Category: 81156-68-5

Electric Literature of 81156-68-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81156-68-5, name is 2,4-Dichlorophenethyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

(ii) 3-[2-(2,4-Dichlorophenyl)-Ethoxy]-4-Ethoxy-Benzoic Acid Ethyl Ester 0.5 g (2.38 mmol) of 4-Ethoxy-3-hydroxy-benzoic acid ethyl ester was dissolved in 10 ml of anhydrous tetrahydrofuran. To this solution was added 0.5 g (2.62 mmol) of 2-(2,4-Dichlorophenyl)-ethanol, 2.38 g (equivalent to 7.13 mmol PPh3) of triphenylphosphine derivatized polystyrene and 1.24 g (7.13 mmol) of DEAD. The solution was shaken for 16 h at RT. The polymer was filtered off and washed with ethyl acetate. The solvent was removed under reduced pressure. The residue was taken-up in ethyl acetate and the solution was washed three times with water and twice with saturated aqueous sodium chloride. The organic phase was dried with magnesium sulphate, filtered and the solvent was removed under reduced pressure. The residue was chromatographed on silica gel eluding with ethyl acetate/n-heptane (1/4).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 81156-68-5, 2,4-Dichlorophenethyl alcohol.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81156-68-5, name is 2,4-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.Recommanded Product: 2,4-Dichlorophenethyl alcohol

Example 5 Preparation of methyl 2- [4- (2-F2. 4-DICHLOROPHENYL) ETHOXY) PHENYL- THIO]ISOBUTYRATE (ST2531) The title product was prepared according to the procedure described in Method B starting from methyl 2- (4- hydroxyphenylthio) iso-butyrate (prepared as described in example 3) (0.280 g, 1.24 mmol) and DIAD (0. 325 g, 1.61 mmol) dissolved in 3 mL of anhydrous THF and added dropwise to a solution of 2,4- dichlorophenetylalcohol (0.260 g, 1.36 mmol) and triphenylphosphine (0.422 g, 1.61 mmol) in 4 mL of anhydrous THF at 0C. The reaction was left overnight under magnetic stirring at room temperature After this period, the solvent was evaporated and the residue purified by silica gel chromatography using HEXANE/ACOET 9.6/0. 4 as eluent. 0.346 g of product were obtained (yield: 70%); Mp: 73-74C ; TLC: silica gel, eluent hexane/AcOEt 9/1, Fr: 0.26 ; 1H NMR (CDCIs, 300 MHz) B : 7.35 (m, 3H), 7.22 (m, 2H), 6.83 (d, 2H), 4.18 (t, 2H), 3.65 (s, 3H), 3.20 (t, 2H), 1.45 (s, 6H); HPLC: Column: Inertisil ODS-3 (5, UM) 4.6 x 250 mm, T: room temperature, mobile phase CH3CN/H20 85/15 (v/v), pH: as is, flow rate: 1 mL/min, 205 nm UV detector, retention time 12.58 min; KF: 0.4 % H20 ; E. A. conforming for CL9H20CL203S.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,81156-68-5, 2,4-Dichlorophenethyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.; WO2004/56355; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81156-68-5, name is 2,4-Dichlorophenethyl alcohol. A new synthetic method of this compound is introduced below., name: 2,4-Dichlorophenethyl alcohol

(i) Toluene-4-sulfonic acid 2-(2,4-dichloro-phenyl)-ethyl ester This compound was prepared using a procedure analogous to that described for the preparation of Example 169 (i), using 2-(2,4-dichloro-phenyl)-ethanol as the starting material. The compound was recrystallized from n-heptane/ethyl acetate. Yield: 7.12 g MS (Cl+): m/e=345, chloro pattern.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 81156-68-5, 2,4-Dichlorophenethyl alcohol.

Reference:
Patent; Nazare, Marc; Essrich, Melanie; Will, David William; Matter, Hans; Ritter, Kurt; Wehner, Volkmar; US2003/199689; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 81156-68-5, Adding some certain compound to certain chemical reactions, such as: 81156-68-5, name is 2,4-Dichlorophenethyl alcohol,molecular formula is C8H8Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81156-68-5.

(ii) 5-[2-(2,4-Dichloro-Phenyl)-Ethoxy]-1-Oxy-Nicotinic Acid Methyl Ester 1.4 g of diphenyl-2-pyridylphosphine and 600 mg 5-Hydroxy-1-oxy-nicotinic acid methyl ester and 0.5 ml 2-(2,4-dichlorophenyl)-ethanol were dissolved in 16 ml of anhydrous THF. The solution was cooled to 0-10 C. and a solution of 1.22 g di-tert-butyl azodicarboxylate in 1 ml anhydrous THF was added dropwise over 20 min. The reaction was warmed to RT and stirred over night. After addition of 14 ml saturated methanolic HCl the reaction mixture was stirred for 1 h and then the solvent was removed under reduced pressure. The residue was dissolved in CH2Cl2 and extracted with half-concentrated hydrochloric acid. The organic layer was evaporated and residue subjected to the subsequent reaction without further purification. Yield: 1.2 g

According to the analysis of related databases, 81156-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 81156-68-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81156-68-5, name is 2,4-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.

(ii) 3-[2-(2,4-Dichlorophenyl)-Ethoxy]-4,5-Dimethoxy-Benzoic Acid 2 g (9.42 mmol) of 3-Hydroxy-4,5-dimethoxy-benzoic acid methyl ester was dissolved in 100 ml of anhydrous tetrahydrofuran. To this solution was added 1.98 g (10.37 mmol) of 2-(2,4-Dichlorophenyl)-ethanol, 9.415 g (equivalent to 28.27 mmol PPh3) of triphenylphosphine derivatized polystyrene and 4.924 g (28.27 mmol) of DEAD. The solution was shaken for 16 h at RT. The polymer was filtered off and washed with ethyl acetate. The solvent was removed under reduced pressure. The residue was taken-up in ethyl acetate and the solution was washed three times with water and twice with saturated aqueous sodium chloride. The organic phase was dried with magnesium sulphate, filtered and the solvent was removed under reduced pressure. The residue was dissolved in 20 ml of dioxan. 1 ml of water was added to the solution followed by 2N aqueous NaOH to give a pH of 13. The reaction solution was heated at 60 C. for 10 hours. The solution was cooled to 0 C., 5 ml water was added, followed by concentrated hydrochloric acid to give a pH of 1 to 2, whereupon the product precipitated from solution. The product was filtered off and dried under reduced pressure.

The chemical industry reduces the impact on the environment during synthesis 81156-68-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 81156-68-5 ,Some common heterocyclic compound, 81156-68-5, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester 1.75 g of triphenylphosphine and 1 g of 5-Hydroxy-isophthalic acid dimethyl ester were dissolved in 17 ml of anhydrous THF. The solution was cooled to 0-10 C. and a solution of 1 ml DEAD in 1 ml anhydrous THF was added dropwise over 20 min. The reaction was warmed to RT and stirred for 45 min. A solution of 11.3 ml 2-(2,4-Dichlorophenyl)-ethanol in 1 ml anhydrous THF was added with cooling. The reaction was stirred at RT for 16 h, then the solvents were removed under reduced pressure. The residue was treated with n-hepane:ethyl acetate/1:1. The filtrate was dried under reduced pressure and the product was purified by silica gel chromatography, eluding with n-heptane:ethyl acetate/4:1 to n-heptane:ethyl acetate/3:1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81156-68-5, its application will become more common.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 81156-68-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81156-68-5, name is 2,4-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.

Example 4 Preparation of methyl 2- [3- (2- (2, 4-dichlorophenyl) ETHOXY) PHENYL- THIOJISOBUTYRATE (ST2534) The title product was prepared according to the procedure described in Method B starting from methyl 2- (3- hydroxyphenylthio) iso-butyrate (prepared as described in example 1) (0.280 g, 1.24 mmol) and DIAD (0.325 g, 1.61 mmol) dissolved in 3 mL of anhydrous THF and added dropwise to a solution of 2,4- dichlorophenetylalcohol (0.260 G, 1.36 mmol), and triphenylphosphine (0.422 g, 1.61 mmol) in 4 mL of anhydrous THF at 0C. The reaction was left overnight under magnetic stirring at room temperature. After this period, the solvent was evaporated and the residue purified by silica gel chromatography using hexane/AcOEt 9.6/0. 4 as eluent. 0.327 g of oily product were obtained (yield: 66 %); TLC: silica gel, eluent hexane/AcOEt 9/1, Fr: 0.34 ; IH NMR (CDC13, 300 MHz) B : 7.40 (d, 1H), 7.20 (m, 3H), 7.00 (m, 2H), 6.90 (dd, 1H), 4.15 (t, 2H), 3.65 (s, 3H), 3.20 (t, 2H), 1.45 (s, 6H); HPLC: Column: Inertisil ODS-3 (5 ZM) 4.6 x 250 mm, T: room temperature, mobile phase CH3CN/H20 90/10 (v/v), pH: as is, flow rate: 0.8 mL/min, 205 nm UV detector, retention time 12.40 min; KF: 0.2 % H20; E. A. conforming for CL9H20CL203S.

The chemical industry reduces the impact on the environment during synthesis 81156-68-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.; WO2004/56355; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts