Category: 93427-13-5

Abramovitch, Rudolph A. published the artcileSolution and flash vacuum pyrolyses of β-(3,5-disubstituted-phenyl)ethanesulfonyl azides. Sultam, pyrindine, and azepine formation, SDS of cas: 93427-13-5, the main research area is pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine.

The solution and flash-vacuum pyrolyzes of azides I (R = Me, Cl, MeO, CF3) are reported. When R = Me, FVP results suggest that the substituents stabilize the intermediate leading to the sultam (II, R = R1 = Me). A new product, pyridine III, is observed, and a modification is proposed in the mechanism proposed earlier to account for the FVP of β-arylethanesulfonyl azides. No dihydropyrindine, which would have required a Me migration, is observed When R = Cl, migration of Cl does occur and a mixture of 5H- and 7H-1-pyrindines is obtained, together with other products. When R = MeO, some MeO migration occurs on FVP to give 6,7-dihydro-3,5-dimethoxy-5H-1-pyrindine. Monodemethoxylation to give II (R = MeO, R1 = H) also takes place, and a possible mechanism is proposed. When R = CF3 the main product on FVP at 300° is the fused azepine IV in respectable yield. This is the first example of the isolation of an N-sulfonylazepine from the intramol. reaction of a sulfonylnitrene and from a FVP.

Journal of Organic Chemistry published new progress about pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, SDS of cas: 93427-13-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Woolard, Katherine J. published the artcileDevelopment of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model, Application of 2-(3,5-Dichlorophenyl)ethanol, the main research area is piperidine alkylation alc mesylation preparation antibiofilm salmonella gallbladder.

Salmonella enterica serovars cause millions of infections each year that result either in typhoid fever or salmonellosis. Among those serovars that cause typhoid fever, Salmonella enterica subspecies Typhi can form biofilms on gallstones in the gallbladders of acutely-infected patients, leading to chronic carriage of the bacterium. These biofilms are recalcitrant to antibiotic-mediated eradication, leading to chronic fecal shedding of the bacteria, which results in further disease transmission. Herein, we report the synthesis and anti-biofilm activity of a 55-member library of small mols. based upon a previously identified hit that both inhibits and disrupts S.Typhi and S. Typhimurium (a nontyphoidal model serovar for S. Typhi) biofilms. Lead compounds inhibit S. Typhimurium biofilm formation in vitro at sub-micromolar concentrations, and disperse biofilms with five-fold greater potentency than the parent compound Three of the most promising compounds demonstrated synergy with ciprofloxacin in a murine model of chronic Salmonella carriage. This work furthers the development of effective anti-biofilm agents as a promising therapeutic avenue for the eradication of typhoidal Salmonella.

European Journal of Medicinal Chemistry published new progress about Antibiofilm agents. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Application of 2-(3,5-Dichlorophenyl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zha, Gao-Feng published the artcileSO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes, Application of 2-(3,5-Dichlorophenyl)ethanol, the main research area is alkyne chemoselective preparation; phenyltriazole phenylacetylene preparation; sulfuryl fluoride DMSO mediated oxidative dehydrogenation elimination alc; beta hydroxy amide secondary alc oxidative elimination sulfuryl fluoride; sequential oxidative elimination primary alc azide alkyne cycloaddition azidobenzene; oxidative elimination primary alc Sonogashira coupling iodobenzene.

Terminal and internal alkynes were prepared directly from primary alcs. and secondary alcs. and β-hydroxyamides by oxidative dehydrogenation and dehydration using sulfuryl fluoride as the leaving group source and DMSO as oxidant; the method does not require transition metal reagents or catalysts. The method was used in one-pot preparations of phenyltriazoles and phenylacetylenes using the oxidative dehydrogenation/elimination reaction in sequence with azide-alkyne cycloaddition with Ph azide and Sonogashira coupling with iodobenzene.

Journal of the American Chemical Society published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Application of 2-(3,5-Dichlorophenyl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yangyang published the artcileNickel-catalyzed migratory alkyl-alkyl cross-coupling reaction, Related Products of alcohols-buliding-blocks, the main research area is alkyl halide migratory cross coupling bond formation nickel catalyst.

A migratory cross-coupling strategy, which can overcome this obstacle to access the desired cross-coupling products ArCH(R)(CH2)nCR1R2R3 (Ar = Ph, 4-fluorophenyl, indol-3-yl, etc.; R = cyclopentyl, cyclohexyl, cycloheptyl, N-benzyl-piperidin-4-yl, 2-methyl-propan-1-yl; R1 = H, D; R2 = H, D; R3 = H; n = 0-3, 5), 1-cyclopentyl-indan, 1-cycloheptyl-indan, (1-cyclopentyl-3-methyl-pentyl)benzene was described. Accordingly, a selective migratory cross-coupling of two alkyl electrophiles (RBr, ArCH(R)(CH2)nCR1R2R3 (R3 = Br or Cl), 2-bromoindan, (5-bromo-1-cyclopentyl-3-methyl-pentyl)benzene) has been accomplished by nickel catalysis. Remarkably, this alkyl-alkyl cross-coupling reaction provides a platform to prepare 2°-2° carbon-carbon bonds from 1° and 2° carbon coupling partners. Preliminary mechanistic studies suggest that chain-walking occurs at both alkyl halides in this reaction, thus a catalytic cycle with the key step involving two alkylnickel(II) species is proposed for this transformation.

Chemical Science published new progress about C-C bond formation. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts