Category: 80-46-6

Szczepanska, Katarzyna;Karcz, Tadeusz;Mogilski, Szczepan;Siwek, Agata;Kuder, Kamil J.;Latacz, Gniewomir;Kubacka, Monika;Hagenow, Stefanie;Lubelska, Annamaria;Olejarz, Agnieszka;Kotanska, Magdalena;Sadek, Bassem;Stark, Holger;Kiec-Kononowicz, Katarzyna published 《Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H₃R ligands》. The research results were published in《European Journal of Medicinal Chemistry》 in 2018.Computed Properties of C11H16O The article conveys some information:

A series of twenty four new tert-Bu and tert-pentyl phenoxyalkylamine derivatives I [R = tetrahydrofuran-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrazin-2-yl; R¹ = Me, Et; Q = (CH₂)n, n = 1,2] was synthesized. Compounds with three to four carbon atoms alkyl chain spacer were evaluated for their binding properties at human histamine H₃ receptor (hH₃R). The highest affinities were observed for compounds I [R = pyridin-4-yl, R¹ = Me, Q = (CH₂)n, n = 1; R = pyridin-4-yl, R¹ = Me, n = 2; R = pyridin-4-yl, R¹ = Et, Q = (CH₂)n, n = 1; R = pyridin-4-yl, R¹ = Et, Q = (CH₂)n, n = 2] (K_i=16.0-120nM). As it was showed in docking studies, those specific heteroaromatic 4-N piperazine substituents might interact with one of the key receptor interacting amino acids. Moreover, the most promising compounds exhibited anticonvulsant activity in the maximal electroshock-induced seizure (MES) model in mice. Furthermore, the blood-brain barrier penetration, the functional H₃R antagonist potency as well as the pro-cognitive properties in the passive avoidance test were demonstrated for compound I [R = pyridin-4-yl, R¹ = Me, Q = (CH₂)n, n = 2]. In order to estimate drug-likeness of compound I [R = pyridin-4-yl, R¹ = Me, Q = (CH₂)n, n = 2] in silico and exptl. evaluation of metabolic stability in human liver microsomes was performed. In addition, paying attention to the results obtained within this study, the 4-pyridyl-piperazino moiety was established as a new bioisosteric piperidine replacement in H₃R ligands. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Computed Properties of C11H16O

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 80-46-6In 2020, Furdikova, Katarina;Machynakova, Andrea;Drtilova, Tereza;Spanik, Ivan published 《Comparison of different categories of Slovak Tokaj wines in terms of profiles of volatile organic compounds》. 《Molecules》published the findings. The article contains the following contents:

The present work deals with the characterization of volatile organic compounds in wines from the Slovak Tokaj wine region. Studied wine samples were divided into 3 groups-varietal wines from registered Tokaj vine varieties, film wines Tokajske samorodne dry, and naturally sweet botrytized wines Tokaj selections. The VOCs from wines were extracted using optimized solid phase microextraction and analyzed by comprehensive two-dimensional gas chromatog. coupled to high-resolution time-of-flight mass spectrometry (HRTOF-MS). In total, 176 VOCs were identified in all 46 studied samples. It was found that the total number of VOCs in varietal wines was generally higher than in botrytized wines. All three studied categories showed characteristic VOC profiles with significant differences. Varietal wines were characterized by higher concentrations of esters and terpenoids originating from grapes. The presence of γ-octalactone, (E)-6-methylhept-2-en-4-one, and lack of benzaldehyde were typical for Tokajske samorodne dry. Tokaj selections expressed the highest concentration of di-Et malate, benzaldehyde, and furfurals. Several interesting trends were also observed The concentration of fermentation products was highest in varietal wines, while long-term matured Tokaj special wines were typified by the presence of compounds related to noble-rotten raisins (2-phenylacetaldehyde, Et 2-phenylacetate, and 2-phenylethanol), wood (cis-whisky lactone), and aging (1,1,6-trimethyl-2H-naphthalene, furfural, and 5-methylfurfural). The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application of 80-46-6

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kang, Jian;Liu, Junjie;Pei, Jingjing published 《The indoor volatile organic compounds (VOCs) characteristics and source identification in a new university campus in Tianjin, China》. The research results were published in《Journal of the Air & Waste Management Association》 in 2017.Name: 4-tert-Amylphenol The article conveys some information:

This study investigates the volatile organic compounds (VOCs) constituents and concentration levels on a new university campus, where all of the buildings including classrooms and student dormitories were newly built and decorated within 1 yr. Investigated indoor environments include dormitories, classrooms, and the library. About 30 dormitory buildings with different furniture loading ratios were measured. The characteristics of the indoor VOCs species are analyzed and possible sources are identified. The VOCs were analyzed with gas chromatog.-mass spectroscopy (GC-MS). It was found that the average total VOC (TVOC) concentration can reach 2.44 mg/m³. Alkenes were the most abundant VOCs in dormitory rooms, contributing up to 86.5% of the total VOCs concentration The concentration of α-pinene is the highest among the alkenes. Unlike the dormitory rooms, there is almost no room with TVOC concentration above 0.6 mg/m³ in classroom and library buildings. Formaldehyde concentration in the dormitory rooms increased about 23.7% after the installation of furniture, and the highest level reached 0.068 mg/m³. Ammonia released from the building antifreeze material results in an average indoor concentration of 0.28 mg/m³, which is 100% over the threshold and should be seriously considered. Further experiments were conducted to analyze the source of the α-pinene and some alkanes in dormitory rooms. The results showed that the α-pinene mainly comes from the bed boards, while the wardrobes are the main sources of alkanes. The contribution of the pinewood bed boards to the α-pinene and TVOC concentration can reach up to above 90%. The same type rooms were sampled 1 yr later and the decay rate of α-pinene is quite high, close to 100%, so that it almost cannot be detected in the sampled rooms. Implications: Anal. of indoor volatile organic compounds (VOCs) in newly built campus buildings in China identified the specific constituents of indoor VOCs contaminants exposed to Chinese college students. The main detected substances α-pinene, β-pinene, and 3-carene originated from solid wood bed boards and should be seriously considered. In addition, the contribution rates of building structure materials and furniture to specific VOCs constituents are quant. calculated Also, the decay rates of these specific constituents within 1 yr are also quant. calculated in this paper. This study can help us to better understand the sources and concentration levels of VOC contaminants in campus buildings, and to help select appropriate materials in buildings. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Name: 4-tert-Amylphenol

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 4-tert-Amylphenol《Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity》 was published in 2020. The authors were Zurlinden, Todd J.;Saili, Katerine S.;Rush, Nathaniel;Kothiya, Parth;Judson, Richard S.;Houck, Keith A.;Hunter, E. Sidney;Baker, Nancy C.;Palmer, Jessica A.;Thomas, Russell S.;Knudsen, Thomas B., and the article was included in《Toxicological Sciences》. The author mentioned the following in the article:

The Stemina devTOX quickPredict platform is a human pluripotent stem cell-based assay that predicts the developmental toxicity potential based on changes in cellular metabolism following chem. exposure. Using this assay, we screened 1065 ToxCast phase I and II chems. in single-concentration or concentration-response for the targeted biomarker (ratio of ornithine to cystine secreted or consumed from the media). The dataset from the Stemina (STM) assay is annotated in the ToxCast portfolio as STM. Major findings from the anal. of ToxCast_STM dataset include (1) 19% of 1065 chems. yielded a prediction of developmental toxicity, (2) assay performance reached 79%-82% accuracy with high specificity (> 84%) but modest sensitivity (< 67%) when compared with in vivo animal models of human prenatal developmental toxicity, (3) sensitivity improved as more stringent weights of evidence requirements were applied to the animal studies, and (4) statistical anal. of the most potent chem. hits on specific biochem. targets in ToxCast revealed pos. and neg. associations with the STM response, providing insights into the mechanistic underpinnings of the targeted endpoint and its biol. domain. The results of this study will be useful to improving our ability to predict in vivo developmental toxicants based on in vitro data and in silico models. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Quality Control of 4-tert-Amylphenol

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4-tert-Amylphenol《QSAR study on toxicities of alcohol and phenol compounds》 was published in 2016. The authors were Deng, Xiaolong;Chen, Yuan;Tan, Siqiao;Yuan, Zheming, and the article was included in《Huanjing Kexue Xuebao》. The author mentioned the following in the article:

The toxicities and features of compounds were generally presented as a non-linear relationship. The compound mol. descriptors calculated by the quantum chem. methods contained numerous irrelevant and redundant features. Although widely used, the current version of minimal redundancy maximal relevance (mRMR) feature selection method was not applicable for continuous dependent variable and the measurement of relevance and redundancy was incomparable. For quant. structure-activity relationship (QSAR), both dependent variables (toxicities) and independent variables (mol. descriptors) were usually continuous. Therefore, we used distance correlation (dCor) to replace Pearson correlation coefficient (R) to solve the measurement comparability between relevance and redundancy, and developed a new feature selection method named mRMR-dCor by combining mRMR with dCor in this work. Based on the inhouse feature selection method and support vector regression (SVR), the independent prediction results of three phenolic and alc. compounds datasets indicated that mRMR-dCor was superior to other reference feature selection methods in the prediction performance, with Q² of 0.954, 0.941 and 0.981, resp. Most of mol. descriptors selected by mRMR-dCor were also reported in previous literatures. Therefore, mRMR-dCor had broad application prospects in various domains such as QSAR and quant. structure-pharmacokinetics relationship. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Reference of 4-tert-Amylphenol

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 80-46-6《Study on capillary GC fingerprint of Guominxing Biyan Granules》 was published in 2016. The authors were Hu, Jun-hua;Ren, Ji-hua;Wang, Xue;Li, Jia-chun;Huang, Wen-zhe;Wang, Zhen-zhong;Xiao, Wei, and the article was included in《Zhongcaoyao》. The author mentioned the following in the article:

Objective To establish the capillary GC fingerprint of Guominxing Biyan Granules and give a new method for quality control. Methods The capillary GC was used. The ingredients of common peaks were analyzed by FID and MS. The HP-5 Ph Me Siloxane (30 m×0.32 mm, 0.25 μm) was used for capillary column. The chromatog. conditions were as follows: the temperature of inlet was 200 degree C in splitless sampling, the detector temperature was 250 degree C, the column initial temperature was 50 degree C, 3 degree C/min rose to 140 degree C, keeping 2 min and 10 degree C/min rose to 200 degree C, keeping 2 min. Results Capillary GC fingerprint of volatile oil in Allergic Rhinitis Particles was established. Twelve peaks were selected as the fingerprint peaks of Allergic Rhinitis Particles. The ingredients of common peaks were designated by GC-MS. The similarity between the fingerprint of 10 batches of Allergic Rhinitis Particles Samples were 0.90. Conclusion The established capillary GC fingerprint has desirable precision, reproducibility, and stability, and can be applied to the quality control of Guominxing Biyan Granules.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Related Products of 80-46-6

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

North, Megan K.;Dalle Zotte, Antonella;Hoffman, Louwrens C. published 《The effects of dietary quercetin supplementation on the meat quality and volatile profile of rabbit meat during chilled storage》 in 2019. The article was appeared in 《Meat Science》. They have made some progress in their research.Application of 80-46-6 The article mentions the following:

Thirty-four New Zealand White rabbits of both sexes were fed a control or supplemented (2 g/kg quercetin dihydrate) diet from weaning until slaughter (13 wk). After post-mortem chilling, excised and minced Longissimus thoracis et lumborum muscles were stored at 3.2 °C under oxygen-permeable wrapping for 1, 3 or 5 days. Color, pH, lipid oxidation (TBARS), antioxidant capacity (FRAP), volatile profile (day 1 and 5) and microbial count (day 5) were determined Quercetin reduced alkane (day 5) and hexanal (day 1) concentrations, but otherwise had minimal antioxidant effect, and did not benefit microbial quality, and thus did not substantially improve the shelf-life. The sex effect was similarly limited. Overall, the pH increased and FRAP decreased during storage, but TBARS did not change and discoloration seemed delayed. The volatile profile was dominated by esters, alcs. and heterocyclic compounds, and while it changed during storage, lipid oxidation products did not increase as expected, suggesting that rabbit meat may have relatively active reducing mechanisms. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application of 80-46-6

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wooding, Madelien;Rohwer, Egmont R.;Naude, Yvette published 《Determination of endocrine disrupting chemicals and antiretroviral compounds in surface water: A disposable sorptive sampler with comprehensive gas chromatography – Time-of-flight mass spectrometry and large volume injection with ultra-high performance liquid chromatography-tandem mass spectrometry》 in 2017. The article was appeared in 《Journal of Chromatography A》. They have made some progress in their research.Application of 80-46-6 The article mentions the following:

Many rural dwellers and inhabitants of informal settlements in South Africa are without access to treated water and collect untreated water from rivers and dams for personal use. Endocrine disrupting chems. (EDCs) have been detected in surface water and wildlife of South Africa. EDCs are often present in complex environmental matrixes at ultra-trace levels complicating detection thereof. We report a simplified multi-residue approach for the detection and quantification of EDCs, emerging EDCs, and antiretroviral drugs in surface water. A low cost (less than one US dollar), disposable, sorptive extraction sampler was prepared inhouse. The disposable samplers consisted of polydimethylsiloxane (PDMS) tubing fashioned into a loop which was then placed in water samples to concentrate EDCs and emerging pollutants. The PDMS samplers were thermally desorbed directly in the inlet of a GC, thereby eliminating the need for expensive consumable cryogenics. Comprehensive gas chromatog. coupled to time-of-flight mass spectrometry (GCxGC-TOFMS) was used for compound separation and identification. Linear retention indexes of EDCs and emerging pollutants were determined on a proprietary Crossbond phase Rtx^–CLPesticides II GC capillary column. In addition, large volume injection of surface water into an ultra-performance liquid chromatograph tandem mass spectrometer (UPLC-MS/MS) was used as complementary methodol. for the detection of less volatile compounds Large volume injection reduced tedious and costly sample preparation steps. Limits of detection for the GC method ranged from 1 to 98 pg/l and for the LC method from 2 to 135 ng/l. Known and emerging EDCs such as pharmaceuticals, personal care products and pesticides, as well as the antiretroviral compounds, efavirenz and nevirapine, were detected in surface water from South Africa at concentration levels ranging from 0.16 ng/l to 227 ng/l.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application of 80-46-6

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hamilton, Lisa A.;Tremblay, Louis A.;Northcott, Grant L.;Boake, Michael;Lim, Richard P. published 《The impact of variations of influent loading on the efficacy of an advanced tertiary sewage treatment plant to remove endocrine disrupting chemicals》. The research results were published in《Science of the Total Environment》 in 2016.Recommanded Product: 80-46-6 The article conveys some information:

The effect of changes in influent load on the removal of endocrine disrupting chems. (EDCs) by sewage treatment has not been fully characterized. This study assessed the efficacy of an advanced tertiary sewage treatment plant (STP) to remove EDCs during normal and peak flow events of sewage influent using trace chem. anal. of selected EDCs and four estrogenic in vitro bioassays. During the summer holiday season, influent volume increased by 68%, nutrient concentrations by ≥26% and hydraulic retention time was reduced by 40% compared with base flow conditions. Despite these pressures on the treatment system the concentrations and mass loading of estrone, 17β-estradiol, estriol, bisphenol A, 4-t-octylphenol and tech. nonylphenol were not significantly higher (p >0.05) during the peak flow conditions compared with base flow conditions. Chem. anal. and in vitro bioassays showed that the efficacy of the STP in removing EDCs was not affected by the different loadings between baseline and peak flow regimes. This study demonstrates that large flow variations within the design capacity of advanced multi-stage STPs should not reduce the removal efficacy of EDCs. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Recommanded Product: 80-46-6

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts