Category: 86-48-6

Zyakun, A. M. published the artcileApplication of High-Performance Liquid Chromatography/High Resolution Mass Spectrometry to the Investigation of the Biodegradation and Transformation of Phenanthrene by a Plasmid Bearing Rhizosphere Bacteria Pseudomonas aureofaciens, SDS of cas: 86-48-6, the publication is Journal of Analytical Chemistry (2019), 74(13), 1355-1361, database is CAplus.

Mass spectrometry identified metabolites and estimated the efficiency of phenanthrene biodegradation and transformation by the rhizospheric bacteria, Pseudomonas aureofaciens BS1393. P. aureofaciens strains BS1393(pOV17) and BS1393(NPL-41) with various naphthalene biodegradation plasmids were used. Strain BS1393(pOV17) contained the pOV17 wild-type naphthalene biodegradation plasmid which determined naphthalene oxidation Krebs cycle metabolites. Strain BS1393(NPL-41) contained the mutant plasmid, NPL-41, governing the initial stages of naphthalene oxidation to salicylic acid. Phenanthrene biodegradation limiting stages in bacteria with various plasmids was identified according to intermediates accumulation. When bacteria were grown on phenanthrene, main metabolites were: 2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid/trans-4-(1-hydroxynaph-2-yl)-2-oxobut-3-enoic acid; 1-hydroxy-2-naphthoic acid; and salicylic acid. For strain BS1393(pOV17), 2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid/trans-4-(1-hydroxynaph-2-yl)-2-oxobut-3-enoic acid was observed during 1-14 days of cultivation. For strain BS1393(NPL-41), an insignificant amount of this metabolite was observed after only 14 days. Availability of 1-hydroxy-2-naphthoic acid in the growth of both strains showed the limited rate of its further decarboxylation. Salicylic acid as final biodegradation product was obsd for BS1393(NPL-41) growth. For strain BS1393(pOV17), this metabolite was not observed, indicating phenanthrene complete oxidation

Journal of Analytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C6H8O6, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Shih-Wei published the artcilePilot production of a sensitive ELISA kit and an immunochromatographic strip for rapid detecting citrinin in fermented rice, Category: alcohols-buliding-blocks, the publication is RSC Advances (2022), 12(31), 19981-19989, database is CAplus and MEDLINE.

Citrinin (CTN) is a mycotoxin primarily produced by Monascus species. Excess consumption of CTN may lead to nephrotoxicity and hepatotoxicity. A pilot study for com. production of competitive direct ELISA (cdELISA) kit and an immunochromatog. strip (immunostrip) for screening CTN in red yeast rice is established in this study. The coating antibody and the CTN-horse radish peroxidase (HRP) concentrations were optimized to increase the sensitivity and specificity of cdELISA kit. The conjugation methods/ratios of CTN to HRP as well as the long-term stability of kit components were also evaluated. The IC50 and detection limit of the ELISA kit were determined to be 4.1 and 0.2 ng mL-1, resp. Anal. of 20 red yeast rice samples using ELISA kits revealed the contamination levels of CTN from 64 to 29 404 ng g-1. The on-site rapid detection of CTN with the immunostrip showed that CTN levels in seven samples exceeded the regulatory limit of 5 ppm. Addnl., the coefficient correlation between the results of HPLC and ELISA kits of 20 samples was 0.96. Sensitive and convenient tools at com. levels for detection of CTN contamination in food are established herein to protect the health of the public.

RSC Advances published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C8H11BO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gajic, Mihajlo published the artcileRepurposing of 8-Hydroxyquinoline-Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors, Formula: C11H8O3, the publication is ChemMedChem (2022), 17(5), e202100694, database is CAplus and MEDLINE.

A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened in vitro for inhibition of DNase I (DNase I). Compounds 22, 8 and 7 are among the most potent synthetic non-peptide DNase I inhibitors reported to date. Three 8-hydroxyquinoline analogs inhibited both DNase I and BChE with IC50 values below 35 μM and 50 nM, resp., while two nitroxoline derivatives inhibited DNase I and Cat B endopeptidase activity with IC50 values below 60 and 20 μM. Selected derivatives were screened for various co-target binding affinities at dopamine D2 and D3, histamine H3 and H4 receptors and inhibition of 5-lipoxygenase. Compound 8 bound to the H3 receptor and is highlighted as the most promising multifunctional ligand with a favorable pharmacokinetic profile and one of the most potent non-peptide DNase I inhibitors. The present study demonstrates that 8-hydroxyquinoline is a structural fragment critical for DNase I inhibition in the presented series of compounds

ChemMedChem published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Seok Hee published the artcilePLGA Microsphere Addition to 1-Hydroxy-2-naphthoic Acid Enhances the Sustained Release of Escitalopram, Related Products of alcohols-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2019), 40(8), 791-795, database is CAplus.

Escitalopram (ET), a selective serotonin reuptake inhibitor, has been utilized for the treatment of depression and anxiety.However, ET has serious side effects such as nausea, leading to an increased therapeutic dose, needing multiple administrations.Therefore, to overcome these issues, we developed ET encapsulated poly (d,l-lactic-co-glycolic acid) (PLGA) microspheres (PLGA-MS) as a sustained release carrier to maintain therapeutic efficacy.The mean particle size of the PLGA-MSs was measured by microscopy.Loading efficiency was measured by high performance liquid chromatog. (HPLC). Morphologies were determined by microscopy and SEM (SEM).Differential scanning calorimetry (DSC) was used for thermal anal. and glass transition temperature determinationMean particle size of the ET-loaded PLGA-MSs was 129 ± 14μm, loading efficiency was 36.8 ± 9.1%, and encapsulation efficiency was up to 70.6 ± 6.8%.Loading efficiency and encapsulation efficiency were increased by the addition of 1-hydroxy-2-naphthoic acid (HNA).ET was released from PLGA-MS for 4 wk, which was longer than ET release from PLGA-MS without the addition of HNA.Taken together, we demonstrate the optimum condition for sustained release of ET from PLGA-MS with the addition of HNA, and that this approach may be useful for depression therapy.

Bulletin of the Korean Chemical Society published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lhotska, Ivona published the artcilePreparation of citrinin-selective molecularly imprinted polymer and its use for on-line solid-phase extraction coupled to liquid chromatography, Quality Control of 86-48-6, the publication is Analytical and Bioanalytical Chemistry (2019), 411(11), 2395-2404, database is CAplus and MEDLINE.

A new selective molecularly imprinted polymer has been prepared and used for extraction in online SPE-HPLC to achieve the selective determination of citrinin. Four different imprinted polymers varying in combinations of components were prepared by bulk polymerization and evaluated in terms of binding capacity and selectivity. Imprinted polymer prepared from a mixture comprising 1-hydoxy-2-naphtoic acid as the template mol., acrylamide as the structural monomer, ethylene dimethacrylate as the cross-linker (in a molar ratio of 1:4:16), and acetonitrile as the porogenic solvent exhibited the best properties. The selectivity of this sorbent was confirmed by comparison with the non-imprinted counterpart prepared using the same polymerization carried out in the absence of template. Imprinted polymer was packed in a 20 × 3 mm i.d. steel cartridge and coupled to the online SPE-HPLC system through a six-port switching valve. The method for determination of citrinin including the online extraction step was then developed and validated. The sample in the form of methanolic extract was loaded, cleaned, and preconcd. in the imprinted SPE cartridge. Subsequent separation of citrinin from residual interferences was achieved using the anal. column Kinetex Biphenyl 100 × 4.6 mm i.d., 5 μm particle size, and fluorescence detection (Ex 335, Em 500 nm). The total anal. time was only 9.50 min. Our fully validated method was also applied to anal. of food supplements based on red yeast rice extracts, the control of which is implemented in European legislation. Only minor yet acceptable contamination was found in tested samples.

Analytical and Bioanalytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mori, Jiro F. published the artcileMultispecies diesel fuel biodegradation and niche formation are ignited by pioneer hydrocarbon-utilizing proteobacteria in a soil bacterial consortium, Quality Control of 86-48-6, the publication is Applied and Environmental Microbiology (2021), 87(1), e02268, database is CAplus and MEDLINE.

A soil bacterial consortium that was grown on diesel fuel and consisted of more than 10 members from different genera was maintained through repetitive subculturing and was utilized as a practical model to investigate a bacterial community that was continuously exposed to petroleum hydrocarbons. Through metagenomics analyses, consortium member isolation, growth assays, and metabolite identification which supported the linkage of genomic data and functionality, two pioneering genera, Sphingobium and Pseudomonas, whose catabolic capabilities were differentiated, were found to be responsible for the creation of specialized ecol. niches that were apparently occupied by other bacterial members for survival within the consortium. Coexisting genera Achromobacter and Cupriavidus maintained their existence in the consortium through metabolic dependencies by utilizing hydrocarbon biotransformation products of pioneer metabolism, which was confirmed through growth tests and identification of biotransformation products of the isolated strains. Pioneering Sphingobium and Pseudomonas spp. utilized relatively water-insoluble hydrocarbon parent compounds and facilitated the development of a consortium community structure that resulted in the creation of niches in response to diesel fuel exposure which were created through the production of more-water-soluble biotransformation products available to cocolonizers. That these and other organisms were still present in the consortium after multiple transfers spanning 15 years provided evidence for these ecol. niches. Member survival through occupation of these niches led to robustness of each group within the multispecies bacterial community. Overall, these results contribute to our understanding of the complex ecol. relationships that may evolve during prokaryotic hydrocarbon pollutant biodegradation

Applied and Environmental Microbiology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jagia, Moksh published the artcileNovel Co-crystals and Eutectics of Febuxostat: Characterization, Mechanism of Formation, and Improved Dissolution, Category: alcohols-buliding-blocks, the publication is AAPS PharmSciTech (2022), 23(1), 43, database is CAplus and MEDLINE.

Co-crystallization studies were undertaken to improve the solubility of a highly water-insoluble drug febuxostat (FXT), used in the treatment of gout and hyperuricemia. The selection of co-crystal former (CCF) mols. such as 1-hydroxy 2-naphthoic acid (1H-2NPH), 4-hydroxy benzoic acid (4-HBA), salicylic acid (SAC), 5-nitro isophthalic acid (5-NPH), isonicotinamide (ISNCT), and picolinamide (PICO) was based on the presence of complementary functional groups capable of forming hydrogen bond and the ΔpKa difference between FXT and CCF. A liquid-assisted grinding (LAG) method was successfully employed for the rapid screening of various pharmaceutical adducts. These adducts were characterized based on their unique thermal (differential scanning calorimetry) and spectroscopic (Fourier transform IR and Raman spectroscopy) profiles. Binary phase diagrams (BPD) were plotted to establish a relationship between the thermal events and adduct formed. Powder X-ray diffraction (PXRD) studies were carried out to confirm the formation of eutectic/co-crystal. Thermogravimetric anal. (TGA) was also performed for the novel co-crystals obtained. The propensity for strong homo-synthons over weak hetero-synthons and strong hetero-synthons over weak homo-synthons during supramol. growth resulted in the formation of eutectics and co-crystals resp. FXT:1H-2NPH (1), FXT:4-HBA (1), FXT:SAC (1, 2), and FXT:5-NPH (2-1) gave rise to pure eutectic systems, while FXT:ISNCT (2-1) and FXT:PICO (1) gave rise to novel co-crystals with characteristic DSC heating curves and PXRD pattern. Addnl., the impact of microenvironmental pH and microspeciation profile on the improved dissolution profile of the co-crystals was discussed.

AAPS PharmSciTech published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Weihua published the artcileDegradation of phenanthrene by consortium 5H under hypersaline conditions, Product Details of C11H8O3, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119730, database is CAplus and MEDLINE.

PAHs have been widely detected to accumulate in saline and hypersaline environments. Moderately halophilic microbes are considered the most suitable player for the elimination of PAHs in such environments. In this study, consortium 5H was enriched under 5% salinity and completely degraded phenanthrene in 5 days. By high-throughput sequencing, consortium 5H was identified as being mainly composed of Methylophaga, Marinobacter and Thalassospira. Combined with the investigation of intermediates and enzymic activities, the degradation pathway of consortium 5H on phenanthrene was proposed. Consortium 5H was identified as having the ability to tolerate a wide range of salinities (1%-10%) and initial PAH concentrations (50 mg/L to 400 mg/L). It was also able to function under neutral to weak alk. conditions (pH from 6 to 9) and the phytotoxicity of the produced intermediates showed no significant difference with distilled water. Furthermore, the metagenome of consortium 5H was measured and analyzed, which showed a great abundance of catabolic genes contained in consortium 5H. This study expanded the knowledge of PAH-degradation under hypersaline environments and consortium 5H was proposed to have good potential for the elimination of PAH pollution in saline/hypersaline environments.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Oudat, Buthina A. published the artcileDesign, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents, HPLC of Formula: 86-48-6, the publication is Bioorganic & Medicinal Chemistry (2020), 28(16), 115608, database is CAplus and MEDLINE.

The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover competitive inhibitors of Glo-I as potential anticancer agents. Herein, the synthesis of a series of diazenylbenzenesulfonamide derivatives 3-R-4-R¹-C₆H₃N=NR² (R = H, sulfamoyl, carboxy; R¹ = H, Me, carboxy, sulfo; R² = 4-amino-6-hydroxynaphthalen-1-yl, 8-hydroxyquinolin-5-yl, 4-hydroxyphenyl, etc.) and their in vitro evaluation against Glo-I and the resulting structure-activity relationships were reported. Among the compounds tested, compounds 3-R-4-R¹-C₆H₃N=NR² (R = sulfamoyl, R¹ = Me, R² = 8-hydroxyquinolin-5-yl) and (R = sulfamoyl, R¹ = Me, R² = 3-carboxy-4-hydroxynaphthalen-1-yl) exhibited the highest activity with IC₅₀ 1.28μM and 1.13μM, resp. Docking studies to explore the binding mode of the compounds identified the key moieties that may contribute to the observed activities. The active compounds will serve as suitable leads for further chem. optimization.

Bioorganic & Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vana, Lubomir published the artcileSynthesis of Aza[n]helicenes (n = 4-7) via Photocyclodehydrochlorination of 1-Chloro-N-aryl-2-naphthamides, Quality Control of 86-48-6, the publication is Journal of Organic Chemistry (2022), 87(11), 7150-7166, database is CAplus and MEDLINE.

A series of 5-aza[4]helicene, e.g., I was synthesized using a photocyclodehydrochlorination of 1-chloro-N-aryl-2-naphthamides, e.g., 1-chloro-N-phenyl-2-naphthamide as a general synthetic procedure introducing the nitrogen atom to the third ring of the helicene framework. The effect of the nitrogen presence in the helicene skeleton on the physicochem. properties of the prepared 5-aza[4]helicene was studied and compared to those of the parent carbo-analogs. The insertion of a nitrogen atom into the outer edge of the helicene mol. has a severe impact on certain physicochem. properties such as optical rotation, electrostatic potentials, and intermol. interactions. On the other hand, some other properties such as UV/vis, fluorescence, and phosphorescence spectra remained almost unaffected when compared to the parent carbohelicenes. A nitrogen atom can be also used for further derivatization, which can lead to further modification of helicene properties, as manifested here in the fluorescence changes induced by protonation.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C10H9ClN2O, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts