Category: 92093-23-7

Pan, Liangkun published the artcileLewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents, Formula: C8H9BrO2, the main research area is diol preparation; acetal regioselective preparation; alkene dioxygenation catalyst phenyliodine bis trifluoroacetate.

1,2-Diols were extremely useful building blocks in organic synthesis. Hypervalent iodine reagents were useful for the vicinal dihydroxylation of olefins to gave 1,2-diols under metal-free conditions, but strongly acidic promoters were often required. Herein, synthesis of 1,2-diols R1CHOHCHOHR2 [R1 = n-hexyl, Ph, Bn, etc.; R2 = H, Ph] and acetals R3CH2CH(OMe)2 [R3 = Ph, 4-MeOC6H4, (4-acetoxyphenyl), etc.] via catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts was reported. The conditions were mild and compatible with various functional groups.

Organic Letters published new progress about Acetals Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Formula: C8H9BrO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Shan-Shui published the artcileAerobic oxidation of alcohols with air catalyzed by decacarbonyldimanganese, Application of 1-(4-Bromophenyl)ethane-1,2-diol, the main research area is manganese catalyzed aerobic oxidation functionalized alc.

The oxidation of alcs. to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of α-H of the alc. is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcs., secondary alcs., 1,2-diols, 1,2-amino alcs., and other α-functionalized alcs. using a com. available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the exptl. results and literature was proposed.

Green Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application of 1-(4-Bromophenyl)ethane-1,2-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Azhong published the artcilePalladium-Catalyzed Direct Oxidation of Alkenes with Molecular Oxygen: General and Practical Methods for the Preparation of 1,2-Diols, Aldehydes, and Ketones, Related Products of alcohols-buliding-blocks, the main research area is terminal disubstituted olefin oxygen base palladium dihydroxylation; diol preparation; oxygen terminal disubstituted olefin PTSA palladium oxidative cleavage; aldehyde Ketone preparation green chem reaction mechanism; dihydroxylation oxidative cleavage catalyst palladium.

Novel and environmentally benign methods for palladium-catalyzed dihydroxylation and oxidative cleavage of olefins with oxygen as sole oxidant are presented. The cleavage reactions were performed with acid as additive in aqueous solution, whereas 1,2-diols were formed in the presence of base. A broad substrate scope has been demonstrated allowing monosubstituted aromatic and aliphatic terminal alkenes, 1,2-disubstituted, and 1,1-disubstituted olefins. The cleavage reactions of dioxo-PdII complexes implicate 1,2-diol might act as a key intermediate of olefin cleavage.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xie, Ya-Fei published the artcileBifunctional organocatalysts for the conversion of CO2, epoxides and aryl amines to 3-aryl-2-oxazolidinones, Related Products of alcohols-buliding-blocks, the main research area is aryl oxazolidinone preparation; epoxide carbon dioxide aryl amine regioselective ring opening cycloaddition.

A route to synthesize 3-aryl-2-oxazolidinones I (R1 = Me, H2C:CHCH2OCH2, Ph, 4-FC6H4, etc.; R2 = Ph, 1-naphthyl, 2-pyridyl, etc.) through a three-component reaction between CO2, aryl amines R2NH2, and the corresponding 2-R1-substituted epoxides with a binary organocatalytic system composed of organocatalysts II (R3 = R4 = Me; R3 = H, R4 = Me, i-Pr, MeSCH2, Ph, 4-HOC6H4; X = I, Br, Cl) and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was developed. The method allows wide scopes of epoxide and aryl amine substrates with various functional groups under mild reaction conditions. The control experiments indicate that a cyclic carbonate is formed via cycloaddition of epoxides with CO2, which further reacts with the β-amino alc. originating from epoxides and aryl amines, resulting in the formation of 3-aryl-2-oxazolidinones.

Organic & Biomolecular Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Tengfei published the artcileHeterogeneous carbon nitride photocatalyst for C-C bond oxidative cleavage of vicinal diols in aerobic micellar medium, SDS of cas: 92093-23-7, the main research area is aryl aldehyde preparation green chem; vicinal diol aerobic oxidation carbon nitride photocatalyst.

A green and efficient visible-light promoted aerobic oxidative C-C bond cleavage of vicinal diols RC(R1)(OH)C(R2)(OH)R3 (R = Ph, pyridin-2-yl, 4-bromophenyl, etc.; R1 = H, Me, Ph; R2 = H, Me, Ph; R3 = H, 4-nitrophenyl, Ph, furan-2-yl, etc.) in micellar medium has been developed. This protocol used graphitic carbon nitride with nitrogen vacancies (CN620) as a metal-free recyclable photocatalyst and CTAB as surfactant in water. Control experiments and the ESR results indicated that superoxide radicals and valence band holes played an important role in the reaction. Further isotope experiments suggested both a β-scission/HAT pathway and an oxidation/hydrolysis/dehydration pathway for the reaction, which is different from previous reports. The semiconductor/micellar catalyst system can be recycled at least 10 times without a significant reduction in activity. Furthermore, this reaction could be carried out under solar light irradiation and was applicable to large-scale reactions with similar results.

Green Chemistry published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, SDS of cas: 92093-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jones, Kevin M. published the artcileMetal-Free Dihydroxylation of Alkenes using Cyclobutane Malonoyl Peroxide, Formula: C8H9BrO2, the main research area is lactone preparation green chem; allylic alc preparation green chem; alkene dihydroxylation cyclobutane malonoyl peroxide.

Cyclobutane malonoyl peroxide I, prepared in a single step from the com. available diacid 6, is an effective reagent for the dihydroxylation of alkenes. Reaction of a chloroform solution of I with an alkene in the presence of 1 equiv of water at 40 °C followed by alk. hydrolysis leads to the corresponding diol, e.g., II, in 30-84% yield. With 1,2-disubstituted alkenes, the reaction proceeds with syn-selectivity (3:1 → 50:1). A mechanism consistent with exptl. findings is proposed, which is supported by deuterium and oxygen labeling studies and explains the stereoselectivity observed Alternative reaction pathways that are dependent on the structure of the starting alkene are also described leading to the synthesis of allylic alcs. and γ-lactones.

Journal of Organic Chemistry published new progress about Allylic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Formula: C8H9BrO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Lingyun published the artcileSelective Transformation of Vicinal Glycols to α-Hydroxy Acetates in Water via a Dehydrogenation and Oxidization Relay Process by a Self-Supported Single-Site Iridium Catalyst, Application In Synthesis of 92093-23-7, the main research area is alpha hydroxy acetate preparation; vicinal glycol dehydrogenation oxidization relay process water; self supported single site iridium catalyst.

α-Hydroxy acids have attracted broad attention because of their prevalence in bioactive mols. and biodegradable polymers, but their conventional syntheses are usually restricted to aromatic substrates, especially, in a stepwise manner. Herein, the transformation of alkyl and aryl vicinal glycols to α-hydroxy acetates in water under the air atm. with the solid self-supported NHC-Ir single-site catalyst is reported. Both aliphatic and aromatic glycols are compatible with a much higher catalytic efficiency in the presence of this solid single-site catalyst than other viable mol. catalysts (93% vs <35%) because of the ""isolation effect"". Remarkably, this catalyst could be reused for 20 runs without an obvious loss in catalytic activity and selectivity. Control experiments and d. functional theory calculations reveal that the reaction firstly undergoes a dehydrogenation facilitated by the catalyst, and then it proceeds through an unexpected oxidization relay step by oxygen in the air, leading to the α-hydroxy acetate formation. This protocol can potentially contribute to the valorization of readily available and inexpensive diols. ACS Catalysis published new progress about Acetates Role: SPN (Synthetic Preparation), PREP (Preparation) (hydroxy). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application In Synthesis of 92093-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chung, Jou-Ku published the artcileStructure-toxicity relationship study of para-halogenated styrene analogues in CYP2E1 transgenic cells, Formula: C8H9BrO2, the main research area is structure toxicity relationship styrene analog bioactivation CYP2E1.

Styrene is one of the most important industrial intermediates consumed in the world and is mainly used as a monomer for reinforced plastics and rubber. Styrene has been found to be hepatotoxic and pneumotoxic in humans and exptl. animals. The toxicity of styrene is suggested to be metabolism-dependent. Styrene-7,8-oxide has been considered as the major metabolite responsible for styrene-induced cytotoxicity. The objective of the study was to investigate the correlation between cytotoxicity of styrene and chem. and biochem. properties of the vinyl group of styrene by development of structure activity relationships (SAR). 4-Fluorostyrene, 4-chlorostyrene and 4-bromostyrene were selected for the SAR study. Cytotoxicity of styrene and the halogenated styrene derivatives with an order of 4-bromostyrene > 4-chlorostyrene > 4-fluorostyrene ≈ styrene was observed in CYP2E1 transgenic cells. Similar orders in the efficiency of the metabolism of styrene and the halogenated styrene analogs to their oxides and in the electrophilicity of the corresponding oxides were observed Addnl., the order of the potency of cellular glutathione depletion and the degree of protein adduction induced by styrene and the halogenated styrenes were consistent with that of their cytotoxicities. The wild-type cells were less susceptible to the toxicity of the corresponding model compounds than CYP2E1 cells. The present study provided insight into the roles of the biochem. and chem. properties of styrene in its cytotoxicity.

Toxicology Letters published new progress about Cytotoxicity. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Formula: C8H9BrO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yan-Bing published the artcileNaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy, Recommanded Product: 1-(4-Bromophenyl)ethane-1,2-diol, the main research area is sodium hydroxide quinoxaline synthesis nitroaniline alc hydrogen transfer.

A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcs. are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.

Journal of Organic Chemistry published new progress about Cyclocondensation reaction (redox cyclocondensation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Recommanded Product: 1-(4-Bromophenyl)ethane-1,2-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bandini, Marco published the artcileAn effective and useful synthesis of enantiomerically enriched arylglycinols, Product Details of C8H9BrO2, the main research area is enantiomerically enriched arylglycinol preparation; amino alc chiral preparation.

A two-step synthesis of racemic arylglycinols, together with a simple and straightforward methodol. for their resolution, is described. This method constitutes a practical means of preparing racemic and optically pure electron-rich or electron-poor substituted arylglycinols, useful building blocks for the synthesis of biol. active mols. and chiral ligands. All of the chiral β-amino alcs. were isolated in good chem. yields and with excellent enantiomeric excesses. Chiral fluoroarom. vicinal amino alcs. can also be obtained with good enantiopurity using such a procedure. The key step of the strategy presented is an easy chromatog. separation of the diastereoisomeric amides prepared from acetyl mandeloyl chloride. The absolute configuration of the perfluorinated amino alcs. was determined by X-ray anal. of the corresponding amide.

European Journal of Organic Chemistry published new progress about. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Product Details of C8H9BrO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts