Category: 94022-96-5

Application of 94022-96-5 ,Some common heterocyclic compound, 94022-96-5, molecular formula is C9H9F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of alcohol 1 (1 mmol), the O, Se acetal 2a (1.4 mmol), solid potassium carbonate (2.0 mmol) and activated 3 A molecular sieves (0.20 g) in dry ethyl acetate (16 mL), solid N-iodosuccinimide (1.4 mmol) was added in portion at room temperature. The mixture was stirred under inert atmosphere and monitored by TLC. Reaction times ranged from 0.5 to 2 h. The brown colored reaction mixture was quenched into 20 mL of 10% aqueous sodium thiosulfate pentahydrate solution, mixed, and separated. The aqueous phase was extracted with 10 mL of ethyl acetate and the combined organic phases were washed with 10 mL of brine, dried over sodium sulfate and concentrated. Purification by silica gel column chromatography afforded the MOM-ether derivative 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94022-96-5, its application will become more common.

Reference:
Article; Temperini, Andrea; Annesi, Diego; Testaferri, Lorenzo; Tiecco, Marcello; Tetrahedron Letters; vol. 52; 25; (2011); p. 3179 – 3182;,
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Related Products of 94022-96-5, Adding some certain compound to certain chemical reactions, such as: 94022-96-5, name is 2-(Trifluoromethyl)phenethyl alcohol,molecular formula is C9H9F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94022-96-5.

General procedure: A mixture of the substituted phenylethyl alcohol (10 mmol), Chloromethyl methyl ether (15mmol) and N,N-diisopropylethylamine (20 mmol) in dry dichloromethane (25 mL)was stirred under nitrogen atmosphere for 2.5 h at rt. The reaction mixture wasthen washed with water (2×50 mL), dried (NaSO4) and the solvent wasremoved in vacuo. The crude MOM acetal was dissolved in dried CH3CN (25mL) and added to cooled (0 oC) solution of Trimethylsilyltrifluoromethanesulfonate (TMSOTf) (10 mmol). The reaction was carried outunder nitrogen atmosphere for 3 h. Then the mixture was quenched by theaddition of l M NaHCO3 (20 mL ). The orgnic phase was washed withbrine (2×50 mL), dried (NaSO4) and evaporated under reducedpressure. Purification by FC afforded relevant substituted isochromans.

According to the analysis of related databases, 94022-96-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhou, Mei-Yan; Kong, Shan-Shan; Zhang, Ling-Qiong; Zhao, Ming; Duan, Jin-Ao; Ou-Yang, Zhen; Wang, Min; Tetrahedron Letters; vol. 54; 30; (2013); p. 3962 – 3964;,
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Synthetic Route of 94022-96-5 , The common heterocyclic compound, 94022-96-5, name is 2-(Trifluoromethyl)phenethyl alcohol, molecular formula is C9H9F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

0.301 g (1 mmol) of (3R)-4-(4-toluenesulfonyl)thiomorpholine-3-carboxylic acid, 0.285 g (1.5 mmol) of (2-trifluoromethyl)-phenylethanol, 0.088 g (0.33 mmol) of CAS, 0.227 g (1.2 mmol) of DCC and 0.04 g (0.33 mmol) of DMAP were dissolved in 15 mL of CH2Cl2. The mixture was stirred for 24 h at room temperature. The solid was filtrated and the solvent was evaporated. The residual was dissolved in a suitable amount of ethyl acetate (20 ml) and then the mixture was filtered to remove insoluble substance. The ethyl acetate was added to 60 ml and then the liquid was washed with 10% NaHCO3 solution, saturated NaCl solution and dried over Na2SO4. After the drying agent was removed and part of ethyl acetate was evaporated, the crude product was purified by flash column chromatography (eluent: ethyl acetate_cyclohexane=1:3) to obtain the product as a oil (0.44 g).

The synthetic route of 94022-96-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Li, Song; Nie, Aihua; Shen, Beifen; Wang, Lili; Pei, Wuhong; Xiao, Junhai; Yang, Songcheng; Yun, Liuhong; Liu, Hongying; Shu, Cuiling; Wang, Hongxia; Rao, Zihe; US2005/130958; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 94022-96-5, 2-(Trifluoromethyl)phenethyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

Example 67 3-(4-[2-(2-Trifluoromethyl-phenyl)-ethoxy]-indol-1-yl)-propionic acid (176) Prepared as described for Example 53 except the alkylation on the indole oxygen was completed in the following manner. 3-(4-Hydroxy-indol-1-yl)-propionic acid methyl ester (1.73 g, 7.89 mmol), triphenylphosphine (2.07 g, 7.89 mmol), and 2-(2-Trifluoromethyl-phenyl)-ethanol (1.25 mL, 7.89 mmol) were dissolved in tetrahydrofuran (35 mL). Diethyl azodicarboxylate (1.28 mL in 5 mL THF, 7.89 mmol) was added dropwise and the reaction stirred at room temperature overnight. The mixture was concentrated and purified by chromatography. Yield=290 mg, 10%. m.p.=126-129, THEORY: 63.66%; C, 4.81%; H, 3.71%; N. ACTUAL: 63.68%; C, 4.97%; H, 3.71%; N.

The synthetic route of 94022-96-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bigge, Christopher Franklin; Bridges, Alexander James; Casimiro-Garcia, Agustin; Fakhoury, Stephen Alan; Lee, Helen Tsenwhei; Reed, Jessica; Schaum, Robert; Schlosser, Kevin Matthew; Sexton, Karen; Zhou, Hairong; US2003/171377; (2003); A1;,
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