Category: 903-19-5

Pospisil, J. published the artcileThe influence of the structure on the activity of hydroquinone-type fat antioxidants, Application of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Fette, Seifen, Anstrichmittel (1964), 66(12), 1043-7, database is CAplus.

The antioxidant activity of hydroquinone (I) was compared with that of 43 I derivatives The neg. effect of 2,5- and 2,6-substitution was confirmed. Increased activity is found with 2-alkyl I derivatives, with 2,6-di-tert-Bu I derivatives in which the 4-OH group is etherified or acetylated, and with 2-tert-Bu- and 2-tert-octyl-4-methoxyphenols.

Fette, Seifen, Anstrichmittel published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Application of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryba, O. published the artcileAntioxidants and stabilizers. IV. Influence of structure on polarographic half-wave potentials of alkylated hydroquinones, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Collection of Czechoslovak Chemical Communications (1965), 30(3), 843-52, database is CAplus.

cf. CA 60, 6772f, 7429d; 61, 5545d. E_1/2 values were determined with a dropping Hg electrode for hydroquinone and for its 21 alkyl derivatives in acetate buffer solutions in 50% EtOH, and were tabulated. The slope of the polarographic waves corresponded to a reversible 2-electron oxidation Substitution in the 2-or 2,5-positions caused a shift of E_1/2 towards neg. values; this shift is a linear function of the sum of steric substitution constants With substitution in the 2,6-positions, the influence of individual substituents is not additive. 37 references.

Collection of Czechoslovak Chemical Communications published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Miyamoto, Akihiko published the artcileLatent-image bleaching in color development, HPLC of Formula: 903-19-5, the publication is Nippon Shashin Gakkaishi (1981), 44(4), 342-5, database is CAplus.

Latent-image bleaching (LIB) in color development was studied using a monodisperse S-sensitized Ag(Br,Cl) emulsion and nondiffusible hydrophobic color couplers. LIB in color development is caused by a local increase in the concentrations of oxidized developing agent and Br^–. LIB influences the characteristic curve mainly in the region from middle ds. to higher ones. The dependences of LIB on the type of coupler and the color developing agent were studied. LIB was observed with CD-3 and CD-4 but not with CD-2. LIB is also influenced by the pH and Br^– concentration of the color developer and also by the presence of a quinonediimine scavenger.

Nippon Shashin Gakkaishi published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, HPLC of Formula: 903-19-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Araki, Naohiro published the artcileScreening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells, Safety of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Toxicology in Vitro (2005), 19(6), 831-842, database is CAplus and MEDLINE.

Recently, there has been great concern about the potential of industrial chems. to act as endocrine disrupters. In this report, we conducted a pilot study to validate the use of AR-EcoScreen cells for tier 1 screening of androgen receptor (AR) agonist and antagonist activities. From 253 test compounds, we identified two AR agonists and nine antagonists. The two agonists, 2-tert-butylanthraquinone and benzoanthrone, were relatively weak (10% maximal activation of the pos. control, 5α-dihydrotestosterone, at 2.54×10^-7 and 4.46×10^-6 M, resp.). The most potent antagonist was 3,3′-dichlorobenzidine dihydrochloride (IC₅₀ = 2.28×10^-7 M). The order of the anti-androgenic activities was 3,3′-dichlorobenzidine dihydrochloride > 4-diethylaminobenzaldehyde > 4,4′-[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] > 2,4,6-trichlorophenylhydrazine = 4-(phenylpropyl)pyridine > 2-hydroxy-4-methoxybenzophenone > 2,2-bis(4-cyanophenyl)propane > 4-methoxy-2-methyldiphenylamine = 2,4-diphenyl-4-methylpentene-1. These results suggest that AR-EcoScreen cell line has the potential to be used as a tool for the large scale tier 1 screening of chems. for androgen receptor agonist and antagonist activity.

Toxicology in Vitro published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Safety of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Aono, Toshiaki published the artcileThe effect of oxygen insulation on the stability of image dyes of a color photographic print and the behavior of alkylhydroquinones as antioxidants, Application of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Journal of Applied Photographic Engineering (1982), 8(5), 227-31, database is CAplus.

Studies concerning the light fading of color prints due to oxidation by O from the ambient atm. are described. From studying the effects of O insulation by various techniques of polymer film lamination, it has been found that O mols., which greatly accelerate the light fading of magenta and yellow dyes in color prints, penetrate most easily through a polyethylene-coated paper support. The acceleration of light fading of the dye image by the migrating O is restrained not only by alkylhydroquinone but also by alkylbenzoquinone, incorporated in the dye image layer. This result can be explained in terms of a photochem. reaction mechanism, namely, alkylbenzoquinone reacts to form alkylhydroquinone derivatives upon exposure to light.

Journal of Applied Photographic Engineering published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Application of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Harder, John W. published the artcileNew interlayer scavenger technology, Formula: C22H38O2, the publication is IS&T’s Annual Conference (1997), 206-209, database is CAplus.

Poor color reproduction can occur when oxidized color developer diffuses from the imaging layer in which it is formed into the color records. Typically, scavengers for oxidized color developers (also known as interlayer scavengers) reduce or eliminate by chem. reaction, the oxidized developer without forming any permanent dyes or other colored stains, nor releasing fragments that have photog. activity. One known class of scavengers are substituted hydroquinones. However, these materials are often prone to aerial oxidation leading to poor film keeping properties. It has been found that both 2-(N,N-disubstitutedcarbamoyl)-1,4-hydroquinones (Formula I) and 4-(N,N-disubstitutedcarbamoyl)-pyrocatechols (Formula II) are reactive scavengers with excellent aerial stability. Another known class of scavengers are acylhydrazides. Although stable to aerial oxidation, these materials are prone to poor activity and undesirable side reactions during processing. It has been found that acylhydrazides of Formula III, where X = an electron-withdrawing and water solubilizing group, are reactive scavengers that avoid undesirable side reactions.

IS&T’s Annual Conference published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elam, Christopher published the artcileDiscovery of novel SERCA inhibitors by virtual screening of a large compound library, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is European Journal of Medicinal Chemistry (2011), 46(5), 1512-1523, database is CAplus and MEDLINE.

Two screening protocols based on recursive partitioning and computational ligand docking methodologies, resp., were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA), a potential target for cancer chemotherapy. A total of 72 compounds that were predicted to be potential inhibitors of SERCA were tested in bioassays and 17 displayed inhibitory potencies at concentrations below 100 μM. The majority of these inhibitors were composed of two Ph rings tethered to each other by a short link of one to three atoms. Putative interactions between SERCA and the inhibitors were identified by inspection of docking-predicted poses and some of the structural features required for effective SERCA inhibition were determined by anal. of the classification pattern employed by the recursive partitioning models.

European Journal of Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Harder, John W. published the artcileNew interlayer scavenger technology, Formula: C22H38O2, the publication is IS&T’s Annual Conference (1997), 206-209, database is CAplus.

Poor color reproduction can occur when oxidized color developer diffuses from the imaging layer in which it is formed into the color records. Typically, scavengers for oxidized color developers (also known as interlayer scavengers) reduce or eliminate by chem. reaction, the oxidized developer without forming any permanent dyes or other colored stains, nor releasing fragments that have photog. activity. One known class of scavengers are substituted hydroquinones. However, these materials are often prone to aerial oxidation leading to poor film keeping properties. It has been found that both 2-(N,N-disubstitutedcarbamoyl)-1,4-hydroquinones (Formula I) and 4-(N,N-disubstitutedcarbamoyl)-pyrocatechols (Formula II) are reactive scavengers with excellent aerial stability. Another known class of scavengers are acylhydrazides. Although stable to aerial oxidation, these materials are prone to poor activity and undesirable side reactions during processing. It has been found that acylhydrazides of Formula III, where X = an electron-withdrawing and water solubilizing group, are reactive scavengers that avoid undesirable side reactions.

IS&T’s Annual Conference published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elam, Christopher published the artcileDiscovery of novel SERCA inhibitors by virtual screening of a large compound library, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is European Journal of Medicinal Chemistry (2011), 46(5), 1512-1523, database is CAplus and MEDLINE.

Two screening protocols based on recursive partitioning and computational ligand docking methodologies, resp., were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA), a potential target for cancer chemotherapy. A total of 72 compounds that were predicted to be potential inhibitors of SERCA were tested in bioassays and 17 displayed inhibitory potencies at concentrations below 100 μM. The majority of these inhibitors were composed of two Ph rings tethered to each other by a short link of one to three atoms. Putative interactions between SERCA and the inhibitors were identified by inspection of docking-predicted poses and some of the structural features required for effective SERCA inhibition were determined by anal. of the classification pattern employed by the recursive partitioning models.

European Journal of Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Scott, W. E. published the artcileVernonia anthelmintica. Effect of storage on the epoxy content of the seed oil and trivernolin, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Journal of the American Oil Chemists’ Society (1965), 42(2), 147-9, database is CAplus.

V. anthelmintica seeds from India and Pakistan varied somewhat in the amount of oil that they contained, but the oils did not vary significantly in their epoxy content. Storage of the whole seed for periods of up to 3 years did not affect the quality of the oil, but the activity of the seed enzyme system seemed to increase with time. Free fatty acid (I) develops rapidly after the seed is ground. The epoxy content of low-I V. anthelmintica oil and trivernolin changed only slightly when these products were stored at room temperature for 6 months. The viscosity of the samples that were exposed to light increased greatly, indicating changes in the phys. nature of the products. A similar behavior was exhibited by both products when they were stored under N at 100° and by trivernolin at 4°.

Journal of the American Oil Chemists’ Society published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C6H4ClNO2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts