Category: 86770-74-3

Reference of 86770-74-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, molecular formula is C8H19NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-mercapto-4-methylpentanoic acid (163 mg, 1.10 mmol) in MeCN (2.0 mL) were added sequentially acetic anhydride (1 14 pL, 1.21 mmol, 1.10 equiv.), Et3N (307 pL, 2.20 mmol, 2.00 equiv.) and DMAP (1.34 mg, 1 1.0 pnnol). The mixture was stirred for 32 minutes, followed by the addition 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (319 mg, 1.65 mmol, 1.50 equiv.). The resulting reaction mixture was stirred for 18 hours at rt and then cone in vacuo. The residue was purified by silica chromatography (1 10% MeOH in DCM). The desired product was obtained as a yellow oil (342 mg, 1.05 mmol, 96%). 1 H NMR (400 MHz, CDC ) d (ppm) 7.22 (bs, 1 H), 3.79-3.71 (m, 4H), 3.71-3.59 (m, 8H), 3.57-3.51 (m, 2H), 3.50-3.41 (m, 2H), 2.43-2.34 (m, 2H), 1.98-1.89 (m, 2H), 1.65 (bs, 1 H), 1.40 (s, 6H). LCMS (ESI+) calculated for CMHSONOSS* (M+H+) 324.18, found 324.36.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; HOOGENBOOM, Jorin; VAN BERKEL, Maria Antonia; VAN DELFT, Floris Louis; (95 pag.)WO2019/110725; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 86770-74-3, blongs to alcohols-buliding-blocks compound. Product Details of 86770-74-3

Example 4 This example describes two methods for the preparation of bis-N,N’-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)perylenetetracarboxylic diimide. Method A: 2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethanol (2.6 g, 13.5 mmol), perylenetetracarboxylic dianhydride (2.2 g, 5.6 mmol), and triethylamine (25 mL, 180 mmol) were mixed with 50 mL of dry DMSO (4A activated MS, 3 days) in a 250-mL flask under argon. After the reaction mixture was stirred for 4 h at 150 C., the reaction solution was cooled to 80 C. and transferred to a 1000-mL flask. A mixture of 600 mL 10% aqueous HCl and 300 mL methanol was added to the reaction solution, then the solution was stirred for additional 2 hours at 60 C. After the mixture was cooled to RT overnight, the precipitate was collected using paper filter. The resulting collection was washed with 400 mL water, and the water layer was re-extracted with 50 mL chloroform. The filtrate could be extracted with chloroform to gain more products, but these products were contaminated and needed column purification. The combined organic layer was concentrated to give the crude title product; further purification was carried out on a silica-gel column eluted with CH2Cl2/CH3OH (5:1). Detection of the products on TLC plates was accomplished using UV light or sulfuiric acid solution (5% conc. sulfuric acid in EtOH). The title compound was obtained as dark-red solid (3.6 g, 86% yield): Rf0.4 (CH2Cl2/CH3OH, 10:1). 1H-NMR (60-70 mg/0.5 ml; CDCl3/CD3OD/100/5) delta7.96 (d, 4H, J=8.1 Hz, aromatic ring), 7.61 (d, 4H, J=8.1 Hz, aromatic ring), 4.32 (t, 4H, J=5.7 Hz, CH2N), 3.65-3.29 (m, 28H, CH2OCH2, HOCH2); 13C-NMR (60-70 mg/0.5 ml; CDCl3/CD3OD/100/5) delta162.7, 133.1, 130.4, 128.1, 124.7, 122.5, 122.4, 72.9, 70.79, 70.76, 70.4, 70.2, 68.0, 61.6, 39.5. 1H-NMR (DMSO-d6) delta7.13 (bd, 4H, aromatic ring), 6.92 (bd, 4H, aromatic ring), 4.59 (t, 4H, J=5.7 Hz, CH2N), 3.65-3.29 (m, 28H, CH2OCH2, HOCH2); 13C-NMR (DMSO-d6) delta161.2, 131.4, 128.8, 125.9, 122.6, 120.2, 72.3, 69.8, 69.7, 69.6, 66.5, 60.2, 45.67. MS (MALDI): m/z 765.82 [M+Na]+. Anal. Calcd. for C40H42N2O12 (742.77): C, 64.68; H, 5.70; N, 3.77. Found: C, 64.24; H, 5.52; N, 3.83.

The synthetic route of 86770-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Washington State University Research Foundation; US7238792; (2007); B2;,
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Reference of 86770-74-3 ,Some common heterocyclic compound, 86770-74-3, molecular formula is C8H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

An oven-dried 200 mL round bottomed flask was charged with Biotin-NHS (1.17 g, 3.43 mmol) and 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethan-1-ol (730 mg, 3.80 mmol). The flask was subjected to three cycles of vacuum/nitrogen backfill before addition of anhydrous DMF (69 mL). To the colorless solution was added triethylamine (960 muL, 6.85 mmol) and after 45 minutes, the solution was concentrated in vacuo. The crude material was purified by flash chromatography (basic alumina: 5 % methanol in CH2Cl2) to provide the title compound as an opaque amorphous solid (1.18 g, 2.81 mmol, 82 % yield). 1H NMR (400 MHz, CDCl3) delta: 7.21 (1H, br t), 5.97 (1H, br s), 5.09 (1H, br s), 4.48 (1H, m), 4.30 (1H, m), 3.78 (1H, m), 3.70 (4H, m), 3.65-3.58 (8H, m), 3.52 (2H, m), 3.41 (2H, m), 3.13 (1H, td, J = 7.4, 4.6 Hz), 2.90 (1H, dd, J = 12.8, 5.0 Hz), 2.73 (1H, d, J = 12.8 Hz), 2.20 (2H, t, J = 7.5 Hz), 1.78 (4H, m), 1.46-1.38 (2H, m); 13C NMR (100 MHz, CDCl3) delta: 173.49, 164.17, 72.60, 70.51, 70.32, 70.17, 70.00, 69.92, 61.78, 61.41, 60.22, 55.65, 40.47, 39.08, 35.90, 28.30, 28.11, 25.69. IR numax/cm-1 (film): 3273, 3085, 2916, 2865, 1690, 1669, 1646, 1551, 1464, 1420, 1264, 1240, 1202, 1101, 869, 693. m/z HRMS (ESI): [M+ H]+ calculated for C18H33N3O6S+ = 442.1982, found 442.1962.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nottingham, Kyle G.; McNally, Andrew; McNaughton, Brian R.; Tetrahedron Letters; vol. 59; 3; (2018); p. 234 – 237;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 86770-74-3, blongs to alcohols-buliding-blocks compound. Product Details of 86770-74-3

Example 28 Synthesis of Compound 122 To the solution of intermediate carbonate 1B obtained in Example 11 (5.04 mumol, 5 mg) in DCM (7.77 mmol, 0.5 mL) was added 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethan-1-ol (0.050 mmol, 9.75 mg) and Hunig’s base (0.050 mmol, 8.81 muL). The reaction mixture was stirred overnight at rt and the volatiles were removed. The crude material was purified by RP-column chromatography to afford Compound 122 (3.1 mg, 58.8%) as a white solid. Observed ESI HRMS: m/z 1045.6173 [M+H]+. The 1H NMR spectrum of Compound 122 is shown in FIG. 44.

The synthetic route of 86770-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sirenas LLC; MACHERLA, Venkat Rami Reddy; SCHAMMEL, Alexander Wayne; USUI, Ippei; STOUT, Elizabeth Paige; BEVERAGE, Jacob Neal; LEE, Bryan Junn; COHEN, Steven Bruce; (304 pag.)US2017/15710; (2017); A1;,
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