Design, Synthesis, and Structure-Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity was written by Ananthan, Subramaniam;Saini, Surendra K.;Zhou, Guangyan;Hobrath, Judith V.;Padmalayam, Indira;Zhai, Ling;Bostwick, J. Robert;Antonio, Tamara;Reith, Maarten E. A.;McDowell, Shea;Cho, Eunie;McAleer, Leah;Taylor, Michelle;Luedtke, Robert R.. And the article was included in Journal of Medicinal Chemistry in 2014.Related Products of 79651-64-2 This article mentions the following:
(Aroylaminobutyl)arylpiperazines such as I were prepared as antagonists or partial agonists of the dopamine D3 receptor selective for D3 receptors over the related dopamine D2 receptors for potential use in treatment of drug addiction and schizophrenia. The calculated lipophilicities of and inhibition of dopamine D3 and D2 receptors by (aroylaminobutyl)arylpiperazines was determined, and the inhibition of mutant and chimeric D3 receptors by selected compounds and the activities of selected compounds in functional assays in human cells were determined Mol. docking calculations of the structures of selected compounds bound to dopamine D3 receptors were performed; the mol. docking studies and evaluation against a set of chimeric and mutant receptors suggest that interactions at the extracellular end of TM7 contribute to the selectivity of the ligands for dopamine D3 receptors over dopamine D2 receptors. In the experiment, the researchers used many compounds, for example, (6-Aminopyridin-2-yl)methanol (cas: 79651-64-2Related Products of 79651-64-2).
(6-Aminopyridin-2-yl)methanol (cas: 79651-64-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 79651-64-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts