873-63-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.873-63-2, name is 3-Chlorobenzyl alcohol, molecular formula is C7H7ClO, molecular weight is 142.58, as common compound, the synthetic route is as follows.
General procedure: A 50 mL round bottom flask was charged with a mixture of aryl chloride (0.5 mmol), arylboronic acid (0.75 mmol), K2CO3 (1.5 mmol), Pd catalyst (0.2 mol %), solvent (6 mL) and the mixture was stirred for required times at appropriate temperature. After completion, the reaction mixture was diluted with water (20 mL) and extracted with ether (20 mL ¡Á3). Combined extract was washed with brine (20 mL ¡Á3) and dried over Na2SO4. After evaporation of the solvent under reduced pressure, the residue was chromatographed (silica gel, ethyl acetate/hexane 1:9) to obtain the desired product. The products were confirmed by comparing the melting points, 1H NMR and mass spectral data with authentic samples.
Statistics shows that 873-63-2 is playing an increasingly important role. we look forward to future research findings about 3-Chlorobenzyl alcohol.
Reference:
Article; Shahnaz, Nasifa; Banik, Biplab; Das, Pankaj; Tetrahedron Letters; vol. 54; 22; (2013); p. 2886 – 2889;,
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