Category: 87-73-0

Filiou, Michaela D.; Nussbaumer, Markus; Teplytska, Larysa; Turck, Christoph W. published the artcile< Behavioral and metabolome differences between C57BL/6 and DBA/2 mouse strains: implications for their use as models for depression- and anxiety-like phenotypes>, Name: D-Glucosaccharic acid, the main research area is depression anxiety metabolome neuropsychiatric disorder hippocampal plasma metabolite; C57BL/6; DBA/2; anxiety; depression; metabolomics; psychiatry.

Mouse models are widely used to study behavioral phenotypes related to neuropsychiatric disorders. However, different mouse strains vary in their inherent behavioral and mol. characteristics, which needs to be taken into account depending on the nature of the study. Here, we performed a detailed behavioral and mol. comparison of C57BL/6 (B6) and DBA/2 (DBA) mice, two inbred strains commonly used in neuropsychiatric research. We analyzed anxiety-related and depression-like traits, quantified hippocampal and plasma metabolite profiles, and assessed total antioxidant capacity (TAC). B6 mice exhibit increased depression-like and decreased anxiety-related behavior compared to DBA mice. Metabolite level differences indicate alterations in amino acid, nucleotide and mitochondrial metabolism that are accompanied by a decreased TAC in B6 compared to DBA mice. Our data reveal multiple behavioral and mol. differences between B6 and DBA mouse strains, which should be considered in the exptl. design for phenotype, pharmacol. and mechanistic studies relevant for neuropsychiatric disorders.

Metabolites published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Min; Li, Ni; Zhang, Xiao-Fei; Zhou, Xing-Kui; Shi, Rui; Su, Yuan-Xiao; Liu, Jian-Jin; Cao, Yi; Mo, Ming He; Ma, Li published the artcile< Sphingobacterium faecale sp. nov., a 1-aminocyclopropane-1-carboxylate deaminase producing bacterium isolated from camel faeces>, SDS of cas: 87-73-0, the main research area is Sphingobacterium fecale camel feces aminocyclopropane carboxylate deaminase bacterium; 16S rRNA gene; Sphingobacterium faecale sp. nov.; camel faeces; polyphasic taxonomic.

An investigation of the diversity of 1-aminocyclopropane-1-carboxylate deaminase producing bacteria associated with camel faeces revealed the presence of a novel bacterial strain designated C459-1T. It was Gram-stain-neg., short-rod-shaped and non-motile. Strain C459-1T was observed to grow optimally at 35°C, at pH 7.0 and in the presence of 0% NaCl on Luria-Bertani agar medium. The cells were found to be pos. for catalase and oxidase activities. The major fatty acids (>10%) were identified as iso-C15 : 0, summed feature 3 (C16 : 1 ω6c and/or C16 : 1 ω7c) and iso-C17 : 0 3-OH. The predominant menaquinone was MK-7. The major polar lipids consisted of phosphatidylethanolamine, one sphingophospholipid, two unknown aminophospholipids, three unknown glycolipids and five unknown lipids. The genomic DNA G + C content was 40.3 mol%. Phylogenetic anal. based on 16S rRNA gene sequences indicated that strain C459-1T was affiliated with the genus Sphingobacterium and had the highest sequence similarity to Sphingobacterium tabacisoli h337T (97.0%) and Sphingobacterium paucimobilis HER1398T (95.6%). The average nucleotide identity and digital DNA-DNA hybridization values between strain C459-1T and S. tabacisoli h337T were 83.8 and 33.8%, resp. Phenotypic characteristics including enzyme activities and carbon source utilization differentiated strain C459-1T from other Sphingobacterium species. Based on its phenotypic, chemotaxonomic and phylogenetic properties, strain C459-1T represents a novel species of the genus Sphingobacterium, for which the name Sphingobacterium faecale sp. nov. is proposed, with strain is C459-1T (CGMCC 1.18716T = KCTC 82381T) as the type strain.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Ji Yong; Kim, Young Joo; Lee, Ji Youn; Lee, Yun-Sang; Jeong, Jae Min published the artcile< Imaging of the third gasotransmitter hydrogen sulfide using 99mTc-labeled alpha-hydroxy acids>, SDS of cas: 87-73-0, the main research area is alpha hydroxy acid 99mTc hydrogen sulfide gasotransmitter imaging; Glucoheptonate; Gluconate; H(2)S; Hypoxia; Inflammation; Ischemia; Technetium.

Various α-hydroxy acids such as glycolate, L-lactate, D-lactate, D-gluconate, D-glucoheptonate, D-glucuronate, D-glucarate, and citrate were labeled with 99mTc in the presence of stannous chloride. The labeled compounds were incubated with 0.2 mM of NaHS, and reactive sulfur species and then analyzed by ITLC/normal saline to detect the formation of insoluble complex. Matrigels containing various concentrations of NaHS were xenografted on the shoulder of normal mice, and an imaging study was performed after i.v. injection of [99mTc]Tc-gluconate. We also obtained autoradiog. image of a rat brain with a temporary brain ischemia after i.v. injection of [99mTc]Tc-gluconate.[99mTc]Tc-gluconate showed the highest formation of insoluble complex (87.8 ± 3.6%) after incubation with 0.2 mM NaHS. The Matrigel containing 2μmol NaHS showed uptake of [99mTc]Tc-gluconate, which proved the feasibility as the specific H2S imaging agent in vivo. Temporary ischemic lesion of rat brain showed high radioactivity accumulation representing the feasibility as endogenous H2S imaging agents. We proved that 99mTc-labeled α-hydroxy acid especially [99mTc]Tc-gluconate is a novel endogenous H2S imaging agent, which might contribute to study and diagnosis of various diseases related with inflammation and hypoxia.

Nuclear Medicine and Biology published new progress about Brain. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Wei; Hu, ChengXiao; Xu, JiaYang; Ming, JiaJia; Zhao, YuanYuan; Cai, MiaoMiao; Sun, XueCheng; Liu, XinWei; Zhao, XiaoHu published the artcile< Dissolved organic matter derived from rape straw pretreated with selenium in soil improves the inhibition of Sclerotinia sclerotiorum growth>, Electric Literature of 87-73-0, the main research area is DOM rape straw selenium soil Sclerotinia; Dissolved organic matter (DOM); Inhibition; Rape straw; Sclerotinia sclerotiorum; Selenium.

Sclerotinia sclerotiorum (S. sclerotiorum) is a soil-borne pathogen with broad host range. Dissolved organic matter (DOM) plays a vital role in regulating microbial activity in soil. Exogenous selenium (Se) inhibits plant pathogen growth and enhances the capacity of plants to resist disease. DOM from rape straw with Se treated in soil (RSDOMSe) was extracted, and the inhibitory effect on S. sclerotiorum growth was investigated. RSDOMSe inhibited S. sclerotiorum growth, which not only caused severe damage to S. sclerotiorum hyphae but also enhanced soluble protein leakage, thereby improving the growth inhibition ratio by 20.9%. As the action in intercellular, RSDOMSe led to a significant increase in oxalic acid and decrease in CWDE (cell wall-degrading enzyme, which helps pathogens to invade plants) activities, downregulation of Bi1 (BAX inhibitor-1, required for S. sclerotiorum virulence), Ggt1 (γ-glutamyl transpeptidase, regulates the ROS antioxidant system), CWDE2 and CWDE10 gene expression levels, compared with non-Se treated RSDOM (RSDOMN). Eight metabolites upregulated in RSDOMSe were identified by GC-TOF-MS, and among these metabolites, fumaric acid, maleic acid, malonic acid, mucic acid, saccharic acid, succunic acid and phenylacetic acid showed significant inhibition on S. sclerotiorum growth. These findings provide valuable insight into a new approach for developing eco-friendly fungicides.

Journal of Hazardous Materials published new progress about BAX inhibitor-1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molina-Menor, Esther; Vidal-Verdu, Angela; Satari, Leila; Calonge-Garcia, Alba; Pascual, Javier; Pereto, Juli; Porcar, Manuel published the artcile< Belnapia mucosa sp. nov. and Belnapia arida sp. nov., isolated from desert biocrust>, Electric Literature of 87-73-0, the main research area is Belnapia desert biocrust fatty acid phylogeny; Alphaproteobacteria; Belnapia; Tabernas Desert; biocrust; novel species.

Two novel Gram-staining-neg., aerobic, cocci-shaped, non-motile, non-spore forming, pink-pigmented bacteria designated strains T6T and T18T, were isolated from a biocrust (biol. soil crust) sample from the vicinity of the Tabernas Desert (Spain). Both strains were catalase-pos. and oxidase-neg., and grew under mesophilic, neutrophilic and non-halophilic conditions. According to the 16S rRNA gene sequences, strains T6T and T18T showed similarities with Belnapia rosea CGMCC 1.10758T and Belnapia moabensis CP2CT (98.11 and 98.55% gene sequence similarity, resp.). The DNA G + C content was 69.80 and 68.96% for strains T6T and T18T, resp.; the average nucleotide identity by blast (ANIb) and digital DNA-DNA hybridization (dDDH) values confirmed their adscription to two novel species within the genus Belnapia. The predominant fatty acids were summed feature 8 (C18 : 1ω7c/C18 : 1ω6c), C16 : 0, C18 : 1 2-OH and summed feature 3 (C16 : 1ω7c/C16 : 1ω6c). According to he results of the polyphasic study, strains T6T and T18T represent two novel species in the genus Belnapia (which currently includes only three species), for which names Belnapia mucosa sp. nov. (type strain T6T = CECT 30228T = DSM 112073T) and Belnapia arida sp. nov. (type strain T18T = CECT 30229T = DSM 112074T) are proposed, resp.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xingru; Guo, Rui; Zhao, Yaxuan; Liu, Danping; Chen, Jing; Miao, Ningning; Gao, Shujuan; Guo, Jixun; Zhang, Tao; Shi, Lianxuan published the artcile< Wild soybean resists the stress of low phosphorus by increasing nutrient reuse between the young and old leaves>, Product Details of C6H10O8, the main research area is Glycine leaf age nutrient phosphorus deficiency metabolomics.

Screening and identification of plant resources with high quality and multi resistance is important for crop breeding. In this study, ion content was determined by ion chromatog. and at. absorption spectrophotometer, and gas chromatog.-mass spectrometry (GC-MS)-based metabolomic anal. was carried out. Then metabolic pathways were constructed using the Kyoto Encyclopedia of Genes and Genomes and the MetaboAnalyst website to compare the changes and differences of young and old leaves of two wild soybean lines with different stress tolerance under low-phosphorus (LP) stress. The aim was to reveal the mechanism of wild soybean resistance to LP stress from insights concerning nutrient accumulation and mobilization. The results showed that in LP-tolerant wild soybean, Ca2+ accumulated and TCA, amino acid and organic acid metabolisms were enhanced in young and old leaves; disaccharide and trisaccharide metabolism was enhanced and phosphohexose metabolism was inhibited in old leaves; Mg2+, disaccharide and trisaccharide contents increased in young leaves, while inorganic P was relatively stable. Our experiment highlighted that LP-tolerant wild soybean adapted to LP stress by enhancing energy and material metabolisms and maintaining the growth and development of young leaves at the expense of old leaves, which is of great significance for the development and utilization of germplasm resources and the breeding of LP-tolerant soybean.

Plant Growth Regulation published new progress about Disaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Product Details of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Bin; Wang, Sijia; Wang, Yakun; Ke, Songze; Jin, Weihua; Chen, Jianwei; Zhang, Huawei; Sun, Jiadong; Henning, Susanne M.; Wang, Jian; Wang, Hong published the artcile< Gut microbiota-mediated xanthine metabolism is associated with resistance to high-fat diet-induced obesity>, Name: D-Glucosaccharic acid, the main research area is gut microbiota xanthine metabolism high fat diet induced obesity; 16S rRNA sequencing; Gut microbiome; High-fat diet resistance; Host-microbial co-metabolism; Metabolomics; Obesity.

Resistance to high-fat diet-induced obesity (DIR) has been observed in mice fed a high-fat diet and may provide a potential approach for anti-obesity drug discovery. However, the metabolic status, gut microbiota composition, and its associations with DIR are still unclear. Here, ultraperformance liquid chromatog.-tandem mass spectrometry-based urinary metabolomic and 16S rRNA gene sequencing-based fecal microbiome analyses were conducted to investigate the relationship between metabolic profile, gut microbiota composition, and body weight of C57BL/6J mice on chow or a high-fat diet for 8 wk. PICRUSt anal. of 16S rRNA gene sequences predicted the functional metagenomes of gut bacteria. The results demonstrated that feeding a high-fat diet increased body weight and fasting blood glucose of high-fat diet-induced obesity (DIO) mice and altered the host-microbial co-metabolism and gut microbiota composition In DIR mice, high-fat diet did not increase body weight while fasting blood glucose was increased significantly compared to chow fed mice. In DIR mice, the urinary metabolic pattern was shifted to a distinct direction compared to DIO mice, which was mainly contributed by xanthine. Moreover, high-fat diet caused gut microbiota dysbiosis in both DIO and DIR mice, but in DIR mice, the abundance of Bifidobacteriaceae, Roseburia, and Escherichia was not affected compared to mice fed a chow diet, which played an important role in the pathway coverage of FormylTHF biosynthesis I. Meanwhile, xanthine and pathway coverage of FormylTHF biosynthesis I showed significant pos. correlations with mouse body weight These findings suggest that gut microbiota-mediated xanthine metabolism correlates with resistance to high-fat DIO.

Journal of Nutritional Biochemistry published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (gene sequencing). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Cui; He, Qian; Zeng, Linlin; Shen, Ling; Luo, Qiaomei; Zhang, Wentao; Zhou, Xia; Wan, Jun published the artcile< Digestion-Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus>, Synthetic Route of 87-73-0, the main research area is digestion promotor dashanzha pill crataegi fructus; Crataegi Fructus; Dashanzha Pill; dyspepsia, gut microbiota; endoplasmic reticulum stress.

Emerging evidence suggests that a high-fat diet (HFD) can influence endoplasmic reticulum (ER) stress and gut microbiota. Crataegi Fructus is a traditional Chinese herb widely used in formulas for dyspepsia, with Dashanzha Pill composed of raw Crataegi Fructus (DR) being a representative drug. Processing products of Crataegi Fructus, however, have a stronger pro-digestive effect, and we hypothesized that Dashanzha Pill composed of charred Crataegi Fructus (DC) is more effective. We found that the contents of glucose 1-phosphate and luteolin in DR and DC were substantially different via ultra-high performance liquid chromatog.-hybrid quadrupole-Orbitrap high-resolution mass spectrometry. DC outperformed DR in improving histopathol. changes, increasing gastrin and motilin, and decreasing vasoactive intestinal peptides in rats with HFD induced dyspepsia. Fecal microbiota anal. revealed that DC could restore the disturbed intestinal microbiota composition, including that of Bacteroides, Akkermansia, and Intestinimonas to normal levels. Furthermore, DC significantly reduced the mRNA and protein levels of glucose-regulated protein 78, protein kinase R-like ER kinase, and eukaryotic initiation factor 2α. Taken together, DC outperformed DR in relieving dyspepsia by regulating gut microbiota and alleviating ER stress.

Chemistry & Biodiversity published new progress about Akkermansia. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iyer, Gayatri R.; Wigginton, Janis; Duren, William; LaBarre, Jennifer L.; Brandenburg, Marci; Burant, Charles; Michailidis, George; Karnovsky, Alla published the artcile< Application of differential network enrichment analysis for deciphering metabolic alterations>, Related Products of 87-73-0, the main research area is metabolome glutathione type 1 2 diabetes pregnancy; differential networks; enrichment analysis; metabolic disorders; metabolomics and lipidomics; partial correlation networks.

Modern anal. methods allow for the simultaneous detection of hundreds of metabolites, generating increasingly large and complex data sets. The anal. of metabolomics data is a multi-step process that involves data processing and normalization, followed by statistical anal. One of the biggest challenges in metabolomics is linking alterations in metabolite levels to specific biol. processes that are disrupted, contributing to the development of disease or reflecting the disease state. A common approach to accomplishing this goal involves pathway mapping and enrichment anal., which assesses the relative importance of predefined metabolic pathways or other biol. categories. However, traditional knowledge-based enrichment anal. has limitations when it comes to the anal. of metabolomics and lipidomics data. We present a Java-based, user-friendly bioinformatics tool named Filigree that provides a primarily data-driven alternative to the existing knowledge-based enrichment anal. methods. Filigree is based on our previously published differential network enrichment anal. (DNEA) methodol. To demonstrate the utility of the tool, we applied it to previously published studies analyzing the metabolome in the context of metabolic disorders (type 1 and 2 diabetes) and the maternal and infant lipidome during pregnancy.

Metabolites published new progress about Alditols, esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schaarschmidt, Stephanie; Glaubitz, Ulrike; Erban, Alexander; Kopka, Joachim; Zuther, Ellen published the artcile< Differentiation of the High Night Temperature Response in Leaf Segments of Rice Cultivars with Contrasting Tolerance>, SDS of cas: 87-73-0, the main research area is Oryza cultivar leaf segment high night temperature; RNA-Seq; high night temperature; leaf segments; metabolomics; rice cultivars; sheath.

High night temperatures (HNT) affect rice yield in the field and induce chlorosis symptoms in leaves in controlled chamber experiments However, little is known about mol. changes in leaf segments under these conditions. Transcript and metabolite profiling were performed for leaf segments of six rice cultivars with different HNT sensitivity. The metabolite profile of the sheath revealed a lower metabolite abundance compared to segments of the leaf blade. Furthermore, pre-adaptation to stress under control conditions was detected in the sheath, whereas this segment was only slightly affected by HNT. No unique significant transcriptomic changes were observed in the leaf base, including the basal growth zone at HNT conditions. Instead, selected metabolites showed correlations with HNT sensitivity in the base. The middle part and the tip were most highly affected by HNT in sensitive cultivars on the transcriptomic level with higher expression of jasmonic acid signaling related genes, genes encoding enzymes involved in flavonoid metabolism and a gene encoding galactinol synthase. In addition, gene expression of expansins known to improve stress tolerance increased in tolerant and sensitive cultivars. The investigation of the different leaf segments indicated highly segment specific responses to HNT. Mol. key players for HNT sensitivity were identified.

International Journal of Molecular Sciences published new progress about Chlorosis (plant). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts