Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 928-51-8, name is 4-Chlorobutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 928-51-8
Solid fe/f-butyldimethylsilyl chloride (137 g, 909 mmol) was dissolved in dichloromethane (800 mL) and stirred with a magnetic stir bar at 0 C. 85% 4-chlorobutanol (100 mL, 852 mmol) was added as a solution in dichloromethane (100 mL). The mixture was stirred at 0 C for 30 minutes, followed by the addition of solid imidazole (71.3 g, 1048 mmol) in a single portion. This mixture was stirred at 0 C until TLC indicated the alcohol was consumed, typically 1.5 hours. The reaction mixture was filtered through a medium glass frit, and the glassware was rinsed with dichloromethane. The filtrate was concentrated in vacuo, and the resulting translucent oil was stored at -20 C for 12 hours. A colorless precipitate formed at this temperature. Hexanes (300 mL) was added, the suspension was passed through a Celite/MgS04 plug over a fine frit, and more hexanes (2×200 mL) was passed through the filter. The filtrate was concentrated in vacuo to give a colorless, transparent oil which weighed 189 g (848 mmol, 99%).
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Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; SHENVI, Ryan; ROACH, Jeremy; SASANO, Yusuke; BOHN, Laura; SCHMID, Cullen; (47 pag.)WO2018/231618; (2018); A1;,
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