Category: 85618-21-9

Ge, Jun published the artcileSustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide, Related Products of alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(47), 9034-9036, database is CAplus and MEDLINE.

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO₂. The microemulsion consists of a tRNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wolfe, Aaron J. published the artcileInterrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy, Safety of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(15), 8013-8020, database is CAplus and MEDLINE.

Understanding how membrane proteins interact with detergents is of fundamental and practical significance in structural and chem. biol. as well as in nanobiotechnol. Current methods for inspecting protein-detergent complex (PDC) interfaces require high concentrations of protein and are of low throughput. Here, the authors describe a scalable, spectroscopic approach that uses nanomolar protein concentrations in native solutions This approach, which is based on steady-state fluorescence polarization (FP) spectroscopy, kinetically resolves the dissociation of detergents from membrane proteins and protein unfolding. For satisfactorily solubilizing detergents, at concentrations much greater than the critical micelle concentration (CMC), the fluorescence anisotropy was independent of detergent concentration In contrast, at detergent concentrations comparable with or below the CMC, the anisotropy readout underwent a time-dependent decrease, showing a specific and sensitive protein unfolding signature. Functionally reconstituted membrane proteins into a bilayer membrane confirmed predictions made by these FP-based determinations with respect to varying refolding conditions. From a practical point of view, this 96-well anal. approach will facilitate a massively parallel assessment of the PDC interfacial interactions under a fairly broad range of micellar and environmental conditions. The authors expect that these studies will potentially accelerate research in membrane proteins pertaining to their extraction, solubilization, stabilization, and crystallization, as well as reconstitution into bilayer membranes.

Analytical Chemistry (Washington, DC, United States) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C18H24N6O6S4, Safety of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Molina-Bolivar, J. A. published the artcileEffect of NaCl on the Self-Aggregation of n-Octyl β-D-Thioglucopyranoside in Aqueous Medium, Product Details of C14H28O5S, the publication is Journal of Physical Chemistry B (2006), 110(24), 12089-12095, database is CAplus and MEDLINE.

This report investigates the effect of sodium chloride (NaCl) on the micellization, surface activity, and the evolution in the shape and size of n-octyl β-D-thioglucopyranoside (OTG) aggregates. By using surface tension measurements, information was obtained on both changes in the critical micelle concentration and adsorption behavior in the air-liquid interface with the electrolyte concentration These data were used to obtain the thermodn. properties of micellization along with the corresponding adsorption parameters in the air-liquid interface. From extended static and dynamic light scattering measurements, the micelle mol. weight, the mean aggregation number, and the second virial coefficient, the apparent diffusion coefficient and the mean hydrodynamic radius of micelles in a range of NaCl concentrations were obtained. The light scattering data have shown that when the surfactant concentration is lower to 4.5 g/L, only spherical micelles are formed. However, an increase in the surfactant concentration induces an increase in micellar size, suggesting a rodlike growth of the micelles. This deviation of micelle geometry from spherical to rodlike is supported both by the ratio between the hydrodynamic radius and the radius of gyration and by the angular dependence of light scattering. On the other hand, the studies performed in the presence of high NaCl concentration (0.2 and 0.5 M) provide strong support for the view that the micelles may overlap together to form an entangled network above certain crossover concentration

Journal of Physical Chemistry B published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Product Details of C14H28O5S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ruiz, C. Carnero published the artcileInteraction between n-octyl-β-D-thioglucopyranoside and bovine serum albumin, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Open Macromolecules Journal (2008), 6-18, database is CAplus.

The binding of the nonionic surfactant n-octyl-β-D-thioglucopyranoside (OTG) to the globular protein bovine serum albumin (BSA) has been investigated by using exptl. techniques such as surface tension, steady-state fluorescence and dynamic light scattering. It was observed that the surfactant micellization is delayed in the presence of protein; this was interpreted as a consequence of the fact that part of the surfactant is not available for the formation of micelles, because it is partitioned into the protein hydrophobic sites. This was taken as an evidence of the interaction between surfactant and protein. The fluorescence emission spectra of intrinsic tryptophans revealed that the protein is partially denatured in the presence of high surfactant concentrations The anal. of the binding features as obtained by two different methods, (i) one based on surface tension measurements, and (ii) another based on the behavior of the intrinsic BSA fluorescence, indicated that the binding process is non-cooperative at low surfactant concentration, but becomes cooperative when it is high enough. The reduction of the average aggregation number in the presence of protein interpreted as a sign of the formation of clusters of surfactant adsorbed on the protein surface. A slight conformational change in the protein structure at low surfactant concentration was revealed by resonance energy transfer from tryptophan residues to 8-anilinonaphthalene-1-sulfonate. A treatment of the autocorrelation functions as obtained by dynamic light scattering measurements, based on the application of appropriate fitting techniques, allowed for the discrimination between two kinds of structures in the OTG/BSA system: surfactant-protein complexes, with a “pearl necklace” structure, in equilibrium with the free micelles of OTG.

Open Macromolecules Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Konidala, Praveen published the artcileMolecular dynamics characterization of n-octyl-β-D-glucopyranoside micelle structure in aqueous solution, SDS of cas: 85618-21-9, the publication is Journal of Molecular Graphics & Modelling (2006), 25(1), 77-86, database is CAplus and MEDLINE.

N-Octyl-β-D-glucopyranoside (OG) is a non-ionic glycolipid, which is used widely in biotech. and biochem. applications. All-atom mol. dynamics simulations from two different initial coordinates and velocities in explicit solvent have been performed to characterize the structural behavior of an OG aggregate at equilibrium conditions. Geometric packing properties determined from the simulations and small angle neutron scattering experiment state that OG micelles are more likely to exist in a non-spherical shape, even at the concentration range near to the critical micelle concentration (0.025 M). Despite few large deviations in the principal moment of inertia ratios, the average micelle shape calculated from both simulations is a prolate ellipsoid. The deviations at these time scales are presumably the temporary shape change of a micelle. However, the size of the micelle and the accessible surface areas were constant during the simulations with the micelle surface being rough and partially elongated. Radial distribution functions computed for the hydroxyl oxygen atoms of an OG show sharper peaks at a min. van der Waals contact distance than the acetal oxygen, ring oxygen, and anomeric carbon atoms. This result indicates that these atoms are pointed outwards at the hydrophilic/hydrophobic interface, form hydrogen bonds with the water mols., and thus hydrate the micelle surface effectively.

Journal of Molecular Graphics & Modelling published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Szabo, Lajos Z. published the artcilePreparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis, Category: alcohols-buliding-blocks, the publication is Carbohydrate Research (2016), 1-4, database is CAplus and MEDLINE.

Here we report a method for the preparation of anomerically pure β-S-glycopyranosides (1,2-trans-glycosides) from the corresponding peracetate donors. S-glycosylation was performed in CHCl₃ at reflux in the presence of a catalytic amount of InBr₃. Deacylation of the intermediate peracetates were achieved under Zemplén conditions. Five pyranose examples, monosaccharides D-glucose and D-galactose and disaccharides cellobiose, maltose, and lactose, were used as donors, and five thiols including an α/ω dithiol and Fmoc-L-cysteine were used as acceptors. M.ps., high res MS, [α]_D and NMR data (¹H and ¹³C, including COSY, HSQC and HMBC) are reported for compounds not previously described.

Carbohydrate Research published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H17BF3NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavez, Damien published the artcileMaize black Mexican sweet suspension cultured cells are a convenient tool for studying aquaporin activity and regulation, Synthetic Route of 85618-21-9, the publication is Plant Signaling & Behavior (2009), 4(9), 890-892, database is CAplus and MEDLINE.

Aquaporins (AQPs) are channel proteins that facilitate and regulate the permeation of water across biol. membranes. Black Mexican sweet suspension cultured cells are a convenient model for studying the regulation of maize AQP expression and activity. Among other advantages, a single cell system allows the contribution of plasma membrane AQPs (PIPs, plasma membrane intrinsic proteins) to the membrane water permeability coefficient (P_f) to be determined using biophys. measurement methods, such as the cell pressure probe or protoplast swelling assay. We generated a transgenic cell culture line expressing a tagged version of ZmPIP2;6 and used this material to demonstrate that the ZmPIP2;6 and ZmPIP2;1 isoforms phys. interact. This kind of interaction could be an addnl. mechanism for regulating membrane water permeability by acting on the activity and/or trafficking of PIP hetero-oligomers.

Plant Signaling & Behavior published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van Truong, Thien published the artcilePromoting crystallization of intrinsic membrane proteins with conjugated micelles, SDS of cas: 85618-21-9, the publication is Scientific Reports (2020), 10(1), 12199, database is CAplus and MEDLINE.

A new technique for promoting nucleation and growth of membrane protein (MP) crystals from micellar environments is reported. It relies on the conjugation of micelles that sequester MPs in protein detergent complexes (PDCs). Conjugation via amphiphilic [metal:chelator] complexes presumably takes place at the micelle/water interface, thereby bringing the PDCs into proximity, promoting crystal nucleation and growth. We have successfully applied this approach to two light-driven proton pumps: bacteriorhodopsin (bR) and the recently discovered King Sejong 1-2 (KS1-2), using the amphiphilic 4,4′-dinonyl-2,2′-dipyridyl (Dinonyl) (0.7 mM) chelator in combination with Zn²⁺, Fe²⁺, or Ni²⁺ (0.1 mM). Crystal growth in the presence of the [metal-chelator] complexes leads to purple, hexagonal crystals (50-75μm in size) of bR or pink, rectangular/square crystals (5-15μm) of KS1-2. The effects of divalent cation identity and concentration, chelator structure and concentration, ionic strength and pH on crystal size, morphol. and process kinetics, are described.

Scientific Reports published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capalbi, Antonio published the artcileSolution properties of alkyl glucosides, alkyl thioglucosides and alkyl maltosides, HPLC of Formula: 85618-21-9, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2004), 246(1-3), 99-108, database is CAplus.

Aqueous solutions containing sugar-based surfactants, alkyl glucosides, thioglucosides and maltosides, were studied in a wide concentration range, at different temperatures Colligative properties (f.p. and vapor pressure depression), volumetric, adiabatic compressibility, surface tension and calorimetric methods were used. The results give information on the Gibbs energy of transfer from H₂O to a micellar environment and on other thermodn. contributions to the overall aggregate stability. The thermodn. quantities derived from the above exptl. methods were interpreted by taking into account the role of polar head groups in modulating micelle formation. Use of a mass action approach allows determining micelle aggregation numbers, 〈N〉, from partial molal quantities. The differences between values obtained from calorimetric, colligative, compressibility, surface and volumetric properties were rationalized on proper grounds.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, HPLC of Formula: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Berger, Bryan W. published the artcileRelating surfactant properties to activity and solubilization of the human adenosine A₃ receptor, Synthetic Route of 85618-21-9, the publication is Biophysical Journal (2005), 89(1), 452-464, database is CAplus and MEDLINE.

The effects of various surfactants on the activity and stability of the human adenosine A₃ receptor (A₃) were investigated. The receptor was expressed using stably transfected HEK293 cells at a concentration of 44 pmol functional receptor per mg membrane protein and purified using over 50 different nonionic surfactants. A strong correlation was observed between a surfactant’s ability to remove A₃ from the membrane and the ability of the surfactant to remove A₃ selectively relative to other membrane proteins. The activity of A₃ once purified also correlates well with the selectivity of the surfactant used. The effects of varying the surfactant were much stronger than those achieved by including A₃ ligands in the purification scheme. Notably, all surfactants that gave high efficiency, selectivity and activity fall within a narrow range of hydrophile-lipophile balance values. This effect may reflect the ability of the surfactant to pack effectively at the hydrophobic transmembrane interface. These findings emphasize the importance of identifying appropriate surfactants for a particular membrane protein, and offer promise for the development of rapid, efficient, and systematic methods to facilitate membrane protein purification

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts