Category: 89466-08-0

《A new fluorescent probe for sensing of biothiols and screening of acetylcholinesterase inhibitors》 was written by Wu, Shengjun; Li, Yuge; Deng, Tao; Wang, Xiaojuan; Hu, Shiyou; Peng, Guiyuan; Huang, Xin-an; Ling, Yanwu; Liu, Fang. SDS of cas: 89466-08-0 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

A new N2O-type BODIPY probe (LF-Bop)(I) has been proposed for the selective and sensitive detection of biol. relevant small mol. thiols. This detection is based on the Michael addition reaction between the thiol and nitrostyrene groups in the probe, which decreases the quenching effect from the nitro group, thus resulting in the recovery of the deep-red fluorescence from the BODIPY structure. LF-Bop is able to detect all tested free thiols through a fluorescence turn-on assay. The lowest limit of detection (LOD) for glutathione is down to nanomolar levels (220 nM). Based on this probe, the authors have developed a new fluorescence assay for the screening of acetylcholinesterase inhibitors. In total, 11 natural and synthetic alkaloids have been evaluated. Both exptl. measurements and theor. mol. docking results reveal that both natural berberine and its synthetic derivative dihydroberberine are potential inhibitors of acetylcholinesterase. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. SDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Rapp, Mario R.; Leis, Wolfgang; Zinna, Francesco; Di Bari, Lorenzo; Arnold, Tamara; Speiser, Bernd; Seitz, Michael; Bettinger, Holger F. published an article in Chemistry – A European Journal. The title of the article was 《Bright Luminescence by Combining Chiral [2.2]Paracyclophane with a Boron-Nitrogen-Doped Polyaromatic Hydrocarbon Building Block》.Name: 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Novel BN-doped compounds based on chiral, tetrasubstituted [2.2]paracyclophane and NBN-benzo[f,g]tetracene were synthesized by Sonogashira-Hagihara coupling. Conjugated ethynyl linkers allow electronic communication between the π-electron systems through-bond, whereas through-space interactions are provided by strong π-π overlap between the pairs of NBN-building blocks. Excellent optical and chiroptical properties in racemic and enantiopure conditions were measured, with molar absorptivities up to ε=2.04 × 105 M-1 cm-1, fluorescence quantum yields up to ΦPL = 0.70, and intense, mirror-image electronic CD and circularly polarized luminescence signals of the magnitude of 10-3 for the absorption and luminescence dissymmetry factors. Computed glum,calculated values match the exptl. ones. Electroanal. data show both oxidation and reduction of the ethynyl-linked tetra-NBN-substituted paracyclophane, with an overlap of 2 redox processes for oxidation leading to a diradical dication. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Name: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Name: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Rhodium-Catalysed Asymmetric Synthesis of 4-Alkyl-4H-Chromenes》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Chang, Zhiqian; Yao, Jian; Dou, Xiaowei. Reference of 2-Hydroxyphenylboronic acid The article mentions the following:

A general method for the catalytic asym. synthesis of 4-alkyl-4H-chromenes I [R1 = Me, Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4; R2 = n-Pr, cyclopropyl, Ph, etc.; R3 = H, 6-Me, 6-Cl, 6-F, 7-F] was developed. With readily available β-alkyl-substituted enones and 2-hydroxylated arylboronic acids, a rhodium-catalyzed asym. conjugate addition/intramol. hemi-acetalization/acid-promoted dehydration sequence led to the formation of 4-alkyl-4H-chromenes in up to 99% yield and with up to >99% ee. The current study remedied the methodol. deficiency in asym. synthesis of 4-alkyl-4H-chromenes I. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Reference of 2-Hydroxyphenylboronic acid) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Reference of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 89466-08-0In 2019 ,《Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Heider, Fabian; Pantsar, Tatu; Kudolo, Mark; Ansideri, Francesco; De Simone, Angela; Pruccoli, Letizia; Schneider, Taiane; Goettert, Marcia Ines; Tarozzi, Andrea; Andrisano, Vincenza; Laufer, Stefan A.; Koch, Pierre. The article conveys some information:

Glycogen synthase kinase-3β (GSK3β) is involved in many pathol. conditions and represents an attractive drug target. We previously reported dual GSK3β/p38α mitogen-activated protein kinase inhibitors and identified N-(4-(4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)pyridin-2-yl)cyclopropanecarboxamide (1) as a potent dual inhibitor of both target kinases. In this study, we aimed to design selective GSK3β inhibitors based on our pyridinylimidazole scaffold. Our efforts resulted in several novel and potent GSK3β inhibitors with IC50 values in the low nanomolar range. 5-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-cyclopropyl-1H-imidazole-2-carboxamide (6g) displayed very good kinase selectivity as well as metabolically stability and inhibits GSK3β activity in neuronal SH-SY5Y cells. Interestingly, we observed the importance of the 2-methylimidazole’s tautomeric state for the compound activity. Finally, we reveal how this crucial tautomerism effect is surmounted by imidazole-2-carboxamides, which are able to stabilize the binding via enhanced water network interactions, regardless of their tautomeric state. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 89466-08-0In 2020 ,《Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Suzuki, Yumiko; Otake, Ayana; Ueno, Satoshi; Hayashi, Kensuke; Ishii, Hirosuke; Miyoshi, Nao; Kuroiwa, Kenta; Tachikawa, Masashi; Fujimaki, Yuki; Nishiyama, Kotaro; Manabe, Kei; Yamazaki, Ryuta; Asai, Akira. The article conveys some information:

As a part of our continuous structure-activity relationship (SAR) studies on 1-(quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ols, the synthesis of derivatives and their cytotoxicity against the human lung cancer cell line A549 were explored. This led to the discovery of 1-(2-(furan-3-yl)quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ol (PVHD303) with potent antiproliferative activity. PVHD303 disturbed microtubule formation at the centrosomes and inhibited the growth of tumors dose-dependently in the HCT116 human colon cancer xenograft model in vivo. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Product Details of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Product Details of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 89466-08-0In 2020 ,《Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy》 appeared in Journal of Medicinal Chemistry. The author of the article were Atobe, Masakazu; Serizawa, Takayuki; Yamakawa, Natsumi; Takaba, Kenichiro; Nagano, Yukiko; Yamaura, Toshiaki; Tanaka, Eiichi; Tazumi, Atsutoshi; Bito, Shino; Ishiguro, Masashi; Kawanishi, Masashi. The article conveys some information:

Two chem. series of novel protein kinase C ζ (PKCζ) inhibitors, 4,6-disubstituted and 5,7-disubstituted isoquinolines, were rapidly identified using our fragment merging strategy. This methodol. involves biochem. screening of a high concentration of a monosubstituted isoquinoline fragment library, then merging hit isoquinoline fragments into a single compound Our strategy can be applied to the discovery of other challenging kinase inhibitors without protein-ligand structural information. Furthermore, our optimization effort identified the highly potent and orally available 5,7-isoquinoline 37(I) from the second chem. series. Compound 37 showed good efficacy in a mouse collagen-induced arthritis model. The in vivo studies suggest that PKCζ inhibition is a novel target for rheumatoid arthritis (RA) and that 5,7-disubstituted isoquinoline 37 has the potential to elucidate the biol. consequences of PKCζ inhibition, specifically in terms of therapeutic intervention for RA. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Organic & Biomolecular Chemistry included an article by Fang, Yuanding; Zhao, Rong; Yao, Yuan; Liu, Yang; Chang, Denghu; Yao, Ming; Shi, Lei. Recommanded Product: 2-Hydroxyphenylboronic acid. The article was titled 《Trichloroacetonitrile as an efficient activating agent for the ipso-hydroxylation of arylboronic acids to phenolic compounds》. The information in the text is summarized as follows:

A metal-free and base-free Cl3CCN mediated method was developed for the ipso-hydroxylation of aryl boronic acids to their corresponding phenols which was promoted by a key unstable Lewis adduct intermediate. This transformation was broad functional group tolerance and late-stage functionalization was successful as well. After simple investigation, two pathways (radical/ionic mechanism) were suggested and the beneficial action of blue light needs to be further studied. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors》 was written by Lanman, Brian A.; Allen, Jennifer R.; Allen, John G.; Amegadzie, Albert K.; Ashton, Kate S.; Booker, Shon K.; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J.; Goodman, Guy; Kopecky, David J.; Liu, Longbin; Lopez, Patricia; Low, Jonathan D.; Ma, Vu; Minatti, Ana E.; Nguyen, Thomas T.; Nishimura, Nobuko; Pickrell, Alexander J.; Reed, Anthony B.; Shin, Youngsook; Siegmund, Aaron C.; Tamayo, Nuria A.; Tegley, Christopher M.; Walton, Mary C.; Wang, Hui-Ling; Wurz, Ryan P.; Xue, May; Yang, Kevin C.; Achanta, Pragathi; Bartberger, Michael D.; Canon, Jude; Hollis, L. Steven; McCarter, John D.; Mohr, Christopher; Rex, Karen; Saiki, Anne Y.; San Miguel, Tisha; Volak, Laurie P.; Wang, Kevin H.; Whittington, Douglas A.; Zech, Stephan G.; Lipford, J. Russell; Cee, Victor J.. HPLC of Formula: 89466-08-0 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-“”undruggable”” target; however clin. viable inhibitors have yet to be identified. Here, we report efforts to exploit a cryptic pocket (H95/Y96/Q99) we identified in KRASG12C to identify inhibitors suitable for clin. development. Structure-based design efforts leading to the identification of a novel quinazolinone scaffold are described, along with optimization efforts that overcame a configurational stability issue arising from restricted rotation about an axially chiral biaryl bond. Biopharmaceutical optimization of the resulting leads culminated in the identification of AMG 510, a highly potent, selective, and well-tolerated KRASG12C inhibitor currently in phase I clin. trials (NCT03600883). The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Zhiqian; Zhu, Huilong; Wu, Changhui; Xing, Junhao; Dou, Xiaowei published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《A rhodium-catalyzed conjugate addition/cyclization cascade for the asymmetric synthesis of 2-amino-4H-chromenes》.Electric Literature of C6H7BO3 The article contains the following contents:

The enantioselective synthesis of 2-amino-4H-chromenes via the cascade rhodium-catalyzed conjugate addition/hetero Thorpe-Ziegler reaction is reported. Moderate to good yields (up to 98%) and high enantioselectivities (up to 92% ee) were obtained with a chiral diene-coordinated rhodium complex as the catalyst. This protocol remedies the methodol. deficiency in the asym. synthesis of 4-aryl 2-amino-4H-chromenes. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Electric Literature of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Electric Literature of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models》 was written by Amaradhi, Radhika; Banik, Avijit; Mohammed, Shabber; Patro, Vidyavathi; Rojas, Asheebo; Wang, Wenyi; Motati, Damoder Reddy; Dingledine, Ray; Ganesh, Thota. Recommanded Product: 2-Hydroxyphenylboronic acid And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathol. in central nervous system diseases such as epilepsy, Alzheimer’s disease, and cerebral aneurysms. A selective and brain-permeable EP2 antagonist will be useful to attenuate the inflammatory consequences of EP2 activation and to reduce the severity of these chronic diseases. We recently developed a brain-permeable EP2 antagonist 1 (TG6-10-1), which displayed anti-inflammatory and neuroprotective actions in rodent models of status epilepticus. However, this compound exhibited moderate selectivity to EP2, a short plasma half-life in rodents (1.7 h) and low aqueous solubility (27μM), limiting its use in animal models of chronic disease. With lead-optimization studies, we have developed several novel EP2 antagonists with improved water solubility, brain penetration, high EP2 potency, and selectivity. These novel inhibitors suppress inflammatory gene expression induced by EP2 receptor activation in a microglial cell line, reinforcing the use of EP2 antagonists as anti-inflammatory agents. After reading the article, we found that the author used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts