Category: 87905-98-4

Biswas, Goutam published the artcileNovel guanidine-containing molecular transporters based on lactose scaffolds: lipophilicity effect on the intracellular organellar selectivity, Application In Synthesis of 87905-98-4, the main research area is disaccharide lactose preparation lipophilicity cellular uptake tissue distribution human; blood brain barrier prodrug lipophilicity organelle tissue selectivity guanidine; guanidine mol transporter lactose scaffold lipophilicity intracellular organellar selectivity.

We have synthesized two lactose-based mol. transporters, each containing seven guanidine residues attached to the lactose scaffold through ω-amino-carboxylate linker chains of two different lengths, and have examined their cellular uptake and intracellular and organellar localizations in HeLa cells, as well as their tissue distributions in mice. Both mol. transporters showed higher cellular uptake efficiencies than Arg8, and wide tissue distributions including the brain. Mitochondrial localization is of special interest because of its potential relevance to “”mitochondrial diseases””. Interestingly, it has been found that the intracellular localization sites of the G7 mol. transporters-namely either mitochondria or lysosomes and endocytic vesicles-are largely determined by the linker chain lengths, or their associated lipophilicities.

Chemistry – A European Journal published new progress about Animal tissue. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Chia-Hui published the artcileSimple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography, Application In Synthesis of 87905-98-4, the main research area is glycoside solid phase preparation TLC reaction analysis; triazole solid phase preparation TLC reaction analysis; amino acid solid phase preparation TLC reaction analysis.

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring mols.; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatog. in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatog. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses.

Synlett published new progress about Click chemistry. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mandal, Satadru Sekhar published the artcileNovel solutions for vaccines and diagnostics to combat brucellosis, Product Details of C13H19NO3, the main research area is vaccine Brucella A antigen polysaccharide tetanus toxoid brucellosis; diagnosis brucellosis Brucella synthetic M antigen polysaccharide.

Brucellosis is diagnosed by detection of antibodies in the blood of animals and humans that are specific for two carbohydrate antigens, termed A and M, which are present concurrently in a single cell wall O-polysaccharide. Animal brucellosis vaccines contain these antigenic determinants, and consequently infected and vaccinated animals cannot be differentiated as both groups produce A and M specific antibodies. We hypothesized that chem. synthesis of a pure A vaccine would offer unique identification of infected animals by a synthetic M diagnostic antigen that would not react with antibodies generated by this vaccine. Two forms of the A antigen, a hexasaccharide and a heptasaccharide conjugated to tetanus toxoid via reducing and nonreducing terminal sugars, were synthesized and used as lead vaccine candidates. Mouse antibody profiles to these immunogens showed that to avoid reaction with diagnostic M antigen it was essential to maximize the induction of anti-A antibodies that bind internal oligosaccharide sequences and minimize production of antibodies directed toward the terminal nonreducing monosaccharide. This objective was achieved by conjugation of Brucella O-polysaccharide to tetanus toxoid via its periodate oxidized terminal nonreducing monosaccharide, thereby destroying terminal epitopes and focusing the antibody response on internal A epitopes. This establishes the method to resolve the decades-long challenge of how to create effective brucellosis vaccines without compromising diagnosis of infected animals.

ACS Central Science published new progress about Animalia. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Serna, Sonia published the artcileConstruction of N-Glycan Microarrays by Using Modular Synthesis and On-Chip Nanoscale Enzymatic Glycosylation, Product Details of C13H19NO3, the main research area is construction glycan microarray modular synthesis chip nanoscale enzymic glycosylation.

An effective chemoenzymic strategy is reported that has allowed the construction, for the first time, of a focused microarray of synthetic N-glycans. Based on modular approaches, a variety of N-glycan core structures have been chem. synthesized and covalently immobilized on a glass surface. The printed structures were then enzymically diversified by the action of three different glycosyltransferases in nanodroplets placed on top of individual spots of the microarray by a printing robot. Conversion was followed by lectin binding specific for the terminal sugars. This enzymic extension of surface-bound ligands in nanodroplets reduces the amount of precious glycosyltransferases needed by seven orders of magnitude relative to reactions carried out in the solution phase. Moreover, only those ligands that have been shown to be substrates to a specific glycosyltransferase can be individually chosen for elongation on the array. The methodol. described here, combining focused modular synthesis and nanoscale on-chip enzymic elongation, could open the way for the much needed rapid construction of large synthetic glycan arrays.

Chemistry – A European Journal published new progress about Affinity. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Houseman, Benjamin T. published the artcileCarbohydrate arrays for the evaluation of protein binding and enzymatic modification, COA of Formula: C13H19NO3, the main research area is carbohydrate array protein binding.

This paper reports a chem. strategy for preparing carbohydrate arrays and utilizes these arrays for the characterization of carbohydrate-protein interactions. Carbohydrate chips were prepared by the Diels-Alder-mediated immobilization of carbohydrate-cyclopentadiene conjugates to self-assembled monolayers that present benzoquinone and penta(ethylene glycol) groups. Surface plasmon resonance spectroscopy showed that lectins bound specifically to immobilized carbohydrates and that the glycol groups prevented nonspecific protein adsorption. Carbohydrate arrays presenting ten monosaccharides were then evaluated by profiling the binding specificities of several lectins. These arrays were also used to determine the inhibitory concentrations of soluble carbohydrates for lectins and to characterize the substrate specificity of β-1,4-galactosyltransferase. Finally, a strategy for preparing arrays with carbohydrates generated on solid phase is shown. This surface engineering strategy will permit the preparation and evaluation of carbohydrate arrays that present diverse and complex structures.

Chemistry & Biology published new progress about Adsorption. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, COA of Formula: C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mandal, Satadru Sekhar published the artcileNovel solutions for vaccines and diagnostics to combat brucellosis, Product Details of C13H19NO3, the main research area is vaccine Brucella A antigen polysaccharide tetanus toxoid brucellosis; diagnosis brucellosis Brucella synthetic M antigen polysaccharide.

Brucellosis is diagnosed by detection of antibodies in the blood of animals and humans that are specific for two carbohydrate antigens, termed A and M, which are present concurrently in a single cell wall O-polysaccharide. Animal brucellosis vaccines contain these antigenic determinants, and consequently infected and vaccinated animals cannot be differentiated as both groups produce A and M specific antibodies. We hypothesized that chem. synthesis of a pure A vaccine would offer unique identification of infected animals by a synthetic M diagnostic antigen that would not react with antibodies generated by this vaccine. Two forms of the A antigen, a hexasaccharide and a heptasaccharide conjugated to tetanus toxoid via reducing and nonreducing terminal sugars, were synthesized and used as lead vaccine candidates. Mouse antibody profiles to these immunogens showed that to avoid reaction with diagnostic M antigen it was essential to maximize the induction of anti-A antibodies that bind internal oligosaccharide sequences and minimize production of antibodies directed toward the terminal nonreducing monosaccharide. This objective was achieved by conjugation of Brucella O-polysaccharide to tetanus toxoid via its periodate oxidized terminal nonreducing monosaccharide, thereby destroying terminal epitopes and focusing the antibody response on internal A epitopes. This establishes the method to resolve the decades-long challenge of how to create effective brucellosis vaccines without compromising diagnosis of infected animals.

ACS Central Science published new progress about Animalia. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Serna, Sonia published the artcileConstruction of N-Glycan Microarrays by Using Modular Synthesis and On-Chip Nanoscale Enzymatic Glycosylation, Product Details of C13H19NO3, the main research area is construction glycan microarray modular synthesis chip nanoscale enzymic glycosylation.

An effective chemoenzymic strategy is reported that has allowed the construction, for the first time, of a focused microarray of synthetic N-glycans. Based on modular approaches, a variety of N-glycan core structures have been chem. synthesized and covalently immobilized on a glass surface. The printed structures were then enzymically diversified by the action of three different glycosyltransferases in nanodroplets placed on top of individual spots of the microarray by a printing robot. Conversion was followed by lectin binding specific for the terminal sugars. This enzymic extension of surface-bound ligands in nanodroplets reduces the amount of precious glycosyltransferases needed by seven orders of magnitude relative to reactions carried out in the solution phase. Moreover, only those ligands that have been shown to be substrates to a specific glycosyltransferase can be individually chosen for elongation on the array. The methodol. described here, combining focused modular synthesis and nanoscale on-chip enzymic elongation, could open the way for the much needed rapid construction of large synthetic glycan arrays.

Chemistry – A European Journal published new progress about Affinity. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Houseman, Benjamin T. published the artcileCarbohydrate arrays for the evaluation of protein binding and enzymatic modification, COA of Formula: C13H19NO3, the main research area is carbohydrate array protein binding.

This paper reports a chem. strategy for preparing carbohydrate arrays and utilizes these arrays for the characterization of carbohydrate-protein interactions. Carbohydrate chips were prepared by the Diels-Alder-mediated immobilization of carbohydrate-cyclopentadiene conjugates to self-assembled monolayers that present benzoquinone and penta(ethylene glycol) groups. Surface plasmon resonance spectroscopy showed that lectins bound specifically to immobilized carbohydrates and that the glycol groups prevented nonspecific protein adsorption. Carbohydrate arrays presenting ten monosaccharides were then evaluated by profiling the binding specificities of several lectins. These arrays were also used to determine the inhibitory concentrations of soluble carbohydrates for lectins and to characterize the substrate specificity of β-1,4-galactosyltransferase. Finally, a strategy for preparing arrays with carbohydrates generated on solid phase is shown. This surface engineering strategy will permit the preparation and evaluation of carbohydrate arrays that present diverse and complex structures.

Chemistry & Biology published new progress about Adsorption. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, COA of Formula: C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Hao published the artcileSynthesis and Enzyme-Specific Activation of Carbohydrate-Geldanamycin Conjugates with Potent Anticancer Activity, Product Details of C13H19NO3, the main research area is glycosylation enzyme prodrug therapy galactosidase synthesis geldanamycin antitumor monosaccharide; human geldanamycin synthesis anticancer antibiotic Hsp90 glucosidase inhibitor hydroxymethydihydroxypyrrolidine.

Geldanamycin (GA) is a potent anticancer antibiotic that inhibits Hsp90. Its potential clin. utility is hampered by its severe toxicity. To alleviate this problem, we synthesized a series of carbohydrate-geldanamycin conjugates for enzyme-specific activation to increase tumor selectivity. The conjugation was carried out at the C-17-position of GA. Their anticancer activity was tested in a number of cancer cell lines. The enzyme-specific activation of these conjugates was evaluated with β-galactosidase and β-glucosidase. Evidently, glycosylation of C-17-position converted GA to an inactive prodrug before enzyme cleavage. Glucose-GA, as pos. control, showed anticancer activity with IC50 of 70.2-380.9 nM in various cancer cells by β-glucosidase activation inside of the tumor cells, which was confirmed by 3-fold inhibition using β-glucosidase specific inhibitor [2,5-dihydroxymethy-3,4-dihydroxypyrrolidine (DMDP)]. Compared to glucose-GA, galactose- and lactose-GA conjugates exhibited much less activity with IC50 greater than 8000-25 000 nM. However, when galactose- and lactose-GA were incubated with β-galactosidase in the cells, their anticancer activity was enhanced by 3- to 40-fold. The results suggest that GA can be inactivated by glycosylation of C-17-position and reactivated for anticancer activity by β-galactosidase. Therefore, galactose-GA can be exploited in antibody-directed enzyme prodrug therapy (ADEPT) with β-galactosidase for enzyme-specific activation in tumors to increase tumor selectivity.

Journal of Medicinal Chemistry published new progress about Antibiotics. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Baldoneschi, Veronica published the artcileActive-Site Targeting Paramagnetic Probe for Matrix Metalloproteinases, Application In Synthesis of 87905-98-4, the main research area is ytterbium lanthanum complex paramagnetism active site matrix metalloproteinase MMP12; DOTA; inhibitors; lanthanides; metalloproteins; molecular probes.

The design and synthesis of the Ln3+ complexes of a DOTA-containing (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) inhibitor of matrix metalloproteinases are reported. The tight binding of the sulfonamide scaffold to the catalytic domain of the investigated matrix metalloproteinase is not impaired by the presence of the Ln3+-DOTA moiety. The paramagnetic properties of the Ln3+ complex are exploited to obtain insights into the structural features of the ligand-protein interactions and to evaluate the influence of the linker length on the quality of the paramagnetic restraints.

ChemPlusChem published new progress about Complexation. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts