Category: 873-76-7

He, Chenxi et al. published their research in Organic Letters in 2022 | CAS: 873-76-7

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 873-76-7

Reinvestigating FeBr3-Catalyzed Alcohol Oxidation with H2O2: Is High-valent Iron Species (HIS) or Reactive Brominating Species (RBS) Responsible for Alcohol Oxidation? was written by He, Chenxi;Ma, Foqing;Zhang, Wei;Tong, Rongbiao. And the article was included in Organic Letters in 2022.Related Products of 873-76-7 This article mentions the following:

The in-situ generated RBS from the related FeBr2/H2O2 or CeBr3/H2O2 systems, (2) This results of a series of controlled experiments, and (3) some related RBS-based precedents (NBS, NBA, or Br2) showing similar high oxidation selectivity of secondary over primary alcs. These studies enable to discover that RBS from CeBr3/H2O2 was much more efficient for the oxidation of secondary and benzylic alcs., which represents a new green protocol for selective oxidation of alcs. to carbonyls. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Related Products of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zahra Alizadeh, Seyedeh et al. published their research in ChemCatChem in 2022 | CAS: 873-76-7

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (4-Chlorophenyl)methanol

From Deep Eutectic Solvents to Nitrogen-rich Ordered Mesoporous Carbons: A Powerful Host for the Immobilization of Palladium Nanoparticles in the Aerobic Oxidation of Alcohols was written by Zahra Alizadeh, Seyedeh;Karimi, Babak;Vali, Hojatollah. And the article was included in ChemCatChem in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:

The preparation of a nitrogen-rich ordered mesoporous carbon (DNOMC) with three-dimensional cubic structure was established via carbonization of a green, inexpensive and safe deep eutectic solvent consisting of choline chloride salt and D-glucose in the presence of KIT-6 template for the first time. The materials were characterized by TEM, N2 adsorption-desorption anal., XPS, TGA, CHN, and FT-IR. The DNOMC was shown to be a powerful support for the immobilization of palladium nanoparticles. The Pd@DNOMC catalyst exhibited high activity in the selective aerobic oxidation of various activated and non-activated primary and secondary benzylic as well as linear and cyclic aliphatic alcs. to the corresponding carboxylic acids RCOOH [R = hexyl, Ph, 4-MeC6H4, etc.] and ketones R1C(O)R2 [R1 = Me, Ph; R2 = Me, pentyl, hexyl; R1R2 = (CH2)6, (CH2)7] in pure water under mol. oxygen. The catalyst system could successfully be reused at least ten times without any significant decrease in either activity or selectivity. It was worth noting that, the hot filtration strongly showed that the catalyst worked in a boomerang-type catalyst pathway. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Feng et al. published their research in ACS Catalysis in 2022 | CAS: 873-76-7

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of (4-Chlorophenyl)methanol

Single Pd-Sx Sites In Situ Coordinated on CdS Surface as Efficient Hydrogen Autotransfer Shuttles for Highly Selective Visible-Light-Driven C-N Coupling was written by Niu, Feng;Tu, Wenguang;Lu, Xinxin;Chi, Haoqiang;Zhu, Heng;Zhu, Xi;Wang, Lu;Xiong, Yujie;Yao, Yingfang;Zhou, Yong;Zou, Zhigang. And the article was included in ACS Catalysis in 2022.Quality Control of (4-Chlorophenyl)methanol This article mentions the following:

Selective synthesis of valuable secondary amines through N-alkylation of amines with alcs. is an important reaction in the modern industry but still remains a challenge in the chem. synthesis technique. Hereby, we report the visible-light-driven photocatalytic N-alkylation of aniline with benzyl alc. over defined single Pd species in situ coordinated on a CdS surface. Encouragingly, an aniline conversion of 100% and an almost 100% product selectivity toward the secondary amine N-benzylaniline are obtained with impressive H2 production (11.8 mmol gcat-1 h-1). The mechanistic studies reveal that the single Pd-Sx species on the CdS surface can trap photogenerated electrons to endow them with a long lifetime to benefit the vibrational coupling of the hydrogen adsorption on Pd-Sx species and then can serve as an efficient hydrogen autotransfer shuttle for the hydrogenation process toward the formation of the secondary amine N-benzylaniline. In addition, the present catalyst possesses good substrate tolerance for photocatalytic N-alkylation of different alcs. and substituted amines under optimized conditions. This work offers an alternative solar-driven catalytic system for the N-alkylation industry under mild conditions. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Quality Control of (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pawar, Gaurav et al. published their research in ChemistrySelect in 2022 | CAS: 873-76-7

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C7H7ClO

Cu(I)-Catalyzed Microwave-Assisted Multicomponent Reaction Towards Synthesis of Diverse Fluorescent Quinazolino[4,3-b]quinazolin-8-ones and Their Photophysical Study was written by Pawar, Gaurav;Ghouse, Shaikh Mohammad;Joshi, Swanand Vinayak;Rana, Preeti;Kar, Swayamsiddha;Sarma, P. Mahesh;Dannarm, Srinivas Reddy;Sonti, Rajesh;Nanduri, Srinivas. And the article was included in ChemistrySelect in 2022.Synthetic Route of C7H7ClO This article mentions the following:

A novel, base- and ligand-free one pot protocol for the synthesis of fused-quinazolinone under microwave irradiation using environmentally friendly PEG-400 as a solvent has been developed. Besides benzaldehyde, various benzyl alcs. and Me arenes were used in this protocol, which extend its synthetic applicability. Photophys. study of this highly fluorescent framework was studied by fluorescent study. DFT and ESI/MS studies were carried out to justify the proposed mechanism. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Synthetic Route of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The origin of a common compound about 873-76-7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 873-76-7, (4-Chlorophenyl)methanol.

Reference of 873-76-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 873-76-7, name is (4-Chlorophenyl)methanol, molecular formula is C7H7ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of polymer-bound triphenylphosphine (1.2 mmol) in anhydrous acetonitrile (10 mL) were added iodine (1 mmol) and 1,6-hexanediol diol (1mmol). The reaction mixture was irradiated in microwave reactor at 120 C for 3 min. The reaction mixture was filtered over a filter paper and washed with chloroform.The filtrate was extracted with aqueous sodium thiosulfate solution and dried with anhydrous sodium sulfate.The reafter, solvent was removed under reduced pressure to obtain 6-iodohexan-1-ol (30) in 93%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 873-76-7, (4-Chlorophenyl)methanol.

Reference:
Article; Das, Diparjun; Chanda, Tridib; Rokhum, Lalthazuala; Acta Chimica Slovenica; vol. 62; 4; (2015); p. 775 – 783;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brief introduction of (4-Chlorophenyl)methanol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-76-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 873-76-7, (4-Chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 873-76-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 873-76-7

General procedure: To a stirred solution of triphenylphosphine (1.5 mmol) in dry dichloromethane was added iodine (1.5 mmol)and polymer supported 4-DMAP (0.4 mmol, 40 mol%). Stirring was continued for 2 min; alcohol (1mmol) was then added. The reaction was monitored by TLC. After complete conversion of the alcohol (as indicated byTLC), the reaction was quenched with an aqueous solution of sodium thiosulfate (20 mL). The organic solventswere removed and the aqueous solution extracted with ethylacetate (50 mL). The combined organic layers weredried using sodium sulfate (anhydrous), filtered and concentrated. The residue was purified by column chromatography (2% EtOAc in hexane) to get the desired iodide product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-76-7, its application will become more common.

Reference:
Article; Das, Diparjun; H Anal, Jasha Momo; Rokhum, Lalthazuala; Journal of Chemical Sciences; vol. 128; 11; (2016); p. 1695 – 1701;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Extracurricular laboratory: Synthetic route of 873-76-7

With the rapid development of chemical substances, we look forward to future research findings about 873-76-7.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 873-76-7, name is (4-Chlorophenyl)methanol, molecular formula is C7H7ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products

With the rapid development of chemical substances, we look forward to future research findings about 873-76-7.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sources of common compounds: (4-Chlorophenyl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,873-76-7, (4-Chlorophenyl)methanol, and friends who are interested can also refer to it.

Application of 873-76-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 873-76-7, name is (4-Chlorophenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: Reactants used were p-methylbenzyl alcohol (122.03g, 1000mmol, i.e., of formula (I) wherein R is methyl, n = 1, m = 0 , X = C),cuprous iodide (9.50 g of , 50mmol), N- phenylglycine (7.51g, 50mmol), TEMPO ( 7.80g, 50mmol),sodium hydroxide (4.00g, 100mmol), aqueous ammonia (300mL, 25 ~ 28%) ,ethanol, 800mL, in an ice bath under the condition, with oxygen round bottom flask is evacuated of air ventilation 3 times, and then the system was stirred at 25 , 24h, after completion of the reaction, the reaction solution was cooled to room temperature, rotary evaporated to remove the solvent, the residue was washed with water filtered and dried The product was 107.64g, yield 92%. The reaction was used for the chlorobenzyl alcohol (28.40g, 200mmol, i.e., of formula (I) wherein R is 4-chloro, X = C, n = 1 , m = 0), the same experimental methods and procedures of Example 2, except that: Cuprous iodide(1.90g, 10mmol), N- phenyl-phenylalanine (2.41g, 10mmol), TEMPO ( 1.56g, 10mmol), sodium hydroxide (0.80g, 20mmol), aqueous ammonia (60mL, 25 ~ 28%) , ethanol 160mL, under condition of 80 stirred for 24h, to give the final product 24.66g, yield 90%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,873-76-7, (4-Chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Zhang, Guofu; Zhang, Guihua; Ding, Chengrong; Li, Shasha; Xu, Shengjun; Shan, Shang; (9 pag.)CN105294646; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analyzing the synthesis route of 873-76-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-76-7, its application will become more common.

Synthetic Route of 873-76-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 873-76-7 as follows.

General procedure: Aq ammonia (28%, 0.5 mmol), the appropriate alcohol 10 (3.4mmol), the catalyst 3 (1 mol% Ir), and the phthalate pH standard solution(0.5 mL, pH 4.01) were mixed in a microwave vial tube at 23 C under air. The vial was sealed with a cap, and the reactionmixture was stirred at 150 C for 24 h in a microwave reactor (25-32 W). After cooling to 23 C, aq NaOH (0.1 M, 1 mL) was addedto the mixture and extracted with EtOAc (3 × 2 mL). The combinedorganic layers were concentrated. The crude product was purifiedby column chromatography over silica gel eluting with hexane-EtOAc (98:2 to 9:1) or CHCl3 to afford the corresponding N-alkylatedamine 11l,o-s

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-76-7, its application will become more common.

Reference:
Article; Yamada, Yoichim. A.; Ohta, Hidetoshi; Yuyama, Yoshinari; Uozumi, Yasuhiro; Synthesis; vol. 45; 15; (2013); p. 2093 – 2100;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple exploration of 873-76-7

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Townsley, Kayla G., once mentioned the application of 873-76-7, Name is (4-Chlorophenyl)methanol, molecular formula is C7H7ClO, molecular weight is 142.58, MDL number is MFCD00004652, category is alcohols-buliding-blocks. Now introduce a scientific discovery about this category, Product Details of 873-76-7.

Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice

Binge drinking is a widespread public health concern with limited effective treatment options. To better select pharmaceutical targets, it is imperative to expand our knowledge of the underlying neural mechanisms involved in binge drinking. Our previous experiments in C57BL/6J female mice found that increasing activity in the nucleus accumbens (NAc) core using excitatory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) reduced binge-like drinking. These results differed from what has been found in males; however, it is unclear whether differences in experimental procedures or sex underlie these discrepancies. We matched the conditions used in our female study and asked whether bidirectional manipulation of NAc core activity has different effects on binge-like drinking in males. Male C57BL/6J mice were stereotaxically injected with AAV2 hSyn-HA hM3Dq (excitatory), -hM4Di (inhibitory), or -eGFP bilaterally into the NAc core. We tested the effects of altering NAc activity on binge-like ethanol intake using Drinking in the Dark (DID). During the first week, mice were pre-treated with vehicle to establish baseline ethanol intake. In week 2, mice were treated with 1 mg/kg CNO prior to DID to determine the effects of DREADD-induced changes in NAc core activity on ethanol intake. Decreasing activity via CNO/hM4Di significantly decreased binge-like drinking in male mice relative to eGFP and hM4Di groups. We also measured intake of sucrose, quinine, and water after CNO treatment and found that increasing NAc core activity via CNO/hM3Dq increased quinine intake, and increased water intake over time. We did not observe significant differences in the GFP or hM4Di groups. This work suggests there exist apparent sex-related differences in NAc core contributions to binge-like alcohol drinking, thus demonstrating the need for inclusion of both sexes in future work. Published by Elsevier Inc.

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Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts