Category: 90-64-2

Ji, Jiacheng published the artcileIntegrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice, Related Products of alcohols-buliding-blocks, the publication is Journal of Functional Foods (2022), 104978, database is CAplus.

The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 wk of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile anal. of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyzes suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 wk of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders.

Journal of Functional Foods published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ting published the artcileThe underlying rationality of Chinese medicine herb pair Coptis chinensis and Dolomiaea souliei: From the perspective of metabolomics and intestinal function, COA of Formula: C8H8O3, the publication is Journal of Ethnopharmacology (2022), 115065, database is CAplus and MEDLINE.

The combination of Coptis chinensis (RC) and Dolomiaea souliei (VR) has long been used as a classic herb pair for the treatment of gastrointestinal diseases, but the underlying mechanisms remain unknown. In this study, the rationality of evidence-based RC and VR combination was explored from the perspective of metabolism, gut microbiota and gastrointestinal function. After 5 wk treatment, VR extracts (700 mg/kg) and RC alkaloids (800 mg/kg) showed no toxic effect on mice. However, RC administration significantly decreased the body weight of mice. Gastric emptying, gastrointestinal motility function and the absorption of FITC dextran were retarded in the mice of RC group, taking RC along with low dose VR (RC-VRL) and high dose VR (RC-VRH) reversed the impaired gastrointestinal function caused by RC. RC administration significantly increased villus height/crypt depth value. Notably, VR administration increased the number of crypts in mice ileum and reduced villus height/crypt depth value in VR and RC combination group. RC treatment significantly increased the expression of occludin compared to NC group; RC-VRL treatment reversed this tendency. While, VR administration increased ZO1 expression by 99.4% compared to NC mice. As for gut microbiota, RC gavage decreased the gut microbiota diversity, but gut microbiota in VR group was similar to NC group, and VR and RC combination increased gut microbiota diversity. RC administration obviously increased the proportion of Akkermansia muciniphila, Bacteroides thetaiotaomicron, Parabacteroides distasonis, and Escherichia coli, compared to NC mice. VR treatment increased the richness of Bacteroides thetaiotaomicron, Parabacteroides distasonis. RC-VRL and RC-VRH treatment dose-dependently increased the richness of Rikenellaceae RC9, Lactobacillus, and decreased the abundance of Psychrobacter, Bacteroides and Ruminococcus in mice. Serum metabolomic anal. revealed that RC gavage significantly down regulated 76 metabolites and up regulated 31 metabolites. VR treatment significantly down regulated 30 metabolites and up regulated 12 metabolites. Weight loss caused by RC may attribute to the elevated methylxanthine level in mice. The potential adverse effects caused by high dose RC intake may partially alleviate by high serum contents of adenosine, inosine and urolithin A resulted from VR coadministration. VR may alleviate RC caused “fluid retention” via normalizing gastrointestinal function, gut microbiota and modulating the perturbed metabolism

Journal of Ethnopharmacology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H4FNO3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gujar, Jitendra B. published the artcileSynthesis of Dihydropyrano[2,3-C]pyrazoles Using Mandelic Acid as an Efficient Catalyst, Formula: C8H8O3, the publication is Organic Preparations and Procedures International (2022), 54(2), 138-144, database is CAplus.

A simple new synthetic protocol for the preparation of dihydropyrano[2,3-C]pyrazole derivatives I (R = 4-methylphenyl, piperonyl, Et, etc.) using conventional and US methods with green characteristics. The model reaction was performed using one-pot MCR of Et acetoacetate, hydrazine hydrate, p-methylbenzaldehyde RCHO, and malononitrile in water at reflux or US method, using mandelic acid as an efficient catalyst. The considerable advantages of these methods include short reaction times, very good yields, and the avoidance of the use of environmentally hazardous solvents.

Organic Preparations and Procedures International published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Hou published the artcileEnantioseparation of amino acid and mandelic acid enantiomers using Garphos derivatives as chiral extractants, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Chirality (2022), 34(9), 1239-1246, database is CAplus and MEDLINE.

In this paper, Garphos with different substituents were employed as chiral extractants to enantiosep. racemic amino acid and mandelic acid. The influences of metal precursors, pH of aqueous solution, Garphos-metal concentration, extraction temperature, and substituent effect on extraction were investigated. The results indicated that the substituent groups significantly affected the π-π interaction between extractant and substrate. And the separation factors (α) for Garphos could be remarkably improved by regulating substituent groups. Garphos-II-Pd, Garphos-VI-Pd, Garphos-III-Pd, Garphos-I-Cu, Garphos-VI-Cu, and Garphos-V-Pd were the most efficient extractants for phenylalanine (Phe), homophenylalanine (Hphe), 4-nitrophenylalanine (Nphe), 3-chlorophenylglycine (Cpheg), mandelic acid (MA), and 2-chlormandelic acid (CMA) with α values of 2.40, 2.37, 5.37, 1.59, 5.98, and 3.69, resp. This work provided an important reference for the design of efficient chiral extractants in future work.

Chirality published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C21H20BrNO4S, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yinli published the artcileEnhanced Molecular Recognition through Substrate-Additive Complex Formation in N-Heterocyclic-Carbene-Catalyzed Kinetic Resolution of α-Hydroxythioamides, COA of Formula: C8H8O3, the publication is ACS Catalysis (2022), 12(10), 6100-6107, database is CAplus.

A new way of understanding enhanced mol. recognition through substrate-additive complex formation and the development of the first catalytic kinetic resolution of α-hydroxythioamides RCH(OH)C(S)NH(R¹) (R = Me, cyclopropyl, Ph, etc.; R¹ = Et, t-Bu, 3,5-bis(trifluoromethyl)phenyl, etc.), which are versatile synthetic building blocks, using chiral N-heterocyclic carbene I-catalyzed enantioselective acylation assisted by a carboxylate additive viz., 9-Julolidinecarboxylic acid was described. Mass spectrometry provided evidence for the role of the additive, which forms a hydrogen-bonded complex with α-hydroxythioamide, resulting in both rate and selectivity enhancements. The synthetic applications of the resolved α-hydroxythioamides highlight the usefulness of the developed method.

ACS Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C7H9NO, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Baker, Sarah I. published the artcileEnhanced Reactivity for Aromatic Bromination via Halogen Bonding with Lactic Acid Derivatives, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Organic Chemistry (2022), 87(13), 8492-8502, database is CAplus and MEDLINE.

Herein, a new method for regioselective aromatic bromination using lactic acid derivatives as halogen bond acceptors with N-bromosuccinimide (NBS) is reported. Several structural analogs of lactic acid affected the efficiency of aromatic brominations, presumably via Lewis acid/base halogen-bonding interactions. Rate comparisons of aromatic brominations demonstrated the reactivity enhancement available via catalytic additives capable of halogen bonding. Computational results demonstrated that Lewis basic additives interact with NBS to increase the electropos. character of bromine prior to electrophilic transfer. An optimized procedure using catalytic mandelic acid under aqueous conditions at room temperature has been developed to promote aromatic bromination on a variety of arene substrates with complete regioselectivity.

Journal of Organic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Safitri, Baiq Firyal Salsabila published the artcileMorphology Modulation in Self-Assembly of Chiral 2-Hydroxy-2-Phenylacetic Acids in Polymeric Diluents, Formula: C8H8O3, the publication is Crystals (2022), 12(6), 807, database is CAplus.

This study focused on the chirality effects that control the lamellar bending sense in self-assembled crystals of chiral 2-hydroxy-2-phenylacetic acids. 2-Hydroxy-2-phenylacetic acid or mandelic acid (MA) was crystallized in the presence of poly(4-vinyl phenol) (PVPh), and its crystalline structures and morphologies were assessed using polarized optical microscopy and SEM . MA of two opposite chiral forms (S- and R-) was crystallized with PVPh as the morphol. modulator; with adjustment of the PVPh content, the morphol. of MA crystals transforms from ring-banded spherulites to highly dendritic spherulites. For MA/PVPh (50/50 weight/weight) blend and neat MA at same T_c, the dendritic spherulites are packed with single crystals where the lamellae bend at a specific direction varying with T_c and chirality. Contrary to conventional thought, the bending senses of the MA lamellae in the dendritic spherulites are not solely governed by the MA mol. chirality (S or R), but also by T_c. Only at high Tc (>65°C) is the lamellar bending direction in dendritic spherulites of (S)-MA or (R)-MA blended with PVPh dictated by the chirality, i.e., displaying counterclockwise and clockwise bending direction for (S)-MA/PVPh and (R)-MA/PVPh, resp. Nevertheless, at low T_c (45°C), the bending sense of dendritic spherulites displays an opposite direction from those at the higher T_c, which is to say that the chirality alone does not control the lamellar bending direction.

Crystals published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Zhong-Lei published the artcileSynthesis of Terpineol from Alpha-Pinene Catalyzed by α-Hydroxy Acids, Quality Control of 90-64-2, the publication is Molecules (2022), 27(3), 1126, database is CAplus and MEDLINE.

We report the use of five alpha-hydroxy acids (citric, tartaric, mandelic, lactic and glycolic acids) as catalysts in the synthesis of terpineol from alpha-pinene. The study found that the hydration rate of pinene was slow when only catalyzed by alpha-hydroxyl acids. Ternary composite catalysts, composed of AHAs, phosphoric acid, and acetic acid, had a good catalytic performance. The reaction step was hydrolysis of the intermediate terpinyl acetate, which yielded terpineol. The optimal reaction conditions were as follows: alpha-pinene, acetic acid, water, citric acid, and phosphoric acid, at a mass ratio of 1:2.5:1:(0.1-0.05):0.05, a reaction temperature of 70°C, and a reaction time of 12-15 h. The conversion of alpha-pinene was 96%, the content of alpha-terpineol was 46.9%, and the selectivity of alpha-terpineol was 48.1%. In addition, the catalytic performance of monolayer graphene oxide and its composite catalyst with citric acid was studied, with acetic acid used as an additive.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Daqian published the artcileTris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases, Product Details of C8H8O3, the publication is Chemico-Biological Interactions (2022), 110027, database is CAplus and MEDLINE.

Tris (2-chloroethyl) phosphate (TCEP) is the most commonly detective organophosphate flame retardant in surroundings. TCEP is also evidenced as endocrine disrupting chems. and has potential adverse effects on metabolic diseases. In this study, we hypothesized that metabolic diseases are adverse outcomes of TCEP exposure. Adult ICR mice was daily treated with TCEP (20 mg/kg and 60 mg/kg, higher than expected level in people) by gavage administration for 9 wk. The results demonstrate that TCEP promoted body weight gain, hypertriglyceridemia, and hepatic steatosis, consistent with upregulation of hepatic lipogenesis-related gene expression. Moreover, TCEP altered the levels of several hepatic metabolites, especially bile acids and downregulated bile acid synthesis pathways. Intriguingly, we found a marked downregulation of the bile acid nuclear reporter, FXR, in TCEP-exposed livers. Mechanistically, TCEP directly interacted with FXR at Lys335 and Lys336. Further studies in this work elucidate the mechanisms of long-term TCEP exposure on hepatic steatosis and obesity in mice via FXR-mediated lipid accumulation. Our results provide insight into the possibility of intermediate TCEP exposure in causing metabolic diseases.

Chemico-Biological Interactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C19H15NO3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dai, Yuxuan published the artcilePhotocatalytic degradation mechanism of phenanthrene over visible light driven plasmonic Ag/Ag₃PO₄/g-C₃N₄ heterojunction nanocomposite, Related Products of alcohols-buliding-blocks, the publication is Chemosphere (2022), 133575, database is CAplus and MEDLINE.

Visible light driven plasmonic Ag/Ag₃PO₄/g-C₃N₄ heterojunction nanocomposite with regular morphol. was prepared via a modified facile method. The two-dimensional ultrathin g-C₃N₄ nanosheet is uniformly wrapped on the surface of Ag₃PO₄ nanopolyhedron. A charge transfer bridge was built between Ag₃PO₄ nanopolyhedron and g-C₃N₄ nanosheet due to the reduction of Ag nanoparticles. This structure can inhibit the recombination of photogenerated electron-hole pairs and promote the transfer of photogenerated carriers, so as to produce more active species for participating in the photocatalytic reaction. In addition, the surface plasmon resonance (SPR) of appropriate Ag nanoparticles enhanced the absorption and utilization of visible light. Compared with Ag₃PO₄ and Ag/Ag₃PO₄, Ag/Ag₃PO₄/g-C₃N₄ showed higher photocatalytic activity. Under visible light irradiation, the degradation rate of phenanthrene (PHE) was 0.01756 min^-1, which was 3.14 times and 2.38 times that of Ag₃PO₄ and Ag/Ag₃PO₄, resp. After four cycles of photocatalytic reaction, the Ag/Ag₃PO₄ /g-C₃N₄ photocatalyst still maintained high photocatalytic activity. The active sites of PHE were predicted by Gaussian simulation calculation and combined with intermediate products identification of GC-MS, the possible degradation pathway of PHE was speculated. This research has reference significance for the construction of plasmonic heterojunction photocatalyst in the field of environmental pollution remediation.

Chemosphere published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts