Category: 87-73-0

Moggia, Giulia; Schalck, Jonathan; Daems, Nick; Breugelmans, Tom published the artcile< Two-steps synthesis of D-glucaric acid via D-gluconic acid by electrocatalytic oxidation of D-glucose on gold electrode: Influence of operational parameters>, Electric Literature of 87-73-0, the main research area is synthesis glucaric gluconic acid electrocatalysis oxidation glucose gold electrode.

Glucose electrooxidation to glucaric acid, a highly valuable platform chem., was conducted, for the 1st time, in two consecutive steps employing a bare Au electrode in a batch reactor. The 1st step, at low potential, enabled the effective formation of the intermediate, gluconic acid, promoted by the oxidation of the aldehyde group on C1. For this reaction step, except for the reaction time, all the operational parameters had a strong impact on the selectivity. At the optimal conditions of pH 11.3, 5° and 0.04M initial glucose, a maximum selectivity of 97.6% was obtained, the highest reported to date for the electrochem. process, with a conversion of 25%. At higher potential, gluconic acid was further converted to glucaric acid by the oxidation of the hydroxymethyl group on C6. For this oxidation step, the variation of the operational parameters (pH, gluconic acid initial concentration, reaction temperature and time) had no conspicuous effect on the selectivity, while the applied potential had a major role: at 1.1 VRHE, a maximum selectivity of 89.5% to glucaric acid was obtained, which is one of the highest values reported in literature so far. In all experiments, irresp. of conditions and reaction time, a maximum concentration of ∼1.2 mM of glucaric acid was achieved, and a drastic decrease of the c.d. was observed in the 1st hours of electrolysis. Addnl. control experiments revealed a poisoning process caused by glucaric acid that, once formed, remains strongly bonded to the catalyst’s active sites, thus deactivating it.

Electrochimica Acta published new progress about Cyclic voltammetry. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vezina, Ben; Judd, Louise M.; McDougall, Fiona K.; Boardman, Wayne S. J.; Power, Michelle L.; Hawkey, Jane; Brisse, Sylvain; Monk, Jonathan M.; Holt, Kathryn E.; Wyres, Kelly L. published the artcile< Transmission of Klebsiella strains and plasmids within and between grey-headed flying fox colonies>, Related Products of 87-73-0, the main research area is plasmid transmission Klebsiella Pteropus.

The gray-headed flying fox (Pteropus poliocephalus) is an endemic Australian fruit bat, known to carry zoonotic pathogens. We recently showed they harbor bacterial pathogen Klebsiella pneumoniae and closely related species in the K. pneumoniae species complex (KpSC); however, the dynamics of KpSC transmission and gene flow within flying fox colonies are poorly understood. High-resolution genome comparisons of 39 KpSC isolates from gray-headed flying foxes identified five putative strain transmission clusters (four intra- and one inter-colony). The instance of inter-colony strain transmission of K. africana was found between two flying fox populations within flying distance, indicating either direct or indirect transmission through a common food/water source. All 11 plasmids identified within the KpSC isolates showed 73% coverage (mean) and ≥95% identity to human-associated KpSC plasmids, indicating gene flow between human clin. and gray-headed flying fox isolates. Along with strain transmission, inter-species horizontal plasmid transmission between K. pneumoniae and Klebsiella africana was also identified within a flying fox colony. Finally, genome-scale metabolic models were generated to predict and compare substrate usage to previously published KpSC models, from human and environmental sources. These models indicated no distinction on the basis of metabolic capabilities. Instead, metabolic capabilities were consistent with population structure and ST/lineage.

Environmental Microbiology published new progress about Food. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Han; Cao, Chujin; Wu, Zhongcai; Zhang, Heping; Sun, Zhihong; Wang, Meng; Xu, Huzi; Zhao, Zhi; Wang, Yuxi; Pei, Guangchang; Yang, Qian; Zhu, Fengming; Yang, Juan; Deng, Xuan; Hong, Yu; Li, Yinzheng; Sun, Jie; Zhu, Fan; Shi, Mengxia; Qian, Kun; Ye, Ting; Zuo, Xuezhi; Zhao, Fenfei; Guo, Jing; Xu, Gang; Yao, Ying; Zeng, Rui published the artcile< The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease>, Quality Control of 87-73-0, the main research area is Lactobacillus casei acute chronic kidney disease progression; Lactobacillus casei Zhang; acute kidney injury; chronic kidney disease; gut microbiota; nicotinamide; short-chain fatty acids.

The relationship between gut microbial dysbiosis and acute or chronic kidney disease (CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, alleviated kidney injury, and delayed its progression to CKD in mice. L. casei Zhang elevated the levels of short-chain fatty acids (SCFAs) and nicotinamide in the serum and kidney, resulting in reduced renal inflammation and damage to renal tubular epithelial cells. We also performed a 1-yr phase 1 placebo-controlled study of oral L. casei Zhang use (Chinese clin. trial registry, ChiCTR-INR-17013952), which was well tolerated and slowed the decline of kidney function in individuals with stage 3-5 CKD. These results show that oral administration of L. casei Zhang, by altering SCFAs and nicotinamide metabolism, is a potential therapy to mitigate kidney injury and slow the progression of renal decline.

Cell Metabolism published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xue, Guiren; Su, Shanshan; Yan, Pengfei; Shang, Jiawei; Wang, Jianxin; Yan, Chengye; Li, Jiaxi; Wang, Qiao; Xiong, Xue; Xu, Huijun published the artcile< Integrative analyses of widely targeted metabolomic profiling and derivatization-based LC-MS/MS reveals metabolic changes of Zingiberis Rhizoma and its processed products>, Application In Synthesis of 87-73-0, the main research area is metabolomic profiling Zingiberis Rhizoma; Chemical derivatization; Differentiate; Processed products; Widely targeted metabolomic analysis; Zingiberis Rhizoma.

Zingiberis Rhizoma (ZR) has nutritional value and application potentiality, while Zingiberis Rhizoma Praeparatum (ZRP) and Carbonised Ginger (CG) are two main processed products of ZR based on different methods. Here, we performed a widely targeted metabolomics method with Sequential Windowed Acquisition of all Theor. fragment ions (SWATH) mode to analyze differential metabolites in ZR, ZRP and CG. Addnl., the chem. derivatization was applied to characterize different submetabolomes and improve the separation effect and MS response of metabolites. In total, 369 metabolites were identified and divided into 14 categories, 104 of which were differential metabolites. Our results suggest that carbohydrates, nucleotides, organic acids, vitamins, lipids, indoles, alkaloids, and terpenes contributed to a downward trend after processing, but the maximum content of flavanones, phenylpropanes and polyphenols appeared in ZRP, and that of alcs. appeared in CG. These findings serve as promising perspectives for developing functional food in ZR, ZRP and CG.

Food Chemistry published new progress about Metabolomics. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Sha; Wang, Jieying; Chen, Lan; Wang, Jun; Zhao, Fazhu published the artcile< Microbial community structure and functional genes drive soil priming effect following afforestation>, Synthetic Route of 87-73-0, the main research area is soil microorganism carbon afforestation biodegradation gene enzyme metagenome; (13)C-glucose labeling; Afforestation; Metagenomic sequencing; Microbial function; Stable C.

Afforestation substantially modifies native soil organic carbon (SOC) decomposition via plant carbon inputs (the priming effect), and in turn, triggers vital biogeochem. processes that influence the regulation of soil carbon dynamics. Soil microbes are crucial in regulating the direction and magnitude of the priming effect. In the present study, we performed metagenomic sequencing and 13C-glucose labeling analyses of microbial communities and priming effects across a Robinia pseudoacacia afforestation chronosequence (14-, 20-, 30-, and 45-yr-old stands) in the Loess Plateau in China, with adjacent farmland being selected as a control. Our results revealed that the cumulative priming effect across five sites along the afforestation chronosequence initially increased and approached a peak value in the 20-yr-old stand, after which it declined. The priming effect was predominantly driven by the microbial community structure (i.e., the fungal-to-bacterial ratios and relative abundances of Proteobacteria and Actinobacteria), and stable C decomposition genes and C-degrading enzymes. Specifically, among the key functional genes correlated with priming effect, which were identified in orders Rhizobiales and Pseudonocardiales, considerably promoted SOC priming. Overall, our findings indicate that afforestation alters soil microbial community structure and function, particularly with respect to enhancing stable soil C decomposition genes, which may promote SOC priming. The findings of the present study could enhance our understanding of fresh C input-induced changes associated with C mineralization in the context of the revegetation of ecol. fragile areas. The sequencing data have been deposited into the NCBI database with the accession number SRP319300.

Science of the Total Environment published new progress about Acidimicrobiales. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Beleggia, Romina; Omranian, Nooshin; Holtz, Yan; Gioia, Tania; Fiorani, Fabio; Nigro, Franca M.; Pecchioni, Nicola; De Vita, Pasquale; Schurr, Ulrich; David, Jacques L.; Nikoloski, Zoran; Papa, Roberto published the artcile< Comparative analysis based on transcriptomics and metabolomics data reveal differences between emmer and durum wheat in response to nitrogen starvation>, COA of Formula: C6H10O8, the main research area is transcriptomics metabolomics emmer durum wheat nitrogen starvation comparative analysis; GABA; Triticum turgidum; glutamate; metabolomics; plant nutrition; stress; transcriptomics.

Mounting evidence indicates the key role of nitrogen (N) on diverse processes in plant, including development and defense. Using a combined transcriptomics and metabolomics approach, we studied the response of seedlings to N starvation of two different tetraploid wheat genotypes from the two main domesticated subspecies: emmer and durum wheat. We found that durum wheat exhibits broader and stronger response in comparison to emmer as seen from the expression pattern of both genes and metabolites and gene enrichment anal. They showed major differences in the responses to N starvation for transcription factor families, emmer showed differential reduction in the levels of primary metabolites while durum wheat exhibited increased levels of most of them to N starvation. The correlation-based networks, including the differentially expressed genes and metabolites, revealed tighter regulation of metabolism in durum wheat in comparison to emmer. We also found that glutamate and γ-aminobutyric acid (GABA) had highest values of centrality in the metabolic correlation network, suggesting their critical role in the genotype-specific response to N starvation of emmer and durum wheat, resp. Moreover, this finding indicates that there might be contrasting strategies associated to GABA and glutamate signaling modulating shoot vs. root growth in the two different wheat subspecies.

International Journal of Molecular Sciences published new progress about ATP-binding cassette transporter ABCA6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, COA of Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kutyna, Dariusz R.; Onetto, Cristobal A.; Williams, Thomas C.; Goold, Hugh D.; Paulsen, Ian T.; Pretorius, Isak S.; Johnson, Daniel L.; Borneman, Anthony R. published the artcile< Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome>, Name: D-Glucosaccharic acid, the main research area is Saccharomyces pan genome neo chromosome genetic diversity phenotypic plasticity.

The Synthetic Yeast Genome Project (Sc2.0) represents the first foray into eukaryotic genome engineering and a framework for designing and building the next generation of industrial microbes. However, the laboratory strain S288c used lacks many of the genes that provide phenotypic diversity to industrial and environmental isolates. To address this shortcoming, we have designed and constructed a neo-chromosome that contains many of these diverse pan-genomic elements and which is compatible with the Sc2.0 design and test framework. The presence of this neo-chromosome provides phenotypic plasticity to the Sc2.0 parent strain, including expanding the range of utilizable carbon sources. We also demonstrate that the induction of programmable structural variation (SCRaMbLE) provides genetic diversity on which further adaptive gains could be selected. The presence of this neo-chromosome within the Sc2.0 backbone may therefore provide the means to adapt synthetic strains to a wider variety of environments, a process which will be vital to transitioning Sc2.0 from the laboratory into industrial applications.

Nature Communications published new progress about Biofuels. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Atanasov, Kostadin Evgeniev; Galbis, David Minana; Gallego, Julia; Serpico, Annabel; Bosch, Montserrat; Altabella, Teresa; Ferrer, Albert published the artcile< Pseudomonas germanica sp. nov., isolated from Iris germanica rhizomes>, Related Products of 87-73-0, the main research area is rhizome Pseudomonas germanica iris plant; Iris germanica; Pseudomonas; average nucleotide identity; digital DNA–DNA hybridization; endophyte; multilocus sequence analysis; type-strain.

Through bacterial plant-endophyte extraction from rhizomes of Iris germanica plant, a Gram-stain-neg., aerobic, catalaseand oxidase-pos. gammaproteobacterial strain, referred to as FIT28T, was isolated. FIT28T shows vigorous growth on nutrient rich media within the temperature range of 4-35°C, with optimal growth at 28°C, a wide pH tolerance from pH 5 to 11, and salt tolerance up to 6% (w/v) NaCl. Colonies are white-yellow and quickly become mucoid. The results of anal. of the 16S rRNA gene sequence placed the strain within the genus Pseudomonas, and multilocus sequence anal. (MLSA) using 16S rRNA, rpoB, gyrB and rpoD concatenated sequences revealed that the closest relatives of FIT28T are Pseudomonas zeae OE48.2T, ‘Pseudomonas crudilactis’ UCMA 17988, Pseudomonas tensinigenes ZA5.3T, Pseudomonas helmanticensis OHA11T , Pseudomonas baetica a390T, Pseudomonas iridis P42T, Pseudomonas atagonensis PS14T and Pseudomonas koreensis Ps 9-14T, within the Pseudomonas koreensis subgroup of the Pseudomonas fluorescens lineage. The genome size of FIT28T is about 6.7Mb with 59.09 mol% DNA G+C content. Average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values calculated from the genomic sequences of FIT28T, and the closely related P. zeae OE48.2T are 95.23 and 63.4%, resp. Biochem., metabolic and chemotaxonomic studies further support our proposal that Pseudomonas germanica sp. nov., should be considered a novel species of the genus Pseudomonas. Hence, the type strain FIT28T (=LMG 32353T =DSM 112698T) has been deposited in public cell-type culture centers.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arias, Pedro L.; Cecilia, Juan A.; Gandarias, Inaki; Iglesias, Jose; Lopez Granados, Manuel; Mariscal, Rafael; Morales, Gabriel; Moreno-Tost, Ramon; Maireles-Torres, Pedro published the artcile< Oxidation of lignocellulosic platform molecules to value-added chemicals using heterogeneous catalytic technologies>, Application of C6H10O8, the main research area is review lignocellulosic platform mol oxidation heterogeneous catalyst.

A review. Currently, much attention is being paid to the development of sustainable catalytic processes for the production of chems. (biofuels, bioproducts, and so on) from lignocellulosic biomass. This minireview pursues to give an exhaustive overview about the heterogeneous catalytic technologies proposed for the oxidation of four key platform mols. (glucose, 5-hydroxymethylfurfural, furfural and levulinic acid) into important chems., such as gluconic acid and gluconates, glucaric and formic acids, 2-diformylfuran, 2,5-furandicarboxylic acid, maleic acid and anhydride, succinic acid, furanones, furoic acid, alkyl furoates, furan-2-acrolein, succinic acid, butanone and 3-hydroxypropanoic acid. The different mechanistic pathways will be highlighted, as well as the requirements in terms of catalytic sites and catalyst stability. The challenges and opportunities will be put forward for each type of oxidation process.

Catalysis Science & Technology published new progress about Heterogeneous catalysis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Lianyu; Jiao, Lu; Ju, Jiasheng; Ma, Xuelan published the artcile< Effect of Sodium Selenite on the Metabolite Profile of Epichloe sp. Mycelia from Festuca sinensis in Solid Culture>, Formula: C6H10O8, the main research area is Epichloe Festuca sinensis sodium selenite metabolite mycelia solid culture; Culture time; Epichloë sp. from Festuca sinensis; Metabolite analysis; Selenium.

Selenium (Se) is an essential micronutrient with many beneficial effects for humans and other living organisms. Numerous microorganisms in culture systems enrich and convert inorganic selenium to organic selenium. In this study, Epichloe sp. from Festuca sinensis was exposed to increasing Na2SeO3 concentrations (0, 0.1, 0.2, 0.3, and 0.4 mmol/L) in Petri dishes with potato dextrose agar (PDA) for 8 wk. Epichloe sp. mycelia were immediately collected after mycelial diameters were measured at 4, 5, 6, 7, and 8 wk of cultivation, resp. Gas chromatog.-mass spectrometer (GC-MS) anal. was performed on different groups of Epichloe sp. mycelia. Different changes were observed as Epichloe sp. was exposed to different selenite conditions and cultivation time. The colony diameter of Epichloe sp. decreased in response to increased selenite concentrations, whereas the inhibitory effects diminished over time. Seventy-two of the 203 identified metabolites did not differ significantly across selenite treatments within the same time point, while 82 compounds did not differ significantly between multiple time points of the same Se concentration However, the relative levels of 122 metabolites increased the most under selenite conditions. Specifically, between the 4th and 8th weeks, there were increases in 2-keto-isovaleric acid, uridine, and maltose in selenite treatments compared to controls. Selenium increased glutathione levels and exhibited antioxidant properties in weeks 4, 5, and 7. Addnl., we observed that different doses of selenite could promote the production of carbohydrates such as isomaltose, cellobiose, and sucrose; fatty acids such as palmitoleic acid, palmitic acid, and stearic acid; and amino acids such as lysine and tyrosine in Epichloe sp. mycelia. Therefore, Epichloe sp. exposed to selenite stress may benefit from increased levels of some metabolite compounds

Biological Trace Element Research published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts