Category: 90-64-2

Liu, Mingyu published the artcileNovel amorphous solid dispersion based on natural deep eutectic solvent for enhancing delivery of anti-tumor RA-XII by oral administration in rats, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is European Journal of Pharmaceutical Sciences (2021), 105931, database is CAplus and MEDLINE.

At present, oral chemotherapy showing the advantages of non-invasiveness, convenience, and high patient compliance, is gradually replacing traditional i.v. chemotherapy to treat patients with cancer. RA-XII, a unique natural cyclopeptide, exhibits various biol. activities, such as anti-tumor, anti-angiogenic, and anti-metastatic activities. Designing an orally available formulation of RA-XII is of great importance in the development of clin. useful anticancer agents. However, RA-XII shows low oral bioavailability in rats due to its poor solubility and low permeability. To overcome these limitations, in this work, a natural deep eutectic solvent (NADES) was designed to efficiently deliver RA-XII by oral administration. A novel NADES composed of betaine and mandelic acid in the molar ratio of 1:1 (Bet-Man NADES) was successfully prepared based on a binary phase diagram of Bet and Man. Acute toxicity studies indicated that Bet-Man NADES was well tolerated with acceptable toxicity. In Bet-Man NADES solutions, the solubility of RA-XII was increased by up to 17.54-fold, and the diffusion and permeability of RA-XII carried out in a Franz cell was also significantly improved 10.35 times. In terms of biopharmaceutical classification this is translated into a change for RA-XII from class IV to class II systems. More importantly, Bet-Man NADES was transferred into the solid formulation by the inclusion of a polymer, and amorphous solid dispersions based on Bet-Man NADES (PVP K30/NADES/RA-XII, ASDs) were successfully prepared to improve uniformity, apparent solubility, dissolution, and cytotoxicity in vitro. Consequently, the oral bioavailability of RA-XII in NADES solutions and ASDs was enhanced by approx. 11.58 and 7.56 times compared with that of pure RA-XII in 0.5% CMC-Na. Thus, it can be seen that a natural deep eutectic solvent and its modified amorphous solid dispersions are appropriate novel strategies for improving dissolution rate and bioavailability of poor soluble natural products such as RA-XII.

European Journal of Pharmaceutical Sciences published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Hiu-Fung published the artcileSynthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase, Category: alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2022), 65(3), 2471-2496, database is CAplus and MEDLINE.

Novel analogs of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and exhibit antimyeloma activity in vivo. A key structural element of these inhibitors is a linker moiety that connects their (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bisphosphonic acid core to various side chains. The structural diversity of this linker moiety, as well as the side chains attached to it, was investigated and found to significantly impact the toxicity of these compounds in MM cells. The most potent inhibitor CML-07-119(13c)(I) was evaluated in mouse and rat for liver toxicity and systemic exposure, resp., providing further optimism for the potential value of such compounds as human therapeutics.

Journal of Medicinal Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ha, Eun Kyo published the artcilePersonal exposure to total VOC is associated with symptoms of atopic dermatitis in schoolchildren, Formula: C8H8O3, the publication is Journal of Korean Medical Science (2022), 37(8), e63, database is CAplus and MEDLINE.

The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with pos. SCORAD index values (defined as SCORAD �5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and pos. SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and pos. SCORAD results. Conclusion: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Journal of Korean Medical Science published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khan, Atta Ullah published the artcileIron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica, Product Details of C8H8O3, the publication is Plant Cell, Tissue and Organ Culture (2021), 147(2), 287-296, database is CAplus and MEDLINE.

The callus cultures of Fagonia indica could prove as factories for the production of important phytochems. when triggered through different types of stress. In this study, we initiated callus cultures from healthy stem explants in the presence of iron-doped zinc oxide nanoparticles (Fe-ZnO-NPs). We performed experiments with the callus cultures of F. indica to determine the impact of Fe-ZnO-NPs in concentrations (15.62-250μg/mL) on biomass accumulation, production of important phenolic and flavonoids, and antioxidative potential. Our results showed that maximum callus biomass [Fresh weight (FW) = 13.6 g and Dry weight (DW) = 0.58 ± 0.01] was produced on day 40 when the media was supplemented with 250μg/mL Fe-ZnO-NPs. Similarly, maximum total phenolic content (268.36μg GAE/g of DW) was observed in 40 days old callus added with 125μg/mL Fe-ZnO-NPs. Maximum total flavonoid content (78.56μg QE/g of DW) was recorded in 20 days old callus grown in 62.5μg/mL Fe-ZnO-NPs containing media. Maximum total antioxidant capacity (390.74μg AAE/g of DW) was recorded in 40 days old callus with 125μg/mL Fe-ZnO-NPs treated cultures, resp. Similarly, the highest free radical scavenging activity (93.02%) was observed in callus derived from media having 15.62μg/mL Fe-ZnO-NPs. The antioxidant potential was observed to have pos. correlation with TPC (r = 0.44). HPLC anal. showed that Fe-ZnO-NPs produced compounds (e.g., Epigallocatechin gallate) that were either absent or in lesser quantities in the control group. These results showed that Fe-ZnO-NPs elicitors could increase the biomass and activate secondary metabolism in F. indica cells.

Plant Cell, Tissue and Organ Culture published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bockova, Jana published the artcileChiroptical activity of hydroxycarboxylic acids with implications for the origin of biological homochirality, Synthetic Route of 90-64-2, the publication is Communications Chemistry (2021), 4(1), 86, database is CAplus.

Circularly polarised light (CPL) interacting with interstellar organic mols. might have imparted chiral bias and hence preluded prebiotic evolution of biomol. homochirality. The L-enrichment of extra-terrestrial amino acids in meteorites, as opposed to no detectable excess in monocarboxylic acids and amines, has previously been attributed to their intrinsic interaction with stellar CPL revealed by substantial differences in their chiroptical signals. Recent analyze of meteoritic hydroxycarboxylic acids (HCAs) – potential co-building blocks of ancestral proto-peptides – indicated a chiral bias toward the L-enantiomer of lactic acid. Here we report on novel anisotropy spectra of several HCAs using a synchrotron radiation electronic CD spectrophotometer to support the re-evaluation of chiral biomarkers of extra-terrestrial origin in the context of absolute photochirogenesis. We found that irradiation by CPL which would yield L-excess in amino acids would also yield L-excess in aliphatic chain HCAs, including lactic acid and mandelic acid, in the examined conditions. Only tartaric acid would show “unnatural” D-enrichment, which makes it a suitable target compound for further assessing the relevance of the CPL scenario.

Communications Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lansdown, Kate published the artcileInvestigations into the stable isotope ratios of 1-phenyl-2-propanone, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Drug Testing and Analysis (2022), 14(3), 496-504, database is CAplus and MEDLINE.

Stable isotope ratio mass spectrometry (IRMS) can be used to determine the precursor and precursor origin of methylamphetamine drug samples. Previous work has shown that methylamphetamine samples can be distinguished as derived from different sources of (pseudo)ephedrine or phenyl-2-propanone (P2P) through the use of IRMS alongside conventional chem. profiling techniques. To date, limited research has been conducted to investigate whether methylamphetamine samples of differing P2P origins can be distinguished through drug profiling. This was investigated by synthesizing methylamphetamine inhouse in a three-step process. Two ‘preprecursors’ were used in this study, phenylacetic acid (PAA) and α-phenylacetoacetonitrile (α-PAAN). Using a combination of profiling techniques, it was found that methylamphetamine samples of PAA preprecursor origin and methylamphetamine samples of α-PAAN preprecursor origin can be distinguished.

Drug Testing and Analysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Yang published the artcilePorous organic cage for enantiomeric fluorescence recognition of amino acid and hydroxy acid, COA of Formula: C8H8O3, the publication is Luminescence (2021), 36(8), 2022-2027, database is CAplus and MEDLINE.

A new method based on the enantioselective recognition of porous organic cages CC3-R was established for the first time. Porous organic cages are widely used for separation, adsorption and host-guest interaction sensing, but are rarely used for fluorescence sensing. Based on the inherent chiral environment of CC3-R and the inherent fluorescence properties of the organic ligands constituting the cage, when different chiral monomers diffuse into the cage, different effects occur to produce changes in fluorescence. We found for the first time that the fluorescence of CC3-R can be enhanced and quenched by tyrosine and mandelic acid, resp., and that different chiral monomers are enhanced or quenched differently at the same concentration Unlike the chiral recognition of other composite luminescent materials, the chiral porous organic cage not only utilizes its own host-guest effect for chiral recognition, but also utilizes the organic ligands constituting the cage for luminescence recognition. This work provides an alternative method to accomplish chiral recognition other than chromatog., that is using porous organic cages (POC), but it can show the advantages of simplicity, low cost and high sensitivity. We believe this work could provide valuable thoughts in the exploration of POC in chiral recognition as new FL probes for the future.

Luminescence published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Joufi, Fakhria A. published the artcileAnabasis articulata (Forssk.) Moq: A Good Source of Phytochemicals with Antibacterial, Antioxidant, and Antidiabetic Potential, SDS of cas: 90-64-2, the publication is Molecules (2022), 27(11), 3526, database is CAplus and MEDLINE.

Anabasis articulata is medicinally used to treat various diseases. In this study, A. articulata was initially subjected to extraction, and the resultant extracts were then evaluated for their antimicrobial, antioxidant, and antidiabetic potentials. After obtaining the methanolic extract, it was subjected to a silica gel column for separation, and fractions were collected at equal intervals. Out of the obtained fractions (most rich in bioactive compounds confirmed through HPLC), designated as A, B, C, and D as well hexane fraction, were subjected to GC-MS anal., and a number of valuable bioactive compounds were identified from the chromatograms. The preliminary phytochem. tests were pos. for the extracts where fraction A exhibited the highest total phenolic and flavonoid contents. The hexane fraction as antimicrobial agent was the most potent, followed by the crude extract, fraction A, and fraction D. DPPH and ABTS assays were used to estimate the free radical scavenging potential of the extracts Fraction C was found to contain potent inhibitors of both the tested radicals, followed by fraction D. The potential antidiabetic extracts were determined using α-glucosidase and amylase as probe enzymes. The former was inhibited by crude extract, hexane, and A, B, C and D fractions to the extent of 85.32 ± 0.20, 61.14 ± 0.49, 62.15 ± 0.84, 78.51 ± 0.45, 72.57 ± 0.92 and 70.61 ± 0.91%, resp., at the highest tested concentration of 1000 μg/mL with their IC50 values 32, 180, 200, 60, 120 and 140 μg/mL correspondingly, whereas α-amylase was inhibited to the extent of 83.98 ± 0.21, 58.14 ± 0.75, 59.34 ± 0.89, 81.32 ± 0.09, 74.52 ± 0.13 and 72.51 ± 0.02% (IC50 values; 34, 220, 240, 58, 180, and 200 μg/mL, resp.). The observed biol. potentials might be due to high phenolic and flavonoid content as detected in the extracts The A. articulata might thus be considered an efficient therapeutic candidate and could further be investigated for other biol. potentials along with the isolation of pure responsible ingredients.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Kaili published the artcileElectrosynthesis of amino acids from biomass-derived α-hydroxyl acids, Related Products of alcohols-buliding-blocks, the publication is Green Chemistry (2022), 24(13), 5320-5325, database is CAplus.

Electrochem. conversion of biomass-derived intermediate compounds to high-value products has emerged as a promising approach in the field of biorefinery. Biomass upgrading allows for the production of chems. from non-fossil-based carbon sources and capitalization on electricity as a green energy input. Amino acids, as products of biomass upgrading, have received relatively little attention. Pharmaceutical and food industries will benefit from an alternative strategy for the production of amino acids that does not rely on inefficient fermentation processes. The use of renewable biomass resources as starting materials makes this proposed strategy more desirable. Herein, we report an electrochem. approach for the selective oxidation of biomass-derived α-hydroxyl acids to α-keto acids, followed by electrochem. reductive amination to yield amino acids as the final products. Such a strategy takes advantage of both reactions at the anode and cathode and produces amino acids under ambient conditions with high energy efficiency. A flow electrolyzer was also successfully employed for the conversion of α-hydroxyl acids to amino acids, highlighting its great potential for large-scale application.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lou, Sunqi published the artcileIn Situ Growth of CsPbBr₃ Perovskite Nanocrystals in Lead-Based Matrix toward Significantly Enhanced Water/Photo Stabilities, Name: 2-Hydroxy-2-phenylacetic acid, the publication is Advanced Optical Materials (2022), 10(1), 2101448, database is CAplus.

Perovskite nanocrystals (NCs) are considered as the next-generation platforms for optoelectronic applications, but their poor stability greatly restricts their development. Here, we present a facile composite strategy to synthesize highly stable CsPbBr₃/Pb-MA composite by in situ embedding the CsPbBr₃ NCs in a C₁₆H₁₄Br₂O₆Pb₂ (Pb-MA) organometallic compound (MOC). The CsPbBr₃/Pb-MA composite powders show intense green emission at 519 nm, with a photoluminescence quantum yield of about 48.5% and a full width at half-maximum of about 17 nm. More interestingly, benefitted from the protection of MOC, the CsPbBr₃/Pb-MA composites can maintain 43% and 83% of initial intensity after being illuminated under blue light for 36 h and being immersed in water for 192 h, resp. Compared to the original CsPbBr₃ NCs, the light/water stability of CsPbBr₃/Pb-MA composites is enhanced by about 40 and 700 times (the PL intensities maintain at about 60% of the initial one), resp. As a proof-of-concept, the as-fabricated devices exhibit a wide color gamut, 97.7% and 98.2% of Rec. 2020 for white light-emitting diodes and laser diodes, resp. These findings demonstrate that the combination of MOC and perovskite NCs is an optimized strategy for the exploitation of high-performance perovskite composites for their future optoelectronic applications.

Advanced Optical Materials published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Name: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts