Category: 926292-63-9

On June 16, 2022, Li, Zhi; Sundara Sekar, Balaji; Lukito, Benedict Ryan published a patent.SDS of cas: 926292-63-9 The title of the patent was Bioproduction of enantiopure (R)- and (S)-2-phenylglycinol from styrene and renewable feedstocks via artificial enzyme cascade. And the patent contained the following:

The present invention relates to methods of bioprodn. of enantiomerically pure or enantiomerically enriched 2- phenylglycinol or a derivative thereof by multiple enzyme-catalyzed chem. transformations in a one-pot reaction system. In a specific embodiment, at least one multiple enzyme is located on one or more plasmids or integrated in the chromosome of each of the one or more recombinant microbial cells. In a further embodiment, one or more recombinant microbial cells are genetically engineered to overexpress multiple enzymes, including styrene monooxygenase, epoxide hydrolase, alc. dehydrogenase, transaminase, phenylalanine ammonia lyase, and phenylacrylic acid decarboxylase. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).SDS of cas: 926292-63-9

The Article related to styrene artificial enzyme cascade phenylglycinol enantiopure, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.SDS of cas: 926292-63-9

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 14, 2020, Zhang, Jiandong; Yang, Xiaoxiao; Dong, Rui; Gao, Lili; Li, Jing; Li, Xing; Huang, Shuangping; Zhang, Chaofeng; Chang, Honghong published an article.Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol The title of the article was Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. And the article contained the following:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol

The Article related to cascade reaction stereoselective aminohydroxylation styrenyl olefin arylglycinol, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 29, 2021, Zhao, Xiao-Jing; Li, Zi-Hao; Ding, Tong-Mei; Tian, Jin-Miao; Tu, Yong-Qiang; Wang, Ai-Fang; Xie, Yu-Yang published an article.Recommanded Product: (R)-2-Amino-2-(m-tolyl)ethanol The title of the article was Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling. And the article contained the following:

A challenging direct asym. catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96% ee) and good yields (up to 80%). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π-π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).Recommanded Product: (R)-2-Amino-2-(m-tolyl)ethanol

The Article related to amino hydroxy binaphthyl enantioselective synthesis coupling naphthylamine naphthol, copper catalyzed aerobic oxidative cross coupling naphthylamine naphthol, 3,3′- disubstituted nobins, asymmetric catalysis, cross-coupling, enantioselectivity, mechanism investigation and other aspects.Recommanded Product: (R)-2-Amino-2-(m-tolyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts