Category: 928-51-8

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 928-51-8, Name is 4-Chlorobutan-1-ol, SMILES is OCCCCCl, in an article , author is Ferrisse, Tulio Morandin, once mentioned of 928-51-8, Category: alcohols-buliding-blocks.

Histoplasmosis is a deep mycosis distributed worldwide and caused by Histoplasma capsulatum. Development countries and underdeveloped countries already considered an endemic disease, and its etiology comes from fungi located in soil contaminated with bird and bat droppings. Habits such as tobacco and alcohol consumption can be factors that can help to the development of disseminated histoplasmosis mainly in immunocompetent patients. Clinical manifestations can include fever, weakness, weight loss, hepatosplenomegaly, mucocutaneous lesions, and ulcer oral lesions. Oral lesions represents a commonly manifestation in the disseminated form of the disease, and it is more frequently observed in immunocompromised patients, mainly on HIV-positive patients. In this study, we presented five cases of disseminated histoplasmosis on HIVnegative patients diagnosed with lesions located in oral cavity and we performed a literature review about cases of disseminated histoplasmosis lesions in head and neck region on HIV-negative patients associating possible factors that may contribute to lesions formatting.

Interested yet? Read on for other articles about 928-51-8, you can contact me at any time and look forward to more communication. Category: alcohols-buliding-blocks.

Reference:
Alcohol – Wikipedia,
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Electric Literature of 928-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 928-51-8, name is 4-Chlorobutan-1-ol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 21 Synthesis of 3-(4-((4-(4-ethynyl- lH-pyrazol- l-yl)butyl)amino)- l-oxoisoindolin-2- -2,6-dione Step 1 : To a solution of 4-iodo-lH-pyrazole (3.88 g, 20 mmol) in CH3CN (140 mL) was added 4-chlorobutan- l-ol (3.3 g, 1.3eq), Cs2C03 (16.4 g, 60 mmol), and Nal (600 mg). The reaction mixture was heated at 50 C for 12 hour. The reaction mixture was filtered and the filtrate was evaporated. The residue was purified by chromatography (EtOAc/Hexanes: 1: 1 to EtOAc) to afford 4-(4-iodo-lH-pyrazol-l- yl)butan-l-ol (4 g, 75%).

According to the analysis of related databases, 928-51-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; LI, Yangbing; AGUILAR, Angelo; ZHOU, Bing; HU, Jiantao; XU, Fuming; QIN, Chong; HU, Yang; XIANG, Weiguo; REJ, Rohan; YANG, Jiuling; HAN, Xin; BAI, Longchuan; YANG, Chao-Yie; (252 pag.)WO2017/176958; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 928-51-8 ,Some common heterocyclic compound, 928-51-8, molecular formula is C4H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of2b(6.52 g, 50.90 mmol) in pyridine (20 mL) was successively added toluene-4-sulfonylchloride (TsCl, 9.72 g, 50.90 mmol) under nitrogen atmosphere, the mixture was stirred at 0 C for 2 h. The resulting mixture was poured into water (110 mL), extracted with ethyl acetate (EA, 2 × 70 mL), The combined organic layers were washed with hydrochloric acid (2 M, 50 mL) and brine, dried over anhydrous Na2SO4and concentrated under vacuum to give3b(10.54 g, 79%) as a colorless oil, Rf(PE /EA, 5:1) = 0.21.1H NMR (CDCl3, 400 MHz) delta = 7.79 (d, J=8.2 Hz, 2H), 7.36 (d, J=8.2 Hz, 2H), 4.07 (t, J=5.6 Hz, 2H), 3.50 (t, J=5.7 Hz, 2H), 2.46 (s, 3H), 1.86-1.79(m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-51-8, its application will become more common.

Reference:
Article; Wei, Zhao; Liu, Yan-Qin; Zhou, Xin-Bo; Luo, Yuan; Huang, Chun-Qian; Wang, Yong-An; Zheng, Zhi-Bing; Li, Song; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5743 – 5748;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 928-51-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 928-51-8, name is 4-Chlorobutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-iodo-lH-pyrazole (3.88 g, 20 mmol) in CH3CN (0943) (140 mL) was added 4-chlorobutan-l-ol (3.3 g, 1.3eq), Cs2C03 (16.4 g, 60 mmol), and Nal (600 mg). The reaction mixture was heated at 50 C for 12 hour. The reaction mixture was filtered and the filtrate was evaporated. The residue was purified by chromatography (EtOAc/Hexanes: 1:1 to EtOAc) to afford 4-(4-iodo-lH-pyrazol-l- yl)butan-l-ol (4 g, 75%).

According to the analysis of related databases, 928-51-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; HU, Yang; QIN, Chong; XU, Fuming; HU, Jiantao; ZHOU, Bing; CHEN, Zhou; FERNANDEZ-SALAS, Ester; BAI, Longchuan; McEACHERN, Donna; (198 pag.)WO2018/52945; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 928-51-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 928-51-8, name is 4-Chlorobutan-1-ol. A new synthetic method of this compound is introduced below.

4-Chlorobutan-l-ol 7-a (180 g, 1658 mmol, CAS 928-51-8) was added to sodium thiomethoxide (656 g, 1965 mmol, 21% solution in water) at 0-5C. After addition, the mixture was allowed to warm to 25C and stirred for 48 h. The mixture was extracted with CHCI3. The separated organic layer was dried over Na2C03, filtered and evaporated under vacuum. The residue was distilled to afford the alcohol 9-a as an oil (144.2 g, 72%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,928-51-8, 4-Chlorobutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN R&D IRELAND; COOYMANS, Ludwig Paul; DEMIN, Samuel Dominique; HU, Lili; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; WO2012/80449; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 928-51-8 , The common heterocyclic compound, 928-51-8, name is 4-Chlorobutan-1-ol, molecular formula is C4H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

REFERENCE EXAMPLE 2 5,5,5-triphenylpentanol t-Butylchlorodimethylsilane (8.3 g, 55 mmol) was added to a stirred mixture of 4-chlorobutanol (5.0 mL, 50 mmol), silver nitrate (12.8 g, 75.1 mmol), and pyridine (4.0 mL, 50 mmol) in 40 mL of dry THF. After 4 hr, the reaction mixture was filtered through Celite and evaporated to give a yellow oil. The material was purified by distillation to provide 4-chlorobutyl t-butyldimethylsilyl ether as a colorless oil (11 g, quantitative).

The synthetic route of 928-51-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Demers; James P.; Johnson; Sigmond; Weidner-Wells; Michele Ann; Kanojia; Ramesh M.; Fraga; Stephanie A.; Klaubert; Dieter; US5874436; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.928-51-8, name is 4-Chlorobutan-1-ol, molecular formula is C4H9ClO, molecular weight is 108.5667, as common compound, the synthetic route is as follows.name: 4-Chlorobutan-1-ol

To a suspension of 4-ethynyl-1H-pyrazole (920 mg, 10 mmol) and4-chlorobutan- 1-ol (216 mg, 20 mmol) in acetonitrile (25 mL) was added K2C03 (4.1 g,30 mmol, 3 eq) and KI (166 mg, 1 mmol, 0.1 eq). The mixture was stirred for 6 hours at85 C under N2 protection. The readion mixture was quenched with water and extractedwith EtOAc. The residue was purified by chromatography (DCM:MeOH 10:1) to afford to afford 1.3 g of 4-(4-ethynyl-1H-pyrazol-1-yl)butan-1-ol with 80% yield. ESI-MS mlz 165.02 [M+Hjt

At the same time, in my other blogs, there are other synthetic methods of this type of compound,928-51-8, 4-Chlorobutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; HU, Yang; QIN, Chong; XU, Fuming; HU, Jiantao; XIANG, Weiguo; ZHOU, Bing; (233 pag.)WO2018/52949; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 928-51-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 928-51-8, name is 4-Chlorobutan-1-ol. A new synthetic method of this compound is introduced below.

Step A: Preparation of 4-(Chlorobutoxy)-3,4,5,6-2H-tetrahydropyran A solution of 4-chlorobutanol (23.2 g, 0.2140 mol) and 2 drops of concentrated hydrochloric acid at 0 C. is treated with 3,4-dihydro-2H-pyran (15 g, 0.1783 mol). The reaction is allowed to warm to room temperature over 3 hours. The reaction mixture is purified by distillation (130 C., 20 mm) to give 18.07 g of 2-(4-chlorobutoxy)-3,4,5,6-2H-tetrahydropyran as a colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-51-8, its application will become more common.

Reference:
Patent; Warner-Lambert Co.; US5045550; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 928-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 928-51-8, name is 4-Chlorobutan-1-ol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of DMSO (10ml) taken in a round bottom flask was added KOH (2equiv) and the solution was stirred at room temperature for 15min. The indole derivative 2 or 7 (1equiv) was then added and the mixture was further stirred for 1h, after which 4-chlorobutan-1-ol or 3-chloropropan-1-ol (1.5equiv) was added dropwise to the reaction mixture. The reaction was monitored by TLC to completion within 5h. The reaction mixture was then quenched by adding water and was extracted with ethyl acetate. Evaporation of the solvent under reduced pressure followed by column chromatography gave the required N-alkylated compounds, 3/8/12/16.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 928-51-8, 4-Chlorobutan-1-ol.

Reference:
Article; Naik, Prajakta N.; Naik, Nilesh H.; Khan, Ayesha; Kusurkar, Radhika S.; Tetrahedron; vol. 69; 32; (2013); p. 6545 – 6551;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 928-51-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 928-51-8, name is 4-Chlorobutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of DMSO (10ml) taken in a round bottom flask was added KOH (2equiv) and the solution was stirred at room temperature for 15min. The indole derivative 2 or 20 (1equiv) was then added and the mixture was further stirred for 1h, after which 4-chlorobutan-1-ol or 3-chloropropan-1-ol (1.5equiv) was added dropwise to the reaction mixture. The reaction was monitored by TLC to completion within 5h. The reaction mixture was then quenched by adding water and was extracted with ethyl acetate. Evaporation of the solvent under reduced pressure followed by column chromatography gave the required N-alkylated compounds, 3/13/21. 4.3.1 1-(4-Hydroxybutyl)-1H-indole-3-carbaldehyde (3) White solid (85%); mp 12 75-77 C.

According to the analysis of related databases, 928-51-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Naik, Prajakta N.; Khan, Ayesha; Kusurkar, Radhika S.; Tetrahedron; vol. 69; 50; (2013); p. 10733 – 10738;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts