Category: 80-09-1

Mandrah, Kapil published the artcileA study on bisphenol S induced nephrotoxicity and assessment of altered downstream kidney metabolites using gas chromatography-mass spectrometry based metabolomics, Product Details of C12H10O4S, the publication is Environmental Toxicology and Pharmacology (2022), 103883, database is CAplus and MEDLINE.

The global use of bisphenol S (BPS) has now been significantly increased for commensurate utilization as a substitute for BPA for its regulatory concerns. Though, previous reports indicated that BPS been also appeared as a toxic congener comparable to BPA. In the present study, we determined nephrotoxicity condition induced due to BPS exposure. Anal. indicated that BPS significantly promoted histopathol. disturbance in the kidney, and altered the levels of biomarkers of kidney damage in serum and urine samples of Wistar rats. It is also indicated that BPS altered the expression of kidney damage biomarkers associated with glomerular and tubular injury. Addnl., we determined the perturbation of kidney metabolites in the underlying pathophysiol. response of kidney injury due to BPS exposure. Gas chromatog.-mass spectrometry based untargeted metabolomics exhibited 20 significantly perturbed metabolites. Moreover, metabolic pathway anal. revealed significant disturbance in the TCA cycle and pyruvate metabolism pathways.

Environmental Toxicology and Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blaauwendraad, Sophia M. published the artcileAssociations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development, Synthetic Route of 80-09-1, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119745, database is CAplus and MEDLINE.

Fetal exposure to bisphenols and phthalates may influence development of the reproductive system. In a population-based, prospective cohort study of 1059 mother-child pairs, we examined the associations of maternal gestational urinary bisphenols and phthalates concentrations with offspring reproductive development from infancy until 13 years. We measured urinary bisphenol and phthalate concentrations in each trimester. We obtained information on cryptorchidism or hypospadias after birth from medical records. At 9.7 years, we measured testicular and ovarian volume by MRI. At 13.5 years, we measured child Tanner stages and menstruation through questionnaire. We performed linear or logistic regression models for boys and girls to assess the associations of maternal urinary average and trimester-specific bisphenols and phthalates with child reproductive outcomes. Next, to further explore potential synergistic or additive effects of exposures together, we performed mixed exposure models using a quantile g computation approach. Models were adjusted for maternal age, ethnicity, body-mass index, education, parity, energy intake, smoking and alc. use, and childs gestational age at birth, birthweight and body-mass index. In boys, no associations of maternal gestational phthalate or bisphenol with offspring cryptorchidism and hypospadias were found. Higher maternal high-mol.-weight phthalate and total bisphenol, but not phthalic acid or low-mol.-weight phthalate, were associated with larger child testicular volume at 10 years. Higher maternal phthalic acid and total bisphenol were associated with earlier genital and pubic hair development at 13 years, resp. (p-values<0.05). In girls, we found no associations of maternal urinary bisphenol and phthalate with ovarian volume or menstrual age. Only higher maternal urinary high-mol.-weight phthalate was associated with earlier pubic hair development at 13 years (p-values <0.05). Higher mixture exposure was associated with earlier pubic hair development in both sexes. In conclusion, higher maternal gestational urinary bisphenol and phthalate concentrations were associated with alterations in offspring reproductive development, mainly in boys.

Environmental Pollution (Oxford, United Kingdom) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Junming published the artcileSynergistic effect of polyphosphazene nanotubes and graphene on enhancing ablative resistance of ethylene propylene diene monomer insulation composites, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Journal of Applied Polymer Science (2022), 139(36), e52834, database is CAplus.

Many advanced fillers were used in ethylene propylene diene monomer (EPDM) insulation composites to enhance the ablative resistance by strengthening char layer. However, the structures of fillers and char layer were usually neglected. In this work, a new type of cross-linked network-like polyphosphazene nanotubes (PNTs) was added in EPDM composites in combination with graphene. The results showed that the ablation performance of EPDM composites was improved by 21.6% with the synergistic effect of PNTs and graphene. Moreover, the ablation mechanism was studied by analyzing ablated char layer using X-ray diffraction (XRD), SEM, energy disperse spectroscopy (EDS) and Raman spectroscopy. PNTs served as skeleton to build the cross-linked network char layer and graphene played a role in enhancing the properties of char layer. The findings of this work emphasize the synergistic effect of structures and properties of fillers when performing ablative modification, which provides a new idea to enhance the ablation properties of EPDM composites.

Journal of Applied Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Yu published the artcileNon-target, suspect and target screening of chemicals of emerging concern in landfill leachates and groundwater in Guangzhou, South China, Product Details of C12H10O4S, the publication is Science of the Total Environment (2022), 155705, database is CAplus and MEDLINE.

Landfill sites have been regarded as a significant source of chems. of emerging concern (CECs) in groundwater. However, our understanding about the compositions of CECs in landfill leachate and adjacent groundwater is still very limited. Here we investigated the CECs in landfill leachates and groundwater of Guangzhou in South China by target, suspect and non-target anal. using high-resolution mass spectrometry (HRMS). A variety of CECs (n = 242), including pharmaceuticals (n = 64), pharmaceutical intermediates (n = 18), personal care products (n = 9), food additives (n = 18), industrial chems. (n = 82, e.g., flame retardants, plasticizers, antioxidants and catalysts), pesticides (n = 26), transformation products (n = 8) and other organic compounds (n = 17) were (tentatively) identified by non-target and suspect screening. 142 CECs were quantitated with target anal., and among them 37, 24 and 27 CECs were detected resp. in the raw leachate (272-1780μg/L), treated leachate (0.25-0.81μg/L) and groundwater (0.10-53.7μg/L). The CECs in the raw leachates were efficiently removed with the removal efficiencies greater than 88.7%. Acesulfame, bisphenol F and ketoprofen were the most abundant compounds in both treated leachate and groundwater. The CECs in groundwater was found most likely to be originated from the landfill sites. Our results highlight the importance of non-target screening in identifying CECs, and reveal the contamination risk of groundwater by landfill leachate.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang, Ming published the artcileBanana-peel-derived magnetic porous carbon as effective adsorbent for the enrichment of six bisphenols from beverage and water samples, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Food Chemistry (2022), 131948, database is CAplus and MEDLINE.

Functionalized magnetic nanoporous carbon derived from banana peel was synthesized through carbonization, porogenesis, carboxylation and magnetization using banana peel and was successfully used as a magnetic solid phase extraction (MSPE) material for the enrichment of six bisphenols (BPs) from beverage and water samples. After the optimization of MSPE process, the enrichment factors of six target analytes were in the range of 74-112 for water samples, and 15-22 for beverage samples. Then, high-performance liquid chromatog.-quadrupole-Orbitrap high-resolution mass spectrometry (HPLC-Q Orbitrap-HRMS) was used for the separation and determination of the target analytes. Results showed that the extraction recoveries for 6 BPs were in the range of 71.9-108.4% with an RSD of 2.5-7.5% (n = 6). These results demonstrated that the as-prepared material could efficiently enrich some aromatic compounds and the proposed method is reliable and robust for the determination of BPs in water and beverage samples.

Food Chemistry published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Zhi-Hui published the artcileEffects of molecular structure on organic contaminants′ degradation efficiency and dominant ROS in the advanced oxidation process with multiple ROS, Computed Properties of 80-09-1, the publication is Environmental Science & Technology (2022), 56(12), 8784-8795, database is CAplus and MEDLINE.

In this study, the previously overlooked effects of contaminants′ mol. structure on their degradation efficiencies and dominant reactive oxygen species (ROS) in advanced oxidation processes (AOPs) are investigated with a peroxymonosulfate (PMS) activation system selected as the typical AOP system. Averagely, degradation efficiencies of 19 contaminants are discrepant in the CoCaAl-LDO/PMS system with production of SO₄^•-, ^•OH, and ¹O₂. D. functional theory calculations indicated that compounds with high E_HOMO, low-energy gap (ΔE = E_LUMO – E_HOMO), and low vertical ionization potential are more vulnerable to be attacked. Further anal. disclosed that the dominant ROS was the same one when treating similar types of contaminants, namely SO₄^•-, ¹O₂, ¹O₂, and ^•OH for the degradation of CBZ-like compounds, SAs, bisphenol, and triazine compounds, resp. This phenomenon may be caused by the contaminants′ structures especially the commonly shared or basic parent structures which can affect their effective reaction time and second-order rate constants with ROS, thus influencing the contribution of each ROS during its degradation Overall, the new insights gained in this study provide a basis for designing more effective AOPs to improve their practical application in wastewater treatment.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C11H19N, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Durcik, Martina published the artcileLast piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction, Product Details of C12H10O4S, the publication is Chemosphere (2022), 303(Part_2), 135133, database is CAplus and MEDLINE.

Bisphenols are endocrine-disrupting chems. ubiquitously present in the environment, with the consequent exposure to humans. In humans, bisphenols are metabolized to glucuronide and sulfate conjugates. Recent studies indicate that sulfation represents an important bisphenol metabolic pathway for the most vulnerable humans, such as the growing fetus. Our aim was to evaluate sulfation kinetics of commonly detected bisphenols in biol. samples: bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF). Furthermore, we evaluated estrogenic agonist potencies and long-term stability of these bisphenol sulfates. BPS and BPF sulfates were prepared by chem. synthesis. Sulfation kinetics of the selected bisphenols were tested in pooled human liver cytosol, as a source for soluble phase II enzymes, including liver sulfotransferases, with quantification by LC-MS/MS. A validated transactivation assay using the hERα-Hela 9903 cell line was used to determine estrogenic agonist potencies. Moreover, BPA, BPS, and BPF sulfate stabilities were examined under various conditions and during storage. In vitro sulfation of BPA and BPS followed Michaelis-Menten kinetics; BPF sulfation followed a substrate inhibition model. Sulfation rates were comparable for these bisphenols, although their K_M values indicated some large differences in affinities. BPA and BPS sulfates are not hERα agonists. The bisphenol sulfates can be considered stable for at least 2 days under these tested media conditions. These data indicate that bisphenol sulfation is an important route in their biotransformation. Compared to glucuronidation, these bisphenols show slower sulfation rates but similar K_M values. BPA and BPS metabolic biotransformation by sulfation provides their detoxification as they are without estrogenic activities.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Coutinho, Rodrigo published the artcileOptimisation of the conditions of dispersive liquid-liquid microextraction for environmentally friendly determination of bisphenols and benzophenone in complex water matrices by LC-MS/MS, HPLC of Formula: 80-09-1, the publication is Microchemical Journal (2022), 107636, database is CAplus.

Due to well-known risks to human and environmental health, the increasing presence of several micropollutants even in very low concentrations in environmental matrixes requires sustainable and advanced anal. methods to expand monitoring programs, particularly for water quality control. The objective of this study was to optimize the conditions of the dispersive liquid-liquid microextraction (DLLME) for a combined group of emerging micropollutants (bisphenol A, bisphenol S, bisphenol F, bisphenol AF and benzophenone) in complex water matrixes. Ten variables were chosen as the most important for DLLME procedure and the Design of Experiments (DoE) approach was applied to find the most relevant variables and optimize the DLLME procedure. The optimized DLLME was then, applied to real complex water samples including raw and treated wastewaters and surface water in Rio de Janeiro city, Brazil, and the extracted samples were analyzed by ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). The variables vortex mixing time (VMT), Dispersive Solvent Volume (DSV) and Extractor Solvent Volume (ESV) are the most important among the variables evaluated. The recovery efficiencies ranged from 60 to 120% after optimization the amounts of target compounds found in the five real aqueous matrixes varied from 0.005 to 150μg L-1. The association of optimized DLLME with the UPLC-MS/MS met the validation requirements adopted and generated anal. results of high quality. The advantages of this extraction technique include reduction of cost per anal.; low volume of samples and low volume of solvent required; no need to use cartridges; reduction of waste generation. The method is, therefore, suitable to process large numbers of samples, particularly in countries with limited budgets for environmental monitoring.

Microchemical Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, HPLC of Formula: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Minguez-Alarcon, Lidia published the artcilePregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study, Related Products of alcohols-buliding-blocks, the publication is Science of the Total Environment (2022), 155191, database is CAplus and MEDLINE.

The epidemiol. literature on associations between urinary phenol concentrations and lipid profiles during pregnancy is limited. We examined whether urinary concentrations of phenol and phenol replacement biomarkers were associated with serum lipid levels among pregnant women. This cross-sectional study included 175 women attending the Massachusetts General Hospital Fertility Center who enrolled in the Environment and Reproductive Health (EARTH) Study between 2005 and 2017 and had data available on urinary phenol biomarkers and serum lipids during pregnancy. We used linear regression models to assess the relationship between groups of urinary phenol and phenol replacement biomarkers and serum lipid levels [total cholesterol, high d. lipoprotein (HDL), non-HDL, low-d. lipoprotein (LDL) cholesterol, and triglycerides], while adjusting for age at sample collection, pre-pregnancy BMI, education, race, infertility diagnosis, cycle type, number of fetuses, trimester and sp. gr. In adjusted models, pregnant women with urinary propylparaben concentrations in the highest tertile had 10% [22 (95% CI = 5, 40) mg/dL], 12% [19 (95% CI = 2, 36) mg/dL] and 16% [19 (95% CI = 3, 35) mg/dL] higher mean total, non-HDL and LDL cholesterol, resp., compared to women with concentrations in the lowest tertile. Similar elevations were observed for urinary bisphenol A concentrations Urinary bisphenol S, benzophenone-3, triclosan, methylparaben, ethylparaben, and butylparaben were unrelated to serum lipids. Among pregnant women, urinary concentrations of bisphenol A and propylparaben were associated with higher serum levels of total, non-HDL and LDL cholesterol.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jamnik, Thomas published the artcileNext-generation biomonitoring of the early-life chemical exposome in neonatal and infant development, Computed Properties of 80-09-1, the publication is Nature Communications (2022), 13(1), 2653, database is CAplus and MEDLINE.

Exposure to synthetic and natural chems. is a major environmental risk factor in the etiol. of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatog.-tandem mass spectrometry approach was developed and validated. The assay enables the anal. of more than 80 highly-diverse xenobiotics in urine, serum/plasma, and breast milk; with detection limits generally in the pg-ng mL-1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method′s applicability for large-scale exposomics-type cohort studies.

Nature Communications published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts