Category: 929-06-6

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-(2-Aminoethoxy)ethanol

Example 1 Tert-butyl 2-(2-hydroxyethoxy)ethylcarbamate In a three-necked flask (1000 mL) equipped with a mechanical stirrer, 52.5 g (500 mmol) of diglycolamine and 200 mL of chloroform were dissolved and cooled to 20C on an ice-water bath. To the flask, a mixture prepared by dissolving 109 g (500 mmol) of (Boc)2O in 200 mL of chloroform was added with stirring. The resultant solution was stirred overnight at room temperature. After reaction completion, 400 mL of water were added, and the organic and aqueous phases were allowed to separate. The resultant organic phase was removed, washed with water twice, saturated brine twice, dried over anhydrous MgSO4, filtered, and vacuum dried to yield 99.607 g of the title compound 1.

With the rapid development of chemical substances, we look forward to future research findings about 929-06-6.

Reference:
Patent; Tianjin Hemey Bio-Tech Co., Ltd.; EP2123283; (2009); A1;,
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Application of 929-06-6 ,Some common heterocyclic compound, 929-06-6, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add a magnet to a 1L round bottom flask.Add (9.542 ml, 95.1113 mmol),Dichloromethane 150ml dissolved,Triethylamine (26.5133 ml, 190.2226 mmol) was added,Boc anhydride was added under stirring (24.9096 g,114.1335mmol). After the reaction was completed, the reaction solution was transferred to a rotary evaporator and concentrated. Methanol was added to dissolve the mixture. Under stirring, sodium bicarbonate powder (13 g) was added to neutralize triethylamine, suction filtered, and silica gel powder was added as a solid solution. Dry method,Column chromatography eluting with a gradient of 10% ethyl acetate/petroleum ether to 50% ethyl acetate/petroleum ether, gradient elution with 3% methanol/ethyl acetate to 6% methanol/ethyl acetate.The product was collected and evaporated to give 16.3341 g of compound in a yield of 83.77%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 929-06-6, 2-(2-Aminoethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chongqing A Pugelei Biological Technology Co., Ltd.; Li Gaoquan; Chen Maofen; Wang Bin; Li Dajun; Zhang Qian; Shui Juyuan; Peng Liangyan; Huang Lei; He Tingting; Zhang Cuifang; Wu Xiaodan; Li Jianhuan; (39 pag.)CN107670050; (2018); A;,
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Synthetic Route of 929-06-6, Adding some certain compound to certain chemical reactions, such as: 929-06-6, name is 2-(2-Aminoethoxy)ethanol,molecular formula is C4H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 929-06-6.

To a round-bottomed flask containing dichloromethane (15 mL), 2-(2-aminoethoxy)ethanol1 (1.580 g, 15.03 mmol) was added. The solution was kept in ice bath (0 C). A dichloromethanesolution (9 mL) containing di-tert-butyl dicarbonate (3.726 g, 17.07 mmol) was added dropwise (25 min)to the round-bottomed flask. The progress of this amine protection reaction could be convenientlymonitored using TLC. The reaction was carried out at room temperature for 6.5 h.After the reaction, the mixture was washed first with 10 wt% citric acid (10 mL), then10 wt% NaHCO3 (10 mL 2), and finally with water (10 mL). The organic layer collected wasdried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residuewas purifed by column chromatography (ethyl acetate /hexane = 1:3, v/v) to aord tert-butyl(2-(2-hydroxyethoxy)ethyl)carbamate (2.646 g, 86% yield) as colorless liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 929-06-6, 2-(2-Aminoethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Hsin-Yi; Chu, Yen-Ho; Molecules; vol. 25; 1; (2020);,
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Adding a certain compound to certain chemical reactions, such as: 929-06-6, 2-(2-Aminoethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H11NO2, blongs to alcohols-buliding-blocks compound. COA of Formula: C4H11NO2

Step 1: Synthesis of tert-butyl N-[2-(2-hydroxyethoxy)ethyl] carbamate (AR)[0549] To a stirred solution of 2-(2-aminoethoxy)ethan-l-ol (AQ, 5.25 g, 49.94 mmol) in tetrahydrofuran (100 mL) was added aqueous solution of sodium bicarbonate (20% (w/w), 40 ml) and (Boc)20 (11.4 g, 52.23 mmol, added in several batches) at 0 C. The resulting mixture was then warmed up slowly to rt and stirred at rt for 5h. The bulk of organic solvent was removed under reduced pressure and the resulting residue was diluted with water (300 mL), extracted with of ethyl acetate (100 mL x 3). The organic layers were combined, washed with saturated aqueous solution of sodium chloride (20 mL x 2), dried over anhydrous sodium sulfate and then concentrated under reduced pressure to give AR (yield: 98%) as colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,929-06-6, 2-(2-Aminoethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; ARVINAS, INC.; JIN, Meizhong; CREW, Andrew, P.; DONG, Hanqing; WANG, Jing; SIU, Kam; FERRARO, Caterina; CHEN, Xin; QIAN, Yimin; (351 pag.)WO2016/118666; (2016); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 929-06-6, 2-(2-Aminoethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 929-06-6, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(2-Aminoethoxy)ethanol

Step 1 2-(2-N-Boc-aminoethoxy)ethanol To a solution of 2-(2-aminoethoxy)ethanol (5.3 g, 50 mmol) and diisopropylethylamine (13 ml, 75 mmol) in DCM (10 ml) at 0 C. was added dropwise a is solution of di-tert-butyl dicarbonate (12 g, 55 mmol) in DCM (20 ml). The reaction was agitated for 4 hours, extracted with DCM and purified by flash chromatography (EtOAc/PE) (75/25) to give the title compound (5.9 g, 60%). 1H NMR (CDCl3) delta 3.65 (dd, J=8.6, 3.8 Hz 2H), 3.47 (m, 5H), 2.23 (dd, J=8.6, 3.8 Hz 2H), 1.35 (s, 9H); 13C NMR (CDCl3) delta 56.1, 79.1, 72.1, 70.1, 61.3, 40.3, 28.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,929-06-6, its application will become more common.

Reference:
Patent; Gustavsson, Anna-Lena; Jendeberg, Lena; Roussel, Patrick; Slater, Martin; Thor, Markus; US2003/73862; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 3,6,11-trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, methyl ester (17) To a stirred solution of 2-(2-aminoethoxyl)ethanol (1.05 g, 10 mmol, 1 equiv) in anhydrous ethanol (15 mL) at 0 C. was added di-tert-butyl dicarbonate (2.2 g, 10 mmol, 1 equiv). The reaction mixture was stirred for 2 hours at room temperature. It was concentrated under reduced pressure, re-dissolved in dichloromethane, and washed with brine. The organic extract was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to give the crude product as a colorless oil. The product 12 was used in the next step without further purification. 1H NMR (600 MHz, CDCl3) delta 1.44 (s, 9H), 3.33-3.34 (m, 2H), 3.54-3.59 (dt, J=10.4, 5.2 Hz, 2H), 3.73-3.75 (dt, J=4.3, 3.4 Hz, 2H).

The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOLEDO; Tillekeratne, L. M. Viranga; Almaliti, Jehad; Al-Hamashi, Ayad; Bhansali, Pravin; (74 pag.)US2015/329560; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 929-06-6, Adding some certain compound to certain chemical reactions, such as: 929-06-6, name is 2-(2-Aminoethoxy)ethanol,molecular formula is C4H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 929-06-6.

Compound 35A: tert-butyl (2-(2-hydroxyethoxy)ethyl)carbamate O / (Boc)20 HzN^^^ ^”^^OH *~ BocHN’ THF 2-(2-aminoethoxy)ethanol (5 g, 47.56 mmol, 1.00 equiv) was dissolved in THF (100 mL) at 0C and sodium hydroxide (2 g, 50.00 mmol, 1.05 equiv) was then added (solution in 25 mL of water). A solution of di-tert-butyl dicarbonate (10.38 g, 47.56 mmol, 1.00 equiv) in THF (20 mL) was added drop-wise and the reaction was then left under agitation overnight at ambient temperature. The reaction was diluted by adding 50 mL of water and the product was extracted with 3 times 75 mL of AcOEt. The organic phases were combined, washed once with 100 mL of NaCl (sat.), then dried over sodium sulfate, filtered and concentrated under reduced pressure to yield 9 g (92 %) of compound 35A in the form of a yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 929-06-6, 2-(2-Aminoethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PIERRE FABRE MEDICAMENT; RILATT, Ian; PEREZ, Michel; GOETSCH, Liliane; BROUSSAS, Matthieu; BEAU-LARVOR, Charlotte; HAEUW, Jean-Francois; WO2015/162293; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 929-06-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 929-06-6, name is 2-(2-Aminoethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

compound C (10.0 g, 0.095 mol) was dissolved in 50 mL of methylene chloride and triethylamine (11.55 g, 0.114 mol) was added to it. The solution was cooled in an ice-bath and di-tert-butylcarbonate (22.83 g, 0.105 mol) in 30 mL of methylene chloride was added through an additional funnel. The reaction was slowly warmed up to room temperature and stirred at room temperature overnight. The reaction was extracted with water and the organic phase was washed with diluted HCl solution and dried over magnesium sulfate. Solvent was evaporated and the crude product was purified by column to give 12.43 g of pure product as an oil, 64% yield. 1H NMR (CDCl3) delta (ppm): 1.45 (s, 9 H), 3.30-3.35 (m, 2 H), 3.48-3.59 (m, 4 H), 3.71-3.76 (m, 2 H), 5.47 (s, br, 1 H).

According to the analysis of related databases, 929-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zheng, Shiying; Wang, Ruizheng; Che, Wenyi; US2008/95699; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 929-06-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PREPARATION 7: T-BUTYL 2-(2-HYDROXYETHOXY)ETHYLCARBAMATE To a single-neck flask was added 2-(2-aminoethoxy)ethanol (10.500 g). Tetrahydrofuran (25 mL) was added to dissolve2-(2-aminoethoxy)ethanol. Anhydrous sodium carbonate (5.300 g) was dissolved in distilled water (30 mL). The solution was added into the single-neck flask and cooled in an ice bath. Di-t-butyl dicarbonate (28.340 g) was dissolved in tetrahydrofuran (70 mL). The resultant solution was slowly dropwise added in the reaction system (for about 1 hr). After the addition, the mixture was stirred for 1.5 hr. After the reaction was completed, the reaction solution was filtered by suction. The filter cake was washed with tetrahydrofuran twice and then discarded. The filtrate was concentrated, then dissolved in ethyl acetate (150 mL) and distilled water (100 mL). The solution was mixed and then stood to separate. The aqueous phase was washed again with ethyl acetate (100 mL * 2) twice. All the organic phases were combined, dried over MgSO4, filtered and concentrated to give the target compound.

According to the analysis of related databases, 929-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Tianjin Hemay Bio-Tech Co., Ltd.; ZHANG, Hesheng; HUO, Aihong; LI, Zhenzhong; EP2824108; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C4H11NO2

To a single-neck flask was added 2-(2-aminoethoxyl)ethanol (10.500 g). Tetrahydrofuran (25 mL) was added to dissolve 2-(2-aminoethoxyl)ethanol. Anhydrous sodium carbonate (5.300 g) was dissolved in distilled water (30 mL). The solution was added into the single-neck flask and cooled in an ice bath. Di-t-butyl dicarbonate (28.340 g) was dissolved in tetrahydrofuran (70 mL). The resultant solution was slowly dropwise added in the reaction system (for about 1 hr). After the addition, the mixture was stirred for 1.5 hr. After the reaction was completed, the reaction solution was filtered by suction. The filter cake was washed with tetrahydrofuran twice and then discarded. The filtrate was concentrated, then dissolved in ethyl acetate (150 mL) and distilled water (100 mL). The solution was mixed and then stood to separate. The aqueous phase was washed again with ethyl acetate (100 mL*2) twice. All the organic phases were combined, dried over MgSO4, filtered and concentrated to give the target compound.

With the rapid development of chemical substances, we look forward to future research findings about 929-06-6.

Reference:
Patent; Zhang, Hesheng; Huo, Aihong; Li, Zhenzhong; US2015/166595; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts