Category: 86-48-6

Kristensen, Mette published the artcileOptimization and validation of a derivatization method with boron trifluoride in ethanol for analysis of aromatic carboxylic acids in water, Synthetic Route of 86-48-6, the publication is Journal of Chromatography A (2019), 21-26, database is CAplus and MEDLINE.

Gas-chromatog. (GC) anal. of carboxylic acids is limited by the high polarity and low volatility of most of these compounds Boron trifluoride (BF₃) mediated alkylation reactions is one of the most commonly used derivatization methods for making carboxylic acids GC compatible. A semi-automated BF₃-EtOH (ethanol) derivatization method was optimized for comprehensive two-dimensional gas chromatog. high-resolution mass spectrometry (GC × GC-HR MS) anal. of carboxylic acids in solid phase extraction (SPE) extracts of oil-polluted water. The optimal derivatization method were found to be with addition of 300 μL BF₃-EtOH per 200 μL sample and reaction at 75° for 24 h. Derivatives of eight selected acids (aliphatic, mono- and diarom.) were stable over 12 h with relative standard deviations (RSDs) of 2.0-10.7%, the derivatization method was repeatable (RSDs of 3.2-17.2%), detection limits (DL) and limit of detections (LODs) was in the range of DL = 0.53-1.63 ppb and LOD = 0.19-2.51 ppb for pure acid standards, and DL = 0.18-3.41 ppb and LOD = 0.28-5.46 ppb for matrix matched acid standards Finally, the method was validated on the acidic fraction of a mixed anion-exchange SPE of oil polluted water. Thousands of degradation products from parent alkylated polycyclic aromatic hydrocarbons (PAHs) and aliphatic hydrocarbons, such as aliphatic acids and mono-, di-, and triarom. acids were analyzed by the applied method and compound groups were tentatively identified.

Journal of Chromatography A published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Synthetic Route of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Meng-Yang published the artcileCopper(II) Acetate Mediated Synthesis of 3-Sulfonyl-2-aryl-2H-chromenes, COA of Formula: C11H8O3, the publication is Synthesis (2019), 51(18), 3419-3430, database is CAplus.

This paper describes a concise, easy-operation, high-yielding method for the synthesis of 3-sulfonyl-2-aryl-2H-chromenes I [R = Me, n-Bu, 4-H₃CC₆H₄, etc.; R¹ = H; R² = H, OCH₃; R¹R² = -CH=CH-CH=CH-; R³ = H, Cl, Br; Ar = 2-furyl, 2-naphthyl, 3,4,5-(H₃CO)₃C₆H₂, etc.] by a one-pot, straightforward two-step synthetic route, which includes (i) Cu(OAc)₂/PyBOP-mediated intermol. [4+2] annulation of substituted salicylic acids 2-OH-3-R¹-4-R²-5-R³C₆HC(O)OH with β-sulfonylstyrenes ArCH=CHS(O)₂R in the presence of DMAP in refluxing DMF, and (ii) sequential O-alkylation of the resulting sulfonylflavanones II with Bu bromide. A plausible mechanism is proposed and discussed. This protocol provides a highly effective annulation via one carbon-oxygen (C-O) and one carbon-carbon (C-C) bond formations.

Synthesis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cabrera-Afonso, Maria J. published the artcileSite-selective Oxidative Dearomatization of Phenols and Naphthols into ortho-Quinols or Epoxy ortho-Quinols using Oxone as the Source of Dimethyldioxirane, Computed Properties of 86-48-6, the publication is Advanced Synthesis & Catalysis (2019), 361(19), 4468-4473, database is CAplus.

A novel reactivity of dimethyldioxirane generated in-situ from oxone and acetone, with substituted phenols and naphthols was reported. This methodol. allowed the synthesis of ortho-quinols or epoxy ortho-quinols from a site-selective oxidative dearomatization process with good yields under very mild conditions. A short total synthesis of natural product lacinilene C Me ether was also described using this process as the key step.

Advanced Synthesis & Catalysis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Winterton, Sarah E. published the artcileDiscovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase, Product Details of C11H8O3, the publication is Journal of Medicinal Chemistry (2018), 61(12), 5199-5221, database is CAplus and MEDLINE.

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an anal. of the structure-activity relationships related to metabolic activation and SCD inhibition.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H21BO2Si, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Na-Na published the artcileA bifunctional probe based on naphthalene derivative for absorbance-ratiometic detection of Ag⁺ and fluorescence “turn-on” sensing of Zn²⁺ and its practical application in water samples, walnut and living cells, Application of 1-Hydroxy-2-naphthoic acid, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2020), 112299, database is CAplus.

In this work, naphthalene with good biocompatibility was selected, and the probe NBOS was synthesized with 2-Amino-phenol and 2-Amino-benzenethiol. The structure of probe NBOS was confirmed by X-ray Crystallog. Furthermore, the probe showed absorbance-ratiometic sensing for Ag⁺ over a pH range from 6 to 7.5 and fluorescence “turn on” signal response towards Zn²⁺ in the pH range of 6-10 in EtOH/H₂O (9/1, V/V, pH = 7.4) mixture The detection limit was obtained to be 4.24μM for Ag⁺ and 3.17 nM for Zn²⁺. Moreover, it could be efficiently recycled by treating Na₂EDTA. The sensing mechanism of probe NBOS toward Ag⁺ and Zn²⁺ was investigated by FT-IR, HNMR, job’plot and ESI-MS. Typically, the coordination mode of NBOS with Zn²⁺ was confirmed by DFT calculation Moreover, probe NBOS was successfully applied in the detection Ag⁺ and Zn²⁺ in real water samples. Importantly, probe NBOS could be used to detect Zn²⁺ in walnut and living cells. Based on the high throughput anal. strategy, absorbance and fluorescence signals of NBOS could be designed as a NOT and OR logic gate controlled by Ag⁺ (Input 1) and Zn²⁺ (Input 2).

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kondratenko, Yulia A. published the artcileDiethanolammonium protic ionic liquids – promising buffers for the synthesis of ⁶⁸Ga- labelled radiopharmaceuticals, Quality Control of 86-48-6, the publication is Journal of Molecular Liquids (2022), 117029, database is CAplus.

Fifteen new protic ionic liquids based on diethanolammonium (DEA) salts of carboxylic acids have been synthesized and identified using a complex of physicochem. methods (NMR, FT-IR spectroscopy, elemental, thermal anal.). The crystal structure of diethanolammonium salts of benzoic and 1-hydroxy-2-naphthoic acids was determined for the first time by XRD. A comparative anal. of the conformations of DEA cations was carried out. The effectiveness of synthesized DEA ionic liquids as buffer agents was demonstrated on ⁶⁸Ga-radiolabeling reactions with different chelators and clin. approved peptides.

Journal of Molecular Liquids published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Kader, Nora S. published the artcileSpectroscopic studies, density functional theory calculations, non-linear optical properties, biological activity of 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid and its chelates with Nickel(II), Copper(II), Zinc(II) and Palladium(II) metal ions, Computed Properties of 86-48-6, the publication is Journal of Molecular Structure (2021), 129203, database is CAplus.

Novel Nickel(II), Copper(II), Zinc(II) and Palladium(II) chelates with 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid (H₃L) have been produced and clarified using several physicochem. techniques. Quantum mech. calculations of energies, geometries were achieved by using the d. functional theory with Becke’s three parameter exchange functional, the Lee_Yang_Parr correlation functional (B3LYP/GEN) combined with 6.311 G (d,p) and LANL2DZ basis sets. The analyses of HOMO and LUMO have been used to justify the charge transfer within the ligand and its chelates. The considered small energy gap between Occupied MO (HOMO) and LUMO energies expressions that the charge transfer occurs within the ligand and its chelates. The results show that the azo dye ligand exists in two tautomeric structures, the first structure (H₃L), the sulfonamide (SO₂NH), while the second one, the sulfonamide group in enolic form (H₂L-OH). The H₂L-OH tautomer has energy of 12.93 kcal/mol higher than that of H₃L. The structure of H₃L was the most stable and used as the ligand in this study. The bond lengths of Ni(II) ion with the donating sites of the ligand in Ni-(H₂L)₂ chelate suggest a distorted octahedral geometry, Cu₂-(L) chelate, suggests a highly distorted tetrahedral geometry, Zn-(HL) chelate displays a distorted octahedral geometry, Pd-(H₂L) chelate approves a distorted square planar geometry around its own central metal ion. Geometrical parameters, mol. electrostatic potential maps and total electron densities analyses of the ligand and its chelates have been carried out. Mol. stability, hyper conjugative interactions, intramol. charge transfer and bond strength have been examined by applying of natural bond orbital (NBO) anal. Total static dipole moment, mean polarizability, anisotropy of the polarizability, mean first-order hyperpolarizability have been also achieved. From the mol. hyperpolarizability (<β>), The computed (<β>) values show that for the ligand (H₃L) and its Ni-(H₂L)₂, Cu₂-(L), Zn-(HL) and Pd-(H₂L) are ∼23, ∼70, ∼44, ∼132 and ∼38 times greater than that of Urea, indicating all the studied ligand and its chelates reveal significant polarizability and first-order hyperpolarizability and are predicted to be successful for Non-Linear Optical (NLO) materials. The analyses of the chelates indicate that the Zn(II) and Pd(II) form 1:1, Ni(II) form 1:2 while Cu(II) ion form 2:1 (M:L) and non-electrolytic behavior of chelates indicate the absence of counter ion. Ni-(H₂L)₂ complex had zero antibacterial activity against E. coli while its activity is higher than the azo dye against Staphylococcus aureus. Pd-H₂L complex had almost the same activity as the azo dye against both types of bacteria. The higher activity of Zn-HL and Cu₂-L complexes can be explained by their chelation.

Journal of Molecular Structure published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Maoqun published the artcileDiscovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Medicinal Chemistry (2020), 63(11), 6164-6178, database is CAplus and MEDLINE.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity vs. other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC₅₀ 0.0192 μM)(I) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC₅₀ 0.0231 μM)(II), displayed >500-fold selectivity vs. P2X2 and P2X3, and 10-fold selectivity vs. P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as neg. allosteric modulators, and mol. modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H26O2, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Kader, Nora S. published the artcileCombined experimental, DFT theoretical calculations and biological activity of sulfaclozine azo dye with 1-hydroxy-2-naphthoic acid and its complexes with some metal ions, Formula: C11H8O3, the publication is New Journal of Chemistry (2019), 43(44), 17466-17485, database is CAplus.

Sulfaclozine-1-hydroxy-2-naphthoic acid azo dye (Scna) and its metal complexes with Ni(II) Cu(II), Zn(II) and Pd(II) metal ions were prepared and characterized using different techniques. The nonisothermal degradation of Pd(II)-(Scna) was studied using Flynn-Wall-Ozawa and Starink methods at various heating rates (5, 10, 15 and 20° min^-1) from the TG/derivative TG (TG/DrTG) and DTA curves. The values of the activation energy (E) obtained using the two methods are in impeccable harmony. Theor. studies (d. functional theory, DFT) were also carried out to support the corresponding exptl. results. Computational calculations were achieved using a DFT/GEN level of theory. Theor. aspects, in terms of geometrical optimization and mol. charge d. plots are also mentioned using the standard basis set LANL2DZ for metal ions. A suitable distorted square planar for Pd-(Scna), distorted tetrahedral for Cu₂-(Scna), and distorted octahedral with Ni-(Scna) and Zn-(Scna)₂ structures were observed for the complexes. The electronic structure and nonlinear optical parameters (NLO) of the complexes were calculated The nature of the interaction between the metal ions and the ligand, mol. stability and bond strengths were studied using DFT calculations employing natural bond orbital (NBO) anal. The complexes are nonplanar and demonstrate the expected optical properties. The synthesized ligand (Scna) and its complexes were screened for antimicrobial activity against bacteria, Staphylococcus aureus as the Gram-pos. and Escherichia coli as the Gram-neg., using the disk diffusion method. The Zn-(Scna)₂ complex displayed the highest activity against both bacteria.

New Journal of Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts