Category: 90-64-2

Fent, Kenneth W. published the artcileFirefighters′ urinary concentrations of VOC metabolites after controlled-residential and training fire responses, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is International Journal of Hygiene and Environmental Health (2022), 113969, database is CAplus and MEDLINE.

Firefighters are exposed to volatile organic compounds (VOCs) during structural fire responses and training fires, several of which (e.g., benzene, acrolein, styrene) are known or probable carcinogens. Exposure studies have found that firefighters can absorb chems. like benzene even when self-contained breathing apparatus (SCBA) are worn, suggesting that dermal absorption contributes to potentially harmful exposures. However, few studies have characterized VOC metabolites in urine from firefighters. We quantified VOC metabolites in firefighters urine following live firefighting activity across two field studies. In two sep. controlled field studies, spot urine was collected before and 3 h after firefighters and firefighter students responded to simulated residential and training fires. Urine was also collected from instructors from the training fire study before the first and 3 h after the last training scenario for each day (instructors led three training scenarios per day). Samples were analyzed for metabolites of VOCs to which firefighters may be exposed. In the residential fire study, urinary metabolites of xylenes (2MHA), toluene (BzMA), and styrene (MADA) increased significantly (at 0.05 level) from pre- to post-fire. In the training fire study, MADA concentrations increased significantly from pre- to post-fire for both firefighter students and instructors. Urinary concentrations of benzene metabolites (MUCA and PhMA) increased significantly from pre- to post-fire for instructors, while metabolites of xylenes (3MHA+4MHA) and acrolein (3HPMA) increased significantly for firefighter students. The two highest MUCA concentrations measured post-shift from instructors exceeded the BEI of 500 μg/g creatinine. Some of the metabolites that were significantly elevated post-fire are known or probable human carcinogens (benzene, styrene, acrolein); thus, exposure to these compounds should be eliminated or reduced as much as possible through the hierarchy of controls. Given stringent use of SCBA, it appears that dermal exposure contributes in part to the levels measured here.

International Journal of Hygiene and Environmental Health published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Torres, Talyta Mayara Silva published the artcilePhenolic compounds recovered from ora-pro-nobis leaves by microwave assisted extraction, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Biocatalysis and Agricultural Biotechnology (2022), 102238, database is CAplus.

Ora-pro-nobis is an ornamental plant, often used as food in some regions of Brazil, and Pereskia grandifolia is one of the less explored specie of this nutritional plant. To understand the antioxidant potential and phenolic profile of ora-pro-nobis leaves, the micro-wave assisted extraction (MAE) was held using the green solvents ethanol and water. An optimization was made using Box-Behnken exptl. design (32), with process time, temperature and solvent (% of water/ethanol) as variables. The evaluated responses were the process yield, combined with antioxidant capacity (DPPH, ABTS and FRAP methods) and total phenolic content (TPC) of the recovered extracts Soxhlet method with ethanol was performed for comparison purpose. The phenolic profile of extract samples was assessed by LC-ESI-MS/MS anal. High yield values were provided by 50% ethanol as solvent at 150°C. Best antioxidant potential from DPPH and FRAP methods were provided by ethanolic extracts at 110°C, while water extracts at 150°C provided best ABTS results. High TPC recovery was found in 50% ethanol samples at 70°C. Overall, 24 phenolic compounds were identified, within caffeic acid, ellagic acid, p-anisic acid, p-coumaric acid kaempferol and quercetin as the main components. Ellagic acid and p-anisic acid were firstly reported associated to ora-pro-nobis leaves. The optimization of the results indicates that 150°C, 12.5 min of MAE and ethanol as solvent provided the best combined responses. The use of MAE for ora-pro-nobis leaves is a novelty that must be followed to explore green methods to value natural products.

Biocatalysis and Agricultural Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C18H34N4O5S, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reddy, Kumbam Lingeshwar published the artcileMandelic acid appended chiral gels as efficient templates for multicolour circularly polarized luminescence, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Nanoscale (2022), 14(13), 4946-4956, database is CAplus and MEDLINE.

Mandelic acid is a medicinally important chiral mol. that is widely used as a vital component in antibiotics, antiseptics and cosmetics. While the medicinal properties of mandelic acid are well known, its aggregation and gelation characteristics, which are crucial to finding applications as cosmetics and ointments, are least explored. We have designed and synthesized a pair of mandelic acid derivatives and investigated their aggregation properties in binary solvent mixtures The compounds undergo self-assembly through various noncovalent interactions, leading to the formation of robust chiral gels. Strong birefringence could be visualised from the individual structures constituting the gel. The large rod-like chiral structures are utilized as efficient templates for the assembly of ultra-small luminescent achiral carbon nanodots. The transfer of optical activity from the chiral host matrix to the fluorescent guest nanoparticles resulted in the generation of circularly polarized luminescence signals from the hybrid nanocomposites. The use of blue, green and red-emitting nanodots led to the fabrication of multicolor chiral light-emitting materials capable of covering the entire visible range. Considering the numerous medicinal benefits offered by mandelic acid and carbon nanodots, the materials constituting the nanocomposites, the distinct dimensions presented in the current work open new avenues for chiral light emitting materials to be used in biomedical research.

Nanoscale published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Riggs, Daniel W. published the artcileEnvironmental exposure to volatile organic compounds is associated with endothelial injury, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Toxicology and Applied Pharmacology (2022), 115877, database is CAplus and MEDLINE.

Volatile organic compounds (VOCs) are airborne toxicants abundant in outdoor and indoor air. High levels of VOCs are also present at various Superfund and other hazardous waste sites; however, little is known about the cardiovascular effects of VOCs. We hypothesized that ambient exposure to VOCs exacerbate cardiovascular disease (CVD) risk by depleting circulating angiogenic cells (CACs). In this cross-sectional study, we recruited 603 participants with low-to-high CVD risk and measured 15 subpopulations of CACs by flow cytometry and 16 urinary metabolites of 12 VOCs by LC/MS/MS. Associations between CAC and VOC metabolite levels were examined using generalized linear models in the total sample, and sep. in non-smokers. In single pollutant models, metabolites of ethylbenzene/styrene and xylene, were neg. associated with CAC levels in both the total sample, and in non-smokers. The metabolite of acrylonitrile was neg. associated with CD45^dim/CD146⁺/CD34⁺/AC133⁺ cells and CD45⁺/CD146⁺/AC133⁺, and the toluene metabolite with AC133⁺ cells. In anal. of non-smokers (n = 375), multipollutant models showed a neg. association with metabolites of ethylbenzene/styrene, benzene, and xylene with CD^45dim/CD146⁺/CD34⁺ cells, independent of other VOC metabolite levels. Cumulative VOC risk score showed a strong neg. association with CD45^dim/CD146⁺/CD34⁺ cells, suggesting that total VOC exposure has a cumulative effect on pro-angiogenic cells. We found a non-linear relationship for benzene, which showed an increase in CAC levels at low, but depletion at higher levels of exposure. Sex and race, hypertension, and diabetes significantly modified VOC associated CAC depletion. Low-level ambient exposure to VOCs is associated with CAC depletion, which could compromise endothelial repair and angiogenesis, and exacerbate CVD risk.

Toxicology and Applied Pharmacology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Larcombe, Chloe N. published the artcileAccessing Diverse Cross-Benzoin and α-Siloxy Ketone Products via Acyl Substitution Chemistry, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Organic Chemistry (2022), 87(14), 9408-9413, database is CAplus and MEDLINE.

An approach to diverse cross-benzoin and α-siloxy ketone products which leverages a simple yet underutilized C-C bond disconnection strategy is reported. Acyl substitution of readily accessible α-siloxy Weinreb amides with organolithium compounds enables access to a broad scope of aryl, heteroaryl, alkyl, alkenyl, and alkynyl derivatives Enantiopure benzoins can be accessed via a chiral pool approach, and the utility of accessible cross-benzoins and α-siloxy ketones is highlighted in a suite of downstream synthetic applications.

Journal of Organic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cipriani, Andreza published the artcilePhenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase, Category: alcohols-buliding-blocks, the publication is Natural Product Research (2022), 36(4), 1134-1137, database is CAplus and MEDLINE.

Eugenia involucrata DC. (Myrtaceae), popularly known as “cereja-do-Rio-Grande”, is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), Et acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chem. composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC50 = 44.19μg mL-1, for FEA) and α-glucosidase (α-Glu) (best result: IC50 = 31.25 ± 0.15μg mL-1, for CHE). The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.

Natural Product Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang, YaoYao published the artcileDirected evolution of PobR allosteric transcription factor to generate biosensor for 4-hydroxymandelic acid, Formula: C8H8O3, the publication is World Journal of Microbiology & Biotechnology (2022), 38(6), 104, database is CAplus and MEDLINE.

Hydroxy-mandelic acid (HMA) is widely applied in pharmaceuticals, food and cosmetics. In this study, we aimed to develop an allosteric transcription factors (aTFs) based biosensor for HMA. PobR, an aTF for HMA analog 4-hydroxybenzoic acid, was used to alter its selectivity and create novel aTFs responsive to HMA by directed evolution. We established a PobR mutant library with a capacity of 550,000 mutants using error-prone PCR and Megawhop PCR. Through our screening, two mutants were obtained with responsiveness to HMA. Anal. of each missense mutation indicating residues 122-126 were involved in its PobR ligand specificity. These results showed the effectiveness of directed evolution in switching the ligand specificity of a biosensor and improving HMA production

World Journal of Microbiology & Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blundell, Toby J. published the artcileEnantiopure and racemic radical-cation salts of B(mandelate)₂^– and B(2-chloromandelate)₂^– anions with BEDT-TTF, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2022), 51(12), 4843-4852, database is CAplus and MEDLINE.

Authors report the first examples of radical-cation salts of BEDT-TTF with spiroborate anions [B(mandelate)₂]^– and [B(2-chloromandelate)₂]^–, synthesized from either enantiopure or racemic bidentate mandelate or chloromandelate ligands. In the salts prepared using enantiopure ligands only one of two diastereoisomers of the spiroborate anion is incorporated, with the boron center having the same stereochem. as the enantiopure ligand. For the racemic salts one racemic pair of spiroborate anions containing an R and an S mandelate ligand is incorporated. In certain solvents helical crystals were obtained when using spiroborate anions with enantiopure ligands. Elec. and magnetic properties, and band structure calculations are reported.

Dalton Transactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fu, Yu published the artcileMandelic Acid as an Interfacial Modifier for High Performance NiO_x-based Inverted Perovskite Solar Cells, HPLC of Formula: 90-64-2, the publication is ChemNanoMat (2022), 8(7), e202200091, database is CAplus.

Nickel oxide (NiO_x) inverted perovskite solar cells have been witnessed as promising solar cells because of the low cast, easy fabrication and negligible hysteresis. However, the inferior interface feature of the link NiO_x and perovskite layer often causes poor device property and repeatability. Here, Mandelic acid (MAD) is introduced to form a modified layer, which could improve the poor interface properties between perovskite layer and NiO_x layer. The contact angel images revels MAD could increase the hydrophobicity and facilitate the growth of perovskite crystal. The X-ray diffraction pattern and Fourier transform IR spectroscopy have confirmed that the MAD small mol. could interact with residual PbI₂ crystal, leading to better interface contact and high crystallinity. This is further demonstrated by the SEM test of NiO_x/MAD/MAPbI₃ film that average grain size is increased from 201.85 nm to 315.17 nm. The space-charge limited current measurement proves the introduction of MAD mol. that result in the decreased trap state d. from 3.58×10¹⁵ cm^-3 to 2.721015 cm^-3. As a consequence, The power conversion efficiency is significantly improved from 14.9% to 18.42% of MAPbI₃-based devices that retained nearly 80% initial PCE after 50 days in N₂ without encapsulation.

ChemNanoMat published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Cheng published the artcileIdentifying Key Metabolites Associated with Glucosinolate Biosynthesis in Response to Nitrogen Management Strategies in Two Rapeseed (Brassica napus) Varieties, Application In Synthesis of 90-64-2, the publication is Journal of Agricultural and Food Chemistry (2022), 70(2), 634-645, database is CAplus and MEDLINE.

A high glucosinolate (GSL) concentration, an undesirable substance, has severely restricted rapeseed (Brassica species) development. We performed widely targeted metabolomics anal. based on the ultra-high-performance liquid chromatog.-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) technol. to analyze the metabolic profiles and identify the differential metabolites and GSL components in response to different nitrogen (N) levels in two rapeseed varieties. A total of 341 metabolites and 38 GSL components were detected in the seeds. A total of 188 differential metabolites, including 34 GSL components, were identified in response to different treatments, which were mapped into 2-oxocarboxylic acid metabolism, tryptophan metabolism, and GSL biosynthesis. Key indicators of GSL components highly responsible for different N levels under two contrasting varieties were recognized, i.e., 1-methylpropyl GSL and 4-methylthiobutyl GSL. This study suggests that the efficient N management and variety selection are important strategies for developing rapeseed with low GSLs.

Journal of Agricultural and Food Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C4H5NS2, Application In Synthesis of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts