Category: 87327-65-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87327-65-9, name is 1-(2,6-Difluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. Safety of 1-(2,6-Difluorophenyl)ethanol

Example 105 2-[1-(2,6-Difluoro-Phenyl)-Ethoxy]-6-(1-Piperazinyl)Pyrazine, Maleate. The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[1-(2,6-difluoro-phenyl)-ethoxy]pyrazine (3.20 g, 11.8 mmol; obtained according to the procedure of example 50, step 1, starting from 2,6-difluoro-alpha-methylbenzyl alcohol), piperazine (3.05 g, 35.4 mmol) and K2CO3 (1.63 g, 11.8 mmol) with the exception that the final filtration through alumina was omitted. The yield of the free base of the title compound was 2.95 g (78%) which was obtained as a colorless oil. The free base was converted into its maleate salt. Purity 100% (HPLC). MS m/z 320 (M)+. HRMS m/z calcd for C16H18F2N4O(M)+320.1449, found 320.1447.

The synthetic route of 87327-65-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nilsson, Bjorn M.; US2002/147200; (2002); A1;,
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Related Products of 87327-65-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.87327-65-9, name is 1-(2,6-Difluorophenyl)ethanol, molecular formula is C8H8F2O, molecular weight is 158.15, as common compound, the synthetic route is as follows.

Example 35A rac-Ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate 5.50 g (23.5 mmol) of ethyl 8-hydroxy-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate Example 20A together with 4.46 g (28.2 mmol) of 1-(2,6-difluorophenyl)ethanol, 5.35 ml (27.0 mmol) of diisopropyl azodicarboxylate and 7.08 g (27.0 mmol) of triphenylphosphine were dissolved in 141 ml of THF, and the mixture was stirred at RT for 2 h. 0.70 ml (3.5 mmol) of diisopropyl azodicarboxylate and 0.62 g (2.3 mmol) of triphenylphosphine were added to the reaction mixture, and the reaction solution was stirred at RT for 1 h. The precipitated solid was filtered off and dried under high vacuum. This gave 4.6 g (52.8% of theory, purity 100%) of the title compound. The filtrate was concentrated and purified twice by silica gel chromatography (cyclohexane/ethyl acetate gradient=8/1 to 4/1). All product-containing fractions were purified again by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% TFA). This gave another 2.16 g (25% of theory) of the target compound. (0676) LC-MS (Method 1): Rt=1.08 min (0677) MS (ESpos): m/z=375 (M+H)+ (0678) 1H-NMR (400 MHz, DMSO-d6): delta=1.34 (t, 3H), 1.79 (d, 3H), 2.25 (s, 3H), 2.58 (s, 3H), 4.33 (q, 2H), 6.17 (q, 1H), 6.73 (s, 1H), 7.06-7.16 (m, 2H), 7.37-7.48 (m, 1H), 8.67 (s, 1H).

Statistics shows that 87327-65-9 is playing an increasingly important role. we look forward to future research findings about 1-(2,6-Difluorophenyl)ethanol.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; VALOT, Gaelle; LINDNER, Niels; FOLLMANN, Markus; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; REDLICH, Gorden; DIETZ, Lisa; Ll, Volkhart Min-Jian; (94 pag.)US2017/57954; (2017); A1;,
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Application of 87327-65-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87327-65-9, name is 1-(2,6-Difluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 82; 5- [1-(2,6- Difluorophenyl)-ethoxy ]-q uinazoline-2,4-diamine; [00258] Step 1; To a cold (ice water) suspension of sodium hydride (409 mg; 10 mmol) in anhydrous DMF (4 mL) is added a solution of 2,6-difluoro-alpha- methylbenzyl alcohol (1.63 g; 10 mmol) in anhydrous DMF (5 mL) over 10 minutes. After allowing to room temperature over 1 hour, this solution is added to a cold (ice water) stirred solution of 2,6-difluorobenzonitrile (1.53 g; 11 mmol) in anhydrous DMF (6 mL), and allowed to room temperature over 2.5 hours. The reaction mixture is poured into ice water with vigorous stirring and the resulting solid is filtered, washed with water, and dried under vacuum at 40 C overnight to give 1.92 grams of 2-[ 1-(2,6-difluorophenyl)-ethoxy]-6-fluorobenzonitrile.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 87327-65-9, 1-(2,6-Difluorophenyl)ethanol.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
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