89466-08-0 Archives - Alcohols-buliding-blocks

Liu, Na’s team published research in ACS Catalysis in 2020 | CAS: 89466-08-0

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Quality Control of 2-Hydroxyphenylboronic acid

《Catalyst-Controlled Chemodivergent Synthesis of Spirochromans from Diarylideneacetones and Organoboronic Acids》 was written by Liu, Na; Zhu, Wanjiang; Yao, Jian; Yin, Long; Lu, Tao; Dou, Xiaowei. Quality Control of 2-Hydroxyphenylboronic acid And the article was included in ACS Catalysis in 2020. The article conveys some information:

A chemodivergent synthesis of two series of spirochromans depending on the catalytic system was developed. Starting from diarylideneacetones and organoboronic acids, asym. rhodium catalysis led to the enantioselective synthesis of 4,4′-disubstituted 2,2′-spirobichromans I [R = H, 8(and 8′)-Br, 6(and 6′)-Cl, etc.; Ar = Ph, 3-thienyl, 4-F3CC6H4, etc.], while acid catalysis led to the formation of 4-substituted spirochroman-2,2′-chromenes such as II [R = 6(and 6′)-MeO; R1 = (E)-styryl, 2-furyl, 3-F-4-MeOC6H3, etc.]. A plausible mechanism of the chemodivergent synthesis was proposed. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Quality Control of 2-Hydroxyphenylboronic acid) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Weimin’s team published research in RSC Advances in 2019 | CAS: 89466-08-0

In 2019,RSC Advances included an article by Ma, Weimin; Huang, Jiawei; Li, Chao; Jiang, Yueren; Li, Baolin; Qi, Ting; Zhu, Xiaozhang. Category: alcohols-buliding-blocks. The article was titled 《One-pot synthesis and property study on thieno[3,2-b]furan compounds》. The information in the text is summarized as follows:

Based on the regioselective intermol. Suzuki coupling and subsequent intramol. Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans I (R1 = H, 3-Cl, 2-n-octyl; R2 = H, 8-F, 8-Me, 7-t-Bu) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh3)4 and 2 mol% copper(I) thiophene-2-carboxylate as the catalysts, K3PO4·3H2O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Category: alcohols-buliding-blocks)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hai-Jun’s team published research in Tetrahedron in 2019 | CAS: 89466-08-0

In 2019,Tetrahedron included an article by Li, Hai-Jun; Mellerup, Soren K.; Wang, Xiang; Wang, Suning. Related Products of 89466-08-0. The article was titled 《Impact of intramolecular H bond and n-π* interactions on photophysical and CO2 sensing properties of laterally appended D-π-A triarylboron compounds》. The information in the text is summarized as follows:

Several examples of laterally appended donor-π-acceptor (D-π-A) B compounds based on a biphenyl unit were synthesized and fully characterized. Intramol. H bonds or n-π* interactions have a great impact on the photophys./fluorescent properties of these compounds Some members of these compounds display fluorescent response toward CO2. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sadek, Omar’s team published research in Tetrahedron in 2020 | CAS: 89466-08-0

《Straightforward convergent access to 2-arylated polysubstituted benzothiazoles》 was published in Tetrahedron in 2020. These research results belong to Sadek, Omar; Perrin, David M.; Gras, Emmanuel. Application In Synthesis of 2-Hydroxyphenylboronic acid The article mentions the following:

A modular access to 2,4-disubstituted benzothiazoles I [R = 2-hydroxyphenyl, 2-aminophenyl, 1-[(tert-butoxy)carbonyl]-1H-indol-2-yl; R1 = Br, 2-aminophenyl] has been achieved though the intermediacy of 4-bromo-2-iodobenzothiazole. The difference in reactivity of both halogens was advantageously exploited to achieve sequential Suzuki-Miyaura cross-coupling giving access to a range of polyaromatic derivatives II [R2 = OH, NH2; R3 = 2-hydroxyphenyl, 2-(methylamino)phenyl, 1H-indol-2-yl] featuring a central benzothiazole core. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ai, Liankun’s team published research in RSC Advances in 2021 | CAS: 89466-08-0

Ai, Liankun; Ajibola, Ibrahim Yusuf; Li, Baolin published their research in RSC Advances in 2021. The article was titled 《Copper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C-O coupling reaction》.Application In Synthesis of 2-Hydroxyphenylboronic acid The article contains the following contents:

An efficient method to synthesize benzothieno[3,2-b]benzofurans such as I [R = H, 3-Cl, 3-t-Bu; R1 = H, 7,8-di-F, 8-Me, etc.] via intramol. dehydrogenative C-H/O-H coupling had been developed. Good to excellent yields (64-91%) could be obtained no matter if the substituted group was electron-donating or electron-withdrawing. Notably, three-to-six fused ring thienofuran compounds I could be constructed using this method. A reaction mechanism study showed that 1,1-diphenylethylene could be completely inhibited the reaction. Therefore, it was a radical pathway initiated by single electron transfer between the hydroxyl of the substrate and the copper catalyst. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Kangkang’s team published research in ChemCatChem in 2022 | CAS: 89466-08-0

In 2022,Li, Kangkang; Li, Jin-Feng; Yin, Bing; Zeng, Fanlong published an article in ChemCatChem. The title of the article was 《Investigation of NNN Pincer Ruthenium(II) Complexes with a Pendant Hydroxyl Group for N-Monomethylation of amines and Nitroarenes by Methanol》.HPLC of Formula: 89466-08-0 The author mentioned the following in the article:

A family of air- and moisture-stable NNN pincer ruthenium(II) complexes with a pendant OH were developed, which exhibit unprecedented high reactivity and selectivity in N-monomethylation of amines and nitroarenes using methanol. The study reveals adopting the combination of 1H-pyrazole-1-yl and 3,5-dimethyl-4-hydroxyethyl-1H-pyrazol-1-yl as the two assistant arms of the pyridyl-backbone is a suitable choice. The mechanism study discloses that, during the catalytic cycle, dehydrogenation of methanol to form formaldehyde is a fast and reversible step. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yao, Jian’s team published research in Green Chemistry in 2019 | CAS: 89466-08-0

In 2019,Green Chemistry included an article by Yao, Jian; Liu, Na; Yin, Long; Xing, Junhao; Lu, Tao; Dou, Xiaowei. Electric Literature of C6H7BO3. The article was titled 《Catalytic asymmetric synthesis of chiral phenols in ethanol with recyclable rhodium catalyst》. The information in the text is summarized as follows:

A general method to access diverse chiral phenols by rhodium-catalyzed asym. conjugate arylation using hydroxylated arylboronic acids in ethanol was developed. Recycling of the rhodium catalyst by flash chromatog. on silica gel was feasible in this system. The synthetic utility of the strategy was demonstrated by efficient synthesis of chiral drug tolterodine.2-Hydroxyphenylboronic acid(cas: 89466-08-0Electric Literature of C6H7BO3) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Dumei’s team published research in Organic Letters in 2020 | CAS: 89466-08-0

ãPalladium-Catalyzed Addition/Cyclization of (2-Hydroxyaryl)boronic Acids with Alkynylphosphonates: Access to Phosphacoumarinsã?was written by Ma, Dumei; Hu, Shanshan; Chen, Sirui; Pan, Jiaoting; Tu, Song; Yin, Yingwu; Gao, Yuxing; Zhao, Yufen. Quality Control of 2-Hydroxyphenylboronic acid And the article was included in Organic Letters in 2020. The article conveys some information:

A facile Pd-catalyzed addition/cyclization of (2-hydroxyaryl)boronic acids with alkynylphosphonates was developed, providing an effective strategy to construct valuable phosphacoumarins. This methodol. features excellent regioselectivity and broad substrate tolerance. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Quality Control of 2-Hydroxyphenylboronic acid)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Joerg, Manuela’s team published research in ChemMedChem in 2021 | CAS: 89466-08-0

Joerg, Manuela; Khajehali, Elham; van der Westhuizen, Emma T.; C. Choy, K. H.; Shackleford, David M.; Tobin, Andrew B.; Sexton, Patrick M.; Valant, Celine; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J. published their research in ChemMedChem in 2021. The article was titled ãDevelopment of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptorã?Application In Synthesis of 2-Hydroxyphenylboronic acid The article contains the following contents:

This study investigated the structure-activity relationships of 4-phenylpyridin-2-one and 6-phenylpyrimidin-4-one M1 muscarinic acetylcholine receptor (M1 mAChRs) pos. allosteric modulators (PAMs). The presented series focuses on modifications to the core and top motif of the reported leads, MIPS1650 and MIPS1780. Profiling of our novel analogs showed that these modifications result in more nuanced effects on the allosteric properties compared to our previous compounds with alterations to the biaryl pendant. Further pharmacol. characterization of the selected compounds in radioligand binding, IP1 accumulation and β-arrestin 2 recruitment assays demonstrated that, despite primarily acting as affinity modulators, the PAMs displayed different pharmacol. properties across the two cellular assays. The novel PAM I is a potential lead candidate for further development of peripherally restricted M1 PAMs, due to its lower blood-brain-barrier (BBB) permeability and improved exposure in the periphery compared to lead MIPS1780.. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Erlong’s team published research in Organic Letters in 2022 | CAS: 89466-08-0

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringCOA of Formula: C6H7BO3

ãSynthesis, Characterization, and Properties of BN-Fluoranthenesã?was written by Li, Erlong; Jin, Mengjia; Jiang, Ruijun; Zhang, Lei; Zhang, Yanli; Liu, Meiyan; Wu, Xiaoming; Liu, Xuguang. COA of Formula: C6H7BO3This research focused onvinylcarbazole preparation carbon hydrogen bond borylation; aminoborylated fluoranthene preparation cross coupling reaction arylboronic acid; crystal structure chlorinated boron nitrogen doped fluoranthene arylated derivative; mol structure chlorinated boron nitrogen doped fluoranthene arylated derivative. The article conveys some information:

B/N-doped fluoranthenes, a new class of BN-doped cyclopenta-fused polycyclic aromatic hydrocarbons, were synthesized via pyrrolic-type N directed C-H borylation. Regioselective bromination of BN-fluoranthene (3a) gave mono- and dibrominated BN-fluoranthenes. The halogenated BN-fluoranthene (3b) can undergo various of further cross-coupling reactions to deliver BN-fluoranthenes. Also, incorporating BN unit in to fluoranthene resulted in a wider HOMO-LUMO energy gaps. The aromaticities of the BN-fluoranthene (3a) were quantified by exptl. and computational studies. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts