Category: 80-46-6

Electric Literature of C11H16O《Catalytic and enantioselective bromoetherification of olefinic 1,3-diols: mechanistic insight》 was published in 2016. The authors were Ke, Zhihai;Tan, Chong Kiat;Liu, Yi;Lee, Keefe Guang Zhi;Yeung, Ying-Yeung, and the article was included in《Tetrahedron》. The author mentioned the following in the article:

How can high enantioselectivity be achieved when the racemic background reaction proceeds at a rate comparable to that of the catalytic asym. reaction. We attempted to rationalize this counterintuitive observation by studying the effect of (1) catalyst structure, (2) temperature and addition sequence of components, (3) catalyst loading, and (4) Bronsted acid additives. In the course of our investigation, it was found that increasing the amount of catalyst used led to inhibition of the stoichiometric reaction. Olefinic 1,3-diol 1, 5 mol % of catalyst 3a, 1 equiv of MsOH, and NBS were added at low temperature in a specific sequence to provide the best performance for the enantioselective bromoetherification. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Electric Literature of C11H16O

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Shin, H.-M.;McKone, T. E.;Bennett, D. H. published 《Model framework for integrating multiple exposure pathways to chemicals in household cleaning products》. The research results were published in《Indoor Air》 in 2017.Recommanded Product: 4-tert-Amylphenol The article conveys some information:

We present a screening-level exposure-assessment method which integrates exposure from all plausible exposure pathways as a result of indoor residential use of cleaning products. The exposure pathways we considered are (i) exposure to a user during product use via inhalation and dermal, (ii) exposure to chem. residues left on clothing, (iii) exposure to all occupants from the portion released indoors during use via inhalation and dermal, and (iv) exposure to the general population due to down-the-drain disposal via inhalation and ingestion. We use consumer product volatilization models to account for the chem. fractions volatilized to air (f_volatilized) and disposed down the drain (f_{down-the-drain}) during product use. For each exposure pathway, we use a fate and exposure model to estimate intake rates (iR) in mg/kg/d. Overall, the contribution of the four exposure pathways to the total exposure varies by the type of cleaning activities and with chem. properties. By providing a more comprehensive exposure model and by capturing addnl. exposures from often-overlooked exposure pathways, our method allows us to compare the relative contribution of various exposure routes and could improve high-throughput exposure assessment for chems. in cleaning products.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Recommanded Product: 4-tert-Amylphenol

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Salafranca, Jesus;Clemente, Isabel;Isella, Francesca;Nerin, Cristina;Bosetti, Osvaldo published 《Influence of oxygen and long term storage on the profile of volatile compounds released from polymeric multilayer food contact materials sterilized by gamma irradiation》. The research results were published in《Analytica Chimica Acta》 in 2015.Reference of 4-tert-Amylphenol The article conveys some information:

The profile of volatile compounds released from 13 different multilayer polymeric materials for food use, before and after their exposure to gamma radiation, has been assessed by solid-phase microextraction-gas chromatog.-mass spectrometry. Thermosealed bags of different materials were filled with either air or nitrogen to evaluate the oxygen influence. One-third of the samples were analyzed without irradiation, whereas the rest were irradiated at 15 and 25 kGy. Half of the samples were processed just after preparation and the other half was stored for 8 mo at room temperature prior to anal. Very significant differences between unirradiated and irradiated bags were found. About 60-80 compounds were released and identified per sample. A huge peak of 1,3-ditertbutylbenzene was present in most of the irradiated samples. An outstanding reproducibility in all the variables evaluated (chromatograms, oxygen percentage, volume of bags) was noticed. Independently of filling gas, the results of unirradiated materials were almost identical. In contrast, the chromatog. profile and the odor of irradiated bags filled with nitrogen were completely different to those filled with air. Principal component anal. was performed and 86.9% of the accumulated variance was explained with the first two components. The migration of compounds from irradiated materials to the vapor phase was much lower than the limits established in the Commission Regulation (EU) No 10/2011. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Reference of 4-tert-Amylphenol

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Lazewska, Dorota;Olejarz-Maciej, Agnieszka;Kaleta, Maria;Bajda, Marek;Siwek, Agata;Karcz, Tadeusz;Doroz-Plonka, Agata;Cichon, Urszula;Kuder, Kamil;Kiec-Kononowicz, Katarzyna published 《4-tert-Pentylphenoxyalkyl derivatives – Histamine H₃ receptor ligands and monoamine oxidase B inhibitors》 in 2018. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Quality Control of 4-tert-Amylphenol The article mentions the following:

The synthesis and biol. activity of 4-tert-pentylphenoxypropyl derivatives I (m = 1, 2, 3, etc.; n = 1; R = H, 2-CH₃, 2,6-(CH₃)₂, 3,5-(CH₃)₂, etc.) are described in this manuscript. All compounds (except one) showed human histamine H₃ receptor affinity with K_i values below 760 nM. The inhibitory activity towards human monoamine oxidase B (hMAO B) was evaluated using a fluorometric Amplex-Red assay, and most of the compounds were found to be effective in the submicromolar range. Among them, 1-(3-(4-tert-pentylphenoxy)propyl)pyrrolidine I (m = 1; n = 1; R = H) exhibited hMAO B inhibitory activity with an IC₅₀ value of 4.5 nM. In addition, hMAO B inhibition by I (m = 1; n = 1; R = H) was shown to be non-competitive and reversible. Further, recently described potent histamine H₃ receptor ligands – 4-tert-pentylphenoxyalkyl derivatives (with a 4-8 carbon spacer) – were evaluated for hMAO B inhibitory activity, and some of them displayed activity in the submicromolar range. Selected compounds were also tested for human MAO A (hMAO A) inhibitory potencies and exhibited no activity. Moreover, mol. modeling studies were carried out for tested compounds to explain their mol. mechanism of hMAO B inhibition and the selectivity of compounds for hMAO B over hMAO A. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Quality Control of 4-tert-Amylphenol

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Mao, Mengmei;Zhang, Le;Yao, Hanlin;Wan, Li;Xin, Zhong published 《Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow》. The research results were published in《ACS Omega》 in 2020.SDS of cas: 80-46-6 The article conveys some information:

A novel method for the synthesis of tri-Ph phosphite and its derivatives was developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. The reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. Scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert-butylphenyl) phosphite was achieved in 88% yield. PCl₃. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. SDS of cas: 80-46-6

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Chen, Zong-yan;Wu, Xiao-lan;Ma, Jun;Xiao, Li;Wang, Tao;Lu, Hui-yi published 《Preparation of high quality tetrachloroethylene by impurity removal method》 in 2018. The article was appeared in 《Huaxue Shiji》. They have made some progress in their research.Application In Synthesis of 4-tert-Amylphenol The article mentions the following:

The purification process of tetrachloroethylene was investigated. The methods of extraction, adsorption, distillation separation and purification of tetrachloroethylene feasibility, and the parameters are optimized. The purity of tetrachloroethylene is improved because of the reduction of p-tert-amylphenol and other impurities. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application In Synthesis of 4-tert-Amylphenol

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Reinisch, Jens;Klamt, Andreas published 《Correction to “Predicting Flash Points of Pure Compounds and Mixtures with COSMO-RS” [Erratum to document cited in CA164:106271]》 in 2016. The article was appeared in 《Industrial & Engineering Chemistry Research》. They have made some progress in their research.SDS of cas: 80-46-6 The article mentions the following:

The final conversion within eq 4 in the original manuscript is incorrect; The correct equation has been given. There is an analog error in eq 11; The corrected equation has been given. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. SDS of cas: 80-46-6

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Alcohol – Wikipedia,
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Computed Properties of C11H16OIn 2020, Bub, Christina L.;Thoennissen, Vinzenz;Patureau, Frederic W. published 《Benzophenothiazine and Its Cr(III)-Catalyzed Cross Dehydrogenative Couplings》. 《Organic Letters》published the findings. The article contains the following contents:

In stark contrast to phenothiazines and their prevalence for cross-dehydrogenative amination reactions, benzophenothiazine has a pronounced preference for cross-dehydrogenative C-C bond-forming reactions. Moreover, the substrate is very versatile, leading to several new classes of C-C bond-forming reactions and many new oxidative coupling product architectures, including unprecedented indole fused paddlewheel-like structures. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Computed Properties of C11H16O

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Hughes-Oliver, Jacqueline M.;Xu, Guangning;Baynes, Ronald E. published 《Skin permeation of solutes from metalworking fluids to build prediction models and test A partition theory》. The research results were published in《Molecules》 in 2018.Synthetic Route of C11H16O The article conveys some information:

Permeation of chem. solutes through skin can create major health issues. Using the membrane-coated fiber (MCF) as a solid phase membrane extraction (SPME) approach to simulate skin permeation, we obtained partition coefficients for 37 solutes under 90 treatment combinations that could broadly represent formulations that could be associated with occupational skin exposure. These formulations were designed to mimic fluids in the metalworking process, and they are defined in this manuscript using: one of mineral oil, polyethylene glycol-200, soluble oil, synthetic oil, or semi-synthetic oil; at a concentration of 0.05 or 0.5 or 5 percent; with solute concentration of 0.01, 0.05, 0.1, 0.5, 1, or 5 ppm. A single linear free-energy relationship (LFER) model was shown to be inadequate, but extensions that account for exptl. conditions provide important improvements in estimating solute partitioning from selected formulations into the MCF. The benefit of the Expanded Nested-Solute-Concentration LFER model over the Expanded Crossed-Factors LFER model is only revealed through a careful leave-one-solute-out cross-validation that properly addresses the existence of replicates to avoid an overly optimistic view of predictive power. Finally, the partition theory that accompanies the MCF approach is thoroughly tested and found to not be supported under complex exptl. settings that mimic occupational exposure in the metalworking industry.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Synthetic Route of C11H16O

Reference:
Alcohol – Wikipedia,
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Category: alcohols-buliding-blocks《Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H₃R ligands》 was published in 2017. The authors were Kuder, Kamil J.;Lazewska, Dorota;Kaleta, Maria;Latacz, Gniewomir;Kottke, Tim;Olejarz, Agnieszka;Karcz, Tadeusz;Fruzinski, Andrzej;Szczepanska, Katarzyna;Karolak-Wojciechowska, Janina;Stark, Holger;Kiec-Kononowicz, Katarzyna, and the article was included in《Bioorganic & Medicinal Chemistry》. The author mentioned the following in the article:

As a continuation of the authors’ search for novel histamine H₃ receptor ligands a series of twenty new tert-amyl phenoxyalkylamine derivatives (2-21) was synthesized. Compounds of four to eight carbon atoms spacer alkyl chain were evaluated on their binding properties at human histamine H₃ receptor (hH₃R). The highest affinities were observed for the pentyl derivatives (K_i = 8.8-23.4 nM range) and among them piperidine derivative 1-(5-(4-(tert-pentyl)phenoxy)pentyl)piperidine hydrogen oxalate (6) with K_i = 8.8 nM. Structures (6), 3-methyl-1-(5-(4-(tert-pentyl)phenoxy)pentyl)piperidine hydrogen oxalate (7) were also classified as antagonists in cAMP accumulation assay (with EC₅₀ = 157 and 164 nM, resp.). Moreover, new compounds were also evaluated for anticonvulsant activity in Antiepileptic Screening Program (ASP) at National Institute of Neurol. Disorders and Stroke (USA). Seven compounds showed anticonvulsant activity at maximal electroshock (MES) test in the dose of 30 mg/kg at 0.5 h. In the s.c. pentetrazole (scMET) test compound 4-methyl-1-(4-(4-(tert-pentyl)phenoxy)butyl)piperidine hydrogen oxalate (4) showed protection at 100 and 300 mg/kg dose at mice, however compounds showed high neurotoxicity in rotarod test at used doses. Also, mol. modeling studies were undertaken, to explain affinity of compounds at hH₃R (taking into the consideration x-ray anal. of compound 1-(8-(4-(tert-pentyl)phenoxy)octyl)piperidine hydrogen oxalate (18)). To estimate “drug-likeness” of selected compounds in silico and exptl. evaluation of lipophilicity, metabolic stability and cytotoxicity was performed. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Category: alcohols-buliding-blocks

Reference:
Alcohol – Wikipedia,
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