Category: 873-75-6

The author of 《The α-alkylation of ketones with alcohols in pure water catalyzed by a water-soluble Cp*Ir complex bearing a functional ligand》 were Meng, Chong; Xu, Jing; Tang, Yawen; Ai, Yao; Li, Feng. And the article was published in New Journal of Chemistry in 2019. Synthetic Route of C7H7BrO The author mentioned the following in the article:

A water-soluble dinuclear Cp*Ir complex bearing 4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine as a bridging ligand was found to be a highly effective catalyst for the α-alkylation of ketones with alcs. in pure water. In the presence of catalyst (0.5 mol%), a series of desirable products were obtained with high reaction economy under environmentally benign conditions. The importance of the hydroxy group in the ligand for catalytic hydrogen transfer was confirmed by mechanism experiments Furthermore, the application of this catalytic system for the synthesis of a biol. active mol. donepezil in pure water was accomplished. Notably, this research would facilitate the progress of C-C bond-forming reactions in water catalyzed by water-soluble metal-ligand bifunctional catalysts. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Synthetic Route of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Synthetic Route of C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
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The author of 《Manganese(I)-Catalyzed α-Alkenylation of Ketones Using Primary Alcohols》 were Gawali, Suhas Shahaji; Pandia, Biplab Keshari; Gunanathan, Chidambaram. And the article was published in Organic Letters in 2019. Recommanded Product: (4-Bromophenyl)methanol The author mentioned the following in the article:

A simple protocol of manganese catalyzed selective α-alkenylation of ketones using primary alcs. is reported. The reactions proceeded well with a low loading of catalyst (0.3 mol%). The overall transformation operates through O-H bond activation of primary alcs. via dearomatization-aromatization metal ligand cooperation in the catalyst to provide the corresponding aldehydes, which further undergo condensation with methylene ketones to deliver α,β-unsaturated ketones. This selective α-alkenylation proceeds with the release of water and liberation of mol. hydrogen. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Development and mechanistic investigation of the manganese(III) salen-catalyzed dehydrogenation of alcohols》 were Samuelsen, Simone V.; Santilli, Carola; Ahlquist, Maarten S. G.; Madsen, Robert. And the article was published in Chemical Science in 2019. Safety of (4-Bromophenyl)methanol The author mentioned the following in the article:

The first example of a manganese(III) catalyst for the acceptorless dehydrogenation of alcs. was presented. N,N’-Bis(salicylidene)-1,2-cyclohexanediaminomanganese(III) chloride was shown to catalyzed the direct synthesis of imines from a variety of alcs. and amines with the liberation of hydrogen gas. The mechanism was investigated exptl. with labeled substrates and theor. with DFT calculations The results indicated a metal-ligand bifunctional pathway in which both imine groups in the salen ligand are first reduced to form a manganese(III) amido complex as the catalytically active species. Dehydrogenation of the alc. then takes place by a stepwise outer-sphere hydrogen transfer generating a manganese(III) salan hydride from which hydrogen gas was released. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6Safety of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Safety of (4-Bromophenyl)methanol It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 873-75-6In 2019 ,《Iridium-Catalyzed Alkylation of Amine and Nitrobenzene with Alcohol to Tertiary Amine under Base- and Solvent-Free Conditions》 was published in Journal of Organic Chemistry. The article was written by Li, Chao; Wan, Ke-feng; Guo, Fu-ya; Wu, Qian-hui; Yuan, Mao-lin; Li, Rui-xiang; Fu, Hai-yan; Zheng, Xue-li; Chen, Hua. The article contains the following contents:

Herein, an efficient and green method for the selective synthesis of tertiary amines has been developed that involves iridium-catalyzed alkylation of various primary amines with aromatic or aliphatic alcs. Notably, the catalytic protocol enables this transformation in the absence of addnl. base and solvent. Furthermore, the alkylation of nitrobenzene with primary alc. to tertiary amine has also been achieved by the same catalytic system. Deuterium-labeling experiments and a series of control experiments were conducted, and the results suggested that an intermol. borrowing hydrogen pathway might exist in the alkylation process. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Application of 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Application of 873-75-6 It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 873-75-6In 2019 ,《Copper-catalyzed tandem oxidative synthesis of quinazolinones from 2-aminobenzonitriles and benzyl alcohols》 appeared in Organic Chemistry Frontiers. The author of the article were Hu, Yongke; Li, Shaozhong; Li, Huaju; Li, Yanxing; Li, Jin; Duanmu, Chuansong; Li, Bindong. The article conveys some information:

An efficient and practical copper-catalyzed process for the synthesis of substituted quinazolinones I (R1 = C6H5, 4-MeOC6H4, 4-FC6H4, etc.; R2 = 6-Me, 6-OMe, 5-F, etc.) from simple and readily available 2-aminobenzonitriles and benzyl alcs. is described. This method features high functional-group tolerance and could afford a variety of desirable products in good to excellent yields with air as the sole oxidant. Moreover, a possible reaction mechanism is proposed according to the control experiments and reported literature. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Application of 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Application of 873-75-6 It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of (4-Bromophenyl)methanolIn 2019 ,《Iridium Supported on Phosphorus-Doped Porous Organic Polymers: Active and Recyclable Catalyst for Acceptorless Dehydrogenation and Borrowing Hydrogen Reaction》 appeared in Advanced Synthesis & Catalysis. The author of the article were Yao, Wei; Duan, Zheng-Chao; Zhang, Yilin; Sang, Xinxin; Xia, Xiao-Feng; Wang, Dawei. The article conveys some information:

Iridium-on-phosphorus-doped porous organic polymers (POP-Ir) were developed by anchoring simple iridium onto the skeleton of porous organic polymers through coordination bonds. This POP-Ir catalyst, which was thoroughly characterized by means of EDS, SEM, TEM, XRD, XPS, and FT-IR, revealed excellent catalytic activity for the reaction of di-Ph phosphinamide with benzyl alcs. through borrowing hydrogen strategy and acceptorless dehydrogenation with wide functional group tolerance. Moreover, this POP-Ir catalyst could be simply recovered and reused for at least five times without a significant loss of activity, and revealed considerable application prospects. The mechanism was investigated to further understand this POP-Ir catalytic system and transformations. Overall, the POP-Ir catalytic system has shown high activity and reusability in the borrowing hydrogen reaction between di-Ph phosphinamides and benzyl alcs. In the experiment, the researchers used (4-Bromophenyl)methanol(cas: 873-75-6Application In Synthesis of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Application In Synthesis of (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iridium-Catalyzed Alkylation of Secondary Alcohols with Primary Alcohols: A Route to Access Branched Ketones and Alcohols》 was published in Journal of Organic Chemistry in 2020. These research results belong to Genc, Sertac; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya. Reference of (4-Bromophenyl)methanol The article mentions the following:

Under borrowing hydrogen conditions, NHC-iridium(I) catalyzed the direct or one-pot sequential synthesis of α,α-disubstituted ketones RCOCH(CH2R1)CH2R2 [R = Ph, 2-naphthyl, 4-MeOC6H4, etc.; R1 = Ph, 1-naphthyl, n-heptyl, etc.; R2 = Ph, 1-naphthyl, 4-MeOC6H4, etc.] via the alkylation of secondary alcs. with primary alcs. was reported. Notably, the present approach provides a new method for the facile synthesis of α,α-disubstituted ketones and featured with several characteristics, including a broad substrate scope, using easy-to-handle alcs. as starting materials, and performing the reactions under aerobic conditions. Moreover, the selective one-pot formation of β,β-disubstituted alcs. PhCH(OH)CH(CH2R3)CH2R4 [R3 = Ph, n-heptyl; R4 = Ph, 4-MeC6H4, 4-BrC6H4] was achieved by the addition of an external hydrogen source to the reaction mixture In addition to this study using (4-Bromophenyl)methanol, there are many other studies that have used (4-Bromophenyl)methanol(cas: 873-75-6Reference of (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Reference of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of (4-Bromophenyl)methanolIn 2020 ,《Ruthenium(II) Complexes of Heteroditopic N-Heterocyclic Carbene Ligands: Efficient Catalysts for C-N Bond Formation via a Hydrogen-Borrowing Strategy under Solvent-Free Conditions》 was published in Inorganic Chemistry. The article was written by Donthireddy, S. N. R.; Mathoor Illam, Praseetha; Rit, Arnab. The article contains the following contents:

Both imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) have evolved to be elite groups of N-heterocyclic carbene (NHC) ligands for homogeneous catalysis. To develop efficient Ru(II)-based catalysts incorporating these ligands for C-N bond-forming reactions via H-borrowing methodol., the authors used chelating ligands integrated with ImNHC and mesoionic tzNHC donors connected via a CH2 spacer with a diverse triazole backbone. The synthesized Ru(II) complexes 3 are highly efficient for C-N bond formation across a wide range of primary amine and alc. substrates under solvent-free conditions, and among all of the complexes studied here, catalyst 3a with a mesityl substituent displayed maximum activity. Catalyst 3a is also effective for the selective mono-N-methylation of various anilines using MeOH as a coupling partner, known to be relatively more difficult than other alcs. Also, complex 3a also delivers various substituted quinolines successfully via the reaction of 2-aminobenzyl alc. with several secondary alcs. Importantly, catalyst 3a exhibited the highest activity among the reported Ru(II) complexes for both the N-benzylation of aniline [achieving a turnover number (TON) of 50000] and the realization of quinoline 8a by reacting 2-aminobenzyl alc. with 2-phenylethanol (attaining a TON of 30000). The significance of electronic tuning in the Ru(II) complexes of chelating ligands featuring a combination of ImNHC and tzNHC donors with various triazole backbones is demonstrated by applying them in diverse C-N bond-forming reactions via a H-borrowing strategy. Notably, the Ru(II) complex 3a having an N-mesityl substituent displayed the highest activity among known Ru(II) complexes for both the N-benzylation of aniline [a turnover number (TON) of 50000] and the synthesis of quinoline via the reaction of 2-aminobenzyl alc. with 2-phenylethanol (a TON of 30000). In the experimental materials used by the author, we found (4-Bromophenyl)methanol(cas: 873-75-6Safety of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Safety of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: (4-Bromophenyl)methanolIn 2019 ,《Iridium(I)-Catalyzed C-C and C-N Bond Formation Reactions via the Borrowing Hydrogen Strategy》 was published in Journal of Organic Chemistry. The article was written by Genc, Sertac; Arslan, Burcu; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya. The article contains the following contents:

Iridium(I) complexes having an imidazol-2-ylidene ligand with benzylic wingtips efficiently catalyzed the β-alkylation of secondary alcs. with primary alcs. and acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones through a borrowing hydrogen pathway. The β-alkylated alcs., including cholesterol derivatives, and substituted quinolines were obtained in good yields by using a minute amount of the catalyst with a catalytic amount of NaOH or KOH under the air atm., liberating water (and H2 in the case of quinoline synthesis) as the sole byproduct. Notably, this system demonstrated turnover numbers of 940,000 (for β-alkylation of secondary alcs. with primary alcs. by using down to 0.0001 mol % = 1 ppm of the catalyst) and 9200 (acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones). After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Name: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Name: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: (4-Bromophenyl)methanolIn 2021 ,《TEMPO-Functionalized Nanoreactors from Bottlebrush Copolymers for the Selective Oxidation of Alcohols in Water》 was published in Journal of Organic Chemistry. The article was written by Wang, Maolin; Xu, Zhenkai; Shi, Yi; Cai, Fang; Qiu, Jiaqi; Yang, Guang; Hua, Zan; Chen, Tao. The article contains the following contents:

Preparation of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-containing nanoreactors by the self-assembly of amphiphilic bottlebrush copolymers was demonstrated. First, a macromonomer having a norbornenyl polymerizable group were prepared by RAFT polymerization of hydrophobic and hydrophilic monomers. The macromonomer were further subjected to ring-opening metathesis polymerization to produce an amphiphilic bottlebrush copolymer. Further, TEMPO, as a catalyst, were introduced into the hydrophobic block through the activated ester strategy. Finally, TEMPO-functionalized polymeric nanoreactors were successfully obtained by self-assembly in water. The nanoreactors exhibited excellent catalytic activities in selective oxidation of alcs. in water. More importantly, the reaction kinetics showed that the turnover frequency was greatly increased compared to that of the similar nanoreactor prepared from liner copolymers under the same conditions. The outstanding catalytic activities of the nanoreactors from bottlebrush copolymers was attributed to the more stable micellar structure using the substrate concentration effect. Work presents a new strategy to fabricate stable nanoreactors, paving the way for highly efficient organic reactions in aqueous solutions In addition to this study using (4-Bromophenyl)methanol, there are many other studies that have used (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts