Category: 80-09-1

Chelcea, Ioana published the artcilePhysiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation, Name: 4,4′-Sulfonyldiphenol, the publication is Environmental Science & Technology (2022), 56(14), 10216-10228, database is CAplus and MEDLINE.

Bisphenol A (BPA) is an industrial chem., which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogs are less well-studied despite their wide use in consumer products. These analogs have been detected in water and aquatic organisms around the world, with some analogs showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicol. relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiol. based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to exptl. data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dracheva, Elena published the artcileIn Silico Identification of Potential Thyroid Hormone System Disruptors among Chemicals in Human Serum and Chemicals with a High Exposure Index, Category: alcohols-buliding-blocks, the publication is Environmental Science & Technology (2022), 56(12), 8363-8372, database is CAplus and MEDLINE.

Data on toxic effects are at large missing the prevailing understanding of the risks of industrial chems. Thyroid hormone (TH) system disruption includes interferences of the life cycle of the thyroid hormones and may occur in various organs. In the current study, high-throughput screening data available for 14 putative mol. initiating events of adverse outcome pathways, related to disruption of the TH system, were used to develop 19 in silico models for identification of potential thyroid hormone system-disrupting chems. The conformal prediction framework with the underlying Random Forest was used as a wrapper for the models allowing for setting the desired confidence level and controlling the error rate of predictions. The trained models were then applied to two different databases: (i) an inhouse database comprising xenobiotics identified in human blood and (ii) currently used chems. registered in the Swedish Product Register, which have been predicted to have a high exposure index to consumers. The application of these models showed that among currently used chems., fewer were overall predicted as active compared to chems. identified in human blood. Chems. of specific concern for TH disruption were identified from both databases based on their predicted activity.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tikker, Priit published the artcileOxidation of aqueous bisphenols A and S by pulsed corona discharge: Impacts of process control parameters and oxidation products identification, SDS of cas: 80-09-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 135602, database is CAplus.

Widespread usage of bisphenol A (BPA) and its potential replacement bisphenol S (BPS) has led to their presence in natural waterbodies. The exptl. research into degradation of both aqueous pollutants by application of gas-phase pulsed corona discharge (PCD) was undertaken with variation of process control parameters, pulse repetition frequency, gas-liquid contact surface and addition of surfactant OH-radical scavenger sodium dodecyl sulfate (SDS). Although the contact surface variation had only a moderate impact on bisphenols degradation, its effect was stronger in total organic carbon removal. The addition of SDS showed a moderately neg. impact on energy efficiency at all studied conditions. The obtained results showed energy efficiency surpassing the closest competitors, ozonation and other elec. discharge processes. The detected major oxidation intermediates were mainly formed through hydroxylation and cracking of benzene rings, followed by further degradation into short chained aliphatic acids. The oxidation end-products were quantified as acetate, formate and oxalate.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C14H26O2, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yifei published the artcileStrontium oxides with enzyme-like activity: A colorimetric sensor array for highly sensitive discrimination of bisphenols, Safety of 4,4′-Sulfonyldiphenol, the publication is Sensors and Actuators, B: Chemical (2022), 131869, database is CAplus.

Bisphenols are widely used in food packaging materials, and because of their endocrine disrupting effects on the human body, fast yet facile detection is essential for food safety and human health. Traditional anal. methods face disadvantages of cumbersome operation and the need of bulk instruments. To circumvent these issues, we constructed colorimetric sensor arrays based on peroxidase-like activities of three strontium oxides for four bisphenols determination Bisphenols are absorbed on surface of strontium oxides, blocking catalytic sites and leading to decline of enzyme-like activities in turn. Different bisphenols have diverse inhibition effect on catalytic activities of the three nanozymes, and each bisphenol possesses a unique fingerprint. Though principal component anal., bisphenol A, bisphenol S, bisphenol B and bisphenol AF with concentrations ranging from 0.0002 to 1μg mL^-1 were discerned well by the developed sensor arrays. Addnl., different concentrations of each bisphenol and different ratios of mixed bisphenols were successfully discriminated, and canned fruit as real sample was applied to evaluate practical applicability of the nanozyme based sensor arrays. This work is expected to provide a simple and fast method for discrimination of structural analogs and contribute to food quality and safety monitoring aspects.

Sensors and Actuators, B: Chemical published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Safety of 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

D. Desai, Prashil published the artcileSynthesis of ultraviolet curable bisphenol-based epoxy acrylates and comparative study on its physico-chemical properties, Related Products of alcohols-buliding-blocks, the publication is Journal of Applied Polymer Science (2022), 139(17), 52022, database is CAplus.

Photocuring resins have emerged as cutting-edge technol. in coatings, adhesives, composites, additive manufacturing, and so forth. In the present work, different bisphenol, namely A, F, and S, were used to synthesize low mol. weight epoxy resin, which was further reacted with acrylic acid monomer to form bisphenol-based epoxy acrylate (BEA). The BEA resins were formulated using reactive diluents, trimethylolpropane triacrylate, and hexanediol diacrylate in the ratio of 0-40 wt% at the increment of 10 wt% alongside a fixed quantity photoinitiator. These resins were then cast into dumbbell-shaped specimens by irradiating them under UV light. The structural elucidation of BEA resins was performed using Fourier transform IR, NMR, and UV-Vis spectroscopy. The formulated resins were also studied for their rheol. properties. Further, the UV cured specimens were evaluated for mech., thermal, contact angle, and extent of curing. These outcomes were utilized for establishing the structure-property relationship based on the functionality, reactivity, and mol. structure of synthesized BEA resins, which controllers the design architecture and crosslinking d. of UV-cured specimens.

Journal of Applied Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shaaban, Heba published the artcileSimultaneous determination of bisphenol A and its analogues in foodstuff using UPLC-MS/MS and assessment of their health risk in adult population, HPLC of Formula: 80-09-1, the publication is Journal of Food Composition and Analysis (2022), 104549, database is CAplus.

Replacing bisphenol A with its analogs may represent a risk to human health because of their potential synergic effects. In this study, a fast, sensitive and reliable UPLC-MS/MS method for the identification and quantification of bisphenol A, bisphenol F, bisphenol S, D8 and pergafast in foodstuff was developed and validated. Sample preparation and clean up were carried out using ultrasonic extraction followed by solid-phase extraction on Oasis HLB cartridges. The developed method was successfully applied for simultaneous determination of the target analytes in 140 food samples from various categories (including: vegetables, dairy products, seafood products, condiments, beverages, oils & fats and others). The recovery ranged from 80.3% to 103.8% with relative standard deviations not higher than 11.5%. Limits of detection were within the range of 0.003-0.015μg kg-1 under the optimized conditions. Bisphenol A was found in the majority of food samples (83%) with the highest concentration of 110μg kg-1. Canned food contained higher concentrations of total bisphenols (23.8μg kg-1) compared to food samples packed in plastic containers (7.68μg kg-1), paper (3.53μg kg-1) or glass (1.14μg kg-1). The estimated daily intake for the detected bisphenols was also calculated (286.7 and 307.8 ng kg-1 BW day-1) for male and female adults, resp. The dietary exposure to total bisphenols through foodstuffs investigated in this study were found to be higher than the recently updated tolerable daily intake value of BPA (0.04 ng kg-1 BW day-1). Also, the calculated hazard index was found to be higher than 1, indicating that the exposure to the detected bisphenols is more likely to cause risk to consumers through the dietary intake. To the best of our knowledge, this is the first report estimating the health risk associated with dietary exposure to bisphenol A and its analogs in Saudi Arabia.

Journal of Food Composition and Analysis published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sobhi, Hamid Reza published the artcileApplication of a modified MWCNT-based d-μSPE procedure for determination of bisphenols in soft drinks, Computed Properties of 80-09-1, the publication is Food Chemistry (2022), 132644, database is CAplus and MEDLINE.

Herein, a facile dispersive micro-solid phase extraction (d-μSPE) procedure using carboxylated multi-walled carbon nanotubes modified with silver nanoparticles (Ag/MWCNTs-COOH) was successfully developed for the adsorption and subsequent determination of low levels of two well-known contaminants, namely bisphenol A and S (BPA and BPS) in water and soft drink samples. The detection and measurement of the above-mentioned compounds were performed by HPLC-UV instrument. The applied d-μSPE procedure has several advantages such as rapidity, high degree of sensitivity, precision and efficiency. A combination of polar/non-polar interactions seems to play a key role in the adsorption process. Under the optimized conditions, the calibration curves were linear over the concentration range of 1-500μg/L for the both targets. The practical limit of quantifications (LOQ) for the both analytes were determined to be 1.0μg/L. The average relative recoveries obtained from the fortified samples varied between 92 and 110% with the relative standard deviations (RSD%) of 2.9-9.5%.

Food Chemistry published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C6H5BrN4, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kovacic, Ana published the artcileDegradation of bisphenol A and S in wastewater during cold atmospheric pressure plasma treatment, Application In Synthesis of 80-09-1, the publication is Science of the Total Environment (2022), 155707, database is CAplus and MEDLINE.

Developing novel, fast and efficient ecol. benign processes for removing organic contaminants is important for the continued development of water treatment. For this reason, this study investigates the implementation of Cold Atm. pressure Plasma (CAP) generated in ambient air as an efficient tool for the removal of Bisphenol A (BPA) and Bisphenol S (BPS)-known endocrine disrupting compounds in water and wastewater, by monitoring degradation kinetics and its transformation products. The highest removal efficiencies of BPA (>98%) and BPS (>70%) were obtained after 480 s of CAP exposure. A pseudo-first-order kinetic revealed that BPA (-k_t = 4.4 – 9.0 ms^-1) degrades faster than BPS (-k_t = 0.4 – 2.4 ms^-1) and that the degradation is also time- and CAP power-dependent, while the initial concentration or matrix type had a negligible effect. This study also tentatively identified three previously reported and one novel transformation product of BPA and four novel transformation products of BPS. Their postulated structures suggested similar breakdown mechanisms, i.e., hydroxylation followed by ring cleavage. The results demonstrate that CAP technol. is an effective process for the degradation of both BPA and BPS without the need for addnl. chems., indicating that CAP is a promising technol. for water and wastewater remediation worthy of further investigation and optimization.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferreira Azevedo, L. published the artcileThe alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells, COA of Formula: C12H10O4S, the publication is Food and Chemical Toxicology (2022), 167(Suppl._1), 113266, database is CAplus and MEDLINE.

Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chems. that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat pancreatic β-cells that could impair energy homeostasis regulation. We assessed the effects on growth, proliferation, and viability of hepatocarcinoma (HepG2) and insulinoma (INS-1E) cells exposed to either BPA or BPS in a full range concentration between 0.001 and 100μM. Both the dose and duration of exposure caused a differential response on growth and viability of both cells. Effects were more pronounced on HepG2, as these cells exhibited non-linear dose-responses following exposure to xenobiotics. For INS-1E, effect was observed only at the highest concentration In addition, we profiled their intracellular state by untargeted metabolomics at 24, 48, and 72 h of exposure. This anal. revealed time- and dose-dependently mol. changes for HepG2 and INS-1E that were similar between BPA and BPS. Both increased levels of inflammatory mediators, such as metabolites pertaining to linolenic and linoleic acid metabolic pathway. In summary, this study shows that BPS also disrupts mol. functions in cells that regulate energy homeostasis, displaying similar but less pronounced responses than BPA.

Food and Chemical Toxicology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, COA of Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Olechowska, Karolina published the artcileThe effect of selected bisphenols on model erythrocyte membranes of different cholesterol content, Category: alcohols-buliding-blocks, the publication is Chemistry and Physics of Lipids (2022), 105224, database is CAplus and MEDLINE.

Bisphenols belong to the group of environmental pollutants with proven harmful impact on human red blood cells. However, the exact effect of these substances may vary depending on the lipid composition of the cell membrane, since this structure is the first barrier between the cell interior and the external environment. The aim of this work was to analyze the influence of bisphenol A (BPA), bisphenol S (BPS) and their 1:1 mixture on model human erythrocyte membranes, composed of sphingomyelin (SM), phospatidylcholine (PC) and cholesterol (Chol). Due to the postulated correlation between the content of cholesterol in biomembranes and the toxic effect of bisphenols the model systems of different sterol concentrations (10, 20 and 40 mol% of Chol) were used in the studies. In the experiments, Langmuir monolayer technique accompanied with Brewster Angle Microscopy were applied and liposome properties were investigated. The obtained findings reveal that, in the investigated range of the sterol content, the effect of BPA, namely the changes of the organization and stability of model membranes and weakening of the attractive lipid-lipid interactions, is strongly dependent on the concentration of Chol in the system. The higher the sterol content, the stronger the BPA-induced alterations in membrane properties. However taking into account the results reported previously for the system containing 33.3% of cholesterol, it seems that the relationship between the effect of BPA and the amount of Chol is not linear for higher sterol concentrations In contrast, BPS shows a much weaker influence on model erythrocyte membranes and does not act selectively on the systems studied. The effect of a mixture of BPA and BPS is intermediate between that of BPA and BPS used sep., however, the observed effects appear to be determined only by the presence of BPA in the system. Thus, the concentration of cholesterol in human erythrocyte membranes, which depends on factors such as age or health status, may play a key role in the toxic effects of BPA but not BPS.

Chemistry and Physics of Lipids published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts