Xie, Jin et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of 2-(Trifluoromethyl)phenethyl alcohol

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety was written by Xie, Jin;Yang, Fengzhi;Zhang, Man;Lam, Celine;Qiao, Yixue;Xiao, Jia;Zhang, Dongdong;Ge, Yuxuan;Fu, Lei;Xie, Dongsheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

A series of caffeic acid phenylethyl ester (CAPE) derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE’s antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50 = 0.4 卤 0.02 & 0.6 卤 0.03 渭M against Hela and DU-145 resp.). In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Quality Control of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fache, Fabienne et al. published their research in Tetrahedron Letters in 1995 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

A catalytic stereo- and chemo-selective method for the reduction of substituted aromatics was written by Fache, Fabienne;Lehuede, Stephan;Lemaire, Marc. And the article was included in Tetrahedron Letters in 1995.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Various substituted aromatics have been reduced using colloidal ruthenium under H2 pressure with good stereoselectivity (cis/trans up to 60). Interesting chemoselectivities are also observed In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lipshutz, Bruce H. et al. published their research in Advanced Synthesis & Catalysis in 2009 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 2-(Trifluoromethyl)phenethyl alcohol

Aminations of Aryl Bromides in Water at Room Temperature was written by Lipshutz, Bruce H.;Chung, David W.;Rich, Brian. And the article was included in Advanced Synthesis & Catalysis in 2009.Name: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Unsym. diarylamines and triarylamines R1C6H4NR2R3 [R1 = H, 4-NC, 4-O2N, etc.; R2 = H, Me, Ph; R3 = 4-FC6H4, 1-naphthyl, 2,4-(MeO)2C6H3, etc.] were obtained via palladium-catalyzed amination at ambient temperatures in water. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Name: 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xie, Jin et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of 2-(Trifluoromethyl)phenethyl alcohol

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety was written by Xie, Jin;Yang, Fengzhi;Zhang, Man;Lam, Celine;Qiao, Yixue;Xiao, Jia;Zhang, Dongdong;Ge, Yuxuan;Fu, Lei;Xie, Dongsheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

A series of caffeic acid phenylethyl ester (CAPE) derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE’s antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50 = 0.4 ± 0.02 & 0.6 ± 0.03 μM against Hela and DU-145 resp.). In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Quality Control of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fache, Fabienne et al. published their research in Tetrahedron Letters in 1995 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

A catalytic stereo- and chemo-selective method for the reduction of substituted aromatics was written by Fache, Fabienne;Lehuede, Stephan;Lemaire, Marc. And the article was included in Tetrahedron Letters in 1995.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Various substituted aromatics have been reduced using colloidal ruthenium under H2 pressure with good stereoselectivity (cis/trans up to 60). Interesting chemoselectivities are also observed In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lipshutz, Bruce H. et al. published their research in Advanced Synthesis & Catalysis in 2009 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 2-(Trifluoromethyl)phenethyl alcohol

Aminations of Aryl Bromides in Water at Room Temperature was written by Lipshutz, Bruce H.;Chung, David W.;Rich, Brian. And the article was included in Advanced Synthesis & Catalysis in 2009.Name: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Unsym. diarylamines and triarylamines R1C6H4NR2R3 [R1 = H, 4-NC, 4-O2N, etc.; R2 = H, Me, Ph; R3 = 4-FC6H4, 1-naphthyl, 2,4-(MeO)2C6H3, etc.] were obtained via palladium-catalyzed amination at ambient temperatures in water. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Name: 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fache, Fabienne et al. published their research in Synlett in 2004 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 94022-96-5

Hexafluoroisopropanol: A powerful solvent for the hydrogenation of functionalized aromatic compounds was written by Fache, Fabienne;Piva, Olivier. And the article was included in Synlett in 2004.SDS of cas: 94022-96-5 This article mentions the following:

Various substituted aromatic compounds have been reduced under H2 using RuCl3. The fluorous solvent hexafluoroisopropanol turned out to be particularly efficient in the case of compounds difficult to reduce in organic solvents. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5SDS of cas: 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hardy, George W. et al. published their research in Journal of Medicinal Chemistry in 1989 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 2-(Trifluoromethyl)phenethyl alcohol

Peripherally acting enkephalin analogs. 2. Polar tri- and tetrapeptides was written by Hardy, George W.;Lowe, Lawrence A.;Mills, Gail;Sang, Pang Yih;Simpkin, Dean S. A.;Follenfant, Rhonda L.;Shankley, Clare;Smith, Terence W.. And the article was included in Journal of Medicinal Chemistry in 1989.Safety of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

The design, synthesis, and biol. activity of a series of D-Arg2-enkephalin-derived tetrapeptide amides and tripeptide aralkylamides are reported. These polar analogs were designed to be excluded from the central nervous system, with their action thus limited to peripheral opioid receptors. The effects of the nature of the aromatic ring, aryl ring substitution and aralkylamide chain length on activity were investigated; in a number of cases the N-terminal amino group of Tyr1 was converted to a guanidino group to further increase hydrophilicity. The peptides were all synthesized by classical solution methodol. The opioid activity of the peptides was assessed in vitro on the guinea pig ileum, and their antinociceptive activity was determined in vivo in chem. induced writhing models (peripheral activity) and in the hot-plate test (central activity) in rodents. The analgesic effects were predominantly mediated in the periphery, as demonstrated by antagonism of antinociception by the peripheral opioid antagonist N-methylnalorphine and by comparison of the activities in the writhing and hot-plate tests. As a class, the tetrapeptides were more potent than the tripeptides; Nα-amidination generally increased activity. A number of compounds exhibited very potent opioid activity and had the desired pharmacol. profile, indicating a high degree of peripheral selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Safety of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nie, Ai Hua et al. published their research in Chinese Chemical Letters in 2005 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C9H9F3O

Drug discovery based on the structure of FKBPs: design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands was written by Nie, Ai Hua;Xiao, Jun Hai;Liu, Hong Ying;Li, Li Wang;Li, Song. And the article was included in Chinese Chemical Letters in 2005.Computed Properties of C9H9F3O This article mentions the following:

Based on the structure of FK506, FKBP12 and calcineurin complex and the interactive characteristics of small mol. ligands with FK-506-binding proteins (FKBPs), a series of L-tetrahydro-1,4-thiazine-3-carboxylic acid derivatives I [X = O, R = PhCH2NMeCH2CH2, PhCH:CHCH2, 3-cyclohexylpropyl, 4-O2NC6H4CH2, etc.; X = NH, R = Me2CHCH2CH(CO2Et), PhCH2CH(CO2CH2Ph), etc.] was designed and synthesized as neuroimmunophilin ligands. The results of evaluation show that I [X = O; R = (PhCH2OCH2)2CH] (N308) has a great promise as a candidate of neuroprotective and neuroregenerative agent. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Computed Properties of C9H9F3O).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ornstein, Paul L. et al. published their research in Journal of Medicinal Chemistry in 1998 | CAS: 94022-96-5

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 94022-96-5

Substituted (2SR)-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution; Pharmacological Characterization, and Bioavailability was written by Ornstein, Paul L.;Bleisch, Thomas J.;Arnold, M. Brian;Wright, Rebecca A.;Johnson, Bryan G.;Tizzano, Joseph P.;Helton, David R.;Kallman, Mary Jeanne;Schoepp, Darryle D.;Herin, Marc. And the article was included in Journal of Medicinal Chemistry in 1998.Reference of 94022-96-5 This article mentions the following:

In this paper the authors describe the synthesis of a series of α-substituted analogs of the potent and selective group II metabotropic glutamate receptor (mGluR) agonist (1S,1’S,2’S)-carboxycyclopropylglycine (I). Incorporation of a substituent on the amino acid carbon converted the agonist I into an antagonist. All of the compounds were prepared and tested as a series of four isomers, i.e., two racemic diastereomers. On the basis of the improvement in affinity realized for the α-phenylethyl analog II (R = CH2Ph), in this paper the authors explored the effects of substitution on the aromatic ring as a strategy to increase the affinity of these compounds for group II mGluRs. Affinity for group II mGluRs was measured using [3H]glutamic acid (Glu) binding in rat forebrain membranes. Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. Meta substitution on the aromatic ring of II (R = CH2Ph) with a variety of substituents, both electron donating (R = 3-R1C6H4CH2; R1 = 3-Me, 3-OH, 3-NH2, 3-OMe, 3-Ph, 3-PhO) and electron withdrawing (R1 = 3-F, 3-Cl, 3-Br, 3-CO2H, 3-CF3) gave from 1.5- to 4.5-fold increases in affinity. Substitution with p-F (II; R = 4-FC6H4CH2) (IC50 = 0.022 ± 0.002), was the exception. Here, a greater increase in affinity was realized than for either the ortho- or meta-substituted analogs; II (R = 4-FC6H4CH2) was the most potent compound resulting from monosubstitution of the aromatic At best, only modest increases in affinity were realized for certain compounds bearing either two chlorines or two fluorines, and two methoxy groups gave no improvement in affinity (all examined in a variety of substitution patterns). Three amino acids II (R1 = CHPh2, 9-xanthyl, 3-MeC6H4CH2) were resolved into their four constituent isomers, and affinity and functional activity for group II mGluRs was found to reside solely in the S,S,S-isomers of each, consistent with I. With an IC50 = 2.9 ± 0.6 nM, the resolved xanthylmethyl compound (S,S,S)-III (LY341495) was the most potent compound from this SAR. (S,S,S)-III demonstrated high plasma levels following i.p. (i.p.) administration and readily penetrated into the brain. This compound, however, had only limited (∼5%) oral bioavailability. Systemic administration of (S,S,S)-III protected mice from limbic seizures produced by the mGluR agonist 3,5-dihydroxyphenylglycine, with an ED50 = 31 mg/kg (i.p., 60 min preinjection). Thus, (S,S,S)-III represents a valuable tool to study the role of group II mGluRs in disease. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Reference of 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts