Category: 90-64-2

Choi, Jong-Won published the artcileOrganic acid-based linear free energy relationship models for green leaching of strategic metals from spent lithium-ion batteries and improvement of leaching performance, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Hazardous Materials (2022), 423(Part_B), 127214, database is CAplus and MEDLINE.

Water-soluble organic acids (e.g., acetic acid, acrylic acid, and ascorbic acid), as green leachants, have been applied to leach strategic metals (Ni, Li, Mn, and Co) from spent lithium-ion batteries (LIBs). Organic acid-based linear free energy relationship models were developed and simulated to predict the feasibility of the leaching efficiency for each of the strategic metals based on in silico calculated descriptors. The developed models, with accuracy (R2) of 0.747-0.831, reveal that hydrogen bond acidity of organic acids promotes the leaching efficiency, whereas mol. volume or excess molar refraction inhibits the efficiency. Furthermore, toxicity (LD 50%) of organic acids was discussed along with the predicted leaching efficiency to explore more green and efficient organic acids. Considering both toxicity and leaching efficiency, citric acid was selected as a green and efficient leachant. To more improve the leaching performance (rate and efficiency) of citric acid, glucose as a green reductant and microwave treatment were addnl. applied. Under the selected conditions, the leaching efficiencies after 1 h for Ni, Li, Mn, and Co were enhanced up to 98.3%, 99.1%, 98.7%, and 97.7%, resp.

Journal of Hazardous Materials published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Lingyun published the artcileSelective Transformation of Vicinal Glycols to α-Hydroxy Acetates in Water via a Dehydrogenation and Oxidization Relay Process by a Self-Supported Single-Site Iridium Catalyst, HPLC of Formula: 90-64-2, the publication is ACS Catalysis (2021), 11(21), 12833-12839, database is CAplus.

α-Hydroxy acids have attracted broad attention because of their prevalence in bioactive mols. and biodegradable polymers, but their conventional syntheses are usually restricted to aromatic substrates, especially, in a stepwise manner. Herein, the transformation of alkyl and aryl vicinal glycols to α-hydroxy acetates in water under the air atm. with the solid self-supported NHC-Ir single-site catalyst is reported. Both aliphatic and aromatic glycols are compatible with a much higher catalytic efficiency in the presence of this solid single-site catalyst than other viable mol. catalysts (93% vs <35%) because of the “isolation effect”. Remarkably, this catalyst could be reused for 20 runs without an obvious loss in catalytic activity and selectivity. Control experiments and d. functional theory calculations reveal that the reaction firstly undergoes a dehydrogenation facilitated by the catalyst, and then it proceeds through an unexpected oxidization relay step by oxygen in the air, leading to the α-hydroxy acetate formation. This protocol can potentially contribute to the valorization of readily available and inexpensive diols.

ACS Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C10H14N2O, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatterjee, Maya published the artcileProduction of lactic acid mediated by compressed carbon dioxide on heterogeneous Ni(II) catalysts: a facile approach, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Green Chemistry (2022), 24(16), 6145-6155, database is CAplus.

Lactic acid is one of the appealing platform mols. in organic synthesis, currently in high demand after the innovation of bio-plastics. The limitations of traditional manufacturing routes (microbial process and chem. synthesis using petroleum resources) directed us to develop economically and environmentally viable catalytic strategies exploring renewable resources to meet the expected demand. In this study, we demonstrated a method of lactic acid synthesis by fixing CO₂ as a waste gas into acetaldehyde used as a biobased feedstock on a highly active, recyclable heterogeneous Ni catalyst. The significance of the developed process lies in the transformation of easily available low-cost starting materials to a high-value product without harsh reaction conditions, extra sensitive reagents, and addnl. steps to derive the right starting material or to remove impurities, which is advantageous in terms of sustainability. Moreover, the optimization of different reaction parameters ensures achieving high yields (>80%) and an excellent production rate of 6700μmol g^-1 h^-1. In addition, the characterization of the catalyst by different spectroscopic techniques suggested an interaction between the substrate and the catalyst, which provides an indication of the possible reaction path, thus a mechanism would be outlined. The successful extension of this process to various aldehydes was possible to produce their corresponding hydroxycarboxylic acid with broad functional group tolerance. Altogether, this methodol. opens up a promising avenue for the production of biochems. from renewable resources, which is a key to develop a sustainable society.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jana, Rahul Dev published the artcileDioxygen Activation and Mandelate Decarboxylation by Iron(II) Complexes of N4 Ligands: Evidence for Dioxygen-Derived Intermediates from Cobalt Analogues, Application In Synthesis of 90-64-2, the publication is Inorganic Chemistry (2022), 61(27), 10461-10476, database is CAplus and MEDLINE.

The isolation, characterization, and dioxygen reactivity of monomeric [(TPA)M^II(mandelate)]⁺ (M = Fe, 1; Co, 3) and dimeric [(BPMEN)₂M₂^II(μ-mandelate)₂]²⁺ (M = Fe, 2; Co, 4) (TPA = tris(2-pyridylmethyl)amine and BPMEN = N¹,N²-dimethyl-N¹,N²-bis(pyridin-2-yl-methyl)ethane-1,2-diamine) complexes are reported. The iron(II)- and cobalt(II)-mandelate complexes react with dioxygen to afford benzaldehyde and benzoic acid in a 1:1 ratio. In the reactions, one oxygen atom from dioxygen is incorporated into benzoic acid, but benzaldehyde does not derive any oxygen atom from dioxygen. While no O₂-derived intermediate is observed with the iron(II)-mandelate complexes, the analogous cobalt(II) complexes react with dioxygen at a low temperature (-80°) to generate the corresponding cobalt(III)-superoxo species (S), a key intermediate implicated in the initiation of mandelate decarboxylation. At -20°, the cobalt(II)-mandelate complexes bind dioxygen reversibly giving μ-1,2-peroxo-dicobalt(III)-mandelate species (P). The geometric and electronic structures of the O₂-derived intermediates (S and P) were established by computational studies. The intermediates S and P upon treatment with a protic acid undergo decarboxylation to afford benzaldehyde (50%) with a concomitant formation of the corresponding μ-1,2-peroxo-μ-mandelate-dicobalt(III) (P1) species. The crystal structure of a peroxide species isolated from the cobalt(II)-carboxylate complex [(TPA)Co^II(MPA)]⁺ (5) (MPA = 2-methoxyphenylacetate) supports the composition of P1. The observations of the dioxygen-derived intermediates from cobalt complexes and their electronic structure analyses not only provide information about the nature of active species involved in the decarboxylation of mandelate but also shed light on the mechanistic pathway of two-electron vs. four-electron reduction of dioxygen.

Inorganic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application In Synthesis of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghosh, Ivy published the artcileSelective oxygenation of C-H and C=C bonds with H₂O₂ by high-spin cobalt(II)-carboxylate complexes, HPLC of Formula: 90-64-2, the publication is Dalton Transactions (2022), 51(6), 2480-2492, database is CAplus and MEDLINE.

Four cobalt(II)-carboxylate complexes [(6-Me₃-TPA)Co^II(benzoate)](BPh₄) (1), [(6-Me₃-TPA)Co^II(benzilate)](ClO₄) (2), [(6-Me₃-TPA)Co^II(mandelate)](BPh₄) (3), and [(6-Me₃-TPA)Co^II(MPA)](BPh₄) (4) (HMPA = 2-methoxy-2-phenylacetic acid) of the 6-Me₃-TPA (tris((6-methylpyridin-2-yl)methyl)amine) ligand were isolated to investigate their ability in H₂O₂-dependent selective oxygenation of C-H and CC bonds. All six-coordinate complexes contain a high-spin cobalt(II) center. While the cobalt(II) complexes are inert toward dioxygen, each of these complexes reacts readily with hydrogen peroxide to form a diamagnetic cobalt(III) species, which decays with time leading to the oxidation of the Me groups on the pyridine rings of the supporting ligand. Intramol. ligand oxidation by the cobalt-based oxidant is partially inhibited in the presence of external substrates, and the substrates are converted to their corresponding oxidized products. Kinetic studies and labeling experiments indicate the involvement of a metal-based oxidant in affecting the chemo- and stereo-selective catalytic oxygenation of aliphatic C-H bonds and epoxidation of alkenes. An electrophilic cobalt-oxygen species that exhibits a kinetic isotope effect (KIE) value of 5.3 in toluene oxidation by 1 is proposed as the active oxidant. Among the complexes, the cobalt(II)-benzoate (1) and cobalt(II)-MPA (4) complexes display better catalytic activity compared to their α-hydroxy analogs (2 and 3). Catalytic studies with the cobalt(II)-acetonitrile complex [(6-Me₃-TPA)Co^II(CH₃CN)₂](ClO₄)₂ (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions. The proposed catalytic reaction involves a carboxylate-bridged dicobalt complex in the activation of H₂O₂ followed by the oxidation of substrates by a metal-based oxidant.

Dalton Transactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guan, Renpeng published the artcileDecarboxylative oxygenation of carboxylic acids with O₂via a non-heme manganese catalyst, HPLC of Formula: 90-64-2, the publication is Green Chemistry (2022), 24(7), 2946-2952, database is CAplus.

Decarboxylative oxygenation of carboxylic acids using a non-heme manganese catalyst under blue light irradiation with O₂ as the sole oxidant. Featuring mild reaction conditions, the protocol allowed readily available carboxylic acids to be converted into a wide variety of valuable aldehydes, ketones and amides. Mechanistic studies indicated that the decarboxylation and oxygenation involved the formation of active Mn-oxygen species.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morlock, Gertrud E. published the artcileEffect-Directed Profiling of Monofloral Honeys from Ethiopia by High-Performance Thin-Layer Chromatography and High-Resolution Mass Spectrometry, HPLC of Formula: 90-64-2, the publication is Molecules (2022), 27(11), 3541, database is CAplus and MEDLINE.

Ethiopian honey is used not only as food but also for treatment in traditional medicine. For its valorization, bioactive compounds were analyzed in nine types of monofloral Ethiopian honey. Therefore, a non-target effect-directed profiling was developed via high-performance thin-layer chromatog. combined with multi-imaging and planar effect-directed assays. Characteristic bioactivity profiles of the different honeys were determined in terms of antibacterial, free-radical scavenging, and various enzyme inhibitory activities. Honeys from Hypoestes spp. and Leucas abyssinica showed low activity in all assays. In contrast, others from Acacia spp., Becium grandiflorum, Croton macrostachyus, Eucalyptus globulus, Schefflera abyssinica, Vernonia amygdalina, and Coffea arabica showed more intense activity profiles, but these differed depending on the assay. In particular, the radical scavenging activity of Croton macrostachyus and Coffea arabica honeys, the acetylcholinesterase-inhibiting activity of Eucalyptus globulus and Coffea arabica honeys, and the antibacterial activity of Schefflera abyssinica honey are highlighted. Bioactive compounds of interest were further characterized by high-resolution mass spectrometry. Identifying differences in bioactivity between mono-floral honey types affects quality designation and branding. Effect-directed profiling provides new insights that are valuable for food science and nutrition as well as for the market, and contributes to honey differentiation, categorization, and authentication.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oliver-Meseguer, Judit published the artcileNanotitania catalyzes the chemoselective hydration and alkoxylation of epoxides, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Molecular Catalysis (2021), 111927, database is CAplus.

The com. available, inexpensive, non-toxic, solid and recyclable nanotitania catalyzed hydration and alkoxylation of epoxides, with water and primary and secondary alcs. but not with phenols, carboxylic acids and tertiary alcs was discussed. In this way, the chemoselective synthesis of different glycols and 1,4-dioxanones, and the implementation of nanotitania for the production in-flow of glycols and alkoxylated alcs., were achieved. Mechanistic studies supported the key role of vacancies in the nano-oxide catalyst.

Molecular Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Huan published the artcileβ-Cyclodextrin covalent organic framework modified-cellulose acetate membranes for enantioseparation of chiral drugs, Application In Synthesis of 90-64-2, the publication is Separation and Purification Technology (2022), 120336, database is CAplus.

Membrane-based chiral separation has attracted widespread research attention. However, traditional chiral membranes remain an unbridgeable trade-off between permeability and selectivity. Chiral covalent organic frameworks (CCOFs) with inherently high porosity and intrinsic chirality are highly promising solutions Herein we report novel CCOF membranes for enantioseparation of chiral drugs. A β-cyclodextrin covalent organic framework (β-CD COF) was used as the chiral selector to fabricate two types of β-CD COF membranes by phys. and chem. modifying cellulose acetate substrates, including a β-CD COF mixed matrix membrane (β-CD COF MMM) and a β-CD COF thin film nanocomposite membrane (β-CD COF TFN). In particular, the β-CD COF TFN was the first reported interfacial polymerized COF membrane for enantioseparation and performed more preferentially than β-CD COF MMM. The optimal enantioselectivities of D, L-tryptophan (e.e% = 100%), (RS)-mandelic acid (e.e% = 58.1%), D, L-phenylalanine (e.e% = 36.3%), and (RS)-propranolol (e.e% = 18.0%) and comparable solute flux (Flux = 1.9-5.4 nmol·cm^-2·h^-1) were achieved using β-CD COF TFN. Benefiting from the remarkable chem. stability of β-CD COF, such membranes also had excellent thermal stability, acid resistance, and long-term storage stability. Moreover, the chiral recognition mechanism was investigated using mol. docking simulations. Fabricated membranes with high enantioseparation performance and stability provide a new perspective on establishing chiral membranes and show potential for industrial application.

Separation and Purification Technology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application In Synthesis of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kurd, Nematullah published the artcileHollow polymer nanospheres (HPSs) as the adsorbent in microextraction by packed sorbent (MEPS) for determining BTEXs chief metabolites in urine samples, Product Details of C8H8O3, the publication is Journal of the Iranian Chemical Society, database is CAplus.

Hollow polymer nanospheres (HPSs) were prepared based on the feeble acid-base interaction-induced assembly in hydrothermal conditions. It was first used as a sorbent in microextraction by packed sorbent method for the separation of the major biomarkers of BTEXs in urine samples. Fourier-transform IR spectroscopy, X-ray diffraction, scanning, and transmission electron microscopy were employed to assess the morphol. and dimensional structures of the products. All parameters affecting the adsorption of the analytes by the sorbent, including sorbent amount, sample volume, washing, and elution solutions, extraction cycles, pH, and temperature of the sample solution, were investigated. Good linear ranges (e.g., 5-1000 μg/mL for MA, r² > 0.98) and good limits of detection (e.g., 0.01 μg/mL for tt-MA) were obtained as well. The values of inter- and intra-day relative standard deviations were in the range of 2.09-3.41 and 5.74-7.12%, resp. The HPS-MEPS technique coupled with HPLC-UV detection was successfully applied to determine tt-MA, HA, MA, and m-MHA in the urine with the extraction recoveries of 104.9, 105.5, 102.6, and 81.8%, resp. Based on the results, HPS as a durable and reusable adsorbent (more than 100 times) with MEPS was excellent for the facile and rapid determination of HA, MA, and tt-MA from urine samples in the shortest time and without using complicated processes. It can also be suggested as an alternative method for earlier procedures in the biomonitoring of BTEX compounds

Journal of the Iranian Chemical Society published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts