Category: 813-99-0

Application of 813-99-0 ,Some common heterocyclic compound, 813-99-0, molecular formula is C5H9Cl3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 46; Preparation of 8-[4-(Difluoromethoxy)phenyl]-8-[3-(2-fluoropyridin-3-yl)phenyl]-2,8-dihydrospiro[imidazo[1,5-a]pyrimidine-3,3′-oxetan]-6-amine; Step a) Preparation of Compound 2; A mixture of 1 (1.0 g, 5.22 mmol) and potassium hydroxide (0.345 g of 85%, 5.22 mmol) in ethanol (2 mL) was heated at reflux for 3 h. The reaction was cooled to room temperature, diluted with ethyl acetate (10 mL) and the solids that formed removed by filtration. The filtrate was concentrated to afford 2 (0.65 g, 80%) as a colorless liquid: 1H NMR (300 MHz, CDCl3) delta 4.47 (s, 4H), 3.95 (s, 4H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 813-99-0, 3-Chloro-2,2-bis(chloromethyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wyeth; US2005/282826; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

3-Chloro-2,2-bis (chloromethyl) propan-1-ol (15.4 g, 80.4 mmol) obtained in the above step 1 was dissolved in 98% ethanol (28 ml) and potassium hydroxide (5.0 g, mmol) was added, and the mixture was heated and refluxed for 30 minutes.The reaction solution was cooled with ice water and stirred for 10 minutes. The resulting solid was filtered off,The pH was adjusted to 7.5 with 2N aqueous hydrochloric acid solution. After removing the solvent by distillation under reduced pressure, water (100 ml) was added to the residue and extracted twice with ethyl acetate (150 ml). The obtained organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 4: 1) to obtain pure 3,3-bis (chloromethyl) oxetane (9.2 g, 74%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 813-99-0, 3-Chloro-2,2-bis(chloromethyl)propan-1-ol.

Reference:
Patent; Korea Research Institute of Chemical Technology; Eseuti Pam Co., Ltd.; Kim Bong-jin; Kim Jae-hak; Lee Il-yeong; Lee Sang-ho; Lee Jong-gyo; Kim Gyeong-jin; Kim Uk-il; Nam Hwa-jeong; (56 pag.)KR101592370; (2016); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 813-99-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol, molecular formula is C5H9Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The product from the previous step (0.66 g, 1.25 mmol) was dissolved in dichloromethane (30 mL). Then 3-chloro-2,2-di(chloromethyl)propane-1-ol(0.24 g, 1.25 mmol) and DMAP (catalytic amount) were added. The reactantswere cooled to 0 C. EDAC (0.24 g, 1.25 mmol) was then added. The reactant was stirred at room temperature for 24h, and distilled under reduced pressure. The residue was purified by silica gel column chromatography (gradient elutionwith eluent: N-hexane/ethyl acetate) to give 3-chloro-2,2-di(chloromethyl)propyl 4-(2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-2,6-dimethyl-phenoxy] butyl)-4-oxo-2-acetamino-butyrate (0.57 g, yield 65%).

According to the analysis of related databases, 813-99-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd; Shanghai Synergy Pharmaceutical Sciences Co., Ltd; GE, Jian; LI, Yunfei; ZHANG, Zhen; WANG, Yijin; WANG, Jiamiao; CHENG, Tao; (57 pag.)EP3348548; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts