amino-1-propanol) have shown the syn isomer to be more stable. The explanation lies in the intramol. π···π stacking of quinaldinates, possible only in this isomer. Magnetic susceptibility measurements revealed antiferromagnetic interactions between S = 1/2 copper(II) spins in all the studied compounds except in [Cu(quin)₂]_n (g) for which weak ferromagnetic couplings are detected.

New Journal of Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paul, Aparup published the artcileDNA/protein binding and molecular docking studies of two tetranuclear Cu(II) complexes with double-open-cubane core like structure, Product Details of C4H11NO, the publication is Inorganica Chimica Acta (2019), 119005, database is CAplus.

Two Cu(II) complexes [Cu₄(L)₂(HL)₂(H₂O)₂](pv)₂ (1) and [Cu₄(L)₂(HL)₂(H₂O)₂](ssal) (2) [H₂L = 2-ethoxy-6-[(1-hydroxymethyl-propylimino)-methyl]-phenol; pv = pivalate; ssal = 2-Hydroxy-5-sulfosalicylate] have been synthesized and characterized by X-ray structure determination Structure determination reveals that both the complexes are tetranuclear with double open cubane core framework, and C-H···π interactions results the formation of 1D supramol. structure. At room temperature 1 and 2 show fluorescence (λ_ex = 267 nm, λ_em = 329, 516 and 620 nm for 1; λ_ex = 277 nm, λ_em = 315 and 413 nm for 2) with fluorescence quantum yield 0.41 and 0.46, resp. Interactions of complexes with calf thymus DNA (CT-DNA), bovine serum albumin (BSA) and human serum albumin (HSA) were studied using UV-vis absorption and fluorescence spectroscopic techniques, and the calculated values of intrinsic binding constants of 1 and 2 with CT-DNA are 2.71(±0.07) × 10⁴ M^-1 and 1.58(±0.11) × 10⁴ M^-1, resp. Mol. docking technique has been used to determine the mode of interaction of complexes with CT-DNA and serum albumins. The docking studies suggest that both the complexes can interact with DNA through groove binding mode, and possible binding sites of complexes with BSA and HSA are in the proximity of Tyr149 and Tyr150, resp.

Inorganica Chimica Acta published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Siyu published the artcileBiogas upgrading with various single and blended amines solutions: Capacities and kinetics, Category: alcohols-buliding-blocks, the publication is Energy (Oxford, United Kingdom) (2022), 124195, database is CAplus.

Biogas is an important renewable energy and biogas upgrading which sep. CH₄/CO₂ to increase the heating value of biogas is necessary for its utilization. Amine scrubbing is a promising biogas upgrading technol. In this study, we applied various single and blended amines solutions for biogas upgrading and reconsidered the evaluation method by comparing the equilibrium CO₂ absorption capacity (qe) and optimal CO₂ absorption capacity under 90 vol% or 95 vol% pure CH₄ requirement (q₉₀%CH₄, q₉₅%CH₄). Three apparent kinetic models and Fourier-transform IR spectroscopy (FT-IR) were applied to study the kinetics. The results showed that, compared with the qe, the new indicator q₉₀%CH₄ and q₉₅%CH₄ could better reveal the difference and improvements between various amines solutions and be more accordance with the real situation of biogas upgrading. The q₉₀%CH₄ increased from 0.15 to 0.82-1.70 mol/kg after adding other amines with methyldiethanolamine (MDEA), but qe was almost the same. For kinetics, the fitting results of Avrami model are the best among the three models. FT-IR anal. before and after absorption showed CO₂ formed different groups with different amine mols. This study provided a new perspective and method on evaluation of amine scrubbing for biogas upgrading, contributing to future research and industrial application.

Energy (Oxford, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Landge, Vinod G. published the artcilePalladium-Catalyzed Regioselective Arylation of Unprotected Allylamines, Recommanded Product: 2-Aminobutan-1-ol, the publication is JACS Au (2021), 1(1), 13-22, database is CAplus and MEDLINE.

A simple protocol for the arylation of cinnamylamines and the diarylation of terminal allylamines to generate a of 3,3-diarylallylamine products using a Pd^II precatalyst was described. Key features of the method were the ability to access relatively mild conditions that facilitate a broad substrate scope as well as direct diarylation of terminal allylamine substrates. In addition, several complex and therapeutically relevant mols. were included to demonstrate the utility of the transformation.

JACS Au published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salaciak, Kinga published the artcileSynthesis and evaluation of the antidepressant-like properties of HBK-10, a novel 2-methoxyphenylpiperazine derivative targeting the 5-HT1A and D2 receptors, Application In Synthesis of 96-20-8, the publication is Pharmaceuticals (2021), 14(8), 744, database is CAplus and MEDLINE.

The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates to fulfill these criteria. In this study, we aimed to synthesize a novel 2-methoxyphenylpiperazine derivative, HBK-10, and investigate its in vitro and in vivo pharmacol. profile. After assessing the affinity for serotonergic and dopaminergic receptors, and serotonin transporter, we determined intrinsic activity of the compound at the 5-HT1A and D2 receptors. Next, we performed behavioral experiments (forced swim test, tail suspension test) to evaluate the antidepressant-like activity of HBK-10 in naive and corticosterone-treated mice. We also assessed the safety profile of the compound We showed that HBK-10 bound strongly to 5-HT1A and D2 receptors and presented antagonistic properties at these receptors in the functional assays. HBK-10 displayed the antidepressant-like effect not only in naive animals, but also in the corticosterone-induced mouse depression model, i.e., chronic administration of HBK-10 reversed corticosterone-induced changes in behavior. Moreover, the compound′s sedative effect was observed at around 26-fold higher doses than the antidepressant-like ones. Our study showed that HBK-10 displayed a favorable pharmacol. profile and may represent an attractive putative treatment candidate for depression.

Pharmaceuticals published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Siewert, Riko published the artcileNon-covalent interactions in molecular systems: thermodynamic evaluation of the hydrogen bond strength in aminoalcohols, Recommanded Product: 2-Aminobutan-1-ol, the publication is Physical Chemistry Chemical Physics (2021), 23(44), 25226-25238, database is CAplus and MEDLINE.

In mols. with two functional groups that form hydrogen bonds, the structure-property relationship can depend significantly on the strength of intra-mol. hydrogen bonding. This bonding can cause a substantial conformational change that is accompanied by a frequency shift in the IR spectrum, which provides the basis for exptl. studies. Despite its great importance in biol. systems, the available literature data for the strength of this bonding are scarce and not in agreement. In this work, we present the results of four thermodn. methods for the determination of the strength of intramol. hydrogen bonds. Comprehensive thermochem. anal. of 1-amino-2-alcs. and 2-amino-1-alcs. was performed with Fourier-transform IR spectroscopy, high-level G4 quantum-chem. calculations, the homomorph scheme with enthalpies of vaporization and a group contribution method. With the combination of these four thermodn. methods, the strength of intramol. hydrogen bonding in 1,2-aminoalcs. and 2,1-aminoalcs. was evaluated quant. The results were correlated with NBO parameters to find an explanation for the different strengths of intramol. hydrogen bonds in total charge transfer and second order stabilization energies.

Physical Chemistry Chemical Physics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C7H14N4, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ubale, Akash S. published the artcileTransition-Metal-Free Alkylative Aromatization of Tetralones using Alcohols/Amino Alcohols Toward the Synthesis of Bioactive Naphthol and Benzo[e/g]indole Derivatives, Name: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(12), 8104-8117, database is CAplus and MEDLINE.

Herein, the synthesis of bioactive naphthols I (R¹ = H, 6-Br, 6-MeO, 7-MeO; R² = Ph, 3-MeC₆H₄, 2-thienyl, etc.) and II or benzindoles III (R³ = Me, Et, PhCH₂, etc.) and IV by alkylative aromatization of the corresponding 1- and 2-tetralones with alcs. R²CH₂OH or amino alcs. H₂NCHR³CH₂OH in the presence of NaOH using aerobic oxidative cross-coupling protocol is reported. This is a general and transition-metal-free method, which uses an inexpensive base, does not require inert conditions, and furnishes water and hydrogen peroxide as byproducts. Moreover, this method is compatible with a wide substrate scope and showed exclusive regioselectivity.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C10H15NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yongjie published the artcilePyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation, HPLC of Formula: 96-20-8, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127712, database is CAplus and MEDLINE.

Tropomyosin receptor kinases (Trks), a transmembrane receptor tyrosine kinases, have attracted more and more attention as antitumor drug targets. Here we reported the structure-based synthesis and biol. evaluation of novel pyrazolo[1,5-a]pyrimidine derivatives, i.e., I, as Trk inhibitors, which exhibited potent Trk inhibitory activities. Particularly, some of the compounds (8a, 8f, 9a, 9b and 9f) (IC₅₀ < 5 nM) showed significant inhibitory potency against Trk.

Bioorganic & Medicinal Chemistry Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H6ClF3, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Steiman, Talia J. published the artcileSynthesis of β-Phenethylamines via Ni/Photoredox Cross-Electrophile Coupling of Aliphatic Aziridines and Aryl Iodides, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of the American Chemical Society (2020), 142(16), 7598-7605, database is CAplus and MEDLINE.

A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl aziridines and com. available (hetero)aryl iodides is reported. This mild and modular method proceeds in the absence of stoichiometric heterogeneous reductants and uses an inexpensive organic photocatalyst to access medicinally valuable β-phenethylamine derivatives Unprecedented reactivity was achieved with the activation of cyclic aziridines. Mechanistic studies suggest that the regioselectivity and reactivity observed under these conditions are a result of nucleophilic iodide ring opening of the aziridine to generate an iodoamine as the active electrophile. This strategy also enables cross-coupling with Boc-protected aziridines.

Journal of the American Chemical Society published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C7H7ClN2S, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Chong published the artcileMultiple Responsive CPL Switches in an Enantiomeric Pair of Perovskite Confined in Lanthanide MOFs, Application In Synthesis of 96-20-8, the publication is Advanced Materials (Weinheim, Germany) (2022), 34(11), 2109496, database is CAplus and MEDLINE.

Circularly polarized luminescence (CPL) switches have attracted widespread attention due to their potential applications in advanced information technologies. However, the design and fabrication of solid-state multiple-responsive CPL switches remain challenging. Here, through self-assembly of chiral metal-organic frameworks (MOFs) and perovskite nanocrystals (NCs), a pair of crystalline enantiomeric (P)-(+)/(M)-(-)-EuMOF⊃MAPbX3 (MA = CH3NH3+, X = Cl-, Br-, I-) adducts is prepared, where the achiral MAPbBr3 perovskite NCs embedded into chiral MOFs inherit the chirality of host MOFs by host-guest EuBr and PbO coordination bonds, which is demonstrated by synchrotron-radiation-based X-ray absorption spectroscopy. The chiral adducts show enhanced photoluminescence quantum yield (PLQY), good thermal stability of CPL in air, and photoswitchable CPL properties upon altering different UV irradiation Based on two chiral emission centers and their different characteristics, reversible CPL switches are realized upon a diversity of external stimuli, for example, chems. (water /CH3NH3Br solution) or temperatures (room temperature/high temperature). Benefiting from the extraordinary stimuli-responsive and highly reversible switchable CPL, multiple information encryptions and decryptions integrated with CPL, together with a chiroptical logic gate are successfully designed. This work opens a new avenue to generally fabricate solid-state CPL composite materials and develops new applications based on switchable CPL.

Advanced Materials (Weinheim, Germany) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C9H7NO4, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts