Category: 89466-08-0

Li, Shuai; Li, Xin-yang; Zhang, Ting-jian; Zhu, Ju; Liu, Kai-li; Wang, De-pu; Meng, Fan-hao published their research in Bioorganic Chemistry in 2021. The article was titled 《Novel 4,5-dihydrospiro[benzo[c]azepine-1,1′-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation》.Reference of 2-Hydroxyphenylboronic acid The article contains the following contents:

To further explore the research of novel PARP-1 inhibitors, design and synthesis of a series of novel 4,5-dihydrospiro[benzo[c]azepine-1,1′-cyclohexan]-3(2H)-one derivatives I (R = H, 2-Cl, 3-F, etc.) PARP-1 inhibitors based on the author’s previous research is reported. Most compounds displayed certain antitumor activities against four tumor cell lines (A549, HepG2, HCT-116, and MCF-7). Specifically, the candidate compound I (R = 2-F) possessed strong anti-proliferative potency toward A549 cells with the IC50 value of 2.01μM and showed low toxicity to lung cancer cell line. And the in vitro enzyme inhibitory activity of compound I (R = 2-F) was better than rucaparib. Mol. docking studies provided a rational binding model of the above compound in complex with rucaparib. The following cell cycle and apoptosis assays revealed that this compound could arrest cell cycle in the S phase and induce cell apoptosis and western blot anal. further showed that it could effectively inhibit the PAR’s biosynthesis and was more effective than rucaparib. Overall, based on the biol. activity evaluation, compound I (R = 2-F) could be a potential lead compound for further developing novel amide PARP-1 inhibitors. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Reference of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Reference of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Stuffed Methyltransferase Catalyzes the Penultimate Step of Pyochelin Biosynthesis》 were Ronnebaum, Trey A.; McFarlane, Jeffrey S.; Prisinzano, Thomas E.; Booker, Squire J.; Lamb, Audrey L.. And the article was published in Biochemistry in 2019. Recommanded Product: 89466-08-0 The author mentioned the following in the article:

Nonribosomal peptide synthetases (NRPSs) use tailoring domains to incorporate chem. diversity into the final natural product. A structurally unique set of tailoring domains are found to be stuffed within adenylation domains and have only recently begun to be characterized. PchF is the NRPS termination module in pyochelin biosynthesis and includes a stuffed methyltransferase domain responsible for S-adenosylmethionine (AdoMet)-dependent N-methylation. Recent studies of stuffed methyltransferase domains propose a model in which methylation occurs on amino acids after adenylation and thiolation rather than after condensation to the nascent peptide chain. Herein, we characterize the adenylation and stuffed methyltransferase didomain of PchF through the synthesis and use of substrate analogs, steady-state kinetics, and onium chalcogen effects. We provide evidence that methylation occurs through an SN2 reaction after thiolation, condensation, cyclization, and reduction of the module substrate cysteine and is the penultimate step in pyochelin biosynthesis.2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cu-Catalyzed Dehydrogenative C-O Cyclization for the Synthesis of Furan-Fused Thienoacenes》 was written by Mitsudo, Koichi; Kobashi, Yoshiaki; Nakata, Kaito; Kurimoto, Yuji; Sato, Eisuke; Mandai, Hiroki; Suga, Seiji. Category: alcohols-buliding-blocksThis research focused onthiophenyl phenol copper catalyst dehydrogenative cyclization coupling; furan fused thienoacene preparation. The article conveys some information:

The first Cu-catalyzed dehydrogenative C-O cyclization for the synthesis of furan-fused thienoacenes is described. A variety of heteroacenes including a thieno[3,2-b]furan or a thieno[2,3-b]furan skeleton were synthesized by intramol. C-H/O-H coupling. The use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and efficiently promoting the reaction. Double C-O cyclization was also conducted to afford highly π-expanded furan-fused thienoacenes. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Category: alcohols-buliding-blocks)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringCategory: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A Gas Phase Route to [18F]fluoroform with Limited Molar Activity Dilution》 were Yang, Bo Yeun; Telu, Sanjay; Haskali, Mohammad B.; Morse, Cheryl L.; Pike, Victor W.. And the article was published in Scientific Reports in 2019. Recommanded Product: 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Positron emission tomog. (PET) is an important imaging modality for biomedical research and drug development. PET requires biochem. selective radiotracers to realize full potential. Fluorine-18 (t1/2 = 109.8 min) is a major radionuclide for labeling such radiotracers but is only readily available in high activities from cyclotrons as [18F]fluoride ion. [18F]fluoroform has emerged for labeling tracers in trifluoromethyl groups. Prior methods of [18F]fluoroform synthesis used difluoro precursors in solution and led to high dilution with carrier and low molar activity (Am). We explored a new approach for the synthesis of [18F]fluoroform based on the radiosynthesis of [18F]fluoromethane from [18F]fluoride ion and then cobaltIII fluoride mediated gas phase fluorination. We estimate that carrier dilution in this process is limited to about 3-fold and find that moderate to high Am values can be achieved. We show that [18F]fluoroform so produced is highly versatile for rapidly and efficiently labeling various chemotypes that carry trifluoromethyl groups, thereby expanding prospects for developing new PET radiotracers. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline-Biphenyl Hybrids》 was written by Coa, Juan Carlos; Yepes, Andres; Carda, Miguel; Conesa-Milian, Laura; Upegui, Yulieth; Robledo, Sara M.; Cardona-G, Wilson. Name: 2-Hydroxyphenylboronic acid And the article was included in ChemistrySelect in 2020. The article conveys some information:

The synthesis, in-silico studies, antiprotozoal and cytotoxic activities of eleven quinoline-biphenyl hybrids I [R = H, 4-HO, 3,4-di-MeO] were described. The structure of the synthesized products was elucidated by a combination of spectrometric anal. The synthesized compounds I were evaluated against Plasmodium falciparum and amastigotes forms both Leishmania (V)panamensis and Trypanosoma cruzi. Cytotoxicity was evaluated against human U-937 macrophages. Compound I [R = H] showed similar activity than meglumine antimoniate and compound I [R = 4-HO] exhibited an activity similar to that of benznidazole. Compound I [R = 3,4-di-MeO] showed the best activity against P. falciparum. Although these compounds were toxic for mammalian U-937 cells, however they may still have potential to be considered as candidates for drug development because of their antiparasite activity. Mol. docking was used to determine the in-silico inhibition of some of the designed compounds against PfLDH and cruzipain, two important pharmacol. targets involved in antiparasitic diseases. All hybrids I were docked to the three-dimensional structures of PfLDH and T. cruzi cruzipain as enzymes using AutoDock Vina. Notably, the docking results showed that the most active compoundsI [R = 4-HO] (CE50: 11.33μg/mL for T. cruzi) and I [R = 3,4-di-MeO] (CE50: 8.84μg/mL for P. falciparum) exhibited the highest scoring pose (-7.5 and -7.7 kcal/mol, resp.). This result showed a good correlation between the predicted scores with the exptl. data profile, suggesting that these ligands could act as competitive inhibitors of PfLDH or T. cruzi cruzipain enzymes resp. Finally, in-silico ADME studies of the quinoline hybrids showed that these novel compounds have suitable drug-like properties, making them potentially promising agents for antiprotozoal therapy. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Name: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Name: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Casalta, Clement; Gourlaouen, Christophe; Bouzbouz, Samir published an article in 2021. The article was titled 《Iridium(III) Catalyzed Z-Selective Allylic Arylation of α-Fluoro But-1-enoic Acid Amides via β-F-Elimination in Water》, and you may find the article in Organic Letters.Computed Properties of C6H7BO3 The information in the text is summarized as follows:

Allylic arylation of α-fluoro but-1-enoic acid amides with arylboronic acids was carried out in water by comparing the catalytic activity of iridium(III) and rhodium(III). Ir(III) has shown a strong superiority over Rh(III) to give allyl-aryl coupling products with excellent stereoselectivity in favor of the Z-isomer. The origin of high stereoselectivity is perhaps because of the a coordination of iridium Ir-N or Ir-O.2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mills, L. Reginald; Gygi, David; Ludwig, Jacob R.; Simmons, Eric M.; Wisniewski, Steven R.; Kim, Junho; Chirik, Paul J. published an article in 2022. The article was titled 《Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands》, and you may find the article in ACS Catalysis.Recommanded Product: 89466-08-0 The information in the text is summarized as follows:

Cobalt(II) halides in combination with phenoxyimine (FI) ligands generated efficient precatalysts in situ for the C(sp2)-C(sp3) Suzuki-Miyaura cross-coupling between alkyl bromides and neopentylglycol (hetero)arylboronic esters. The protocol enabled efficient C-C bond formation with a host of nucleophiles and electrophiles (36 examples, 34-95%) with precatalyst loadings of 5 mol %. Studies with alkyl halide electrophiles that function as radical clocks support the intermediacy of alkyl radicals during the course of the catalytic reaction. The improved performance of the FI-cobalt catalyst was correlated with decreased lifetimes of cage-escaped radicals as compared to those of diamine-type ligands. Studies of the phenoxy(imine)-cobalt coordination chem. validate the L,X interaction leading to the discovery of an optimal, well-defined, air-stable mono-FI-cobalt(II) precatalyst structure. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Ding, Pin; Han, Lingbo; Bai, Jiaxing; Liu, Jingjing; Luan, Xinjun published an article in Science China: Chemistry. The title of the article was 《Fine-tuning hydroxylamines as single-nitrogen sources for Pd(0)-catalyzed diamination of o-bromo(or chloro)-biaryls》.Recommanded Product: 89466-08-0 The author mentioned the following in the article:

An efficient Pd(0)-catalyzed inter-mol. [4+1] annulation of o-bromo(or chloro)-biaryls with bifunctional secondary hydroxylamines for the one-step assembly of synthetically useful carbazoles was reported. Noteworthily, a linchpin for this domino reaction was the judicious selection of both the amino-sources and Pd(0)-catalysts for enabling the prerequisite oxidative addition of aryl halides to Pd(0)-species in the presence of hydroxylamines with a labile N-O bond. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C6H7BO3In 2020 ,《A Bi-functional Second Coordination Sphere for Electrocatalytic CO2 Reduction: The Concerted Improvement by a Local Proton Source and Local Coulombic Interactions》 appeared in Chemistry Letters. The author of the article were Matsubara, Yasuo; Shimojima, Miho; Takagi, Shohei. The article conveys some information:

A homogeneous rhenium(I) electrocatalyst possessing hydroxy and ammonio groups in the second coordination sphere is reported for the reduction of carbon dioxide (CO2) to carbon monoxide, wherein the former and latter groups induce a high local concentration of protons and local coulombic interactions with a metallocarboxylate reaction intermediate, resp. In a comparison with precedent catalysts possessing single functional groups in the spheres, we found that the catalyst exhibits a concerted improvement over these single functional groups in the efficiencies of catalysis, based on exptl. standard electrode potentials for the reduction in aqueous N,N-dimethylformamide or acetonitrile solutions and the equilibrium potentials depending on the catalytic systems.2-Hydroxyphenylboronic acid(cas: 89466-08-0Synthetic Route of C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Synthetic Route of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 2-Hydroxyphenylboronic acidIn 2020 ,《Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems》 was published in Organic Letters. The article was written by DeRatt, Lindsey G.; Lawson, Edward C.; Kumar, Kiran; Hwang, Soyon S.; DesJarlais, Renee L.; Kuduk, Scott D.. The article contains the following contents:

A tandem one-pot reaction featuring a cross-coupling followed by an intramol. oxetane ring opening by mild nucleophiles is reported. The overall transformation comprises a carbon-carbon bond formation along with a carbon-heteroatom bond construction providing diverse multicyclic ring systems with a pendant hydroxymethyl handle for further elaboration. This approach constitutes a convergent method for rapid access to various scaffolds. Furthermore, a comparison of computed low-energy conformers is presented to rationalize instances in which cyclization was not observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringApplication In Synthesis of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts