Category: 86-48-6

Zhao, Xin-qi published the artcileNon targeted metabonomics analysis of small molecular substances in fermented cereal drinks, Computed Properties of 86-48-6, the publication is Xiandai Shipin Keji (2021), 37(10), 96-102, 18, database is CAplus.

Millet, glutinous rice and other cereals were used as main raw materials. Two probiotics, L. paracasei L1 and L. casei YQ336, isolated from naturally fermented sweet potato sour liquid and tofu sour liquid were used as fermentation bacteria. Non targeted metabonomics technol. was used to analyze the differences of small mol. substances in cereal drinks before and after fermentation Through principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA), it was found that there were 25 categories and 145 differential metabolites with significant changes (VIP>1 and p<0.05) in beverages before and after fermentation, mainly including 34 organic acids and their derivatives, 21 flavonoids, 20 sugars and their derivatives, 16 alkaloids, 10 nucleotides and their derivatives 10 amino acids and their derivatives The bioactive substances with significantly increased content after fermentation include 36668 times of 1-hydroxy-2-naphthoic acid, 1000 times of dihydroresveratrol, 800 times of 2-hydroxyvaleric acid, 517 times of daidzein, 488 times of vitexin, 238 times of apigenin, 148 times of isoerucic acid, 130 times of genistein, etc. The anal. of KEGG metabolic pathway showed that there were 19 metabolic pathways with significant differences. It is speculated that grain substrate may have certain effects on the synthesis and accumulation of secondary metabolism of L. paracasei L1 and L. casei YQ336. This study will lay a theor. foundation for the fermentation of plant matrix food by lactic acid bacteria and the metabolic mechanism of plant matrix.

Xiandai Shipin Keji published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C6H8N2, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Chunyang published the artcilePharmaceutical Cocrystals of Nicorandil with Enhanced Chemical Stability and Sustained Release, Synthetic Route of 86-48-6, the publication is Crystal Growth & Design (2020), 20(10), 6995-7005, database is CAplus.

Nicorandil (NCD) is a chem. unstable drug and sensitive to humidity, heat, and mech. stress in manufacturing processes. In this work, the cocrystals of NCD with organic acids were designed and synthesized to enhance the stability of NCD. Cocrystals of NCD with 1-hydroxy-2-naphthoic acid, salicylic acid, 3-hydroxybenzoic acid, and 2,5-dihydroxybenzoic acid were obtained. Hydrothermal stability study showed that cocrystals performed with remarkable stability advantages compared with pure NCD. On the basis of mechanism research, the stability improvements of NCD mols. can be attributed to the realignments of NCD mols. in cocrystals. After the formation of cocrystals, the novel packing styles of NCD break the self-catalyzed decomposition process in pure NCD structure. Moreover, intrinsic dissolution rate characterizations showed that the formation of cocrystals could also optimize the dissolution behavior of NCD to realize the objective of sustained release. The novel cocrystals stabilize nicorandil at mol. levels through lengthening the distances between N1 and C8 of adjacent mols.

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Synthetic Route of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jaskowska, Jolanta published the artcileNew pharmaceutical salts of trazodone, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Molecules (2021), 26(3), 769, database is CAplus and MEDLINE.

New pharmaceutically acceptable salts of trazodone (trazodone hydrogen bromide and trazodone 1-hydroxy-2-naphthonic acid) for the treatment of central nervous system disorders are synthesized and described. Although trazodone salts are poorly crystalline, single-crystal X-ray diffraction data for trazodone 1-hydroxy-2-naphthonic acid were collected and analyzed as well as compared to the previously described crystal structure of com. available trazodone hydrochloride. The powder samples of all new salts were characterized by Fourier transform IR spectroscopy, X-ray diffraction and ¹³C solid-state NMR spectroscopy. Spectroscopic studies were supported by gauge including projector augmented wave (GIPAW) calculations of carbon chem. shielding constants The main goal of our research was to find salts with better physicochem. properties and to make an attempt to associate them with both the anion structure and the most prominent interactions exhibited by the protonated trazodone cation. The dissolution profiles of trazodone from tablets prepared from various salts with lactose monohydrate were investigated. The studies revealed that salts with simple anions show a fast release of the drug while the presence of more complex anion, more strongly interacting with the cation, effects a slow-release profile of the active substance and can be used for the preparation of the tables with a delay or prolonged mode of action.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Meng published the artcileEffect of hydroxypropyl-β-cyclodextrin on the cometabolism of phenol and phenanthrene by a novel Chryseobacterium sp., Application of 1-Hydroxy-2-naphthoic acid, the publication is Bioresource Technology (2019), 56-62, database is CAplus and MEDLINE.

Cometabolic degradation is an effective method to remove the polycyclic aromatic hydrocarbons (PAHs) with phenol as growth substrate from coal chem. wastewater (CCW). Unfortunately, the toxicity and low solubility of PAHs always restrict their degradation In this study, Chryseobacterium sp. H202 was firstly isolated from the aerobic segment of CCW. Then, to improve the cometabolic degradation of PAHs, the effects of hydroxypropyl-β-cyclodextrin (HPCD) were investigated. Phenanthrene removal was accelerated in the presence of phenol; however, the degradation of phenol was inhibited because of the toxicity of phenanthrene. Addition of 50 mg/L HPCD accelerated the degradation of phenol and effectively improved the phenanthrene removal rate by about 55%. Inclusion of HPCD appeared to increase the apparent solubility and reduce the toxicity of phenanthrene, thereby improving the cometabolic degradation of phenol and phenanthrene. Therefore, HPCD can enhance the degradation of phenanthrene with phenol as the growth substrate during CCW treatment.

Bioresource Technology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C4H6N2, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shamim, Khalida published the artcileApplication of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection, Quality Control of 86-48-6, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127906, database is CAplus and MEDLINE.

Zika virus has emerged as a potential threat to human health globally. A previous drug repurposing screen identified the approved anthelminthic drug niclosamide as a small mol. inhibitor of Zika virus infection. However, as antihelminthic drugs are generally designed to have low absorption when dosed orally, the very limited bioavailability of niclosamide will likely hinder its potential direct repurposing as an antiviral medication. Here, we conducted SAR studies focusing on the anilide and salicylic acid regions of niclosamide to improve physicochem. properties such as microsomal metabolic stability, permeability and solubility We found that the 5-bromo substitution in the salicylic acid region retains potency while providing better drug-like properties. Other modifications in the anilide region with 2′-OMe and 2′-H substitutions were also advantageous. We found that the 4′-NO₂ substituent can be replaced with a 4′-CN or 4′-CF₃ substituents. Together, these modifications provide a basis for optimizing the structure of niclosamide to improve systemic exposure for application of niclosamide analogs as drug lead candidates for treating Zika and other viral infections. Indeed, key analogs were also able to rescue cells from the cytopathic effect of SARS-CoV-2 infection, indicating relevance for therapeutic strategies targeting the COVID-19 pandemic.

Bioorganic & Medicinal Chemistry Letters published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C10H11ClO2S, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Ke published the artcileTranscriptional response of Mycobacterium sp. strain A1-PYR to multiple polycyclic aromatic hydrocarbon contaminations, Related Products of alcohols-buliding-blocks, the publication is Environmental Pollution (Oxford, United Kingdom) (2018), 243(Part_B), 824-832, database is CAplus and MEDLINE.

Cometabolism mechanisms of organic pollutants in environmental microbes have not been fully understood. In this study, a global anal. of Mycobacterium sp. strain A1-PYR transcriptomes on different PAH substrates (single or binary of pyrene (PYR) and phenanthrene (PHE)) was conducted. Comparative results demonstrated that expression levels of 23 PAH degradation enzymes were significantly higher in the binary substrate than in the PYR-only one. These enzymes constituted an integrated enzymic system to actualize all transformation steps of PYR, and most of their encoded genes formed a novel gene cascade in the genome of strain A1-PYR. The roles of different genotypes of enzymes in PYR cometabolism were also discriminated even though all of their gene sequences were presented in the genome of this strain. NidAB and PdoA2B2 instead of NidA3B3 served the initial oxidization of PAHs, and PcaL replaced PcaCD to catalyze the formation of 3-oxoadipate. Novel genes associated with PYR cometabolism was also predicted by the relationships between their transcription profiles and PYR removal. The results showed that ABC-type transporters probably played important roles in the transport of PAHs and their metabolites through cell membrane, and [4Fe-4S] ferredoxin might be essential for dioxygenases (NidAB and PdoA2B2) to achieve oxidative activities. This study provided mol. insight in that microbial degrader subtly cometabolized recalcitrant PAHs with relatively more degradable ones.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H14, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maciag, Monika published the artcileEvaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish, Computed Properties of 86-48-6, the publication is Toxicology and Applied Pharmacology (2022), 115812, database is CAplus and MEDLINE.

Cardiovascular toxicity represents one of the most common reasons for clin. trial failure. Consequently, early identification of novel cardioprotective strategies could prevent the later-stage drug-induced cardiac side effects. The use of zebrafish (Danio rerio) in preclin. studies has greatly increased. High-throughput and low-cost of assays make zebrafish model ideal for initial drug discovery. A common strategy to induce heart failure is a chronic β-adrenergic (βAR) stimulation. Herein, we set out to test a panel of βAR agonists to develop a pharmacol. heart failure model in zebrafish. We assessed βAR agonists with respect to the elicited mortality, changes in heart rate, and morphol. alterations in zebrafish larvae according to Fish Embryo Acute Toxicity Test. Among the tested βAR agonists, epinephrine elicited the most potent onset of heart stimulation (EC50 = 0.05 mM), which corresponds with its physiol. role as catecholamine. However, when used at ten-fold higher dose (0.5 mM), the same compound caused severe heart rate inhibition (-28.70 beats/min), which can be attributed to its cardiotoxicity. Further studies revealed that isoetharine abolished body pigmentation at the sublethal dose of 7.50 mM. Addnl., as a proof of concept that zebrafish can mimic human cardiac physiol., we tested βAR antagonists (propranolol, carvedilol, metoprolol, and labetalol) and verified that they inhibited fish heart rate in a similar fashion as in humans. In conclusion, we proposed two novel pharmacol. models in zebrafish; i.e., epinephrine-dependent heart failure and isoetharine-dependent transparent zebrafish. We provided strong evidence that the zebrafish model constitutes a valuable tool for cardiovascular research.

Toxicology and Applied Pharmacology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bai, Xinxin published the artcileRemediation of phenanthrene contaminated soil by coupling soil washing with Tween 80, oxidation using the UV/S₂O₈^2- process and recycling of the surfactant, Application of 1-Hydroxy-2-naphthoic acid, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2019), 1014-1023, database is CAplus.

Surfactant-enhanced soil washing was applied to phenanthrene (PHE)-polluted soil, followed by a sulfate radical-based advanced oxidation process. Soil washing experiments were conducted using the nonionic surfactant Tween 80 (TW 80), assessing the effect of washing temperature, TW 80 concentration, and liquid:soil ratio on PHE removal. Maximum PHE removal (90.0%) was achieved with 15 g/L TW 80 and a 10:1 (mL/g) liquid:soil ratio at 20°. A UV/S₂O₈^2- process was used to selectively oxidize PHE in the effluent and recover TW 80. The regenerated effluent was re-used for soil washing; results showed PHE removal efficiency was nearly the same as with fresh surfactant solution The UV/S₂O₈^2- oxidation reaction was also assessed, including possible intermediate products detection by liquid chromatog./mass spectrometry; a corresponding degradative pathway of target pollutants was proposed. Overall result indicated toil washing with TW 80 and subsequent selective UV/S₂O₈^2- oxidation may provide a potential option to remediate polycyclic aromatic hydrocarbon-polluted soil.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xue-Zhen published the artcileSynthesis, Structures, and Fluorescence Properties of Dimeric Aluminum Oxo Clusters, COA of Formula: C11H8O3, the publication is Inorganic Chemistry (2021), 60(10), 7089-7093, database is CAplus and MEDLINE.

Aluminum is an important component for luminescence. However, the fluorescent aluminum complex with unambiguous structural information is still limited. Herein, we report a series of fluorescence aluminum oxo clusters (AlOCs). By introducing an addnl. coordination site to the aromatic conjugation ligand, cluster nuclearity increment and fluorescence variation are observed Al₈(OH)₂(μ₄-O)₂(1-NA)₂(OEt)₁₆ (AlOC-41, 1-NA = 1-naphthoic acid, OEt = ethanol) is made up of two tetrahedral subunits. By introducing an addnl. coordination site to the aromatic conjugation ligand, we isolate a high nuclearity compound Al₁₀(μ₃-O)₂(3-HNA)₂(OEt)₂₂ (AlOC-47, 3-HNA = 3-hydroxy-2-naphthoic acid). Correspondingly, their luminescence performance is different (blue fluorescence in AlOC-41 and green in AlOC-47). Present herein is a platform to illustrate the relationship between synthesis, structure, and fluorescence properties.

Inorganic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C23H43NP2, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tao, Xueqin published the artcileInteractions between polycyclic aromatic hydrocarbons (PAHs)-degrading strain Sphingomonas sp. GY2B and nano bamboo charcoal, Formula: C11H8O3, the publication is Desalination and Water Treatment (2021), 221-228, database is CAplus.

As the global consumption of engineered nanomaterials such as nano bamboo charcoal (NBC) steadily increases, so does the potential for their release into the environment through human activity. In this study, the aggregation and dispersion of NBC, and its effect on GY2B, a polycyclic aromatic hydrocarbons (PAHs)-degrading strain of Sphingomonas sp., were investigated. Results showed that NBC aggregation was affected by both its concentration and GY2B, while the zeta potential of NBC was mainly influenced by GY2B and less so by its concentration With the addition of NBC, the biodegradation rate of phenanthrene was enhanced while GY2B growth was inhibited initially, however, cell growth inhibition was attenuated and eliminated with NBC aggregation and sedimentation which adsorbed toxic metabolites, such as 1-hydroxy-2-naphthoic acid, eventually resulting in more favorable conditions. This work indicates that NBC has the potential to be used in environmental remediation.

Desalination and Water Treatment published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C28H29NO4, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts