Category: 78782-17-9

《Desymmetrization of C2-Symmetric Bis(Boronic Esters) by Zweifel Olefinations》 was published in Chemistry – A European Journal in 2020. These research results belong to Linne, Yannick; Schoenwald, Axel; Weissbach, Sebastian; Kalesse, Markus. Electric Literature of C13H26B2O4 The article mentions the following:

Anti-Configured 1,3-di-Me deoxypropionate motifs are important sub structures in natural products. Herein, we describe a bidirectional approach for the rapid construction of natural products featuring such motifs by using C2-sym. 1,3-bis(boronic esters). As for its application in convergent syntheses it was important to establish a selective mono-Zweifel olefination we describe the scope and limitations by using different 1,3-bis(boronic esters) and nucleophiles. This protocol takes advantage of the combination of the Hoppe-Matteson-Zweifel chem., which was elegantly put into practice by Aggarwal et al. In order to show its applicability the total syntheses of two natural products, serricornin and (+)-invictolide, were performed. The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Electric Literature of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Electric Literature of C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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Manenti, Marco; Gazzotti, Stefano; Lo Presti, Leonardo; Molteni, Giorgio; Silvani, Alessandra published an article in 2021. The article was titled 《Highly diastereoselective entry to chiral oxindole-based β-amino boronic acids and spiro derivatives》, and you may find the article in Organic & Biomolecular Chemistry.Recommanded Product: 78782-17-9 The information in the text is summarized as follows:

The first Cu-catalyzed, diastereoselective 1,2-addition of bis[(pinacolato)boryl]methane to chiral ketimines I (R = Me, allyl, Bn, triphenylmethyl; R1 = H, Br, CF3; R2 = H, OMe, Cl; R3 = H, Me; R4 = H, Cl) for the synthesis of quaternary stereocenters II (R5 = dihydroxyboranyl, tetramethyl-1,3,2-dioxaborolan-2-yl) and spiro compds III and IV (X = O, NH) was described here. The method provides easy access to a range of chiral, highly functionalized compounds, namely oxindole-based β,β’-disubstituted β-amino boronates V, boron-containing peptidomimetics VI and six-, seven-membered spirocyclic hemiboronic esters III and IV. Such unprecedented compounds are mostly obtained in high yields and easily isolated as single diastereoisomers, paving the way to a more intense exploitation of boron-containing compounds in diversity-oriented chem. and drug-discovery programs. Concerning stereochem., the application of Ellman’s auxiliary strategy allows in principle to access both steric series of target compounds The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.Recommanded Product: 78782-17-9

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The author of 《Chemoselective Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of (Diborylmethyl)silanes with Alkenyl Bromides》 were Kim, Junghoon; Lee, Eunsung; Cho, Seung Hwan. And the article was published in Asian Journal of Organic Chemistry in 2019. Name: Bis[(pinacolato)boryl]methane The author mentioned the following in the article:

Herein, the authors report the development of a Pd-catalyzed chemoselective cross-coupling of (diborylmethyl)silanes with alkenyl bromides. The reaction shows broad scope with respect to alkenyl bromides and (diborylmethyl)silanes, affording a range of α-silyl-substituted allylic boronate esters in good-to-excellent yields. The practicality of the developed coupling reaction is demonstrated by the gram-scale synthesis of α-silyl-substituted allylic boronate ester. The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Name: Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Name: Bis[(pinacolato)boryl]methane

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In 2017,Liu, Xun; Deaton, T. Maxwell; Haeffner, Fredrik; Morken, James P. published 《A Boron Alkylidene-Alkene Cycloaddition Reaction: Application to the Synthesis of Aphanamal》.Angewandte Chemie, International Edition published the findings.Application In Synthesis of Bis[(pinacolato)boryl]methane The information in the text is summarized as follows:

The authors describe an unusual net [2+2] cycloaddition reaction between B alkylidenes and unactivated alkenes. This reaction provides a new method for the construction of carbocyclic ring systems bearing versatile organoboronic esters. Aside from surveying the scope of this reaction, the authors provide details about the mechanistic underpinnings of this process, and examine its application to the synthesis of the natural product aphanamal. In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Application In Synthesis of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.Application In Synthesis of Bis[(pinacolato)boryl]methane

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In 2017,Wang, Lu; Zhang, Tao; Sun, Wei; He, Zeyu; Xia, Chungu; Lan, Yu; Liu, Chao published 《O Functionalization of α-Oxyboronates: A Deoxygenative gem-Diborylation and gem-Silylborylation of Aldehydes and Ketones》.Journal of the American Chemical Society published the findings.COA of Formula: C13H26B2O4 The information in the text is summarized as follows:

A deoxygenative gem-diborylation and gem-silylborylation of aldehydes and ketones is described. The key for the success of this transformation is the base-promoted C-O bond borylation or silylation of the generated α-oxyboronates. Exptl. and theor. studies exhibit that the C-O bond functionalization proceeds via an intramol. five-membered transition-state, boryl migration followed by a 1,2-metalate rearrangement with OBpin as a leaving group. The transformation occurs with an inversion on the C center. Direct conversion of aldehydes and ketones to gem-diboron compounds was achieved by combining Cu catalysis with this base-promoted C-OBpin borylation. Various aldehydes and ketones were deoxygenatively gem-diborylated. Gem-Silylborylation of aldehydes and ketones were achieved by a stepwise operation, in which B2pin2 initially react with those carbonyls followed by a silylation with Bpin-SiMe2Ph. In addition to this study using Bis[(pinacolato)boryl]methane, there are many other studies that have used Bis[(pinacolato)boryl]methane(cas: 78782-17-9COA of Formula: C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.COA of Formula: C13H26B2O4

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The author of 《Efficient and Selective Methane Borylation Through Pore Size Tuning of Hybrid Porous Organic Polymer Based Iridium Catalysts》 were Chen, Qi; Dong, Anwang; Wang, Dongxu; Qiu, Lu; Ma, Chunxin; Yuan, Yihui; Zhao, Yunpeng; Jia, Na; Guo, Zhanhu; Wang, Ning. And the article was published in Angewandte Chemie, International Edition in 2019. Recommanded Product: Bis[(pinacolato)boryl]methane The author mentioned the following in the article:

As a new energy source that could replace petroleum, the global reserves of methane hydrate (combustible ice) are estimated to be approx. 20 000 trillion cubic meters. A large amount of methane hydrate has been found under the seabed, but the transportation and storage of methane gas far from coastlines are tech. unfeasible and expensive. The direct conversion of methane into value-added chems. and liquid fuels is highly desirable but remains challenging. Herein, we prepare a series of iridium complexes based on porous polycarbazoles with high specific areas and good thermochem. stabilities. Through structure tuning we optimized their catalytic activities for the selective monoborylation of methane. One of these catalysts (CAL-3-Ir) can produce Me boronic acid pinacol ester (CH3Bpin) in 29% yield in 9 h with a turnover frequency (TOF) of approx. 14 h-1. Because its pore sizes favor monoborylated products, it has a high chemoselectivity for monoborylation (CH3Bpin:CH2(Bpin)2=16:1). The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Recommanded Product: Bis[(pinacolato)boryl]methane Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

Referemce:
Alcohol – Wikipedia,
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《Synthesis of 1,3-Bis-(boryl)alkanes through Boronic Ester Induced Consecutive Double 1,2-Migration》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to You, Cai; Studer, Armido. HPLC of Formula: 78782-17-9 The article mentions the following:

A general and efficient approach for the preparation of 1,3-bis(boryl)alkanes is introduced. It is shown that readily generated vinylboron ate complexes react with com. available ICH2Bpin to valuable 1,3-bis-(boryl)alkanes. The introduced transformation, which is exptl. easy to conduct, shows broad substrate scope and high functional-group tolerance. Mechanistic studies reveal that the reaction does not proceed via radical intermediates. Instead, an unprecedented boronic ester induced sequential bis-1,2-migration cascade is suggested. The results came from multiple reactions, including the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9HPLC of Formula: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.HPLC of Formula: 78782-17-9

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Guo, Lin; Dutton, Oliver J.; Kucukdisli, Murat; Davy, Matthew; Wagnieres, Olivier; Butts, Craig P.; Myers, Eddie L.; Aggarwal, Varinder K. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains》.Synthetic Route of C13H26B2O4 The article contains the following contents:

Conformationally controlled flexible mols. are ideal for applications in medicine and materials, where shape matters but an ability to adapt to multiple and changing environments is often required. The conformation of flexible hydrocarbon chains bearing contiguous Me substituents is controlled through the avoidance of syn-pentane interactions: alternating syn-anti isomers adopt a linear conformation while all-syn isomers adopt a helical conformation. From a simple diamond lattice anal., larger substituents, which would be required for most potential applications, result in significant and unavoidable syn-pentane interactions, suggesting substantially reduced conformational control. Through a combination of computation, synthesis, and NMR anal., we have identified a selection of substitution patterns that allow large groups to be incorporated on conformationally controlled linear and helical hydrocarbon chains. Surprisingly, when the Me substituents of alternating syn-anti hydrocarbons are replaced with acetoxyethyl groups, the main chain of almost 95% of the population of mols. adopt a linear conformation. Here, the side chains adopt nonideal eclipsed conformations with the main chain, thus minimizing syn-pentane interactions. In the case of all-syn hydrocarbons, concurrent removal of some Me groups on the main chain adjacent to the large substituents is required to maintain a high population of mols. adopting a helical conformation. This information can now be used to design flexible hydrocarbon chains displaying functional groups in a defined relative orientation for multivalent binding or cooperative reactivity, for example, in targeting the interfaces defined by disease-relevant protein-protein interactions. The results came from multiple reactions, including the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Synthetic Route of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Synthetic Route of C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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Alcohol – Wikipedia,
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《Boron-Promoted Ether Interchange Reaction: Synthesis of Alkyl Nitroaromatic Ethers from Methoxynitroarenes》 was written by Liu, Zhenwei; Luan, Nannan; Lu, Hongtao; Liang, Apeng; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng. SDS of cas: 78782-17-9 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

In the presence of either bis(pinacolatoboryl)methane or Ph pinacolboronate, aryl ethers such as 2-nitroanisole underwent ether exchange reactions with alcs. ROH (R = t-Bu, EtCMe2, i-Pr, s-Bu, i-Bu, n-Pr, Bu, BuCH2, H2C:CHCH2, H2C:CMeCH2, cyclopropylmethyl, 2-tetrahydrofurfuryl, 4-tetrahydropyranmethyl, MeOCH2CH2OCH2CH2, H2C:CHCH2OCH2CH2) mediated by KOt-Bu at 90° to yield nitroaryl ethers such as 2-O2NC6H4OR (R = t-Bu, EtCMe2, i-Pr, s-Bu, i-Bu, n-Pr, Bu, BuCH2, H2C:CHCH2, H2C:CMeCH2, cyclopropylmethyl, 2-tetrahydrofurfuryl, 4-tetrahydropyranmethyl, MeOCH2CH2OCH2CH2, H2C:CHCH2OCH2CH2). In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9SDS of cas: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.SDS of cas: 78782-17-9

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《Stereodivergent Asymmetric Synthesis of α,β-Disubstituted β-Aminoalkylboronic Acid Derivatives via Group-Selective Protodeboronation Enabling Access to the Elusive Anti Isomer》 was published in Journal of the American Chemical Society in 2020. These research results belong to Li, Xiangyu; Hall, Dennis G.. Quality Control of Bis[(pinacolato)boryl]methane The article mentions the following:

Chiral β-aminoalkylboronates generate growing interest as versatile synthetic building blocks to access β-aminoalcs. and other useful compounds, and also as bioisosteres of β-amino acids in drug discovery. In this study, the lack of methodol. to access both syn and anti diastereomers of optically enriched, acyclic α,β-disubstituted β-aminoalkylboronates is addressed with the development of a divergent, diastereoselective strategy for the monoprotodeboration of β-amino gem-bis(boronate) precursors. To this end, new reaction conditions were successfully optimized to provide the elusive anti diastereomer by inverting a sequence of desulfinylation and protodeboronation. The desired syn or anti isomers are isolated independently in good yields and excellent diastereoselectivity (up to >20:1 dr) for a wide scope of substituents. The diastereotopic group selectivity of the new conditions yielding the anti isomer is rationalized by invoking a reactive rotamer featuring two ammonium-boronate hydrogen bonds, which enables phosphate coordination to boron with a concomitant, stereoretentive protonation of the C-B bond. The accessibility and utility of both diastereomers of these α,β-disubstituted β-aminoalkylboronates is exemplified with the functionalization of the amino group, stereospecific oxidation to β-amino alcs. and C-C bond transformations of the secondary alkylboronate, and the preparation of free boronic acids and hemiboronic heterocycles. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Quality Control of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Quality Control of Bis[(pinacolato)boryl]methane Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

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