Category: 86-48-6

Derz, Wiebke published the artcileGuiding Molecularly Imprinted Polymer Design by Pharmacophore Modeling, Quality Control of 86-48-6, the publication is Molecules (2021), 26(16), 5101, database is CAplus and MEDLINE.

Molecularly imprinted polymers (MIP) combine the selectivity of immunoaffinity chromatog. with the robustness of common solid-phase extraction in what is referred to as molecularly imprinted solid-phase extraction (MISPE). This contribution shows how MIP design may be guided by pharmacophore modeling for the example of citrinin, which is an emerging mycotoxin from cereals. The obtained pharmacophore model allowed searching public databases for a set of citrinin-mimicking mol. surrogates. Imprinted and non-imprinted polymers were subsequently obtained through bulk and core-shell polymerization in the presence of these surrogates. Evaluation of their binding ability for citrinin and structurally related ochratoxin A revealed a promising MIP derived from rhodizonic acid. A protocol for MISPE of citrinin from cereals was subsequently developed and compared to immunoaffinity chromatog. with respect to clean-up efficiency and recovery.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Macchi, Marianela published the artcileDesign and evaluation of synthetic bacterial consortia for optimized phenanthrene degradation through the integration of genomics and shotgun proteomics, Formula: C11H8O3, the publication is Biotechnology Reports (2021), e00588, database is CAplus and MEDLINE.

Two synthetic bacterial consortia (SC) composed of bacterial strains Sphingobium sp. (AM), Klebsiella aerogenes (B), Pseudomonas sp. (Bc-h and T), Burkholderia sp. (Bk) and Inquilinus limosus (Inq) isolated from a natural phenanthrene (PHN)-degrading consortium (CON) were developed and evaluated as an alternative approach to PHN biodegradation in bioremediation processes. A metabolic network showing the potential role of strains was reconstructed by in silico study of the six genomes and classification of dioxygenase enzymes using RHObase and AromaDeg databases. Network anal. suggested that AM and Bk were responsible for PHN initial attack, while Inq, B, T and Bc-h would degrade PHN metabolites. The predicted roles were further confirmed by physiol., RT-qPCR and metaproteomic assays. SC-1 with AM as the sole PHN degrader was the most efficient. The ecol. roles inferred in this study can be applied to optimize the design of bacterial consortia and tackle the biodegradation of complex environmental pollutants.

Biotechnology Reports published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Macchi, Marianela published the artcileAssessing interactions, predicting function, and increasing degradation potential of a PAH-degrading bacterial consortium by effect of an inoculant strain, Related Products of alcohols-buliding-blocks, the publication is Environmental Science and Pollution Research (2019), 26(25), 25932-25944, database is CAplus and MEDLINE.

A natural phenanthrene-degrading consortium CON was inoculated with an exogenous strain Sphingobium sp. (ex Sp. paucimobilis) 20006FA yielding the consortium called I-CON, in order to study ecol. interactions into the bacterial community. DGGE and proteomic profiles and analyses by HTS (High-Throughput Sequencing) technologies demonstrated inoculant establishment and changes on CON composition Inoculation increased degradation efficiency in I-CON and prevented intermediate HNA accumulation. This could be explained not only by the inoculation, but also by enrichment in Achromobacter genus at expense of a decrease in Klebsiella genus. After inoculation, cooperation between Sphingobium and Achromobacter genera were improved, thereby, some competition could have been generated, and as a consequence, species in minor proportion (cheaters), as Inquilinus sp. and Luteibacter sp., were not detected. Sequences of Sphingobium (corresponding to the inoculated strain) did not vary. PICRUSt predicted a network with bacterial phylotypes connected with enzymes, showing functional redundancy in the phenanthrene pathway, with exception of the first enzymes biphenyl-2,3-diol 1,2-dioxygenase and protocatechuate 4,5-dioxygenase that were only encoded in Sphingobium sp. This is the first report where a natural consortium that has been characterized by HTS technologies is inoculated with an exogenous strain in order to study competitiveness and interactions.

Environmental Science and Pollution Research published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reis, Joel S. published the artcileOxazoline as acceptor moiety for excited-state intramolecular proton transfer, Quality Control of 86-48-6, the publication is Tetrahedron (2018), 74(48), 6866-6872, database is CAplus.

Excited state intramol. proton transfer (ESIPT) is a widespread phenomenon that has been exploited in several anal. and technol. applications. Here we describe the synthesis of two ESIPT-active halogen-substituted naphthol-oxazolines that can be conveniently functionalized to develop tailored sensors, and a bis-oxazoline that showcases the potential of oxazolines to undergo double ESIPT. The photophys. properties of these compounds in solution were investigated using polar aprotic solvents and the results were rationalized using DFT/TD-DFT calculations

Tetrahedron published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Zechao published the artcileDesign, Synthesis, and Characterization of Binaphthalene Precursors as Photoactivated DNA Interstrand Cross-Linkers, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2018), 83(16), 8815-8826, database is CAplus and MEDLINE.

Most recently, alkylation via photo-generated carbocations has been identified as a novel mechanism for photo-induced DNA interstrand crosslink (ICL) formation by bifunctional aryl compounds However, most compounds showed a low efficiency for DNA crosslinking. Here, the authors have developed a series of new 1,1′-binaphthalene analogs that efficiently form DNA ICLs upon 350 nm irradiation via generated 2-naphthalenylmethyl cations. The DNA crosslinking efficiency depends on the substituents at the position-4 of the naphthalene moiety as well as the leaving groups. Compounds with NO2, Ph, H, Br, or OMe substituents led to 2-4 times higher DNA ICL yields than those with a boronate ester group. Compounds having tri-Me ammonium salt as a leaving group showed slightly better crosslinking efficiency than those with bromo as a leaving group. Some of these compounds showed a better crosslinking efficiency than that of traditional alkylating agents, such as nitrogen mustard analogs or quinone methide precursors. These highly efficient photo-activated carbocation precursors allow determination and characterization of the adducts formed between the photo-generated naphthalenyl cations and four natural nucleosides, indicating that the alkylation sites for these naphthalene analogs are dG, dA, and dC.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Razek, A. S. published the artcileBioelimination of phenanthrene using degrading bacteria isolated from petroleum soil: safe approach, Safety of 1-Hydroxy-2-naphthoic acid, the publication is Desalination and Water Treatment (2020), 131-140, database is CAplus.

Polyaromatic hydrocarbon contamination is considered as serious pollution resulted from industrial activities. Phys. or chem. methods used for remediation of hydrocarbons might cause the transfer of the remediated compounds from the polluted sites into other clean locations. Our study is concerned by the bioremediation of phenanthrene, using microbial degraders that will eventually, result in the release of non-toxic structures, as end products. Successfully, three bacterial isolates; Enterobacter cloacae, Bacillus sp. and Bacillus thuringiensis with accession numbers; MK559694, MK561601 and MK559693, resp., showed higher phenanthrene biodegradation ability. The examined conditions indicated that the isolates were active in a wide range of temperatures, pH and hydrocarbon concentrations The gas chromatog.-mass spectrum anal. of the formed byproducts showed the existence of intermediate structures with varied carbon values, ranged from C4H8O2 to C12H22O11. However, these byproducts did not show cytotoxic effect against Vero cell lines, compared with the tested undegraded phenanthrene. The obtained results revealed that these bacterial isolates can be used as potent phenanthrene degraders with safe and non-toxic end products, which allow the treated water to be used for non-potable water applications.

Desalination and Water Treatment published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Safety of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diez, Stefan J. published the artcileCrystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates, HPLC of Formula: 86-48-6, the publication is Crystal Growth & Design (2018), 18(6), 3263-3268, database is CAplus.

A crystal growth technique, interfacial cocrystn., is demonstrated to be a simple and effective method for preparing multi-component crystal forms. The technique is based on the generation of a liquid-liquid interface between two immiscible solutions of cocrystal-forming compounds, and its utility is demonstrated through the preparation of polymorphs and hydrates of caffeine cocrystals, involving three different hydroxy-2-naphthoic acids, including the formation of some with unexpected compositions

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ait Amiri, Sabrina published the artcileIdentification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation, SDS of cas: 86-48-6, the publication is Journal of Medicinal Chemistry (2021), 64(9), 5667-5688, database is CAplus and MEDLINE.

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biol. evaluation of KLK6′s low-mol.-weight inhibitors, para-aminobenzyl derivatives Interestingly, selected hit compounds were selective of the KLK6 proteolytic network encompassing KLK1 and plasmin that also participate in the development of MS physiopathol. Moreover, hits were found noncytotoxic on primary cultures of murine neurons and oligodendrocyte precursor cells (OPCs). Among them, two compounds (32 and 42) were shown to promote the differentiation of OPCs into mature oligodendrocytes in vitro constituting thus emerging leads for the development of regenerative therapies.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Qian-Qian published the artcileModulation of Solid-State Optical Properties of o-Hydroxynaphthoic Acids through Formation of Charge Transfer Cocrystals with TCNB, Formula: C11H8O3, the publication is Crystal Growth & Design (2020), 20(11), 7492-7500, database is CAplus.

Charge transfer cocrystals offer an opportunity to alter the photophys. characteristics of organic chromophores in the solid state. A set of new charge transfer cocrystals of three positional isomers of o-hydroxynaphthoic acid with 1,2,4,5-tetracyanobenzene (TCNB) as the electron acceptor was prepared and subjected to single-crystal and powder X-ray diffraction, thermal anal., vibrational, and UV-vis absorption and fluorescence spectroscopic measurements. Crystal structure analyses reveal that the donor and acceptor mols. are combined in a 2:1 stoichiometric ratio and stacked alternately through a typical mixed face-to-face arrangement (DAD···DAD), forming a columnlike charge transfer structure involving π-stacking interactions. All of the cocrystals exhibit distinct tunable emission colors and photoluminescence characteristics due to the charge transfer transition states. This research indicates that the cocrystal strategy can be applied to effectively modulate the optical properties of o-hydroxynaphthoic acid compounds, which have a great research value in optoelectronic applications. A set of new charge transfer cocrystals of three positional isomers of o-hydroxynaphthoic acid with TCNB as the electron acceptor was successfully prepared and fully characterized, and they exhibit distinct tunable photoluminescence characteristics due to the mixed DAD···DAD columnlike charge transfer structures.

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shafaei, Armaghan published the artcileSimultaneous quantitative analysis of polyphenolic compounds in human plasma by liquid chromatography tandem mass spectrometry, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Separation Science (2019), 42(18), 2909-2921, database is CAplus and MEDLINE.

A diet rich in polyphenolic compounds has recognized health benefits, and as such is routinely monitored as part of dietary intervention studies. A method for the simultaneous determination of 36 phenolic compounds, including phenolic acids and flavonoids, using liquid chromatog. and tandem mass spectrometry is described here. The target analytes were quantified based on their specific mass spectral fragments using a selected reaction monitoring approach. A C18 column with embedded aromatic functionality ensured separation of all phenolic compounds studied which included several pairs of isomers. Sample preparation involved the use of β-glucuronidase to release the phenolic compounds from their conjugated forms. The intra-day and inter-day precision and accuracy was less than 7% for all phenolic compounds studied. Recoveries, where plasma was spiked with three different concentrations of the analytes, ranged from 95-115%. The limits of detection and quantification were 0.23-3.89 and 1.15-7.79 nM, resp. The method was successfully applied to real samples and the range reported for each phenolic compound, with the exception of hydroferulic acid, nordihydroguaiaretic acid, methylgallate, and m-coumaric acid, was at least an order of magnitude higher than the limit of quantification for the method.

Journal of Separation Science published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C16H20N2, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts