Category: 89466-08-0

《Synthesis and catalytic activity of cationic dinuclear palladium(II) complexes supported by thioether ligands containing two di-(2-picolyl) amine arms》 was written by Sandoval-Chavez, Cesar Ignacio; Velazquez-Jimenez, Rene; Martinez-Otero, Diego; Salazar-Pereda, Veronica; Andrade-Lopez, Noemi; Gonzalez-Montiel, Simplicio. Category: alcohols-buliding-blocks And the article was included in Polyhedron in 2020. The article conveys some information:

The design, synthesis and characterization of a series of dithioether ligands featuring two di-(2-picolyl)amine arms (2a-2d) and their corresponding cationic dinuclear palladium(II) complexes (3a-d) are reported. Crystal structures of ligand 2b and complexes 3b and 3d were determined by x-ray diffraction studies. The mol. structures of 3b and 3d display each of the two di-(2-picolyl)amine fragments coordinated to one palladium(II) atom in a (κ3-N,N,N) tridentate fashion and with the cationic metal centers displaying square-planar geometries. Weak interactions between the metal centers and the thioether fragments are observed All bimetallic complexes 3a-d were tested as catalytic precursors in the Suzuki couplings of different o- or p-substituted iodo- or bromoaryls with boronic acids. The overall catalytic results indicate that complex 3b is the best precursor of the series demonstrating even more efficient performance compared to com. palladium sources such as Pd(OAc)2 and the Najera Catalysts. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Category: alcohols-buliding-blocks) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Medicinal Chemistry included an article by Shen, Jiayi; Zhang, Tao; Zhu, Su-Jie; Sun, Min; Tong, Linjiang; Lai, Mengzhen; Zhang, Rong; Xu, Wei; Wu, Ruibo; Ding, Jian; Yun, Cai-Hong; Xie, Hua; Lu, Xiaoyun; Ding, Ke. Application of 89466-08-0. The article was titled 《Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S)》. The information in the text is summarized as follows:

Azaheterocyclyl-substituted pyridopyrimidinones such as I were prepared as selective inhibitors of the mutant epidermal growth factor receptor (EGFR) EGFRL858R/T790M/C797S with selectivity over the wild-type EGFR for potential use in treating osimertinib-resistant non-small-cell lung cancer. I exhibited an IC50 of 27.5 nM against the EGFRL858R/T790M/C797S mutant, while being significantly less potent against the wild-type EGFR with an IC50 value of > 1.0 μM. Cocrystallog. structure determination and computational investigation were conducted to elucidate its target selectivity. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Polymers (Basel, Switzerland) included an article by Chen, Shuang; Liu, Feng; Wang, Chao; Shen, Jinghui; Wu, Yonggang. Formula: C6H7BO3. The article was titled 《Simple route to synthesize fully conjugated ladder isomer copolymers with carbazole units》. The information in the text is summarized as follows:

Two isomer polymers, P3 and P6, with fully conjugated ladder structures are presented by simple synthetic routes. The well-defined structures of fully conjugated ladder polymers P3 and P6 were ensured by the high yields of every reaction step. The fully rigid ladder structures were confirmed by NMR (NMR), fourier transform IR spectroscopy (FTIR), and photophys. test. Polymers P3 and P6 with bulky alkyl side chains exhibit good solution processability and desirable thermostable properties. After the intramol. cyclization reaction, the band gaps of polymers P3 and P6 become lower (2.86 eV and 2.66 eV, resp.) compared with polymers P1 and P4. This initial study provides insight for the rational design of fully ladder-conjugated isomeric polymers with well-defined structures. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Pyridine-bridged bifunctional organocatalysts for the synthesis of cyclic carbonates from carbon dioxide》 were Liu, Quan-Yao; Shi, Lei; Liu, Ning. And the article was published in Journal of Chemical Research in 2019. Quality Control of 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Hydroxyl- and carboxyl-functionalized imidazolium halides were used as efficient bifunctional organocatalysts for the synthesis of cyclic carbonates from CO2 and epoxides under mild reaction conditions. Control experiments suggested that the cycloaddition reaction was realized by the combination of the nucleophilic halide anions with hydroxyl and carboxyl groups as hydrogen bond donors. Moreover, the bifunctional organocatalysts was easily recycled five times by simple filtration; however, a loss of activity was observed In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Quality Control of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Quality Control of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《One-Pot Generation of Functionalized Benzynes from Readily Available 2-Hydroxyphenylboronic Acids》 was written by Ikawa, Takashi; Sun, Jing Kai; Takagi, Akira; Akai, Shuji. Related Products of 89466-08-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A one-pot method for the generation of benzynes from a range of readily available 2-hydroxyphenylboronic acids 2-OH-3-R-4-R1-5-R2-C6HB(OH)2 (R = H, Me, F; R1 = H, F; R2 = H, F, CN, OCF3, etc.) was developed. This method features the in situ activation of both boronic acid and hydroxyl groups of the substrate to enhance benzyne generation at 60°C. Such mild conditions facilitate the generation of functionalized benzynes that immediately react with diverse arynophiles e.g., 1,3-diphenylisobenzofuran to produce multisubstituted fused benzenes e.g., 9,10-diphenyl-9,10-dihydro-9,10-epoxyanthracene. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhu, Huilong; Zhou, Qianqian; Liu, Na; Xing, Junhao; Yao, Weijun; Dou, Xiaowei published an article in Advanced Synthesis & Catalysis. The title of the article was 《Relay Rhodium(I)/Acid Catalysis for Rapid Access to Benzo-2H-Pyrans and Benzofurans》.Formula: C6H7BO3 The author mentioned the following in the article:

Relay rhodium(I)/Broensted acid catalysis for tandem arylation-cyclization reaction was developed. Chemodivergent syntheses of benzo-2H-pyrans I [R = H, 6-Cl, 6-Me; R1 = n-Pr, cyclopropyl, i-BuCH2, PhCH2, PhCH2OCH2; R2 = Ph, R3 = Me, n-Pr, Ph, 4-MeOC6H4, etc.; R2 = H, R3 = H, Et, Ph; R2R3 = (CH2)4, o-C6H4-o-C6H4; etc.] and benzofurans II (R = H, 4-F, 5-Me, 6-F; R1 = Ph, 4-MeOC6H4, 2-thienyl, etc.; R2 = H, Me, n-pentyl, Ph; R3 = H) from propargyl alcs. R1CCCR2R3OH and R-substituted ortho-hydroxylated arylboronic acids were achieved under this relay catalysis system. An ortho-hydroxy effect on changing the chemoselectivity and reactivity was observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bae, Eun Jung; Choi, Won Gun; Pagire, Haushabhau S.; Pagire, Suvarna H.; Parameswaran, Saravanan; Choi, Jun-Ho; Yoon, Jihyeon; Choi, Won-il; Lee, Ji Hun; Song, Jin Sook; Bae, Myung Ae; Kim, Mijin; Jeon, Jae-Han; Lee, In-Kyu; Kim, Hail; Ahn, Jin Hee published an article in 2021. The article was titled 《Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease》, and you may find the article in Journal of Medicinal Chemistry.Computed Properties of C6H7BO3 The information in the text is summarized as follows:

Tryptophan hydroxylase 1 (TPH1) has been recently suggested as a promising therapeutic target for treating obesity and fatty liver disease. A new series of 1,2,4-oxadiazolylphenyl alanine derivatives were identified as TPH1 inhibitors. Among them, compound 23a was the most active in vitro, with an IC50 (half-maximal inhibitory concentration) value of 42 nM, showed good liver microsomal stability, and showed no significant inhibition of CYP and hERG. Compound 23a inhibited TPH1 in the peripheral tissue with limited BBB penetration. In high-fat diet-fed mice, 23a reduced body weight gain, body fat, and hepatic lipid accumulation. Also, 23a improved glucose intolerance and energy expenditure. Taken together, compound 23a shows promise as a therapeutic agent for the treatment of obesity and fatty liver diseases. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 2-Hydroxyphenylboronic acidIn 2019 ,《Ruthenium(III)-bis(phenolato)bipyridine/TiO2 hybrids: unprecedented photocatalytic hydrogen evolution》 was published in Dalton Transactions. The article was written by Mongal, Binitendra Naath; Tiwari, Amritanjali; Malapaka, Chandrasekharam; Pal, Ujjwal. The article contains the following contents:

In this work, two new bis-(hydroxyphenyl)bipyridine based ruthenium complexes with 4-picoline (coded as MCS-B4M) and isonicotinic acid (coded as MCS-B5M), which act as ancillary ligands, have been synthesized and employed for the first time as photosensitizers in photocatalytic hydrogen evolution studies. The photocatalyst MCS-B5M/TiO2-Pt showed an impressive hydrogen generation rate of up to 4.2 mmol h-1 and turnover number (TON) of 84 959 after 5 h. The better performance of B5TP over B4TP was due to the higher excited state lifetime of MCS-B5M (∼2.6 ns) than that of MCS-B4M (∼1.4 ns). This leads to a higher probability of electron transfer to the TiO2/Pt composite in the case of the former and a stronger coupling of MCS-B5M excited states with the conduction band of the TiO2/Pt composite by the -COOH linkers of the isonicotinic acid moiety, resulting in better photosensitization as observed in the UV-Vis (DRS mode) absorbance study. The comparative study of the two dyes clearly shows the manifestations of their resp. ancillary ligands having contrasting electronic properties. This work gives a new class of ruthenium photosensitizers as efficient light harvesting photocatalysts.2-Hydroxyphenylboronic acid(cas: 89466-08-0Safety of 2-Hydroxyphenylboronic acid) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Safety of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 89466-08-0In 2021 ,《Cross-Coupling through Ag(I)/Ag(III) Redox Manifold》 was published in Chemistry – A European Journal. The article was written by Demonti, Luca; Saffon-Merceron, Nathalie; Mezailles, Nicolas; Nebra, Noel. The article contains the following contents:

Trifluoromethyl argentates(III) undergo reductive elimination with arylboronic acids, yielding trifluoromethylarenes. In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e- redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through AgI/AgIII redox catalysis (i. e. CEL coupling), namely: (i) easy AgI/AgIII 2e- oxidation mediated by air; (ii) bpy/phen ligation to AgIII; (iii) boron-to-AgIII aryl transfer; and (iv) ulterior reductive elimination of benzotrifluorides from an [aryl-AgIII-CF3] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]+[AgIII(CF3)4]- (K-1), [(bpy)AgIII(CF3)3] (2) and [(phen)AgIII(CF3)3] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [AgIII(aryl)(CF3)3]- intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringSDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 89466-08-0In 2020 ,《Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis》 was published in Journal of Medicinal Chemistry. The article was written by Wanior, Marek; Preuss, Franziska; Ni, Xiaomin; Kraemer, Andreas; Mathea, Sebastian; Goebel, Tamara; Heidenreich, David; Simonyi, Svenja; Kahnt, Astrid S.; Joerger, Andreas C.; Knapp, Stefan. The article contains the following contents:

Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails by the bromodomain-containing proteins SMARCA2 (BRM), SMARCA4 (BRG1), and polybromo-1. Dysregulation of chromatin remodeling leads to aberrant cell proliferation and differentiation. Here, we have characterized a set of potent and cell-active bromodomain inhibitors with pan-selectivity for canonical family VIII bromodomains. Targeted SWI/SNF bromodomain inhibition blocked the expression of key genes during adipogenesis, including the transcription factors PPARγ and C/EBPα, and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes. Our data highlight the role of SWI/SNF bromodomains in adipogenesis and provide a framework for the development of SWI/SNF bromodomain inhibitors for indirect targeting of key transcription factors regulating cell differentiation. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringSDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts