Category: 862135-61-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 862135-61-3, name is 5-Bromoindan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 862135-61-3

To a solution of NaH (60%, 160 mg, 3.99 mmol) in dry THF (5 mL) at 0 C. was added a solution of 5-bromo-2,3-dihydro-1H-inden-2-ol (500 mg, 2.347 mmol) in dry THF (5 mL). The resulting solution was stirred for 30 min at 0 C. Benzyl bromide (0.335 mL, 2.82 mmol) was added and the solution was stirred at 25 C. for 15 h. The mixture was quenched by saturated, aqueous ammonium chloride (10 mL), which was extracted with EtOAc (40 mL¡Á3). The combined organic layers were washed by brine (15 mL¡Á3) and concentrated to give the crude product, which was purified by silica gel chromatography (1:0-10:1 petroleum ether: EtOAc) to afford the title compound. 1H NMR (400 MHz, CDCl3): delta 7.25-7.37 (7H, m), 7.07 (1H, d, J=8.0 Hz), 4.57 (2H, s), 4.38-4.47 (1H, m), 2.95-3.23 (4H, m).

The synthetic route of 862135-61-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
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Reference of 862135-61-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 862135-61-3, name is 5-Bromoindan-2-ol, molecular formula is C9H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 5-bromoindan-2-ol (Combi-Blocks, cat No.QA3834: 114 mg, 0.535 mmol), potassium acetate (160 mg, 1.6 mmol) and 4,4,5,5,4′,4′,5′,5′-octamethyl-[2,2′]bi[[1,3,2]dioxaborolanyl](200 mg, 0.80 mmol) in 1,4-dioxane (2.4 mL) was first degassed with stream of nitrogen for ?5 min, then [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1:1) (20 mg, 0.03 mmol) was added and the mixture was heated to 100 C. overnight. The reaction mixture was cooled to room temperature, concentrated then diluted with 1:1 ethyl acetate/hexanes, filtered through celite, and concentrated. The residue obtained was purified by flash chromatography on a silica gel column eluting with 0 to 40% EtOAc/Hexanes to provide the desired intermediate in nearly quantitative yield.

According to the analysis of related databases, 862135-61-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Incyte Corporation; Wu, Liangxing; Courter, Joel R.; He, Chunhong; Li, Jingwei; Lu, Liang; Sun, Yaping; Wang, Xiaozhao; Yao, Wenqing; Zhang, Colin; Zhuo, Jincong; (87 pag.)US2016/9720; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts